Assessment of Shame and Stigma in Head and Neck Cancer: A Meta-Analysis.

Background: Head and neck cancer is the most common cancer around the globe, following lung cancer and breast cancer. Treatment at advanced stages of head and neck cancer is usually followed intense surgical procedures, which leads to mutilation among patients. Mutilation imparts a sense of disgrace and causes a feeling of shame and stigma in the patient. The feeling of shame and stigma persists over time and affects the overall long-term survival of patients by deteriorating their quality of life. Objectives: Since shame and stigma is an important psychological domain of head and neck cancer, the present article aims toward evaluating the studies published so far for the assessment of shame and stigma in head and neck cancer and highlighting the lacunae in the existing research designs. The present study also aims to design a checklist that could be followed while developing, translating, or validating a psychometric instrument that aims to measure shame and stigma in head and neck cancer. Methods: In the present metanalysis, all articles published in the past years on shame and stigma in head and neck cancer was compiled using a predefined data extraction matrix. The available literature was compiled for major objectives of the study, the sample size used, major findings, and critical lacunae that need to be addressed. Results: Shame and stigma is a very important domain of psychological well-being in head and neck cancer patients, which yet not appropriately addressed and further need to be researched. Conclusion: Future studies could be based on the lacunae highlighted in the existing literature, and the prescribed methodology checklist could be taken into consideration while conducting further studies involving developing, translating, or validating a psychometric instrument related to shame and stigma in the head and neck cancer.

Assessment of biomass-derived carbon dots as highly sensitive and selective templates for the sensing of hazardous ions.

Access to safe drinking water and a hygienic living environment are the basic necessities that encourage healthy living. However, the presence of various pollutants (especially toxic heavy metal ions) at high concentrations in water renders water unfit for drinking and domestic use. The presence of high concentrations of heavy-metal ions (e.g., Pb2+, Hg2+, Cr6+, Cd2+, or Cu2+) greater than their permissible limits adversely affects human health, and increases the risk of cancer of the kidneys, liver, skin, and central nervous system. Therefore, their detection in water is crucial. Due to the various benefits of "green"-synthesized carbon-dots (C-dots) over other materials, these materials are potential candidates for sensing of toxic heavy-metal ions in water sources. C-dots are very small carbon-based nanomaterials that show chemical stability, magnificent biocompatibility, excitation wavelength-dependent photoluminescence (PL), water solubility, simple preparation strategies, photoinduced electron transfer, and the opportunity for functionalization. A new family of C-dots called "carbon quantum dots" (CQDs) are fluorescent zero-dimensional carbon nanoparticles of size < 10 nm. The green synthesis of C-dots has numerous advantages over conventional chemical routes, such as utilization of inexpensive and non-poisonous materials, straightforward operations, rapid reactions, and renewable precursors. Natural sources, such as biomass and biomass wastes, are broadly accepted as green precursors for fabricating C-dots because these sources are economical, ecological, and readily/extensively accessible. Two main methods are available for C-dots production: top-down and bottom-up. Herein, this review article discusses the recent advancements in the green fabrication of C-dots: photostability; surface structure and functionalization; potential applications for the sensing of hazardous anions and toxic heavy-metal ions; binding of toxic ions with C-dots; probable mechanistic routes of PL-based sensing of toxic heavy-metal ions. The green production of C-dots and their promising applications in the sensing of hazardous ions discussed herein provides deep insights into the safety of human health and the environment. Nonetheless, this review article provides a resource for the conversion of low-value biomass and biomass waste into valuable materials (i.e., C-dots) for promising sensing applications.

Accuracy of a self-reported Measure in Psychological Assessment when the Instrument is self-administered by the Patient or when Administrated by the Clinician.

Background: Self-reported measures are the questionnaire-based instrument that are routinely used in the clinical scenario to assess psychological health. Technically, the self-reported measure should be administrated by the patients themselves but due to the complexity of tools and illiteracy among patients, clinicians often tend to interview the patients. Objective: Present article aims to compare the accuracy of a self-reported measure in the assessment of the psychological health of a patient when the instrument is self-administrated by the patient and when administrated by the clinician or researcher. Methods: We have recruited 43 patients of oral cancer in the study who have a tumor in the buccal mucosa region. The Hindi version of the shame and stigma scale was used to analyse the shame and stigma in patients. The questionnaire was first provided to the patient for the self-administration and after that clinician administrated the questionnaire to the patient by keeping the clinician blinded to the patient self-administrated responses. Results: There was no significant difference in the global mean score and mean score of various subdomains of shame and stigma scale in the self-administered and clinician-administered mode of interview. However, the clinician-administered mode could provide more accurate measures as it helps the patient towards a better understanding of questions. Conclusion: It is recommended that the newly developed or translated self-reported measure should be tested for both patient administrated and clinician administrated compatibility. Questionnaires could be administrated by the clinician in the case when the patient is illiterate or in the case when the patient does not understand the language of the instrument.

Health risk assessment from exposure to ambient VOCs and particulate matter in different functional zones in Dhanbad, India.

This study evaluates the non-cancer risks (NCR) and cancer risks (CR) in outdoor working personnel in Dhanbad city, exposed to volatile organic compounds (VOCs) and particulate matter (PM) present in the ambient air. Dhanbad is known for its coal mines and is one of the most polluted cities in India and the world. Sampling was conducted in different functional zones; namely, traffic intersections, industrial, and institutional areas, to estimate the concentration of different PM-bound heavy metals and VOCs in the ambient air using Inductively coupled plasma-optical emission spectrometry (ICP-OES) and gas chromatography (GC) respectively. Our results show that the concentration levels (of VOCs and PM) and health risks were maximum at the traffic intersection area, followed by the industrial and institutional areas. The major contribution to CR came from chloroform, naphthalene, and PM-bound chromium, while the contribution to NCR mainly came from naphthalene, trichloroethylene, xylenes, and PM-bound chromium, nickel, and cadmium. It was observed that CR and NCR from VOCs are quite comparable (average CRvoc 8.92E-05 and NCRvoc 6.82) to that from the PM-bound heavy metals (average CRPM 9.93E-05 and NCRPM 3.52). According to the sensitivity analysis performed using Monte-Carlo Simulation, it was also found that the output risk is most significantly influenced by the pollutant concentration followed by exposure duration and exposure time. The study reveals that Dhanbad city is not only a critically polluted area but also a highly hazardous and cancer-prone area due to the pollution arising from incessant coal mining activities and heavy vehicular movement. Given the paucity of data on exposure to VOCs in ambient air and their risk assessment pertaining to coal mining cities of India, our study provides useful information and insight for the regulatory and enforcing authorities to devise appropriate strategies for air pollution and health risk management in such cities.

Sustainable synthesis of biomass-derived carbon quantum dots and their catalytic application for the assessment of α,ß-unsaturated compounds.

Herein, we demonstrate a simple, reproducible, and environment-friendly strategy for the synthesis of carbon quantum dots (CQDs) utilizing the mango (Mangifera indica) kernel as a renewable green carbon source. Various analytical tools characterized the as-prepared CQDs. These fluorescent CQDs showed significant water solubility with a uniform size of about 6 nm. The as-synthesized CQDs show significantly enhanced catalytic activity for the production of α,ß-unsaturated compounds from the derivatives of aromatic alkynes and aldehydes under microwave irradiation in aqueous media. A potential mechanistic pathway and role of carboxylic functionalities were also revealed via various control experiments. The protocol shows outstanding selectivity towards the assessment of α,ß-unsaturated compounds over other possible products. A comparative evaluation suggested the as-synthesized CQDs show higher catalytic activity under microwave radiation as compared to the conventional ways. These recyclable CQDs represent a sustainable alternative to metals in synthetic organic chemistry. A cleaner reaction profile, low catalyst loading, economic viability and recyclability of the catalyst, atom economy, and comprehensive substrate applicability are additional benefits of the current protocol according to green chemistry.

Distribution of VOCs in urban and rural atmospheres of subtropical India: Temporal variation, source attribution, ratios, OFP and risk assessment.

This paper reports the first study which comprises the seasonal, diurnal variability, source characterization, ozone forming potential and risk assessment of volatile organic compounds (VOCs) at three sites (two urban and one rural) in the National Capital Territory of Delhi, India. The study was performed during three seasons of the year 2013-14 and two different categories of VOCs (aromatics and halogenated) have been selected. The study used the sampling and analytical procedures of NIOSH methods. Results showed that the mean concentration of sum of VOCs (∑VOC) is significantly higher at urban sites (110.0 and 137.4µg/m3 for JN and CP, respectively) as compared to the rural site, DP (56.5µg/m3). The contribution of individual to total VOC concentrations is noticed to be very similar at all the three sites. Most of the VOCs are observed to be significantly higher in winter followed by summer and autumn. Diurnal cycles of aromatic VOCs are highly influenced by the vehicular traffic and photochemical oxidations which showed higher and lower levels during morning/evening and daytime, respectively. Diagnostic ratios of the toluene/benzene (ranged from 0.65 to 13.9) infers the vehicular traffic might be the main contributing source in the urban sites while xylene/benzene ratio (ranged from 0.7 to 2.8) confirms the VOCs are transported to rural site from the nearby urban areas. Correlation and factor analysis suggested the sources are group of different species (traffic emissions, solvent usage and industrial) rather than single gas. The analysis of reactivity in terms of Prop-Equiv concentrations and ozone forming potential indicated that m/p-xylene and toluene are the main VOC contributing to the total ozone formation in urban and rural sites, respectively. Hazard ratios and lifetime cancer risk values exceeded the permissible standards established by USEPA and WHO suggests that the people are at significant risk.

Statistical modeling of O3, NOx, CO, PM2.5, VOCs and noise levels in commercial complex and associated health risk assessment in an academic institution.

Indoor Air Quality (IAQ) is considered to be of great concern due to its adverse impact on the human health nowadays. The presence of different air pollutants along with noise may aggravate the IAQ. The present study attempts to examine IAQ in terms of major criteria air pollutants (O3, NOx=NO+NO2, CO and PM2.5) along with total volatile organic compound (TVOC), individual VOC and noise pollution in indoor and outdoor environment of a Commercial Shopping Complex (CSC) in Delhi. Real time measurements have been carried out for O3, NOx, CO, PM2.5, TVOC and noise while thirteen individual VOCs have been estimated using NIOSH method was performed using Gas Chromatograph. The study also aimed to find out the relationship among VOCs, source estimation using Principal Component Analysis. The observed results for the targeted pollutants were also compared with international and national recommended permissible values. The mean values of O3, NOx, CO, PM2.5 and TVOC are found to be 17.6/(15.0) ppb, 15.8/(14.1) ppb, 8.4/(1.9) ppm, 125.4/(74.6) µg/m3 and 412.5/(226.5) µg/m3 for indoor/(outdoor), respectively. Among the individual VOC, toluene was the most abundant followed by xylene-isomers and benzene. The noise pollution level in Indoor/outdoor were found to be 51.5/46.4dB which is below the guideline value (65dB) provided by the WHO. Most of the pollutants were found to have indoor sources. The different kinds of pollutants and noise may have synergistic effect and aggravate the health of the people working and visiting the CSC.

An assessment of ozone levels, UV radiation and their occupational health hazard estimation during photocopying operation.

This study investigates the levels of ozone concentration along with an ultraviolet (UV) and visible spectral radiation at eight photocopy centers in an academic institute, Delhi. Sampling was done in two types of locations, i.e., basement photocopy centers (BPC) and ground floor photocopy centers (GPC) for 8h. Measurements of levels of ozone, UV and visible radiation were done by ozone analyzer, UV radiometer and Field spectra instrument, respectively. Results show that the hourly mean concentration of ozone was observed to be in the range of 1.8-10.0 ppb and 5.3-45.8 ppb for BPC and GPC, respectively. In terms UV radiations, energy lies between 5.0×10(-3) and 7.0×10(-3) mW/cm(2) for ultraviolet A (UVA), 1.0×10(-3) and 2.0×10(-3) mW/cm(2) for ultraviolet B (UVB) and 6.0×10(-3) and 8.0×10(-3) mW/cm(2) for ultraviolet C (UVC). Correlation between the UV radiations and ozone production observed was statistically insignificant. To know the health hazard occurred to the workers, the standard erythema dose (SED) value was calculated for emitting UV radiation. The SED was estimated to be in the range of 0.02-0.04 and 0.02-0.32 for direct and indirect methods which is less than the guideline prescribed by Commission Internationale del' Eclairage (CIE). In nutshell, person involved in photocopy operation for their livelihood must be trained and should have knowledge for the long term gradual build up health problems due to ozone and UV production from photocopier. The manufactures should be ultimated with the significant ozone production, so that photocopier machine can be redesigned.

Assessment of indoor air concentrations of VOCs and their associated health risks in the library of Jawaharlal Nehru University, New Delhi.

The present work investigated the levels of total volatile organic compounds (TVOC) and benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX) in different microenvironments in the library of Jawaharlal Nehru University in summer and winter during 2011-2012. Carcinogenic and non-carcinogenic health risks due to organic compounds were also evaluated using US Environmental Protection Agency (USEPA) conventional approaches. Real-time monitoring was done for TVOC using a data-logging photo-ionization detector. For BTEX measurements, the National Institute for Occupational Safety and Health (NIOSH) standard method which consists of active sampling of air through activated charcoal, followed by analysis with gas chromatography, was performed. Simultaneously, outdoor measurements for TVOC and BTEX were carried out. Indoor concentrations of TVOC and BTEX (except benzene) were higher as compared to the outdoor for both seasons. Toluene and m/p-xylene were the most abundant organic contaminant observed in this study. Indoor to outdoor (I/O) ratios of BTEX compounds were generally greater than unity and ranged from 0.2 to 8.7 and 0.2 to 4.3 in winter and summer, respectively. Statistical analysis and I/O ratios showed that the dominant pollution sources mainly came from indoors. The observed mean concentrations of TVOC lie within the second group of the Molhave criteria of indoor air quality, indicating a multifactorial exposure range. The estimated lifetime cancer risk (LCR) due to benzene in this study exceeded the value of 1 × 10(-6) recommended by USEPA, and the hazard quotient (HQ) of non-cancer risk came under an acceptable range.

Minimal difference in the prevalence of asthma in the urban and rural environment.

Multiple risk factors can be modified to decrease asthma incidence. It is important to understand early risks to decrease exposure to harmful conditions in the environment that can trigger asthma which may not be clinically evident in children until they reach adulthood. A retrospective literature review of articles on the prevalence of asthma in the urban versus rural environment was initiated in order to understand the effect of the environment on asthma. The urban-living effect is a global problem in the face of growing population, industrialization and pollution. The socioeconomic dichotomy in the urban versus rural environment also affects access and quality of health care. Articles reviewed had differences in the urban versus rural prevalence of asthma. However, further analysis of specific risk factors and socioeconomic trends that increased susceptibility to asthma was the same in these studies. Some rural areas may have similar environmental and socioeconomic issues that place them at the same risk for the development of asthma as their urban counterparts. Urban locations generally tend to have the prototype environment that can lead to the predisposition of asthma. Ultimately, the incidence of asthma can be decreased if these environmental and socioeconomic issues are addressed. However, every effort is needed from the level of the individual to the community at large.