Histological assessment of mandibular bone tissue after guided bone regeneration with customized computer-aided design/computer-assisted manufacture titanium mesh in humans: A cohort study.

BACKGROUND: Innovative customized computer-aided design/computer-assisted manufacture (CAD-CAM) titanium meshes have been proposed for guided alveolar bone regeneration. Histological confirmation on the quality of the regenerated bone is needed. Purpose of the study is to assess the integration capabilities of these innovative meshes and to evaluate the histological features of the regenerated alveolar bone. MATERIALS AND METHODS: Twenty partially edentulous patients, with severe posterior mandibular atrophy, underwent a guided bone regeneration technique by means of customized CAD-CAM titanium mesh in association with a mixture of autologous bone in chips and deproteinized bovine bone (1:1). At 9 months of healing, titanium meshes and bone samples were collected and histomorphometrically analyzed. RESULTS: In all patients, implants were placed according to the original plan. At histologic analysis, mesh appeared well osseointegrated, except that in sites where membrane exposure occurred. In all sites, newly formed tissue resulted highly mineralized, well-organized, and formed by 35.88% of new lamellar bone, 16.42% of woven bone, 10.88% of osteoid matrix, 14.10% of grafted remnants, and 22.72% of medullary spaces. Blood vessels were the 4% of the tissue. CONCLUSIONS: Data from this study support the use of customized CAD/CAM titanium mesh for regeneration of vital, well-structured, and vascularized alveolar bone.

Functional jaw muscle assessment in patients with a full fixed prosthesis on a limited number of implants: a review of the literature.

BACKGROUND: Full fixed prosthesis on a limited number of implants (FFP) are a viable treatment option for edentulous patients with a reduced amount of residual bone. Jaw muscular function in FFP patients has been evaluated in several studies, however heterogeneous data emerge from literature. PURPOSE: The aim of this review of the literature was to assess the function of jaw muscles in edentulous patients restored with full fixed prostheses on a limited number (≤ 6) of implants, as compared to dentate subjects and edentulous subjects wearing dentures, implant-supported overdentures or full fixed prostheses supported by more than six implants. MATERIALS AND METHODS: An electronic search of databases up to December 2013 was performed. The articles were selected using specific inclusion criteria, independent of the study design. RESULTS: A total of 1598 records were identified. After removing the duplicates and excluding records based on title and abstract, only 37 eligible records were identified. After full-text review, seventeen studies were selected for analysis according to the inclusion criteria. From the included studies, only one evaluated masseter muscle thickness in a cross sectional study by means of ultrasound, while the 16 remaining papers evaluated muscular function by using electromyography (EMG). Those studies analysed several heterogeneous parameters throughout the execution of five functional tests and were therefore described and pooled according to the following task categories: clenching; swallowing; reflex and fatigue for statics; and chewing for dynamics. CONCLUSIONS: The results of selected studies seem to indicate that, compared to dentate controls, FFP patients display a global satisfactory neuromuscular equilibrium in static activities, but still have some impairment during chewing.