Assessment of the oxidative status in mother-child couples from Seville (Spain): A prospective cohort study.

Pregnancy requires a high demand of energy, which leads to an increase of oxidative stress. The aim of this study was to assess the oxidative status in 200 couples of pregnant women-newborns at the time of delivery, for the first time, who gave birth in two University Hospitals from the province of Seville. Recruited women filled an epidemiological questionnaire with their demographic characteristics and dietary habits during pregnancy. At the time of delivery, both maternal and cord blood samples were collected. Protein oxidation, superoxide dismutase, and catalase levels were measured to assess the oxidative status of these women, together with the levels of vitamins D, B12, Zn, Se, and Cu. Our results showed a tendency for all biomarkers measured to be higher in cord blood than in maternal blood. For the correlations established between the OS markers and sociodemographic characteristics, only significant differences for carbonyl groups values were found on both maternal and cord blood, relating these higher values to the use of insecticides in the women's homes. For newborns, only a significant correlation was detected between antioxidant enzymes and the newborn's weight, specifically for superoxide dismutase activity. Additionally, the higher values obtained in cord blood might suggest metabolization, while a higher production of ROS and antioxidant enzymes might be required to maintain the balance. Measured levels for Se were similar in both maternal and cord blood, unlike Cu and Zn, where higher levels were found for maternal blood than cord blood, indicating a correlation between maternal Se values and SOD as OS biomarker. Furthermore, vitamin D levels were around the optimum values established, finding a relationship between vitamin D and new-born's height, unlike for vitamin B12 values, where a correlation with maternal food consumption characteristics was established. Overall values were inside normal ranges and consistent for our population.

Experience on how to implement a preanalytical and POCT unit in Madrid's IFEMA field hospital during this unprecedented COVID-19 emergency.

To fight the virus SARS-CoV-2 spread to Europe from China and to give support to the collapsed public health system, the Spanish Health Authorities developed a field hospital located in the facilities of Madrid exhibition centre (IFEMA) to admit and treat patients diagnosed with SARS-CoV-2 infectious disease (COVID-19). The Department of Laboratory Medicine of La Paz University Hospital in Madrid (LMD-HULP) was designated to provide laboratory services. Due to the emergency, the IFEMA field hospital had to be prepared for patient admission in less than 1 week and the laboratory professionals had to collaborate in a multidisciplinary group to assure that resources were available to start on time. The LMD-HULP participated together with the managers in the design of the tests portfolio and the integration of the healthcare information systems (IS) (hospital IS, laboratory IS and POCT management system). Laboratorians developed a strategy to quickly train clinicians and nurses on test requests, sample collection procedures and management/handling of the POCT blood gas analyser both by written materials and training videos. The IFEMA´s preanalytical unit managed 3782 requests, and more than 11,000 samples from March 27th to April 30th. Furthermore, 1151 samples were measured by blood gas analysers. In conclusion, laboratory professionals must be resilient and have to respond timely in emergencies as this pandemic. The lab's personnel selection, design and monitoring indicators to maintain and further improve the quality and value of laboratory services is crucial to support medical decision making and provide better patient care.

La inaceptable exclusión de género del principio pro homine en salud y las subreglas de su aplicación / Unacceptable gender discrimination of the pro homine principle in health and the sub-rules of its application

La obligación de garantizar la equidad de género no es un asunto exclusivamente jurídico. Por el contrario, se trata de una necesidad social que le compete a todas las disciplinas. Las Ciencias de la Salud y el Derecho deben comprender y comprometerse con dicho mandato así uno de los principios (pro homine) de la nueva Ley Estatutaria de la Salud sea patriarcal, en tanto mantiene el lenguaje que otorga predominio a lo masculino sobre lo femenino. La novedad e importancia de este artículo radica en la refelexión sobre el carácter orientador que la mencionada ley está llamada a cumplir en los próximos años y en los compromisos internacionales del Estado colombiano con la equidad de género. Sólo la comprensión general de que por principio "pro homine" debe entenderse como principio "pro persona", evitará mantener factores discriminatorios en un sistema de salud en el que aún persisten exclusiones y que con las subreglas jurisprudenciales permitirá una aplicación a favor del derecho a la salud de todas las personas.

The obligation to ensure gender equality is not a merely legal issue. On the contrary, it is a social need that is the responsibility of all disciplines. The health sciences and law need to understand and engage with such a mandate, so one of the new statutory law of health principles (pro homine) is patriarchal, as long as it maintains a male language over the feminine one. The novelty and importance of this article lies in the reflection on the guiding character that the mentioned law is called to meet in the coming years and in the international commitments of the Colombian State with gender equality. Only the general understanding that the principle "pro homine", which should be understood as the principle "pro person", will prevent discriminatory factors in a health system in which there are still exclusions, and with the help of the jurisprudence sub-rules, it will enable an application in favor of the right to health of all people.

[Academic and psycho-socio-familiar factors associated to anxiety and depression in university students. Reliability and validity of a questionnaire]. / Fiabilidad y validez de un cuestionario para medir en estudiantes universitarios la asociación de la ansiedad y depresión con factores académicos y psicosociofamiliares durante el curso 2004-2005.

BACKGROUND: The high frequency of anxiety and depression in university students is related to social, family factors and academic stress. The aim of this research is to determine the internal consistency and validity of a questionnaire on socio-familiar and academic situations which may be related to psychopathological situations in university students. METHODS: The research was carried out at the Universidad Católica San Antonio de Murcia with 700 students, to whom a questionnaire made by the researchers was given. This questionnaire included items which evaluated academic and socio-familiar aspects. Variables regarding various stressful situations amongst students, and the Goldbergs level of anxiety and depression scale were used as independent facts of research in order to measure the validity of the questionnaire. RESULTS: The reliability of the questionnaire was shown after obtaining an intraclass correlation coefficient of 0.819. The original questionnaire with 19 items was reduced to 15 items after the homogeneity analysis, obtaining a Cronbach alpha of 0.758. The validity of constructio was evaluated with the factor analysis of the questionnaire, with a result of two factors which represented academic aspects and socio-familiar aspects. Those students with a positive anxiety and depression test were the ones who obtained the higher score on the global questionnaire and in both factors, proving the validity of the criteria. CONCLUSIONS: The research questionnaire is an agile and easy to use tool for the assessment and early detection of anxiety and depression in university students.