Assessment of the safety of dietary fish oil supplements in terms of content and quality.

The fatty acid composition of top-selling fish oil dietary supplements in the markets was compared with the content stated on product label, and their oxidative qualities and heavy metal contents were evaluated in this study. While all the capsule groups (C) confirmed the label information, it was observed that one-third of the syrup groups (S) had less than the specified content. Capsule groups generally had richer EPA and DHA contents than syrup groups in the samples examined. The peroxide values (PV) of all fish oil capsules and syrups were found in the range of 1.97-2.89 mEq/kg and 2.22-18.30 mEq/kg, respectively. As for free fatty acids (FFA) values, the C4, S6, S9, and S10 groups were above the 3% oleic acid limit recommended for high-quality oils. However, thiobarbituric acid reactive substances (TBARs) values were found below 1 mg MA/kg in all groups. All fish oil supplements were within the limits specified in terms of As (0.50-4.19 µg/g), Cd (0.14 µg/g detected for one group, C5), Cu (not detected), Fe (0.32-15.7 µg/g), and Hg (≤ 0.1 µg/g). On the other hand, two fish oil supplements from the capsule group (0.17 for C6 and 1.01 µg/g for C8) and one group from the syrup group (0.29 µg/g for S10) exceeded the recommended limit in terms of Pb (0.1 mg/kg). As a result of the research, it can be concluded that the chemical quality of fish oils in syrup form needs to be improved and their reliability in terms of fatty acid content should be increased. Considering the heavy metals, it seems significant to follow up the fish oil products more strictly.

Metal Bioaccumulation in the Gill, Liver, and Muscle of Bluefish (Pomatomus saltatrix) From the Northeastern Mediterranean and Human Health Risk Assessment Associated with Their Seasonal Consumption.

Heavy metals are continuously released into the oceans from both natural and anthropogenic sources. They are serious threats to both ecosystem and human health because of their toxicity, persistence, bioaccumulation, and biomagnification. We present metal concentrations in the economically important bluefish from Iskenderun Bay, providing valuable information on Northeastern Mediterranean aquatic ecosystem health, as well as the human health risk. The concentrations of manganese, iron, copper, zinc, selenium, cadmium, lead, and mercury were determined in the gill, liver, and muscle tissues of bluefish (Pomatomus saltatrix) caught in Iskenderun Bay (Turkey) during four seasons. Samples were analysed via inductively coupled plasma mass spectrometer. Fe and Zn were detected in the highest concentrations during all four seasons. The ranges of Fe concentrations were 61.15-108.76, 229.78-377.02, and 6.35-8.63 and those of Zn were 25.21-44.25, 42.25-76.08, and 6.27-13.59 in the gills, livers, and muscles, respectively. In contrast, Hg and Cd were not found in the bluefish tissues in any season with the exception of Cd in the gills during the spring (0.757 mg/kg, above the legal limit of 0.5 mg/kg). On a seasonal basis, no meaningful accumulation trend was observed for the muscles or gills, while the highest concentrations of Mn, Fe, Cu, Zn, and Se in the liver were found in the spring. Liver tissues possessed higher metal concentrations than gill and muscle tissues. Estimated daily and weekly intakes of the metals due to human consumption of the bluefish were considerably lower than the provisional tolerable intake. In this study, there was an inflow of metals into Iskenderun Bay; however, no significant metal accumulation was found in bluefish tissues at a rate that would harm human health.