Safety and risk assessment of psychedelic psychotherapy: A meta-analysis and systematic review.

Psychotherapies assisted by psychedelic substances have shown promising results in the treatment of psychiatric disorders. The aim of this systematic review and meta-analysis was to evaluate safety data in human subjects. We carried out a search on MEDLINE, Embase and PsycINFO databases between 2000 and 2022. Standardized mean differences between different dose ranges and between acute and subacute phases were calculated for cardiovascular data after psychedelic administration. Risk differences were calculated for serious adverse events and common side effects. Thirty studies were included in this meta-analysis. There were only nine serious adverse events for over 1000 administrations of psychedelic substances (one during the acute phase and 8 during the post-acute phase). There were no suicide attempts during the acute phase and 3 participants engaged in self-harm during the post-acute phase. There was an increased risk for elevated heart rate, systolic and diastolic blood pressure for all dose range categories, as well as an increased risk of nausea during the acute phase. Other common side effects included headaches, anxiety, and decreased concentration or appetite. This meta-analysis demonstrates that psychedelics are well-tolerated, with a low risk of emerging serious adverse events in a controlled setting with appropriate inclusion criteria.

[The assessment of episodic memory: theory and practice]. / L'évaluation de la mémoire épisodique: théorie et pratique.

Episodic memory refers to a system which stores personally experienced events located in time and in space. It is characterized by autonoetic consciousness allowing a subject to be aware of his/her own identity throughout subjective time and to perceive the present as both a continuation of his/her past and as a prelude to his/her future. Current studies of episodic memory should take into account all these features. However, most episodic memory tests are restricted to memory performance and do not really measure episodic memory. In this article, after defining the terms of context and states of awareness, we describe two original tasks designed specially to investigate episodic memory: the 'Quoi-Où-Quand' (What-Where-When) and the 'TEMPau'. The first task allows the study of anterograde amnesia whereas the second consists of an assessment of retrograde amnesia. These two tasks include both scores of memory performance and measures of states of awareness using a procedure derived from the Remember/Know paradigm.

[The assessment of long-term memory and semantic knowledge]. / L'évaluation de la mémoire du passé lointain et des connaissances sémantiques.

Following a previous review about the different components of memory (Eustache et al., Revue Neurologique, 1998), this paper is devoted to the evaluation of both autobiographical and semantic memory. An original method to analyse autobiographical memory is proposed. The different tasks used for the analysis of semantic memory are detailed with a particular emphasis given to the category -specific semantic impairments.

[The study of psychotherapy. Analysis of the psychotherapies given in an ambulatory psychiatric service]. / Contribution à l'étude de la psychothérapie. Analyse de l'ensemble des psychothérapies effectuées à un moment donné dans un service de psychiatrie extrahospitalier (ambulatoire).

Using critisized statistical technics, the authors have studied the psychotherapies done at a given time in a university psychiatric outpatient clinic. Thereupon they display some correlations, more specifically, the importance of sex gender, of patients' socio-cultural level, of unconscious socio-cultural stereotypes present in the therapists, of diagnosis and of the motivation to seek treatment by psychotherapy. Statistical analysis allows a more coherent approach of these problems.