Modeling risk of occupational zoonotic influenza infection in swine workers.

Zoonotic transmission of influenza A virus (IAV) between swine and workers in swine production facilities may play a role in the emergence of novel influenza strains with pandemic potential. Guidelines to prevent transmission of influenza to swine workers have been developed but there is a need for evidence-based decision-making about protective measures such as respiratory protection. A mathematical model was applied to estimate the risk of occupational IAV exposure to swine workers by contact and airborne transmission, and to evaluate the use of respirators to reduce transmission. The Markov model was used to simulate the transport and exposure of workers to IAV in a swine facility. A dose-response function was used to estimate the risk of infection. This approach is similar to methods previously used to estimate the risk of infection in human health care settings. This study uses concentration of virus in air from field measurements collected during outbreaks of influenza in commercial swine facilities, and analyzed by polymerase chain reaction. It was found that spending 25 min working in a barn during an influenza outbreak in a swine herd could be sufficient to cause zoonotic infection in a worker. However, this risk estimate was sensitive to estimates of viral infectivity to humans. Wearing an excellent fitting N95 respirator reduced this risk, but with high aerosol levels the predicted risk of infection remained high under certain assumptions. The results of this analysis indicate that under the conditions studied, swine workers are at risk of zoonotic influenza infection. The use of an N95 respirator could reduce such risk. These findings have implications for risk assessment and preventive programs targeting swine workers. The exact level of risk remains uncertain, since our model may have overestimated the viability or infectivity of IAV. Additionally, the potential for partial immunity in swine workers associated with repeated low-dose exposures or from previous infection with other influenza strains was not considered. Further studies should explore these uncertainties.

The contributions of strategy use to working memory span: a comparison of strategy assessment methods.

In two experiments, we tested whether individual differences in strategy production account for individual differences in performance on a working memory span task. We measured the strategies used during a standard experimenter-paced operation span (OSPAN) task by having participants make both set-by-set reports of strategy use for individual item sets and global reports of strategy use. In Experiment 1, although normatively effective strategies were self-reported on only a small proportion of OSPAN sets, individual differences in effective strategy use correlated with span performance. Experiment 2 replicated this outcome using a sample of 100 participants but, as important, it demonstrated that individual differences in effective strategy use did not mediate the relationship between OSPAN and measures of verbal ability. Discussion focuses on the interpretation of strategy-span relationships and the relative utility of general reports of strategy use versus the set-by-set reports introduced here for the OSPAN task.