Interactive influences of meteorological and socioeconomic factors on ecosystem service values in a river basin with different geomorphic features.

Ecosystem service value (ESV) is influenced by land use and land cover (LULC), and is closely related to natural conditions and human activities. However, the interactions between human and natural systems and ESV remain unclear, especially concerning widely discussed meteorological and socioeconomic factors. In this study, three periods of LULC patterns (2000, 2010, and 2020) in the Haihe River Basin, northern China, were collected to determine the relationship between changes in LULC and ESV over time. Natural and socioeconomic data associated with ESV were obtained and the structural equation model was used to decouple interactions between these factors. Results showed that the total value of regional ecosystem services has decreased as cultivated land shrunk and artificial surfaces increased over the past two decades. The ESV was significantly decreased in the middle of the basin. The direct effects of meteorological factors and socioeconomic factors on ESV were positive (0.094) and negative (-0.203), respectively. The indirect effect of socioeconomic factors on ESV through meteorological and LULC factors was 0.149. Structural equation modeling demonstrated that under the dominance of LULC, interactions between natural and socioeconomic factors affected ESV in a complex manner. These results implied that identifying the direct and indirect effects of economic development and human activities on ESV could guide and implement effective land management policies.

A pharmacoeconomic evaluation of the pharmacotherapeutic options for painful diabetic neuropathy.

INTRODUCTION: Painful diabetic neuropathy (PDN) is a high incidence and severe complication of diabetes mellitus, significantly compromising patients' quality of life and causing tremendous economic burden. Considering drug costs becomes part of treatment decisions, with the growing choice of monotherapy or combination treatment strategies for PDN treatment. AREAS COVERED: This systematic review aims to identify the cost-effectiveness of pharmacotherapies in PDN, summarize key findings, and assess the quality of studies to inform healthcare resource allocation decisions and future research. Economic evaluations were identified by searching PubMed, Web of Science, Scopus and health technology assessment (HTA) databases, as well as screening reference lists of previously identified studies. Relevant data was extracted, and the CHEERS checklist was used to assess the quality of the studies. EXPERT OPINION: Collectively, the findings indicate that more pharmacoeconomics research is urgently needed to directly compare high-quality research for PDN combination medication/sequential treatment, and which is performed from a societal perspective. Simultaneously, to strengthen the reliability of the analysis, metrics such as adherence, incidence of adverse drug reactions, and pain levels utility value should be examined to verify the robustness of the basic results.