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1.
Poult Sci ; 101(12): 102194, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36274436

RESUMO

For many producers, introduction of improved animal welfare systems is a turning point in their future production strategies as it increases production costs. The increase in egg retail prices is of growing concern not only for producers, but also for retailers and consumers. However, no report has calculated the estimated production costs or retail prices associated with introducing practices that support improved animal welfare in poultry farms in Japan. Therefore, this study aimed to estimate the production costs and table egg prices of 6 types of laying hen systems: conventional cage (CC): 8- and 12-tiers (CC8, CC12), enriched cage (EC): 8- and 12-tiers (EC8, EC12), aviary (AV), and barn systems (BR). Production costs include land purchases, construction costs of facilities, equipment and machinery, quantity of feed provided, farming materials invested, and wages. As a result, farm gate prices were estimated as CC8 = 12.19, CC12 = 12.19, EC8 = 14.52, EC12 = 14.52, AV = 21.14, and BR = 28.74 [yen/egg], and the production cost, including building the new farm, increased by EC8 = 19.1%, EC12 = 19.1%, AV = 73.4%, and BR = 135.7%, respectively, referring to the value of CC. The results show that the prices increase in systems between CC and BN. The retail price or table egg price was estimated to be CC8 = 24.68, CC12 = 24.68, EC8 = 28.07, EC12 = 28.07, AV = 37.27, and BR = 48.53 [yen/egg]. The retail price of BR is approximately twice that of CC. In addition, assuming that all of Japan's eggs were produced in the BR system, the soaring cost of eggs would likely affect the prices of factory eggs, such as liquid eggs and other products, thus affecting the prices of various food products. Understanding the significant management costs that affect the retail price of eggs would facilitate improved policies and practical approaches to support poultry farms and sustainable farming activities while addressing public concerns.


Assuntos
Criação de Animais Domésticos , Abrigo para Animais , Animais , Feminino , Criação de Animais Domésticos/métodos , Galinhas , Aves Domésticas , Japão , Óvulo
2.
J Dent Res ; 99(12): 1356-1362, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32735476

RESUMO

Despite their prevalence and burdens, oral diseases are neglected in universal health coverage. In Japan, a 30% copayment (out of pocket) by the user and a 70% contribution by Japan's universal health insurance (JUHI) are required for dental and medical services. From the age of 70 y, an additional 10% is offered by JUHI (copayment, 20%; JUHI, 80%). This study aimed to investigate the effect of cost on dental service use among older adults under the current JUHI system. A regression discontinuity quasi-experimental method was used to investigate the causal effect of the JUHI discount policy on dental visits based on cross-sectional data. Data were derived from the 2016 Japan Gerontological Evaluation Study. This analysis contained 7,161 participants who used JUHI, were aged 68 to 73 y, and responded to questions regarding past dental visits. Analyses were controlled for age, sex, number of teeth, and equalized household income. Mean ± SD age was 72.1 ± 0.79 y for the discount-eligible group and 68.9 ± 0.78 y for the noneligible group. During the past 12 mo, significantly more discount-eligible participants had visited dental services than noneligible participants (66.0% vs. 62.1% for treatment visits, 57.7% vs. 53.1% for checkups). After controlling for covariates, the effect of discount eligibility was significant on dental treatment visits (odds ratio [OR], 1.36; 95% CI, 1.32 to 1.40) and dental checkups (OR, 1.49; 95% CI, 1.44 to 1.54) in the regression discontinuity analysis. Similar findings were observed in triangular kernel-weighted models (OR, 1.38 [95% CI, 1.34 to 1.44]; OR, 1.52 [95% CI, 1.47 to 1.56], respectively). JUHI copayment discount policy increases oral health service utilization among older Japanese. The price elasticity for dental checkup visits appears to be higher than for dental treatment visits. Hence, reforming the universal health coverage system to improve the affordability of relatively inexpensive preventive care could increase dental service utilization in Japan.


Assuntos
Cobertura Universal do Seguro de Saúde , Idoso , Estudos Transversais , Humanos , Japão , Análise de Regressão
4.
Nihon Geka Gakkai Zasshi ; 103(3): 314-7, 2002 Mar.
Artigo em Japonês | MEDLINE | ID: mdl-11968764

RESUMO

Due to an increase in the number of medical accidents and medical conflicts, the administration of medical safety has recently introduced the following measures to cope with this situation; the process and the structure (reason) of error is analyzed based upon evidential facts, the origin of the errors is analyzed mainly in terms of teamwork and specialized medicine and structures rather than in terms of the ability of the individual, and the strategy against medical errors has been converted from aspects of management to prevention. The comprehensive strategy pursued now covers the field of social medical systems in addition to medical institutions. However, the judicial decisions in 90% of medical conflicts ruled that these were caused by the lack of knowledge and skills of the medical doctor, and a survey performed by the Japan Medical Association based on medical insurance research has reported incidences of repeated medical errors by the same physician. This has led to some criticism from the victim's viewpoint that insufficient administration of medical quality result in increased numbers of accidents which are due to repeated medical errors, under "legal" medical practice by "incompetent" doctors who should have been systematically reeducated or dismissed. In recent years, several societies and research groups of the Ministry of Health, Labour and Welfare have constructed medical guidelines based on evidence-based medicine techniques. The introduction of the clinical pathway offers the medical team access to information, directed to the appropriate roles, which may be helpful in performing constant safety checks. This medical check method that involves the patient's input will also contribute to the prevention of medical errors and promotion of safety.


Assuntos
Cirurgia Geral , Gestão da Segurança , Procedimentos Clínicos , Medicina Baseada em Evidências , Humanos , Consentimento Livre e Esclarecido , Erros Médicos/prevenção & controle , Encaminhamento e Consulta , Gestão de Riscos
5.
Pediatr Cardiol ; 23(2): 192-9, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-11889534

RESUMO

The aim of our study was to assess the ability of myocardial contrast echocardiography (MCE) with harmonic power Doppler imaging (HPDI) to identify perfusion abnormalities in patients with Kawasaki disease at rest and during pharmacological stress imaging with dipyridamole. Results were compared with those of 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) imaging as the clinical reference standard. MCE with HPDI was performed on 20 patients with a history of Kawasaki disease. Images were obtained at baseline and during dipyridamole infusion (0.56 mg x kg(-1)) in the apical two- and four-chamber views. Myocardial opacification suitable for the analysis was obtained in all patients. Nine patients with stenotic lesions had a reversible defect after dipyridamole infusion detected by both MCE with HPDI and SPECT, and 3 patients with a history of myocardial infarction had a partially or completely irreversible defect detected by both methods. Three patients with coronary aneurysm without stenotic lesion, 4 patients with regressed coronary aneurysm, and 2 patients with normal coronary artery in acute phase also had normal perfusion at rest and after pharmacological stress by both methods. A 96% concordance (kappa = 0.87) was obtained when comparing the respective segmental perfusion scores using the two methods at baseline, and an 86% concordance (kappa = 0.81) was obtained at postdipyridamole infusion. After combining baseline and postdipyridamole images, each segment was labeled as having normal perfusion, irreversible defects, or reversible defects. Using these classifications, concordance for the two methods was 92% (kappa = 0.87). MCE with HPDI is a safe and feasible method by which to detect asymptomatic ischemia due to severe stenotic lesion, and it may be an important addition to the modalities used to identify patients at risk for myocardial infarction as a complication of Kawasaki disease.


Assuntos
Estenose Coronária/diagnóstico por imagem , Ecocardiografia Doppler , Ecocardiografia sob Estresse , Síndrome de Linfonodos Mucocutâneos/diagnóstico por imagem , Adolescente , Adulto , Criança , Pré-Escolar , Circulação Coronária , Estenose Coronária/etiologia , Dipiridamol , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Masculino , Síndrome de Linfonodos Mucocutâneos/complicações , Síndrome de Linfonodos Mucocutâneos/fisiopatologia , Infarto do Miocárdio/etiologia , Tomografia Computadorizada de Emissão de Fóton Único , Vasodilatadores
6.
Toxicol Appl Pharmacol ; 177(1): 38-45, 2001 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-11708898

RESUMO

The aim of this study was to examine whether the RT-PCR method for various Th1/Th2 cytokines is appropriate for determination of response to allergens using C57BL/6 and Balb/c mice, which are known to preferentially demonstrate Th1 and Th2 responses, respectively. To this end, both strains of mice were sensitized by skin painting with the contact allergen dinitrochlorobenzene (DNCB) or the respiratory allergen trimellitic anhydride (TMA). We used the sensitizing protocol adopted by Kimber and coworkers (Toxicology 103, 63-73, 1995). At various time points after the last application, the levels of mRNA expression for Th1-type cytokines IFN-gamma, IL-18, and IL-12p40, as well as receptor IL-18R, and the Th2-type cytokine IL-4 and the receptor ST2L, in lymph nodes were measured. The results suggest that differential expression of IL-12p40 and IL-4 mRNA after 24 h allows clear discrimination between DNCB and TMA in C57BL/6 mice, more obviously than in Balb/c mice. Furthermore, to examine this method, C57BL/6 mice were exposed to OXA, DNFB, and TNCB (Th1-predominant allergens) or PA, TDI, and MDI (Th2-predominant allergens). Elevation of IL-12p40 expression was significant with the Th1 inducers, while the level of IL-4 was higher with Th2-predominant allergens. The results of the present study demonstrate, for the first time, that differential expression of IL-12p40 and IL-4 in C57BL/6 mice may be useful as a parameter for assessing influence of contact and respiratory allergens.


Assuntos
Alérgenos/toxicidade , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Células Th1/efeitos dos fármacos , Células Th2/efeitos dos fármacos , Alérgenos/química , Alérgenos/classificação , Animais , Primers do DNA/química , Dinitroclorobenzeno/toxicidade , Dinitrofluorbenzeno/toxicidade , Interleucina-12/biossíntese , Interleucina-12/genética , Interleucina-4/biossíntese , Interleucina-4/genética , Isocianatos/toxicidade , Ensaio Local de Linfonodo , Linfonodos/efeitos dos fármacos , Linfonodos/metabolismo , Linfonodos/patologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Peso Molecular , Oxazóis/toxicidade , Anidridos Ftálicos/toxicidade , Cloreto de Picrila/toxicidade , RNA Mensageiro/biossíntese , Especificidade da Espécie , Células Th1/metabolismo , Células Th2/metabolismo , Tolueno 2,4-Di-Isocianato/toxicidade
7.
Br J Neurosurg ; 15(3): 239-41, 2001 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-11478059

RESUMO

We describe two recent cases of spontaneous intracranial hypotension. A 38-year-old woman developed a severe postural headache. Magnetic resonance imaging (MRI) showed marked dural enhancement. Histopathological findings of dural biopsy showed numerous dilated vessels in the dura, rather than hypertrophic change. Lumber CSF pressure was 5 cmH2O and RI cisternography suggested CSF leakage. A 58-year-old woman with postural headache and vertigo had bilateral subdural haematoma associated with diffuse dural enhancement on MRI. Lumber CSF monitoring confirmed persistent low pressure ranging from 0-5 cm H2O. MRI myelography revealed multiple CSF pouches along the whole spinal axis. CSF leakage was demonstrated on Radioisotope (RI) cisternography. Both cases described in this report were diagnosed as spontaneous intracranial hypotension caused by CSF leakage from spinal meningeal diverticula and were successfully treated by intravenous Factor XIII administration.


Assuntos
Pressão do Líquido Cefalorraquidiano , Divertículo/fisiopatologia , Cefaleia/etiologia , Hipotensão Intracraniana/diagnóstico , Doenças da Medula Espinal/fisiopatologia , Adulto , Pressão do Líquido Cefalorraquidiano/fisiologia , Fator XIII/uso terapêutico , Feminino , Cefaleia/diagnóstico , Cefaleia/tratamento farmacológico , Humanos , Hipotensão Intracraniana/tratamento farmacológico , Hipotensão Intracraniana/etiologia , Imageamento por Ressonância Magnética/métodos , Meninges , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X/métodos
8.
Endoscopy ; 33(7): 568-73, 2001 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-11473326

RESUMO

BACKGROUND AND STUDY AIMS: This study assessed the indications for and limitations of endoscopic mucosal resection (EMR) for early colorectal cancer, focusing on the way in which the lesion lifts after submucosal injection. PATIENTS AND METHODS: The study included 94 patients with early colorectal cancer who received EMR treatment. The lifting of the lesion after submucosal injection was analyzed (classified as completely lifted/soft; completely lifted/hard; incompletely lifted; and non-lifted) along with the endoscopic findings, pathological findings, and clinical course. RESULTS: Almost all completely lifted/soft lesions were mucosal cancers. Some of the completely lifted/hard lesions were staged as sm2. The incompletely lifted lesions included stages sm1 to sm3. Non-lifting lesions were almost always deeper than sm3. The lifting condition was significantly associated with the depth of invasion, and the lesion type was related to the extent of lifting but not to tumor size or recurrent disease. Recurrent disease was noted in three patients who underwent piecemeal EMR. CONCLUSIONS: The indication for EMR is easily assessed on the basis of the lifting characteristics of the tumor after submucosal injection, which was found to be significantly related to the depth of invasion. The factor limiting the indication for EMR is not the size of a tumor, but its lifting condition.


Assuntos
Neoplasias Colorretais/cirurgia , Endoscopia Gastrointestinal , Mucosa Intestinal/cirurgia , Idoso , Neoplasias Colorretais/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica
9.
Circulation ; 103(5): 664-9, 2001 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-11156877

RESUMO

BACKGROUND: The aim of the present study was to investigate the feasibility and potential value of the computer-controlled, 3D, echocardiographic reconstruction of the color Doppler-imaged vena contracta (CDVC) and the flow convergence (FC) region as a means of accurately and quantitatively estimating the severity of a ventricular septal defect (VSD). METHODS AND RESULTS: We performed a 3D reconstruction of the CDVC and the FC region in 19 patients with an isolated VSD using an ultrasound system interfaced with a Tomtec computer. The variable asymmetric geometry of the CDVC and the FC region could be 3D-visualized in all patients. The 3D-measured areas of CDVC correlated well with volumetric measurements of the severity of VSD (r=0.97, P:<0.001). Regression analysis between the shunt flow rate (calculated from the product of the area of CDVC and the continuous Doppler-derived velocity time integral) and the corresponding reference results (calculated by cardiac catheterization) demonstrated a close correlation (r=0.95, P:<0.001). There was also a good correlation between shunt flow rates calculated using the conventional 2D, 1-axis measurement of the FC isovelocity surface area with the hemispheric assumption (r=0.95, P:<0.001); shunt flow rates calculated using 3D, 3-axis measurements of the FC region (r=0.97, P:<0.01); and reference results by cardiac catheterization. However, the 2D method substantially underestimated the actual shunt flow rate. CONCLUSIONS: The 3D reconstruction of the CDVC and the FC region may aid in quantifying the severity of VSD.


Assuntos
Ecocardiografia Doppler em Cores/métodos , Comunicação Interventricular/diagnóstico , Criança , Pré-Escolar , Ecocardiografia Tridimensional , Estudos de Viabilidade , Humanos , Processamento de Imagem Assistida por Computador , Lactente , Estudos Prospectivos , Fluxo Sanguíneo Regional , Índice de Gravidade de Doença
10.
Neurotoxicology ; 21(4): 501-11, 2000 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-11022859

RESUMO

Vincristine is an effective chemotherapeutic agent for a variety of human neoplasms, but has dose-limiting neurotoxicity. Since laboratory rodents have proven to be refractive in such neurotoxicological studies, we conducted a neuropathological and behavioral assessment in rabbits treated with vincristine at doses known to be both chemotherapeutically effective and neurotoxic in humans. Rabbits (Kbl: NZW) were given vincristine intravenously at doses of 0 (saline), 200, 250 or 300 microg/kg once a week for 6 weeks, 500 microg/kg once a week for 3 weeks, or a single 500 microg/kg administration. Detailed periodic neurologic examination revealed ataxia in a few animals. Pathologically, axonal injury progressing to fiber degeneration was observed in sensory tracts such as the posterior spinocerebellar tract and posterior funiculus, and in peripheral nerves after treatment with vincristine. These alterations were observed even after a single dose of 500 microg/kg. In the group given weekly doses of 500 microg/kg, neuronal chromatolysis was also found in the spinal cord. These results suggest the rabbit is responsive to vincristine neurotoxicity producing a predominantly sensory neuropathy and confirming earlier studies.


Assuntos
Antineoplásicos Fitogênicos/toxicidade , Síndromes Neurotóxicas/patologia , Vincristina/toxicidade , Animais , Comportamento Animal/efeitos dos fármacos , Encéfalo/patologia , Gânglios Espinais/patologia , Masculino , Fibras Nervosas/patologia , Síndromes Neurotóxicas/psicologia , Coelhos , Nervo Isquiático/patologia , Medula Espinal/patologia , Fatores de Tempo
11.
J Surg Oncol ; 74(4): 282-5, 2000 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10962461

RESUMO

BACKGROUND: Cervical lymph node metastases (CLM) from esophageal carcinoma are regarded as a part of the M component of the TNM classification. Patients with CLM, however, can experience extended survival after cervical lymph node dissection, unlike patients with other M components. METHODS: Among 844 patients with thoracic esophageal carcinoma, 197 underwent esophagectomy with three-field dissection of the cervical, mediastinal, and abdominal lymph nodes (3FD). The survival of patients with CLM was compared with that of patients with hematogenous metastasis (HM), and the prognostic value of CLM was assessed. RESULTS: The survival curve for patients with CLM was significantly better than that for patients with HM (P = 0. 002). Among the 197 patients who underwent 3FD, 46 (23.4%) had histologic CLM. Of the 165 patients without hematogenous metastases, 22 (13.3%) had histologic CLM. The survival curve for the patients with histologic CLM was not significantly differ from that for patients with mediastinal or abdominal lymph node metastasis (P = 0. 127, P = 0.155) by univariate analyses. CONCLUSIONS: The significantly better survival of patients with CLM compared with that of patients with HM strongly suggests that CLM carries a prognosis different from the other M components in the staging of thoracic esophageal carcinoma. Because the survival curve for patients after 3FD was similar to that of patients with metastasis in the mediastinum or abdomen, we feel CLM should be included in the N component.


Assuntos
Carcinoma/patologia , Carcinoma/secundário , Neoplasias Esofágicas/mortalidade , Neoplasias Esofágicas/patologia , Linfonodos/patologia , Estadiamento de Neoplasias/classificação , Adulto , Idoso , Carcinoma/mortalidade , Feminino , Humanos , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Pescoço , Invasividade Neoplásica , Prognóstico , Sensibilidade e Especificidade , Análise de Sobrevida , Taxa de Sobrevida
12.
Hepatogastroenterology ; 47(33): 672-7, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10919009

RESUMO

BACKGROUND/AIMS: Portal scintigraphy is a useful non-invasive method for the determination of portosystemic shunts in patients with liver cirrhosis. Several procedures have been reported for its execution in clinical practice but most of them failed to show sufficient sensitivity for the diagnosis of portosystemic shunt. In the present study, we evaluated whether summation of radioisotope counts obtained during intrarectal or intraduodenal administration of 201thalium chloride is useful for increasing the diagnostic yield of porto-systemic shunts in patients with chronic liver disease. METHODOLOGY: Seven patients with chronic viral hepatitis and 8 with liver cirrhosis secondary to viral hepatitis were enrolled in this study. Following the conventional protocol, 201thalium chloride was administered per rectum and the 60-second-heart-to-liver uptake (conv-H/L-R) ratio was calculated after 20 min. Continuous measurement of the radioactivity signals during 20 min were also done and the summated heart-to-liver uptake (sum-H/L-R) ratio from the total radioactivity count were calculated. Measurement of the conventional heart-to-liver uptake (conv-H/L-D) ratio and the summated (sum-H/L-D) ratio were also done as described above after the intraduodenal administration of 201thalium chloride by endoscopy. RESULTS: All ratios (conv-H/L-R, conv-H/L-D, sum-H/D-R, sum-H/L-D) were significantly higher in patients with liver cirrhosis than in those with chronic hepatitis. Among all heart/liver ratios, only the sum-H/L-R ratio was significantly different between patients with and without esophageal varices. Serum hyaluronate level and other liver function tests were found to be significantly correlated with all heart-to-liver ratios, but they were more strongly correlated with the sum-H/D-R and sum-H/L-D ratios than with the conv-H/L-R and conv-H/L-D ratios. CONCLUSIONS: The results of this study showed that the heart-to-liver ratio calculated by summation of radioactivity is better than the conventional method for the diagnosis of portosystemic shunt in patients with chronic liver disease.


Assuntos
Hepatite C Crônica/diagnóstico por imagem , Cirrose Hepática/diagnóstico por imagem , Cirrose Hepática/fisiopatologia , Sistema Porta , Radioisótopos de Tálio , Adulto , Feminino , Hepatite B Crônica/diagnóstico por imagem , Hepatite B Crônica/fisiopatologia , Hepatite C Crônica/fisiopatologia , Humanos , Testes de Função Hepática , Masculino , Pessoa de Meia-Idade , Cintilografia , Sensibilidade e Especificidade
13.
J Am Soc Echocardiogr ; 12(12): 1058-64, 1999 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-10588781

RESUMO

A Doppler index combining systolic and diastolic time intervals (Tei index) has been reported to be useful for assessing global left ventricular (LV) function and predicting clinical outcome in adult patients with LV dysfunction. However, normal values in children and age-related changes in the index have not yet been clarified. The aim of this study was to prospectively determine normal values of the Tei index and the effect of aging on the index in children and to assess the global cardiac function in patients with dilated cardiomyopathy with this index. The subjects included 161 consecutive normal children aged 30 days to 18 years and 5 patients with dilated cardiomyopathy. The Tei index was defined as the sum of the isovolumetric contraction time and the isovolumetric relaxation time divided by the ejection time and was measured from conventional LV outflow and inflow Doppler velocity profiles. The Tei index correlated significantly with the logarithm of age (r = 0.51, P <. 001). The index decreased with aging until 3 years and then did not change after age 3 years. The Tei index in children under age 3 years (0.40 +/- 0.09, n = 80) was significantly higher than that in children ranging in age from 3 to 18 years old (0.33 +/- 0.02, n = 81). The index in patients with dilated cardiomyopathy (0.78 +/- 0. 28) was markedly increased compared with that in normal subjects. Age-related changes in the Tei index may reflect maturational or developmental alterations in the LV properties in infants. The data in this study give basic information for further quantitative assessment of global cardiac function in children with congenital or acquired heart disease.


Assuntos
Cardiomiopatia Dilatada/fisiopatologia , Ecocardiografia Doppler de Pulso , Ventrículos do Coração/fisiopatologia , Função Ventricular Esquerda , Adolescente , Envelhecimento/fisiologia , Velocidade do Fluxo Sanguíneo , Cardiomiopatia Dilatada/diagnóstico por imagem , Criança , Pré-Escolar , Ecocardiografia Doppler de Pulso/normas , Frequência Cardíaca , Ventrículos do Coração/diagnóstico por imagem , Humanos , Lactente , Contração Miocárdica , Variações Dependentes do Observador , Estudos Prospectivos , Reprodutibilidade dos Testes , Índice de Gravidade de Doença , Volume Sistólico
15.
Pediatr Int ; 41(1): 1-7, 1999 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-10200128

RESUMO

BACKGROUND: High-dose intravenous gamma-globulin (IVGG) plus aspirin (ASA) treatment is effective in preventing coronary artery complications in acute Kawasaki disease (KD). However, gamma-globulin is very expensive, especially in Japan. Furthermore the indication for IVGG treatment and the optimal dose of gamma-globulin remain controversial. OBJECTIVES: To examine these two issues, we used Harada's scoring system to investigate whether a single 2 g/kg dose therapy has any advantage over the 5 day 400 mg/kg per day therapy. METHODS: We studied 203 patients with KD who had no coronary artery complications on admission. Of these, 145 patients scored 4 or more on Harada score within the first 9 days of illness and were treated with IVGG treatment. Using a random number table, 72 patients were selected to receive a single 2 g/kg dose (2 g group), while the remaining 73 patients were treated with 400 mg/kg per day for 5 consecutive days (400 mg group). Those who had a Harada score of three or less received no IVGG (non-IVGG group) treatment (58 patients). RESULTS: The incidence rate of coronary artery complications in the 2 g group was significantly lower than in the 400 mg group. The duration of high fever, positive duration of C-reactive protein and the number of hospital days in the 2 g group were each significantly shorter than in the 400 mg group. The total medical expense in the 2 g group was significantly lower than in the 400 mg group. There were no coronary artery complications in the non-IVGG group. CONCLUSIONS: It was found to be clinically more effective and more cost effective to select a patient by Harada's scoring system and, where a score of four or more was obtained, to administer a single 2 g/kg intravenous dose of gamma-globulin for acute KD.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Aspirina/uso terapêutico , Doença das Coronárias/prevenção & controle , Imunização Passiva , Imunoglobulinas Intravenosas/uso terapêutico , Síndrome de Linfonodos Mucocutâneos/terapia , gama-Globulinas/uso terapêutico , Proteína C-Reativa/metabolismo , Doença das Coronárias/etiologia , Análise Custo-Benefício , Árvores de Decisões , Custos de Medicamentos , Quimioterapia Combinada , Feminino , Humanos , Imunoglobulinas Intravenosas/economia , Lactente , Tempo de Internação/estatística & dados numéricos , Masculino , Síndrome de Linfonodos Mucocutâneos/sangue , Síndrome de Linfonodos Mucocutâneos/complicações , Síndrome de Linfonodos Mucocutâneos/imunologia , Seleção de Pacientes , Índice de Gravidade de Doença , gama-Globulinas/economia
16.
Diagn Ther Endosc ; 6(1): 9-16, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-18493519

RESUMO

Methods A cost-effectiveness analysis was carried out for photodynamic therapy (PDT) performed in early stage lung cancer cases, which by definition have no lymph node metastasis. The alternative treatment method was lobectomy, which conventionally would have been the first choice of treatment. Costs (C) and effectiveness (E) both of the PDT group and operation group were compared. Effectiveness was determined using quality adjusted life years saved (QALYs) which is the 5-year survival rate adjusted in terms of the quality of life of the patient, and the cost-effectiveness rate was obtained based on the costs of treatment methods during the patient's stay in the hospital. Health care costs, including drugs, were calculated according to the 1992 National Health Insurance list in yen. Costs which were non-reimbursable by the public insurance system, such as for special rooms and sun block cream, were also expressed in yen.Results The total cost of the operated group was yen1,793,832 and that for the PDT group was yen1,017,104. The cost-effectiveness rate of the operated group, that is the average cost of treatment per postoperative living month, was yen37,537, while that of the entire PDT group was yen30,003. This indicates that the cost-effectiveness rate for the operated group is apparently 1.3 times higher than that of the PDT group. The monthly cost-effectiveness rate for the PDT group of lesions smaller than 2 cm was yen25,533. Therefore the cost in the operated group is 1.5 times higher.Conclusions This study demonstrated the merits of PDT for early stage lung cancer from the point of view of cost-effectiveness.

17.
Anticancer Res ; 18(2A): 907-10, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-9615739

RESUMO

We used hepatic metastasis models to determine the mechanism and effect of levamisole. BALB/c mice and Colon 26 cells were used. Group I was injected with tumor cells through the portal vein. Group II was primed with tumor cells before tumor cells injecting. Group III was same as Group II, but treated with levamisole. Surface antigens of intrahepatic lymphocytes and spleen cells were determined by FACScan with Anti-CD3, anti-CD4, anti-CD8, anti-CD45, anti-NK1.1 and anti-F4/80. Nodules on the liver were greatest in Group I and fewest in Group III. Concerning intrahepatic lymphocytes, Group II, when compared with Group I, had increases of CD3+, CD4+ and CD8+ cells, and decreases of CD45+ and NK1.1+ cells. Group III when compared with Group II, showed increased CD8+ cells and decreased of NK1.1+ cells. Levamisole is considered to be effective in the prevention of liver metastasis and is suggeste to enhanced CD8+ cells.


Assuntos
Adjuvantes Imunológicos/farmacologia , Levamisol/farmacologia , Neoplasias Hepáticas/secundário , Linfócitos/imunologia , Animais , Antígenos de Superfície/análise , Neoplasias Hepáticas/imunologia , Neoplasias Hepáticas/prevenção & controle , Masculino , Camundongos , Camundongos Endogâmicos BALB C
18.
Acta Cytol ; 42(1): 33-49, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-9479322

RESUMO

ISSUES: The colposcope was developed in 1925 and is well established in clinical gynecologic practice for defining and delineating cytologically detected lesions mainly of the cervix but also the vagina and vulva. Additionally, various endoscopic procedures in gastroenterology, pulmonary and urologic lesions enhance the cytologic detection and histologic verification of precancerous and cancerous lesions. The cost-effectiveness of all these devices and their applicability, particularly in countries with a limited health budget, is a major issue. This task force considered aspects of the present state of the art and the challenges in the 21st century. CONSENSUS POSITION: Automated cytology can interface with colposcopic examination in a number of significant ways. Automated cytologic analysis of conventional cervical smears can potentially direct colposcopic examination by predicting the nature of a lesion, assist in determining which patients should receive colposcopy and, in some settings, thereby reduce the number of colposcopies. Potentially, various combinations of automated cytology and colposcopy may be used to generate screening protocols that might result in more effective and inexpensive screening. The role of cervicography, or high-resolution cervical photography, as a screening device remains to be defined. Sensitivity for high grade lesions is generally no greater than that in cytology, and specificity appears lower. The interpretation of cervical photographs in triage of mildly abnormal cytology may prove to be useful in countries with established cytology programs. In areas of the world where cytology screening programs are not in place, the interpretation of cervical photographs may have its most dramatic effect. Cost-effectiveness analyses are needed. There are, at present, insufficient data for the evaluation of speculoscopy, a procedure using chemiluminescent illumination of the cervix for visualization of acetowhite areas. Basic training in colposcopy should be integrated into the residency programs of obstetrics and gynecology. Criteria for the adequate training of colposcopists should be developed. Continuing education programs in colposcopy should be developed when they are not already in existence. The cost-effectiveness of integrating colposcopy as a primary screening technique should be evaluated. Following a high-grade squamous intraepithelial lesion (HSIL) cytology result, colposcopically directed punch biopsy should be taken with or without endocervical curettage. This generally should precede the loop electrosurgical excision procedure (LEEP); however, in certain circumstances direct LEEP may be indicated. LEEP under colposcopic vision is an efficient way to treat an HSIL lesion of the cervix because the histologic extent and margins can be determined, unlike with laser surgery or cryosurgery. It is also more cost-effective than cold knife conization because general anesthesia and an operating room are unnecessary. Following LEEP, the endocervical canal should be examined colposcopically for any evidence of involvement. Lesions in the endocervix can then be removed with a different-shaped loop. Further research into Raman spectroscopy as a diagnostic aid in cervical pathology is needed, as is the use of micrococolpohysteroscopy for in vivo cytologic analyses, especially of the endocervical canal and transformation zone. Hysteroscopy is the most direct method for the diagnosis and treatment of intrauterine diseases. Hysteroscopic endometrial biopsy is more accurate than conventional biopsy methods. Cervical invasion of endometrial cancer can be detected by hysteroscopy. The depth of invasion, however, is more accurately determined by magnetic resonance imaging or computed tomography. ONGOING ISSUES: Many topics for ongoing research and/or implementation are mentioned under "Consensus Position," above. (ABSTRACT TRUNCATED)


Assuntos
Broncoscopia , Colo do Útero/citologia , Colposcopia , Endométrio/citologia , Histeroscopia , Neoplasias Pulmonares/patologia , Fotografação/métodos , Escarro/citologia , Automação , Biópsia , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Colposcopia/economia , Técnicas Citológicas/economia , Países em Desenvolvimento/economia , Eletrocirurgia , Neoplasias do Endométrio/patologia , Neoplasias do Endométrio/prevenção & controle , Feminino , Previsões , Ginecologia/educação , Humanos , Histeroscopia/economia , Neoplasias Pulmonares/diagnóstico , Programas de Rastreamento/economia , Programas de Rastreamento/métodos , Ciência de Laboratório Médico/educação , Avaliação de Processos e Resultados em Cuidados de Saúde , Fotografação/economia , Sensibilidade e Especificidade , Análise Espectral Raman , Tecnologia de Alto Custo , Estados Unidos , United States Food and Drug Administration , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/prevenção & controle , Doenças Uterinas/diagnóstico , Doenças Uterinas/patologia
19.
Nihon Koshu Eisei Zasshi ; 45(10): 988-99, 1998 Oct.
Artigo em Japonês | MEDLINE | ID: mdl-9893467

RESUMO

The purpose of this study was to obtain basic information of factors which improve the dietary behavior of urban residents. For this reason, we studied the relation between dietary behavior and BMI, serum lipids and socioeconomic factors. We surveyed the dietary behavior of those who underwent medical examinations at a health center in the city of A. The subjects for this study were 2,627 persons aged 30 to 69 years. For purposes of analysis, the data derived in the survey was divided into two types of categories. One category is that of practicing and non-practicing group relative to specific dietary behaviors. The other is that of better dietary behaviors group and worse dietary behaviors group. (1) A comparison between the practicing and non-practicing group showed that the mean value of the total cholesterol values for the former was lower than for the latter. Similar results for the triglyceride values was obtained. The mean value of the HDL-cholesterol values for the practicing group was higher than for the non-practicing group. (2) We also compared the better dietary behaviors group with the worse group. For women, the mean value of the body mass indices in the better dietary behaviors group was lower than in worse group. We obtained similar differences for women with regard to the mean values of total cholesterol values and triglyceride values. (3) More of Breslow's health practices were followed by the better dietary behaviors group than by the worse group. (4) The number of good dietary practices was significantly related to the following socioeconomic factors: marital status, floor area of residence, steady employment, and working hours. Better dietary behaviors showed parallel correlation with better health status. Dietary behaviors of younger generations and temporary workers showed a tendency of needing to be improved.


Assuntos
Índice de Massa Corporal , Dieta , Comportamento Alimentar , Lipídeos/sangue , Saúde da População Urbana , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Fatores Socioeconômicos
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