[Reliability and validity of SF-36 scale for evaluating the quality of life of Tuva adults in the Xinjiang Uygur Autonomous Region].

OBJECTIVE: To assess the reliability and validity of SF-36 scale in measuring quality of life of Tuva adults in Xinjiang Uygur Autonomous Region. METHODS: A total of 437 Tuva adults were selected by multistage sampling method, in Tuva families lived in Baihaba Village Habahe county and Kanasi and Hemu Villages Buerjin County in Artay Xinjiang Uygur Autonomous Region in 2016, including 100 males and 50 females, the three age groups 18-29, 30-49, 50 and above accounted for 30. 66%, 54. 00% and 15. 33% respectively. SF-36 scale was be used to measure the quality of life. The scale's reliability was assessed by internal consistency reliability and half-fold reliability, and the validity was assessed by set validity, discriminate validity and structural validity. RESULTS: The Cronbach's α coefficient of the SF-36 scale was 0. 838, and all of the Cronbach's α coefficients were more than 0. 750 after corresponding dimensions were deleted. The Spearman-Brown coefficient was 0. 828. The achievement ratio of aggregation tests and discrimination tests were 100% and 99. 59%, respectively. Thirty-five items were included in EFA. Seven common factors were extracted through maximum balanced rotation method, and the cumulative contribution rate was 68. 97%. Eight-dimensional data were included in EFA, and two common factors were extracted with a cumulative contribution rate of 66. 44%. The fitting degree of confirmatory factor analysis model is invalid. CONCLUSION: SF-36 has showed a good reliability, set validity and discrimination validity in evaluating the quality of life of Tuva adults in Xinjiang, but its structural validity needs to be improved.

Updated hypertension prevalence, awareness, and control rates based on the 2017ACC/AHA high blood pressure guideline.

In 2017, the American College of Cardiology/American Heart Association (ACC/AHA) updated the Guideline of Prevention, Detection, Evaluation and Management and Management of High Blood Pressure (HBP) in Adults. The purpose of the current study was to evaluate the potential impact of the 2017ACC/AHA HBP guideline on hypertension prevalence, awareness, and control rates. The data were collected from Physical Examination Center of the Second Hospital of Hebei Medical University from January 2012 to December 2017 (N = 66 977), including demographic information and risk factors of hypertension. The hypertension prevalence, awareness, and control rates of people were evaluated according to the new guideline. Additionally, the factors related to hypertension prevalence were also assessed. According to previous HBP guideline, hypertension prevalence, awareness, and control rate were 30.54%, 44.33%, and 13.04%, respectively. However, when the 2017 ACC/AHA HBP guideline was introduced, the population with hypertension increased from 20 453 to 34 460, the hypertension prevalence rate increased from 30.54% to 51.45%, the awareness rate decreased from 44.33% to 26.31%, and the control rate declined from 13.04% to 2.72%. The most newly diagnosed hypertension patients were from the low-risk population with young age and without the above histories. The 2017ACC/AHA HBP guideline indicated that high hypertension prevalence rate still existed with a substantial increase, while the awareness and control rates were relatively lowered.

Comparative Assessment of the Bioremedial Potentials of Potato Resistant Starch-Based Microencapsulated and Non-encapsulated Lactobacillus plantarum to Alleviate the Effects of Chronic Lead Toxicity.

Lead (Pb) is a well-recognized and potent heavy metal with non-biodegradable nature and can induce the oxidative stress, degenerative damages in tissues, and neural disorders. Certain lactic acid bacterial strains retain the potential to mitigate the lethal effects of Pb. The present work was carried out to assess the Pb bio-sorption and tolerance capabilities of Lactobacillus plantarum spp. Furthermore, potato resistant starch (PRS)-based microencapsulated and non-encapsulated L. plantarum KLDS 1.0344 was utilized for bioremediation against induced chronic Pb toxicity in mice. The experimental mice were divided into two main groups (Pb exposed and non-Pb exposed) and, each group was subsequently divided into three sub groups. The Pb exposed group was exposed to 100 mg/L Pb(NO3)2 via drinking water, and non-Pb exposed group was supplied with plain drinking water during 7 weeks prolonged in vivo study. The accumulation of Pb in blood, feces, renal, and hepatic tissues and its pathological damages were analyzed. The effect of Pb toxicity on the antioxidant enzyme capabilities in blood, serum, as well as, on levels of essential elements in tissues was also calculated. Moreover, KLDS 1.0344 displayed remarkable Pb binding capacity 72.34% and Pb tolerance (680 mg/L). Oral administration of both non- and PRS- encapsulated KLDS 1.0344 significantly provided protection against induced chronic Pb toxicity by increasing fecal Pb levels (445.65 ± 22.28 µg/g) and decreasing Pb in the blood up to 137.63 ± 2.43 µg/L, respectively. KLDS 1.0344 microencapsulated with PRS also relieved the renal and hepatic pathological damages and improved the antioxidant index by inhibiting changes in concentrations of glutathione peroxidase, glutathione, superoxide dismutase, malondialdehyde, and activated oxygen species, which were affected by the Pb exposure. Overall, our results suggested that L. plantarum KLDS 1.0344 either in free or encapsulated forms hold the potentiality to deliver a dietetic stratagem against Pb lethality.