RESUMO
This paper reports the conclusions of a recent workshop that was established to discuss how health impact assessments (HIAs) might be evaluated. The main purposes of HIA are: (a) to predict the consequences of different decisions; (b) to make the decision-making process more open by involving stakeholders; and (c) to inform the decision makers. 'Prediction', 'participation' and 'informing decision makers' are thus the three domains in which HIA should be evaluated. In the 'prediction' domain, process criteria scrutinize the methods used to see if it is likely that they would produce reliable predictions. Outcome criteria involve verifying the predictions, but this is frequently impractical and predictions for the counter factual (the option not chosen) can never be verified. In the 'participation' domain, process criteria examine the ways in which stakeholders were involved, while outcome criteria explore the degree to which the stakeholders felt included. In the 'informing decision makers' domain, process criteria are concerned with the communication between decision makers and those doing the HIA, and should reflect upon the relevance of the HIA content to the decision makers' agenda. Outcome criteria explore the degree to which the decision makers considered that they had been informed by the HIA. This paper concludes with suggestions for the types of information that should be included in HIA reports in order to permit the readers to make an assessment of the 'quality' of the HIA using the three domain criteria outlined above.
Assuntos
Planejamento em Saúde Comunitária/métodos , Tomada de Decisões Gerenciais , Avaliação das Necessidades/organização & administração , Planejamento em Saúde Comunitária/economia , Política de Saúde , Humanos , Avaliação das Necessidades/economia , Administração em Saúde Pública/métodos , Reprodutibilidade dos TestesRESUMO
The grounding of the Sea Empress oil tanker resulted in the release of 72,000 tonnes of crude oil into Milford Haven, Wales, UK. Our initial studies indicated that this contamination resulted in elevated levels of DNA adducts in one of the area's native marine species Lipophrys pholis [B.P. Lyons, J.S. Harvey, J.M. Parry, An initial assessment of the genotoxic impact of the Sea Empress oil spill by the measurement of DNA adduct levels in the intertidal teleost Lipophrys pholis, Mutat. Res. 390 (1997) 263-268]. These original studies were extended and the genotoxic impact of the oil contamination was investigated in the invertebrates Halichondria panicea and Mytilus edulis, along with the vertebrate fish species L. pholis, Pleuronectes platessa and Limanda limanda. DNA adduct levels were assessed in these species over a period of 2-17 months after the incident. The studies indicate differences in the impact of acute oil contamination upon vertebrate and invertebrate species. The oil contamination did not induce any detectable elevations in adduct levels in the invertebrate species H. panicea and M. edulis. In contrast, the oil contamination did appear to induce adducts in the vertebrate teleost species L. pholis, P. platessa and Lim. limanda. Despite some difficulties in sampling, the data obtained 12-17 months after the spill suggested that the affected species recovered from the oil contamination. While the studies indicate that the genetic impact of the oil contamination was less severe than might have been expected, it remains possible that the DNA adducts detected in the teleosts could lead to genetic changes in these species in the future.
Assuntos
Adutos de DNA/análise , Petróleo/toxicidade , Poluentes Químicos da Água , Animais , Bivalves , Peixes , Linguado , Invertebrados , Água do Mar , País de Gales , Poluição Química da ÁguaRESUMO
The Sea Empress oil spill resulted in the release of vast quantities of potentially genotoxic contaminants into the coastal environment of the county of Pembrokeshire (UK). We are at present attempting to determine the potential genotoxic impact of the incident upon the native marine species of the area. Here we describe the levels of DNA adducts in specimens of the intertidal teleost, Lipophrys pholis, exposed to extensive oil extensive oil contamination as an indication of exposure to potential genotoxins. We detected elevated levels of adducts in L. pholis specimens from an area that underwent heavy oil contamination as compared to specimens from a clean reference area devoid of oil contamination. These preliminary studies indicated that the oil contamination induced DNA adducts in the L. pholis specimens, which could potentially cause genetic damage in this native marine species. Further studies are now required to assess the full extent of the genotoxic impact of the oil spill upon the Pembrokeshire area's native marine life.
Assuntos
Adutos de DNA/análise , Peixes/genética , Testes de Mutagenicidade , Mutagênicos/toxicidade , Petróleo , Poluentes Químicos da Água/toxicidade , Animais , Biomarcadores , DNA/química , DNA/isolamento & purificação , Brânquias/química , Marcação por Isótopo , Fígado/química , Radioisótopos de FósforoRESUMO
Within the framework of its' Environment Research and Development Programme, the European Communities (EC) Directorate General (DG) XII has supported a research project aimed at developing and validating assay systems for the detection and evaluation of chemicals capable of inducing numerical chromosome changes such as aneuploidy and polyploidy. A range of test chemicals were selected, which include a core set comprising; colchicine, econazole nitrate, chloral hydrate, hydroquinone, diazepam, thiabendazole, cadmium chloride, thimerosol, pyrimethamine and vinblastine sulphate. These test chemicals were used to evaluate the ability of test systems ranging from tubulin polymerisation, fungal cultures, cultured mammalian cells and intact rodents to detect chemical aneugens and to assess the significance of such activity to exposed human populations.
Assuntos
Aneuploidia , Poluentes Ambientais/toxicidade , Mutagênicos/toxicidade , Animais , Aspergillus/efeitos dos fármacos , Cádmio/toxicidade , Cloreto de Cádmio , Ciclo Celular/efeitos dos fármacos , Células Cultivadas , Hidrato de Cloral/toxicidade , Cloretos/toxicidade , Colchicina/toxicidade , Diazepam/toxicidade , Econazol/toxicidade , Europa (Continente) , União Europeia , Hidroquinonas/toxicidade , Mamíferos , Testes de Mutagenicidade , Pirimetamina/toxicidade , Salmonella typhimurium/efeitos dos fármacos , Tiabendazol/toxicidade , Timerosal/toxicidade , Vimblastina/toxicidadeRESUMO
The objectives of the European Economic Community's Environmental Research and Development Programmes are to provide a scientific basis for current environmental policy and future environmental management. This paper reviews the work and achievements of the studies carried out by the collaborating laboratories during the period 1981-1985 of the 3rd Programme within the research area 'The Genetic Effects of Environmental Chemicals'. Research efforts supported by the programme may be divided into (i) those involving the validation of current genotoxicity assays and the evaluation of their use in community regulatory activities such as the classification and labelling of chemicals, (ii) those involving the characterization of the metabolic and genotoxic profile of specific chemicals and (iii) those involving the development of new technologies suitable for the hazard identification and risk evaluation of genotoxins. Validation studies have included those of the host mediated assay (and its various modifications), unscheduled DNA synthesis assays and a variety of Drosophila genotoxicity assays. New developments include assays for the detection of chromosome aneuploidy, protocols for cell transformation studies, the detection and quantification of genotoxic lesions, techniques for the study of transplacental genotoxicity, assays for the detection of genotoxic activity in the liver and in germ cells and monitoring techniques for the assessment of both environmental quality and genotoxin exposure in individuals and in populations. The coordination of research effort, such as that described here provides an effective mechanism for the concentration of research on specific problems, for the rapid dissemination of experimental data and the transfer of technology within the European Community.