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Global urbanization has not only promoted social and economic development, but also contributed to seriously ecological challenges. As a type of sustainable landscape patterns, ecological security pattern is considered as an effective spatial pathway to simultaneously conserve ecological security and maintain social-economic development. However, the fragmentation issue of ecological sources of ecological security pattern has not been effectively addressed, although many case studies have been conducted to identify ecological security pattern. In this study, we used spatial conservation prioritization to identify the ecological security pattern of the city belt along the Yellow River in Ningxia, China. Ecological sources were selected using Zonation model while ecological corridors and key ecological nodes were identified with circuit model. The results showed that the ecological security pattern was composed of 97 ecological sources, 226 ecological corridors, 267 pinch points and 22 barriers, covering a total area of 7713.1 km2 and accounting for 34% of the study area. Ecological sources were concentrated in the Helan Mountain, Xiang Mountain and along the Yellow River. Besides, ecological corridors were dense in the southern and eastern part of the study area. Both indicated that the Yellow River and Helan Mountain were the conservation hotspots. Landscape connectivity of ecological sources identified through Zonation-based spatial conservation prioritization was better than that with the scoring approach based on ecosystem service importance. Particularly, in the Zonation approach the landscape connectivity increased with 44% while the average patch area increased with 28% when comparing with the scoring approach. The spatial conservation prioritization approach proposed in this study provides a new effective tool to construct ecological security pattern, which is conducive to the synergic enhancement of landscape connectivity and ecosystem services conservation.
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Ecologia , Ecossistema , Conservação dos Recursos Naturais , Cidades , Análise Espacial , ChinaRESUMO
As a class of promising cathodes in the field of large-scale power storage systems especially for alkali-metal-ion batteries (MIBs), Prussian blue (PB) and its analogues (PBAs) have received wide research attention due to their open framework, high theoretical specific capacity, and simple synthesis method. For large-scale applications, cathode materials with low-cost and long cycle life are preferred. However, only a few of the review papers have concentrated on the detailed analysis of low-cost PBAs, including Fe-based and Mn-based PBAs, which also show excellent electrochemical performance. This review aims to first provide an all-sided understanding of low-cost PBAs in terms of their application and recent progress in MIBs. Then, the major challenges such as inferior electrochemical properties of low-cost PBAs are discussed. Meanwhile, we provide feasible strategies to prepare PBA electrodes with advanced electrochemical performance. Finally, we present some personal perspectives and guidance for future research, aiming to narrow the gap between laboratory investigation and practical application.
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Terrestrial ecosystems, occupying 28.26% of Earth's surface, are extensively at risk from droughts, which is likely to propagate into human communities owing to loss of vital services. Ecosystem risk also tends to fluctuate within anthropogenically-forced nonstationary environments, raising considerable concerns about effectiveness of mitigation strategies. This study aims to assess dynamic ecosystem risk induced by droughts and identify risk hotspots. Bivariate nonstationary drought frequency was initially derived as a hazard component of risk. By coupling vegetation coverage and biomass quantity, a two-dimensional exposure indicator was developed. Trivariate likelihood of vegetation decline was calculated under arbitrary droughts to intuitively determine ecosystem vulnerability. Ultimately, time-variant drought frequency, exposure and vulnerability were multiplied to derive dynamic ecosystem risk, followed by hotspot and attribution analyses. Risk assessment implemented in the drought-prevalent Pearl River basin (PRB) of China during 1982-2017 showed that meteorological droughts in eastern and western margins, although less frequent, were prolonged and aggravated in contrast to prevalence of less persistent and severe droughts in the middle. In 86.12% of the PRB, ecosystem exposure maintains high levels (0.62). Relatively high vulnerability (>0.5) occurs in water-demanding agroecosystems, exhibiting a northwest-southeast-directed extension. A 0.1-degree risk atlas unveils that high and medium risks occupy 18.96% and 37.99% of the PRB, while risks are magnified in the north. The most pressing hotspots with high risk continuing to escalate reside in the East River and Hongliu River basins. Our results provide knowledge of composition, spatio-temporal variability and driving mechanism of drought-induced ecosystem risk, which will assist in risk-based mitigation prioritization.
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Secas , Ecossistema , Humanos , China , Medição de Risco , Probabilidade , Mudança ClimáticaRESUMO
Ecosystem services (ES) are the important component supporting the United Nations Sustainable Development Goals (SDGs) realization. In recent decades, rapid urbanization has strongly affected the relationship between ES and SDGs, resulting in the decoupling of ES and SDGs. However, the key urbanization factors dominating the relationship between ES and SDGs are still unclear. In this study, a structural equation model was constructed to explore the impact path and its change of urbanization structure and scale factors on the relationship between ES and SDGs. The results showed that the economic urbanization structure indicator (Engel coefficient) under the influence of technology import significantly impacted the relationship between ES and SDGs in different periods. Under the influence of changes in urban and rural population, population urbanization structure indicator (labor force population proportion) had significant impact on the relationship between ES and economic SDGs, which was significantly stronger in the period of 2010-2015 than in the period of 2000-2005. Land urbanization scale indicators (construction land proportion, and protected natural area proportion) also significantly impacted the relationship between ES and SDGs. Especially for ecological SDGs, the negative impact of construction land on protected natural area increased significantly in the period of 2010-2015, which might further weaken the ES's contribution to SDGs. This study highlighted that along with the continuous transformation of China's society, the key impacts on the relationship between ES and SDGs resulted from the urbanization indicators of scale as well as structure, which provided an extensive support for the sustainable development and social transformation of developing countries and regions.
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Desenvolvimento Sustentável , Urbanização , China , Conservação dos Recursos Naturais , Ecossistema , Humanos , Nações UnidasRESUMO
OBJECTIVE: The aim of this systematic review was to summarise the psychometric properties of patient-reported outcome measures (PROMs) measuring financial toxicity (FT) in cancer survivors. DESIGN: This systematic review was conducted according to the guidance of the Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) methodology. DATA SOURCES: Comprehensive searches were performed in PubMed, MEDLINE, Embase, CINAHL, PsycINFO, Web of Science, ProQuest and Cochrane Library from database inception to February 2022. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: We included studies that reported any PROMs for measuring FT in cancer survivors who were ≥18 years old. FT was defined as perceived subjective financial distress resulting from objective financial burden. Studies that were not validation studies and that used a PROM only as an outcome measurement were excluded. DATA EXTRACTION AND SYNTHESIS: Two reviewers independently extracted data from the included papers. We used the COSMIN criteria to summarise and evaluate the psychometric properties of each study regarding structural validity, internal consistency, reliability, measurement error, hypothesis testing for construct validity, cross-cultural validity/measurement invariance, criterion validity and responsiveness. RESULTS: A total of 23 articles (21 PROMs) were eligible for inclusion in this study. The findings highlighted that the Comprehensive Score for Financial Toxicity (COST) had an adequate development process and showed better psychometric properties than other PROMs, especially in internal consistency (Cronbach's α=0.92), reliability (intraclass correlation coefficient=0.80) and hypothesis testing (r=0.42-0.20). CONCLUSIONS: From a psychometric property perspective, the COST could be recommended as the most suitable worldwide available measure for use in research and clinical practice across different contexts. We suggest that PROMs should be selected only after careful consideration of the local socioeconomic context. Future studies are warranted to develop various FT PROMs based on different social and cultural backgrounds and to clarify the theoretical grounds for assessing FT.
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Sobreviventes de Câncer , Neoplasias , Adolescente , Estresse Financeiro , Humanos , Medidas de Resultados Relatados pelo Paciente , Psicometria , Qualidade de Vida , Reprodutibilidade dos Testes , AutorrelatoRESUMO
Previous research has mainly focused on the positive effects of organizational citizenship behavior (OCB). This study questions the positive impact of OCB, arguing that there is a health cost of OCB. Based on the conservation of resource theory, this study expects that OCB triggers citizenship fatigue, which, in turn, negatively affects employees' health and results in health complaints. This study also seeks to find a moderator (health-promoting leadership) that could mitigate the negative effects of citizenship fatigue (caused by engaging in OCB) on health complaints. To test our predictions, we collected three-wave data from 207 leader-subordinate dyads. The results of regression analyses show that OCB is positively related to employees' health complaints, which is mediated by citizenship fatigue. Health-promoting leadership weakens the positive relationship between citizenship fatigue and health complaints, thus negatively moderating the indirect relationship between OCB and health complaints via citizenship fatigue. This study provides theoretical and practical implications for future research directions.
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Liderança , Cultura Organizacional , Cidadania , Fadiga , Custos de Cuidados de Saúde , HumanosRESUMO
Increasingly growing consumption-based water use (WU) combined with climate change have exacerbated water stress globally and regionally, yet little is known about how the WU change is affected by metacoupled processes which involve human-nature interactions across space; within and across adjacent and distant places. This study aims to unveil the spatio-temporal pattern of China's WUs during 2007-2015 and its underlying local and non-local drivers. Results show that China's total WU exhibited an upward trend from 386.7 billion m³; in 2007 to 431.2 billion m³ in 2012 but dropped to 412.6 billion m³ by 2015. Widespread and continuous water use efficiency improvement contributed most to offsetting the increase in WU driven by the rising affluence and growing population in the context of rapid urbanization and industrialization. Economic structure drove a relatively large WU reduction (responsible for -23.7% of the WU change during 2007-2015), in line with China's ongoing transform from a capital investment-driven economy to a consumption-driven one and decoupling economic growth from environmental pressure. The population share representing the non-local factor of migration effect was large enough to be seen clearly in the changing WUs across China: the WUs of coastal areas ascended while inland areas descended, which was in accordance with migration patterns. Our findings could make a valuable contribution to decision-making in identifying hotspot areas, charting systematic courses for sustainable water use, and combining demand-oriented and supply-oriented measures.
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Desenvolvimento Econômico , Urbanização , China , Humanos , Investimentos em SaúdeRESUMO
BACKGROUND: Longitudinal measurement of tumor burden with magnetic resonance imaging (MRI) is an essential component of response assessment in pediatric brain tumors. We developed a fully automated pipeline for the segmentation of tumors in pediatric high-grade gliomas, medulloblastomas, and leptomeningeal seeding tumors. We further developed an algorithm for automatic 2D and volumetric size measurement of tumors. METHODS: The preoperative and postoperative cohorts were randomly split into training and testing sets in a 4:1 ratio. A 3D U-Net neural network was trained to automatically segment the tumor on T1 contrast-enhanced and T2/FLAIR images. The product of the maximum bidimensional diameters according to the RAPNO (Response Assessment in Pediatric Neuro-Oncology) criteria (AutoRAPNO) was determined. Performance was compared to that of 2 expert human raters who performed assessments independently. Volumetric measurements of predicted and expert segmentations were computationally derived and compared. RESULTS: A total of 794 preoperative MRIs from 794 patients and 1003 postoperative MRIs from 122 patients were included. There was excellent agreement of volumes between preoperative and postoperative predicted and manual segmentations, with intraclass correlation coefficients (ICCs) of 0.912 and 0.960 for the 2 preoperative and 0.947 and 0.896 for the 2 postoperative models. There was high agreement between AutoRAPNO scores on predicted segmentations and manually calculated scores based on manual segmentations (Rater 2 ICC = 0.909; Rater 3 ICC = 0.851). Lastly, the performance of AutoRAPNO was superior in repeatability to that of human raters for MRIs with multiple lesions. CONCLUSIONS: Our automated deep learning pipeline demonstrates potential utility for response assessment in pediatric brain tumors. The tool should be further validated in prospective studies.
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Neoplasias Cerebelares , Aprendizado Profundo , Glioma , Meduloblastoma , Criança , Glioma/diagnóstico por imagem , Glioma/patologia , Glioma/cirurgia , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Meduloblastoma/diagnóstico por imagem , Meduloblastoma/cirurgia , Estudos Prospectivos , Carga TumoralRESUMO
PURPOSE: Patients with mid-to low-rectal cancer can have various dysfunctions of defecation after sphincter-saving resection. Defecation dysfunction can manifest as incontinence, urgency, or frequent bowel movements, and is called low anterior resection syndrome (LARS). This study aimed to examine LARS score and objective anorectal function indices in Chinese patients receiving sphincter-saving surgery for mid-to low-rectal cancer. METHOD: This was a single-center cross-sectional study of patients undergoing sphincter-saving resection for low- or mid-rectal cancer and had restoration of trans-anal defecation for at least 1 month seen between January 2019 and June 2020. Patients completed a questionnaire regarding clinical characteristics, and Low Anterior Resection Syndrome (LARS) score and high-resolution anorectal manometry (HR-ARM) were used to assess defecation function. Multivariable analysis was used to identify variables significantly associated with defecation dysfunction. RESULTS: 146 patients completed and returned the questionnaires. 25 healthy adults also participated as control group for the anorectal manometry. Approximately 76% of patients developed LARS after surgery, of which 35.6% had major LARS. In these patients, anorectal manometry indices including initial rectal sensory capacity and rectal fecal sensory capacity, were significantly lower than normal. Logistic regression analysis showed that preoperative chemo-radiotherapy and the tumor inferior margins being close to the dentate line, especially 2-5 cm, were independent risk factors for defecation dysfunction after surgery. CONCLUSIONS: Defecation dysfunction is a frequent occurrence after sphincter-saving resection for mid- and low-rectal cancer. Preoperative chemo-radiotherapy and a shorter tumor inferior margins distance to the dentate line are independent factors for defecation dysfunction.
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Incontinência Fecal , Neoplasias Retais , Adulto , Canal Anal/cirurgia , Estudos Transversais , Defecação , Incontinência Fecal/etiologia , Humanos , Complicações Pós-Operatórias , Neoplasias Retais/cirurgia , Síndrome , Resultado do TratamentoRESUMO
Background Atrial fibrillation causes ischemic stroke when thrombi dislodge from a cardiac outpouching, the left atrial appendage (LAA), and embolize to the brain. LAA occlusion with the Watchman™ device (Boston Scientific Corporation, MA, USA), which prevents stroke, requires accurate LAA measurements for device sizing. We explore whether standard fluoroscopic LAA measurements improve when obtained at CT-derived viewing angles personalized to LAA anatomy while concurrently referring to three-dimensional (3D) CT. Methods Left atrial 3D reconstructions created from contrast CT (n=28) were analysed to identify personalized viewing angles wherein LAA dimensions (LAA maximum landing zone diameter and LAA length) were best observed. The 3D-CT reconstructions were then 3D printed with stands. Fluoroscopy of anatomically oriented models in the catheter lab simulated LAA angiography. Fluoroscopic images were acquired at standard (caudal 20Ë/right anterior oblique 30Ë) and personalized viewing angles. Repeated measurements of LAA dimensions were taken from CT (Control), fluoroscopy at standard angles (Standard), personalized angles (Blinded), and personalized angles while concurrently referring to 3D CT (Referred). Results Control measurements correlated and agreed better with Referred and Blinded measurements than with Standard measurements (diameter correlation and agreement: Control/Standard r=.554, limits of agreement [LOAs]=6.83/-5.91; Control/Blinded r=.641, LOA =5.67/-5.54; Control/Referred r=.741, LOA=4.69/-4.14; length correlation and agreement: Control/Standard rs=.829, LOA=9.61/-3.02; Control/Blinded rs=0.789, LOA=7.13/-4.94; Control/Referred rs=.907, LOA=4.84/-4.13). Personalized angles resulted in hypothetical device size predictions more consistent with Control (device size correlation: Control/Standard rs=.698, Control/Blinded rs=.731, Control/Referred rs=.893, P<0.001). False ineligibility rates were Standard=6/28, Blinded=6/28, and Referred=2/28. Conclusion This simulation suggests that personalized fluoroscopic viewing angles with in-procedural reference to 3D CT may improve the accuracy of LAA maximum landing zone diameter and length measurements at the Watchman landing zone. This improvement may result in more consistent device size selection and procedural eligibility assessment. Further clinical research on these interventions is merited.
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INTRODUCTION: Due to the higher costs associated with advancements in cancer treatment and longer duration of cancer survivorship, increasing financial toxicity has become a great threat to survivors, caregivers and public healthcare systems. Since accurate and reproducible measures are prerequisites for robust results, choosing an acceptable measure with strong psychometric properties to assess financial toxicity is essential. However, a description of the psychometric properties of existing measures is still lacking. The aim of this study is to apply COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology to systematically review the content and structural validity of patient-reported outcome measures (PROMs) of financial toxicity for cancer survivors. METHODS AND ANALYSIS: PubMed/Medline, Medline (Ovid), Embase (Ovid), CINAHL (EBSCO), Web of Science, ProQuest Dissertations and Theses, and Cochrane Library (Wiley) will be comprehensively searched from database inception to 15 November 2019. Studies that report the measurement properties of PROMs assessing financial toxicity for cancer survivors will be included. The evaluation of measurement properties, data extraction and data synthesis will be conducted according to the COSMIN methodology. ETHICS AND DISSEMINATION: No individual data are involved in this systematic review. The results will be disseminated to a clinical audience and policy-makers though peer-reviewed journals and conferences and will support researchers in choosing the best measure to evaluate the financial toxicity of cancer survivors.
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Sobreviventes de Câncer , Neoplasias , Humanos , Medidas de Resultados Relatados pelo Paciente , Psicometria , Autorrelato , Inquéritos e Questionários , Revisões Sistemáticas como AssuntoRESUMO
With the increasing expansion of cities associated with rapid urbanization, the ecological environment is being severely damaged, exposing cities to frequent extreme weather events. Urban ecological ecosystems are under great threat. Research on urban disaster resilience is conducive to a better understanding of disaster prevention and mitigation capacity, and provides valuable references for resilient city construction. In this study, a typical city under rapid urbanization in China - Shenzhen - was chosen as the research area, including the city's 57 sub-districts. Urban disaster resilience to rainfall-induced landslides was conceptually framed into the dimensions of physical resilience and social resilience. Support vector machine (SVM) was applied to evaluate the physical resilience and a Delphi-analytic hierarchy process (Delphi-AHP) model was used to assess social resilience on a sub-district scale in 2016. The results show that the physical resilience and social resilience of Shenzhen demonstrate obvious spatial concentration trends. Areas with low physical resilience were located in sub-districts of Dapeng New District with intense rainfall and complex topography, as well as those in Guangming New District with lateritic red earth derived from arenaceous shale. Areas with low social resilience were mainly located in eastern Shenzhen, including sub-districts in Longgang District and Dapeng New District, with undeveloped economy, inadequate infrastructures and many vulnerable people. All sub-districts in the three districts of Pingshan New District, Dapeng New District and Guangming New District need attention because of their low comprehensive resilience. Comparison of the physical resilience and social resilience indicated that the performance of physical resilience was significantly better than that of social resilience; only 26% of the sub-districts of Shenzhen had a higher level of social resilience than of physical resilience. Therefore, the government should strengthen urban management of social services and physical infrastructure provision to improve social resilience to cope with urban disasters.
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The employment of mobile vehicles to charge sensors via wireless energy transfer is a promising technology to maintain the perpetual operation of wireless sensor networks (WSNs). Most existing studies assumed that sensors are powered with off-the-shelf batteries, e.g., Lithium batteries, which are cheap, but it takes some non-trivial time to fully charge such a battery (e.g., 30â»80 min). The long charging time may incur long sensor dead durations, especially when there are many lifetime-critical sensors to be charged. On the other hand, other studies assumed that every sensor is powered with an ultra-fast charging battery, where it only takes some trivial time to replenish such a battery, e.g., 1 min, but the adoption of many ultra-fast sensors will bring about high purchasing cost. In this paper, we propose a novel heterogeneous sensor network model, in which there are only a few ultra-fast sensors and many low-cost off-the-shelf sensors. The deployment cost of the network in the model is low, as the number of ultra-fast sensors is limited. We also have an important observation that we can significantly shorten sensor dead durations by enabling the ultra-fast sensors to relay more data for lifetime-critical off-the-shelf sensors. We then propose a joint charging scheduling and routing allocation algorithm, such that the longest sensor dead duration is minimized. We finally evaluate the performance of the proposed algorithm through extensive simulation experiments. Experimental results show that the proposed algorithm is very promising and the longest sensor dead duration by it is only about 10% of those by existing algorithms.
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The construction of regional ecological security pattern can effectively protect regional ecological security and achieve regional sustainable development, which has become one of the key topics in landscape ecology. The construction of regional ecological security pattern is particularly important for the Inner Mongolia Plateau, which is characterized by relatively fragile ecological environment and single land cover type. Considering regional natural environment characteristics, five typical ecosystem services, such as food supply, carbon fixation and oxygen release, soil conservation, water yield and habitat conservation, were selected to assess the importance of natural habitats with Hangjin Banner of Inner Mongolia Autonomous Region as a case study area. Based on comprehensive consideration of single ecosystem service quality and landscape multi-functionality, ecological sources were identified. The basic ecological resistance surface based on the land cover was revised by the surface humid index. The minimum cumulative resistance model was used to identify the ecological corridors, to construct the ecological security pattern of Hangjin Banner. The results showed that the ecological source of Hangjin Banner was 6781.70 km2, accounting for 35.9% of the whole area, which mainly located in the northern Hetao Plain and southern Ordos steppe zone. The total ecological corridor length of Hangjin Banner was 498.51 km, which was divided into two groups from north to south by Kubuqi Desert. Based on the arid and ecologically fragile characteristics in the agro-pastoral ecotone in northern China, this study constructed regional ecological security pattern to provide decision-making guidelines for local economic development and ecological conservation.
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Agricultura , Conservação dos Recursos Naturais , Ecossistema , China , Ecologia , SoloRESUMO
Several studies have reported the efficacy of a zero-fluoroscopy approach for catheter radiofrequency ablation of arrhythmias in a digital subtraction angiography (DSA) room. However, no reports are available on the ablation of arrhythmias in the absence of DSA in the operating room. To investigate the efficacy and safety of catheter radiofrequency ablation for arrhythmias under the guidance of a Carto 3 three-dimensional (3D) mapping system in an operating room without DSA. Patients were enrolled according to the type of arrhythmia. The Carto 3 mapping system was used to reconstruct heart models and guide the electrophysiologic examination, mapping, and ablation. The total procedure, reconstruction, electrophysiologic examination, and mapping times were recorded. Furthermore, immediate success rates and complications were also recorded. A total of 20 patients were enrolled, including 12 males. The average age was 51.3â±â17.2 (19-76) years. Nine cases of atrioventricular nodal re-entrant tachycardia, 7 cases of frequent ventricular premature contractions, 3 cases of Wolff-Parkinson-White syndrome, and 1 case of typical atrial flutter were included. All arrhythmias were successfully ablated. The procedure time was 127.0â±â21.0 (99-177) minutes, the reconstruction time was 6.5â±â2.9 (3-14) minutes, the electrophysiologic study time was 10.4â±â3.4 (6-20) minutes, and the mapping time was 11.7â±â8.3 (3-36) minutes. No complications occurred. Radiofrequency ablation of arrhythmias without DSA is effective and feasible under the guidance of the Carto 3 mapping system. However, the electrophysiology physician must have sufficient experience, and related emergency measures must be present to ensure safety.
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Arritmias Cardíacas/diagnóstico por imagem , Arritmias Cardíacas/cirurgia , Ablação por Cateter/métodos , Imageamento Tridimensional , Adulto , Idoso , Arritmias Cardíacas/fisiopatologia , Ablação por Cateter/economia , Eletrocardiografia , Feminino , Humanos , Imageamento Tridimensional/economia , Masculino , Pessoa de Meia-Idade , Salas Cirúrgicas , Resultado do Tratamento , Adulto JovemRESUMO
Branched-chain amino acids (BCAA) have been clearly demonstrated to have anabolic effects on muscle protein synthesis. However, little is known about their roles in the regulation of net AA fluxes across skeletal muscle in vivo. This study was aimed to investigate the effect and related mechanisms of dietary supplementation of BCAA on muscle net amino acid (AA) fluxes using the hindlimb flux model. In all fourteen 4-week-old barrows were fed reduced-protein diets with or without supplemental BCAA for 28 d. Pigs were implanted with carotid arterial, femoral arterial and venous catheters, and fed once hourly with intraarterial infusion of p-amino hippurate. Arterial and venous plasma and muscle samples were obtained for the measurement of AA, branched-chain α-keto acids (BCKA) and 3-methylhistidine (3-MH). Metabolomes of venous plasma were determined by HPLC-quadrupole time-of-flight-MS. BCAA-supplemented group showed elevated muscle net fluxes of total essential AA, non-essential AA and AA. As for individual AA, muscle net fluxes of each BCAA and their metabolites (alanine, glutamate and glutamine), along with those of histidine, methionine and several functional non-essential AA (glycine, proline and serine), were increased by BCAA supplementation. The elevated muscle net AA fluxes were associated with the increase in arterial and intramuscular concentrations of BCAA and venous metabolites including BCKA and free fatty acids, and were also related to the decrease in the intramuscular concentration of 3-MH. Correlation analysis indicated that muscle net AA fluxes are highly and positively correlated with arterial BCAA concentrations and muscle net BCKA production. In conclusion, supplementing BCAA to reduced-protein diet increases the arterial concentrations and intramuscular catabolism of BCAA, both of which would contribute to an increase of muscle net AA fluxes in young pigs.
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Aminoácidos de Cadeia Ramificada/administração & dosagem , Anabolizantes/administração & dosagem , Dieta com Restrição de Proteínas/veterinária , Desenvolvimento Muscular , Proteínas Musculares/biossíntese , Músculo Esquelético/metabolismo , Regulação para Cima , Aminoácidos/sangue , Aminoácidos/metabolismo , Aminoácidos de Cadeia Ramificada/sangue , Aminoácidos de Cadeia Ramificada/metabolismo , Anabolizantes/sangue , Anabolizantes/metabolismo , Animais , China , Cruzamentos Genéticos , Dieta com Restrição de Proteínas/efeitos adversos , Ácidos Graxos não Esterificados/sangue , Ácidos Graxos não Esterificados/metabolismo , Membro Posterior , Técnicas de Diluição do Indicador , Cetoácidos/sangue , Cetoácidos/metabolismo , Masculino , Metabolômica/métodos , Metilistidinas/sangue , Metilistidinas/metabolismo , Músculo Esquelético/irrigação sanguínea , Músculo Esquelético/crescimento & desenvolvimento , Orquiectomia/veterinária , Fluxo Sanguíneo Regional , Sus scrofa , Aumento de PesoRESUMO
As an anode material for sodium-ion batteries (SIBs), hard carbon (HC) presents high specific capacity and favorable cycling performance. However, high cost and low initial Coulombic efficiency (ICE) of HC seriously limit its future commercialization for SIBs. A typical biowaste, mangosteen shell was selected as a precursor to prepare low-cost and high-performance HC via a facile one-step carbonization method, and the influence of different heat treatments on the morphologies, microstructures, and electrochemical performances was investigated systematically. The microstructure evolution studied using X-ray diffraction, Raman, Brunauer-Emmett-Teller, and high-resolution transmission electron microscopy, along with electrochemical measurements, reveals the optimal carbonization condition of the mangosteen shell: HC carbonized at 1500 °C for 2 h delivers the highest reversible capacity of â¼330 mA h g-1 at a current density of 20 mA g-1, a capacity retention of â¼98% after 100 cycles, and an ICE of â¼83%. Additionally, the sodium-ion storage behavior of HC is deeply analyzed using galvanostatic intermittent titration and cyclic voltammetry technologies.
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As an important approach to the realization of agricultural sustainable development, multifunctionality has become a hot spot in the field of urban agriculture. Taking 13 agricultural counties of Beijing City as the assessing units, this study selects 10 assessing index from ecological, economic and social aspects, determines the index weight using Analytic Hierarchy Process (AHP) method, and establishes an index system for the integrated agricultural function. Based on standardized data from agricultural census and remote sensing, the integrated function and multifunctionality of urban agriculture in Beijing City are assessed through the index grade mapping. The results show that agricultural counties with the highest score in ecological, economic, and social function are Yanqing, Changping, and Miyun, respectively; and the greatest disparity among those counties is economic function, followed by social and ecological function. Topography and human disturbance may be the factors that affect integrated agricultural function. The integrated agricultural function of Beijing rises at the beginning then drops later with the increase of mean slope, average altitude, and distance from the city. The whole city behaves balance among ecological, economic, and social functions at the macro level, with 8 out of the 13 counties belonging to ecology-society-economy balanced areas, while no county is dominant in only one of the three functions. On the micro scale, however, different counties have their own functional inclination: Miyun, Yanqing, Mentougou, and Fengtai are ecology-society dominant, and Tongzhou is ecology-economy dominant. The agricultural multifunctionality in Beijing City declines from the north to the south, with Pinggu having the most significant agricultural multifunctionality. The results match up well with the objective condition of Beijing's urban agriculture planning, which has proved the methodological rationality of the assessment to a certain extent.