RESUMO
Malnutrition in children with chronic cholestasis is a prevalent issue and a major risk factor for adverse outcomes. Fat soluble vitamin (FSV) deficiency is an integral feature of cholestatic disease in children, often occurring within the first months of life in those with neonatal cholestasis and malnutrition. This review focuses on FSVs in cholestasis, with particular emphasis on a practical approach to surveillance and supplementation that includes approaches that account for differing local resources. The overarching strategy suggested is to incorporate recognition of FSV deficiencies in cholestatic children in order to develop practical plans for close monitoring and aggressive FSV repletion. Routine attention to FSV assessment and supplementation in cholestatic infants will reduce long periods of inadequate levels and subsequent adverse clinical sequalae.
Assuntos
Colestase , Hepatopatias , Criança , Colestase/complicações , Suplementos Nutricionais , Humanos , Lactente , Recém-Nascido , Hepatopatias/complicações , Vitaminas/uso terapêuticoAssuntos
Comitês Consultivos , Pesquisa Translacional Biomédica , Comitês Consultivos/organização & administração , Pesquisa Biomédica/economia , Pesquisa Biomédica/organização & administração , Comportamento Cooperativo , Docentes de Medicina , Humanos , Modelos Organizacionais , Ohio , Apoio à Pesquisa como Assunto , Pesquisa Translacional Biomédica/economia , Pesquisa Translacional Biomédica/organização & administraçãoRESUMO
OBJECTIVES: : In 2001, the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition created Teaching and Tomorrow, a novel pediatric subspecialty recruitment program to provide prospective fellows the opportunity to participate in the society's annual meeting and to interact with current trainees and members. The aims of this report are to describe participant survey data from the first 4 years of the program and to explore potential influences of participation on outcomes and proposed career choices. MATERIALS AND METHODS: : Pre- and postprogram surveys were administered during opening and closing breakfast meetings, respectively, to ascertain demographics, certainty of career intent, factors influencing choice of specialty, and anticipated benefits from participation. RESULTS: : Among 189 applications, 107 (57%) participated and 107 (57%) matriculated into gastroenterology(GI) fellowship. The matriculation rate was similar between participants and nonparticipants. Among applicants who became GI fellows, there was a 42% lower odds of being female than male (OR 0.42; chi = 8.48, P < 0.01). Among participants who completed both pre- and postprogram surveys (n = 91) and who reported certainty about entering GI both before and after, 79% entered GI fellowship. Among participants who reported uncertainty about entering GI both before and after, 8% entered GI. More participants were interested in jobs as clinician-investigators and funded clinical or translational investigators. CONCLUSIONS: : In a selected population of pediatric residents with high interest in pediatric gastroenterology, there was no difference in the matriculation rate into pediatric GI fellowship training among those who participated compared with those who did not. However, those who eventually matriculated had a higher odds of being male than female. There was a high retention rate of participants who were initially certain and a modest conversion rate of those who were initially uncertain about pursuing a career in pediatric GI.