Trihalomethanes in global drinking water: Distributions, risk assessments, and attributable disease burden of bladder cancer.

This study aimed to assess the global spatiotemporal variations of trihalomethanes (THMs) in drinking water, evaluate their cancer and non-cancer risks, and THM-attributable bladder cancer burden. THM concentrations in drinking water around fifty years on a global scale were integrated. Health risks were assessed using Monte Carlo simulations and attributable bladder cancer burden was estimated by comparative risk assessment methodology. The results showed that global mean THM concentrations in drinking water significantly decreased from 78.37 µg/L (1973-1983) to 51.99 µg/L (1984-2004) and to 21.90 µg/L (after 2004). The lifestage-integrative cancer risk and hazard index of THMs through all exposure pathways were acceptable with the average level of 6.45 × 10-5 and 7.63 × 10-2, respectively. The global attributable disability adjusted of life years (DALYs) and the age-standardized DALYs rate (ASDR) dropped by 16% and 56% from 1990-1994 to 2015-2019, respectively. A big decline in the attributable ASDR was observed in the United Kingdom (62%) and the United States (27%), while China experienced a nearly 3-fold increase due to the expanded water supply coverage and increased life expectancy. However, China also benefited from the spread of chlorination, which helped reduce nearly 90% of unsafe-water-caused mortality from 1998 to 2018.

Occurrence, spatial variation, seasonal difference, and ecological risk assessment of organophosphate esters in the Yangtze River, China: From the upper to lower reaches.

A comprehensive contamination profile of organophosphate esters (OPEs) in the Yangtze River in China has not yet been characterized. In this study, we investigated the occurrence, spatial variation, and seasonal difference of 18 selected OPEs in surface water samples of the Yangtze River mainstream. To characterize the contamination profile of the OPEs, we collected 144 Yangtze River water samples from 72 sampling sites in December 2020 and June 2021. Four alkyl-OPEs [trimethyl phosphate, triethyl phosphate (TEP), tributyl phosphate, and tris(2-butoxyethyl) phosphate (TBOEP)] and three halogenated OPEs [tris(2-chloroethyl) phosphate (TCEP), tris(1-chloro-2-propyl) phosphate (TCIPP), and tris(1,3-dichloro-2-propyl) phosphate] were the most frequently detected target compounds (>95%). TCIPP (median: 34.6 ng/L), TEP (median: 26.2 ng/L), and TCEP (median: 17.9 ng/L) were the most abundant compounds, while the median values of the others were below 10 ng/L. Additionally, the concentrations of most OPEs gradually/dramatically increased from upstream to downstream Yangtze River. Notably, the median concentration of summed OPEs in Shanghai (415 ng/L; downstream) was approximately ten times higher than that in Qinghai (45.7 ng/L; upstream). Urban sampling sites had significantly or slightly higher concentrations of most OPEs than rural sampling sites. Moreover, the OPE concentrations in the river water differed between the winter and summer. The concentrations of summed OPEs (median: 117 vs. 106 ng/L), summed alkyl-OPEs (67.0 vs. 45.8 ng/L; p < 0.05), and summed aryl-OPEs (0.48 vs. 0.17 ng/L; p < 0.05) were slightly or significantly higher in December than those in June; nevertheless, summed halogenated OPEs were slightly higher in June (62.2 vs. 50.2 ng/L) than that in December. Compared with previously reported data for OPEs in other major rivers worldwide, the Yangtze River water had relatively lower concentrations of the OPEs than those in the rivers of developed countries and regions. Ecological risk assessment suggested that tris(2-ethylhexyl) phosphate and TCEP posed relatively high risks (RQ: 1.01 and 0.98, respectively) at the maximum concentration, and TBOEP posed a moderate risk (RQ: 0.25). This is the first study to comprehensively characterize the contamination profile of the Yangtze River by the OPEs.