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1.
Environ Res ; 252(Pt 3): 119020, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38679276

RESUMO

Government governance reform is not only a vital motivation for high economic quality but also an important factor in stimulating the government's environmental governance responsibility. The article empirically examines the fiscal Province-Managing-County (PMC) pilot reform on the synergic governance of haze and carbon reduction and its mechanism. The results show that the policy helps to realize the synergic governance of haze and carbon reduction, and the reform of fiscal Province-Managing-County promotes regional haze and carbon reduction mainly through structural effect, innovation effect, and fiscal expenditure responsibility effect. The heterogeneity analysis shows that the policy has an asymmetric effect on haze and carbon reduction under different administrative structures, economic structures and levels of government intervention. Further analysis shows a policy linkage effect between this policy and the Green Fiscal Policy. The policy has the situation of blood-sucking in the provincial capital city and leads to an increase in financial funds. The above results prove that the policy can help to realize haze and carbon reduction and provide practical ideas for the further expansion of the policy. At the same time, it provides the direction for the local government to realize the double-carbon goal.


Assuntos
Poluição do Ar , Poluição do Ar/prevenção & controle , Poluição do Ar/economia , Poluição do Ar/legislação & jurisprudência , Carbono , Política Ambiental/economia , Política Ambiental/legislação & jurisprudência , Política , Governo Local
2.
Artigo em Inglês | MEDLINE | ID: mdl-36768098

RESUMO

As a new engine to promote high-quality development and a sustainable economy, the digital economy (DE) plays a key role in achieving carbon reduction targets. In this paper, we use the "broadband China (BC)" policy as a proxy variable for the DE and employ the panel data of Chinese prefecture-level cities from 2006 to 2019 to investigate the effect of DE development on carbon emission intensity and its mechanism of action. It is found that (1) DE development significantly reduces the carbon emissions of cities and presents dynamic and sustainable characteristics; (2) the results of mechanism tests indicate that DE development is more inclined to reduce carbon emission intensity by improving regional innovation quality than by improving regional innovation quantity; (3) the impact of DE development on carbon emission intensity differs among cities with different characteristic attributes and different environmental regulation intensity, and the emission reduction effect is more obvious in non-resource-based cities, cities with lower environmental regulation intensity, and cities with weaker environmental target constraints; (4) the impact of DE development and innovation-driven development strategies on reducing carbon emission intensity has a policy linkage effect.


Assuntos
Poluição do Ar , Carbono , China , Cidades , Desenvolvimento Econômico , Poluição do Ar/prevenção & controle
3.
Front Endocrinol (Lausanne) ; 13: 1013397, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36578954

RESUMO

Objective: The objective of this study was to analyze the quantitative association between advanced glycation end products (AGEs) and adjusted FRAX by rheumatoid arthritis (FRAX-RA) in postmenopausal type 2 diabetic (T2D) patients. The optimal cutoff value of AGEs was also explored, which was aimed at demonstrating the potential value of AGEs on evaluating osteoporotic fracture risk in postmenopausal T2D patients. Methods: We conducted a cross-sectional study including 366 postmenopausal participants (180 T2D patients [DM group] and 186 non-T2D individuals [NDM group]). All the subjects in each group were divided into three subgroups according to BMD. Physical examination, dual-energy x-ray absorptiometry (DXA), and serum indicators (including serum AGEs, glycemic parameters, bone turnover markers and inflammation factors) were examined. The relationship between FRAX-RA, serum laboratory variables, and AGEs were explored. The optimal cutoff value of AGEs to predict the risk of osteoporotic fracture was also investigated. Results: Adjusting the FRAX values with rheumatoid arthritis (RA) of T2D patients reached a significantly increased MOF-RA and an increasing trend of HF-RA. AGEs level was higher in the DM group compared to the NDMs, and was positively correlated with MOF-RA (r=0.682, P<0.001) and HF-RA (r=0.677, P<0.001). The receiver operating characteristic curve analysis revealed that the area under the curve was 0.804 (P<0.001), and the optimal AGEs cut-off value was 4.156mmol/L. Subgroup analysis for T2D patients revealed an increase in TGF-ß, IL-6 and SCTX in the osteoporosis group, while a decreased PINP in the osteoporosis group compared to the other two subgroups. AGEs were positively associated with FBG, HbA1c, HOMA-IR, S-CTX, IL-6 and TGF-ß in T2D patients, and negatively associated with PINP. Conclusions: RA-adjusted FRAX is a relevant clinical tool in evaluating fracture risk of postmenopausal T2D patients. Our study analyzed the relationship between AGEs and FRAX-RA, and explored the threshold value of AGEs for predicting fracture risk in postmenopausal T2D patients. AGEs were also associated with serum bone turnover markers and inflammation factors, indicating that the increasing level of AGEs in postmenopausal T2D patients accelerated the expression of inflammatory factors, which led to bone metabolism disorders and a higher risk of osteoporotic fractures.


Assuntos
Artrite Reumatoide , Diabetes Mellitus Tipo 2 , Osteoporose , Fraturas por Osteoporose , Humanos , Fraturas por Osteoporose/epidemiologia , Fraturas por Osteoporose/etiologia , Densidade Óssea , Estudos Transversais , Pós-Menopausa , Interleucina-6 , Medição de Risco , Osteoporose/diagnóstico , Artrite Reumatoide/complicações , Inflamação/complicações , Diabetes Mellitus Tipo 2/complicações , Produtos Finais de Glicação Avançada
4.
Environ Sci Pollut Res Int ; 29(48): 73542-73551, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-35624362

RESUMO

China is the most polluted economy in the world, facing the challenges of increased CO2 emissions. In this way, energy consumption is a key factor in CO2 emissions. To this end, this study empirically examines the effects of financial inclusion and education on energy consumption by employing the ARDL approach for China during the period 1995-2019. The results suggest that financial inclusion has a positive effect on renewable energy consumption, but a negative impact on renewable energy and total energy consumption. The results show that education reduces non-renewable consumption and increases renewable energy consumption in the long term. Long-run and short-run findings are also consistent and robust in the sensitivity analysis. Based on findings, China should invest in the education sector and increase financial inclusion to reduce energy consumption to meet environmental sustainability.


Assuntos
Dióxido de Carbono , Desenvolvimento Econômico , Dióxido de Carbono/análise , China , Energia Renovável
5.
J Diabetes Investig ; 8(6): 788-797, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28160451

RESUMO

AIMS/INTRODUCTION: Carotid intima-media thickness (CIMT) is an established predictor of cardiovascular disease and stroke. We aimed to identify the association between CIMT and blood glucose, as well as the risk factors associated with increased CIMT in a low-income Chinese population. MATERIALS AND METHODS: Stroke-free and cardiovascular disease-free residents aged ≥45 years were recruited. B-mode ultrasonography was carried out to measure CIMT. RESULTS: There were 2,643 participants (71.0%) in the normal group, 549 (14.7%) in the impaired fasting glucose group and 533 (14.3%) in the diabetes mellitus group. The determinants of increased CIMT were older age; male sex; low education; hypertension; smoking; high levels of systolic blood pressure, fasting blood glucose and low-density lipoprotein cholesterol; and low levels of diastolic blood pressure, triglycerides and high-density lipoprotein cholesterol, after adjusting for covariates. Age and hypertension were the common risk factors for increased CIMT in all three groups. Furthermore, male sex, smoking and high low-density lipoprotein cholesterol level were positively associated with the mean CIMT in the normal group; high triglycerides levels were negatively associated with the mean CIMT in the impaired fasting glucose group; and alcohol consumption was an independent risk factor for mean CIMT in the diabetes mellitus group. Hypertension was the greatest risk factor for increased CIMT. CONCLUSIONS: These findings suggest that it is crucial to manage and control traditional risk factors in low-income populations in China in order to decelerate the recent dramatic increase in stroke incidence, and to reduce the burden of stroke.


Assuntos
Glicemia , Espessura Intima-Media Carotídea , Adulto , Fatores Etários , Idoso , Doenças Cardiovasculares/epidemiologia , China , Estudos Transversais , Jejum , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Fatores de Risco , População Rural , Fatores Sexuais , Fatores Socioeconômicos
6.
PLoS One ; 11(6): e0156393, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27304904

RESUMO

BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with ß cell impairment. Agonists of the glucagon-like peptide 1 (GLP-1) receptor (such as liraglutide and exenatide) can increase the number of pancreatic ß cells and improve cell function. These drugs contribute to the long-term control of T2DM. OBJECTIVE: To evaluate the cost-effectiveness of metformin combined with liraglutide or exenatide in Chinese patient with T2DM. METHODS: Patients with T2DM from the Third Hospital of Hebei Medical University were treated with oral metformin combined with liraglutide (0.6 mg/day, could be increased by 0.6 mg weekly until 1.2 or 1.8 mg) or exenatide (5 µg bid for four weeks, increased to 10 µg bid). The computer simulation model CORE was used to calculate the 30-year expected life expectancy, quality-adjusted life years (QALY), direct costs, HbA1c levels, body mass index (BMI), and the incidence of cardiovascular, renal, and ocular complications of T2DM. Patients were followed up for 52 weeks. Medication costs were calculated according to retail prices in China. A 3% annual discount was adopted in this study. RESULTS: The 30-year simulation showed that the total direct medical costs were lower using liraglutide compared to exenatide by 2130 RMB/QALY yearly, while the expected life expectancy and QALY were increased by 0.471 years and 0.388, respectively, using liraglutide with an incremental cost-effectiveness of -11,550 RMB/QALYs. CONCLUSION: Liraglutide 1.2 mg/day was superior to exenatide 10 µg bid with respect to cost-effectiveness in Chinese patients with T2DM.


Assuntos
Diabetes Mellitus Tipo 2/tratamento farmacológico , Liraglutida/uso terapêutico , Metformina/uso terapêutico , Peptídeos/uso terapêutico , Peçonhas/uso terapêutico , Adulto , Povo Asiático , China , Simulação por Computador , Análise Custo-Benefício , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/etnologia , Esquema de Medicação , Quimioterapia Combinada/economia , Exenatida , Feminino , Hemoglobinas Glicadas/metabolismo , Humanos , Hipoglicemiantes/uso terapêutico , Expectativa de Vida , Masculino , Pessoa de Meia-Idade , Anos de Vida Ajustados por Qualidade de Vida , Análise de Sobrevida , Fatores de Tempo , Resultado do Tratamento
7.
J Sci Food Agric ; 96(11): 3853-9, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26689292

RESUMO

BACKGROUND: Microbial contamination is a vital obstacle needed to overcome for food safety of condiments. Radio frequency (RF) pasteurisation is a new technology to solve this obstacle. Temperature distribution and heating uniformity of sample, which are influenced by different factors, are the most important things affecting the nutritional ingredients and microbial safety of sample in the process of RF pasteurisation. This study demonstrated the location of cold spot in chili powder by analysing temperature distribution in horizontal and vertical direction. The related models were established and the accuracy was verified. RESULTS: Cold spot located on the centre of sample surface in the process of RF pasteurisation. The averaged temperature of sample increased linearly. The uniformity index decreased as the averaged temperature increased. Both the correlation coefficient of two equations were greater than 0.91. The error value of heating rate and heating uniformity index was 0.54% and 0.75% between the measured value and predicted value. CONCLUSION: Electric field was not uniformly distributed between RF parallel-plate electrodes in the RF pasteurisation of chili powder. The heating models were reliable to predict experiment results with high precision and accuracy. © 2015 Society of Chemical Industry.


Assuntos
Capsicum/química , Frutas/química , Modelos Químicos , Pasteurização/métodos , Ondas de Rádio , Especiarias/análise , Algoritmos , Capsicum/economia , Capsicum/efeitos da radiação , China , Eletrodos , Frutas/microbiologia , Frutas/efeitos da radiação , Temperatura Alta/efeitos adversos , Humanos , Cinética , Valor Nutritivo , Pasteurização/instrumentação , Projetos Piloto , Ondas de Rádio/efeitos adversos , Reprodutibilidade dos Testes , Especiarias/economia , Especiarias/microbiologia , Especiarias/efeitos da radiação , Propriedades de Superfície , Água/análise
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