Regional differences, dynamic evolution, and spatial spillover effects of carbon emission intensity in urban agglomerations.

Taking three major urban agglomerations in China as examples, this paper uses the Dagum Gini coefficient and its decomposition method, a Kernel density estimation method, and Markov chain and spatial Markov chain to study the regional differences, dynamic evolution characteristics, and spatial spillover effects of carbon emission intensity (CEI) of urban agglomerations, and accordingly, it proposes differentiated emission reduction and carbon reduction policies. The following results were obtained: (1) The overall CEI of the three major urban agglomerations and each individual urban agglomeration were found to have declined significantly over time, with an overall spatial pattern of "high in the north and low in the south," with inter-group differences being the main source of the overall differences. (2) The imbalance in CEI between cities was more obvious within the Beijing-Tianjin-Hebei (BTH) urban agglomeration, while the synergistic emission reduction effect of the Yangtze River Delta (YRD) and Pearl River Delta (PRD) urban agglomerations increased over the study period. (3) The probability of a city maintaining a stable level of CEI was much higher than the probability of a state shift, and there was a spatial spillover effect of carbon emissions between neighboring cities. This study can provide theoretical support for the global response to greenhouse gas emissions, promoting green development and carbon reduction in various countries and urban agglomerations and providing a quantitative basis for the formulation of relevant policies.

Clarithromycin versus furazolidone for naïve Helicobacter pylori infected patients in a high clarithromycin resistance area.

BACKGROUND AND AIM: The increase in antibiotic resistance makes the eradication of Helicobacter pylori more difficult. Considering the limitations of the application of susceptibility-guided therapy, it is important to find an effective empirical regimen. The aim of the study is to compare the efficacy, safety, and cost-effectiveness of clarithromycin-based bismuth-containing quadruple therapy (C-BQT) and furazolidone-based bismuth-containing quadruple therapy (F-BQT) in naïve H. pylori positive patients. METHODS: This was an open-label, randomized controlled, crossover trial. The trial comprised two phases. In C-F group, patients received C-BQT in the first phase; those who were still positive for H. pylori infection after the first phase entered the second phase to receive F-BQT as rescue treatment. In F-C group, patients were treated with F-BQT firstly and rescued with C-BQT. RESULTS: As first-line treatments, the eradication rates of C-BQT and F-BQT were 89.7% (157/175) and 92.0% (161/175) (P = 0.458) in intention-to-treat analysis and 93.4% (156/167) and 95.8% (161/168) (P = 0.327) in per-protocol analysis, respectively. The cumulative eradication rates of the C-F group and the F-C group were both 94.3% in intention-to-treat analysis (P = 1.000). Cost-effectiveness indexes of F-BQT and C-BQT were 0.54 and 1.24 in first-line treatments. Frequencies of adverse events in F-BQT and C-BQT had no differences (36.0% in C-BQT vs 32.6% in F-BQT, P = 0.499). CONCLUSIONS: Furazolidone-based bismuth-containing quadruple therapy should be preferred for its excellent cost-effectiveness and acceptable safety.

Susceptibility-guided quadruple therapy is not superior to medication history-guided therapy for the rescue treatment of Helicobacter pylori infection: A randomized controlled trial.

OBJECTIVE: In this study we aimed to compare the efficacy and safety of two personalized rescue therapies for Helicobacter pylori infection. METHODS: An open-label, single-center, randomized controlled trial was conducted. Patients who had failed one or two regimens for H. pylori infection were randomized to receive a 14-day bismuth-containing quadruple therapy guided by antimicrobial susceptibility testing (AST) or personal medication history (PMH). In the AST group, either two of amoxicillin, clarithromycin, metronidazole or levofloxacin were prescribed according to the AST. In the PMH group, amoxicillin plus either levofloxacin or furazolidone were prescribed based on the patient's history of quinolone use. The primary outcomes were eradication rates confirmed by an urea breath test 6 weeks after treatment. The secondary outcomes were adherence, incidence of adverse events (AE) and cost-effectiveness. RESULTS: Altogether 164 with a positive culture received AST-guided therapy and 192 received PMH-guided therapy, respectively. Both AST- and PMH-guided therapies achieved comparable eradication rate (intention-to-treat analysis: 78.10% vs 74.29%, P = 0.42; per-protocol analysis: 87.10% vs 88.64%, P = 0.80). The AST clarithromycin regimen had a lower per-protocol eradication rate than the levofloxacin (75.47% vs 96.30%, P = 0.03) or furazolidone-containing regimen (75.47% vs 92.75%, P = 0.02). Both groups had high compliance with low incidences of AE, and PMH-guided therapy had a lower medical cost. CONCLUSIONS: AST-guided therapy was not superior to PMH-guided therapy as a second- or third-line treatment for H. pylori infection. Considering the cost-effectiveness, PMH therapy is clinically more favorable.

A Dynamic Health Assessment Approach for Shearer Based on Artificial Immune Algorithm.

In order to accurately identify the dynamic health of shearer, reducing operating trouble and production accident of shearer and improving coal production efficiency further, a dynamic health assessment approach for shearer based on artificial immune algorithm was proposed. The key technologies such as system framework, selecting the indicators for shearer dynamic health assessment, and health assessment model were provided, and the flowchart of the proposed approach was designed. A simulation example, with an accuracy of 96%, based on the collected data from industrial production scene was provided. Furthermore, the comparison demonstrated that the proposed method exhibited higher classification accuracy than the classifiers based on back propagation-neural network (BP-NN) and support vector machine (SVM) methods. Finally, the proposed approach was applied in an engineering problem of shearer dynamic health assessment. The industrial application results showed that the paper research achievements could be used combining with shearer automation control system in fully mechanized coal face. The simulation and the application results indicated that the proposed method was feasible and outperforming others.

[Spatiotemporal dynamics of maize water suitability and assessment of agricultural drought in Liaoning Province, China from 1981 to 2010].

Maize water suitability (MWS) model was developed at growth stage scale. Frequency and severity of drought were evaluated by combining MWS estimates and agricultural meteorological drought indexes. The MWS at each growth stage was calculated by using maize observational data and conventional meteorological data at 52 sites in Liaoning during the period from 1981 to 2010. Based on the climatic trend and abrupt change analysis, spatiotemporal dynamics of MWS were investigated. Meanwhile, occurrence of agricultural drought and its severity were also estimated. The results showed that the variation of MWS largely differed at different growth stages. Climatic abrupt change happened in 1994, 1996 and 1999 at the stages of emergence to seven leaves (II), jointing to tasseling (IV) and physiological maturity to maturity (VI). During the past 30 years, MWS showed an obvious increasing trend at the stages of sowing to emergence(I) , seven leaves to jointing(III), IV and tasseling to physiological maturity(V), while it showed a decreasing trend at the stages of II and VI, and that at VI stage was statistically significant. In addition, the climatic trend of MWS showed apparently spatial variability. The frequencies of drought at different severities varied with maize growth stages. Areas of high variability of MWS were located in the Northwest and South of Liaoning at the stages of I , II , III and VI, where were also the regions of high frequency of mid- and severe-drought. At the stages of IV and V, the frequency of drought was low and only light- and mid-drought occurred in few areas. In conclusion, the regional mean MWS could be capable to reasonably assess the agricultural drought in Liaoning at the regional scale.