Gender differences in the assessment and treatment of myocardial infarction. / Kjønnsforskjeller i utredning og behandling av hjerteinfarkt.

BACKGROUND: Previous studies have shown that there are gender-related differences in the assessment and treatment of myocardial infarction, despite international guidelines that prescribe identical treatment for women and men. We investigated whether these differences occurred in Norway. MATERIAL AND METHOD: All patients admitted to Norwegian hospitals with myocardial infarction from 1 January 2013 to 31 December 2014 and registered in the Norwegian Myocardial Infarction Registry were included. Data from the registry were used to analyse differences in the assessment, treatment, complications and survival of women and men in different age groups. RESULTS: A total of 26 447 myocardial infarctions were registered in the Norwegian Myocardial Infarction Registry in the period 2013 ­ 2014. Fewer women than men were assessed by means of coronary angiography. Percutaneous coronary intervention (PCI) was used to virtually the same extent for both genders if coronary stenosis was found. Women were recommended secondary prophylactic medication to a lesser extent than men. There were no major differences between men and women in the incidence of complications in the course following myocardial infarction or in survival. INTERPRETATION: Fewer women than men suffering acute myocardial infarction were assessed by means of coronary angiography, and women were recommended secondary prophylactic medication less often than men. The reason for the gender differences is not known, but comorbidity and a potentially greater risk of adverse reactions in women may be contributory factors. The different views of doctors providing treatment may also play a part.

Longitudinal assessment of atrioventricular annulus excursion by grey-scale m-mode and colour tissue Doppler imaging in premature infants.

BACKGROUND: There is a lack of standardized echocardiographic parameters to quantify ventricular function in newborn infants. Long-axis systolic ventricular shortening is a useful parameter of global ventricular function. AIMS: Serial assessment of long-axis systolic atrioventricular annulus excursion in premature infants. METHODS: Two-centre, prospective observational study. Fifty-seven premature infants (26 girls), median (range) gestational age 33(+5) (31(0)-34(+6)) weeks(+days), birth weight 1925 (1127-2836) grams were included. Echocardiographic examinations were performed at the first three days of life and at expected term. OUTCOME MEASURES: Systolic annulus excursion by grey-scale m-mode and colour tissue Doppler imaging (cTDI). RESULTS: A consistent longitudinal pattern was found for annulus excursion by grey-scale m-mode and cTDI. All parameters showed a pronounced increase at expected term (p < 0.001). After normalizing for ventricular size the increase at term was less pronounced. Results were lower by cTDI than by grey-scale m-mode for the left and right ventricular walls (p < 0.001). Intraobserver variability (range 1.5-9.8%) was lower than interobserver variability (5.5-18%). CONCLUSIONS: Serial assessment of longitudinal ventricular shortening in premature infants by grey-scale m-mode and cTDI was feasible and the measurements displayed a consistent pattern. cTDI excursion measurements were lower and more dependent on image quality than m-mode measurements. Lower intraobserver variability suggests that repeated measurements should preferably be performed by the same observer. Annulus excursion varies with ventricular size and we suggest normalizing measurements by ventricular size.

Myocardial infarction: psychosocial aspects, gender differences and impact on pre-hospital delay.

AIM: This paper is a report of a study to explore gender differences in psychosocial aspects in the year prior to first-time myocardial infarction, and the association between these aspects and pre-hospital delay. BACKGROUND: The time from symptom onset to hospital admission is critical for patient survival; therefore influences on pre-hospital delay are of interest. The prevalence of stressful psychosocial factors is higher among patients before acute myocardial infarction than among healthy controls. METHOD: Patients diagnosed with first-time acute myocardial infarction were recruited from five Norwegian hospitals over a 13-month period in 2003-2004. Of 738 eligible patients, 149 women and 384 men completed a self-administered questionnaire (response rate 72%). FINDINGS: Depression, high family stress, high work stress and major life events had no statistically significant impact on patient delay or total pre-hospital delay. Depression, sleep disturbances and high family stress were reported among more women than men in the year prior to the event. Women and men aged 65 years and younger were more likely to report major depression and major life events than those older than 65. Low education and low partner education predicted prolonged patient delay in men but not in women. Low partner education also predicted prolonged total pre-hospital delay in men. CONCLUSION: The process between symptom onset and hospital admittance is complex, and more knowledge about factors influencing this process is vital to reduce pre-hospital delay. Significant others should be included in information-giving in relation to myocardial infarction as they seem to play a vital role in patients' decision-making processes.