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1.
Eur J Med Res ; 28(1): 296, 2023 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-37626380

RESUMO

BACKGROUND: Soft-tissue swelling after limb fractures in pediatric patients is well known to be a risk factor for developing acute compartment syndrome (ACS). Clinical assessment alone is uncertain in specific cases. Recently, we proposed a non-invasive ultrasound-based method to objectify muscle compartment elasticity for monitoring. We hypothesize a strong correlation between the soft-tissue swelling after stabilization of upper limb fractures and the compartment elasticity objectified with a novel ultrasound-based approach in pediatric trauma. PATIENTS AND METHODS: In a prospective clinical study, children suffering forearm fractures but not developing an ACS were included. The muscle compartment elasticity of the m. flexor carpi ulnaris was assessed after surgical intervention by a non-invasive, ultrasound-based method resulting in a relative elasticity (RE in %) in both the control (healthy limb) and study group (fractured limb). Soft-tissue swelling was categorized in four different levels (0-3) and correlated with the resulting RE (%). RESULTS: The RE in the study group (15.67%, SD ± 3.06) showed a significantly decreased level (p < 0.001) compared with the control (22.77%, SD ± 5.4). The categorized grade of soft-tissue swelling resulted in a moderate correlation with the RE (rs = 0.474). CONCLUSIONS: The presented study appears to represent a novel approach to assess the posttraumatic pressure changes in a muscle compartment after fracture stabilization non-invasively. In this first clinical study in pediatric cases, our measurement method represents a low-cost, easy, and secure approach that has the potential to substitute invasive measurement of suspected ACS in muscle compartment conditions. Further investigations in lager cohorts are required to prove its daily clinical practicability and to confirm the expected reliability.


Assuntos
Antebraço , Fraturas Ósseas , Humanos , Criança , Antebraço/diagnóstico por imagem , Estudos Prospectivos , Reprodutibilidade dos Testes , Fraturas Ósseas/diagnóstico por imagem , Elasticidade , Músculos
2.
Injury ; 52(4): 724-730, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33902865

RESUMO

PURPOSE: The development of acute compartment syndrome is a serious threat to trauma patients. The clinical assessment alone is not reliable enough to determine the need for fasciotomy in many cases. The Physician´s assessment of the elasticity of the muscle compartment might be particularly important to objectively evaluate the pressure in this enclosed space. The purpose of this study was to determine the observer´s reproducibility, of compartment elasticity measurements by a novel ultrasonic approach. METHODS: Increasing intra-compartmental pressures (ICP) were simulated in a water filled in-vitro model. Pressure related ultrasound was used to determine the relative elasticity (RE) of soft tissue compartments. A pressure transducing probe head was combined with the ultrasonic probe to obtain cross section views of the simulated compartment and to detect the amount of applied pressure by the observer. In this model, the compartment depth without compression (P0) was set to be 100%. Changes of the compartment depth due to a probe pressure of 80 mmHg (P80) were correlated to P0 and an elasticity quotient as a value for RE (%) was calculated. Twelve blinded observers performed measurements for RE determination (%) under three pressure conditions. Reproducibility was calculated using intraclass correlation coefficient (ICC). RESULTS: Measurements (n = 432) revealed that the RE (%) in the control group was 17,06% (SD+/-2,13), whereas the RE of the group ICP30 significantly decreased to 12,66% (SD+/- 1,19) (p<0,001). The ICP50 group revealed a further significant decrease to 8,43% (SD+/- 0,67) (p<0,001). Repeated measurement of RE and ICP showed a high level of correlation (spearman correlation coefficient: roh=0,922). A RE <14% resulted in a sensitivity of 96% and a specificity of 90,3% for diagnosis of an ICP >30 mmHg. ICCinter was 0,986; 95%, CI: 0,977-0,992 (p<0,001). DISCUSSION: The presented ultrasound-based approach reliably assesses the elasticity in a simulated compartment model. In this pioneer study investigating the inter- and intra-observer reproducibility, this method of measurement appears to be of low cost in addition to being an easy and secure approach that may have the potential to substitute invasive measurement. Further investigations are required to improve its feasibility and to confirm the reliability under clinical conditions.


Assuntos
Síndromes Compartimentais , Síndromes Compartimentais/diagnóstico por imagem , Elasticidade , Humanos , Pressão , Reprodutibilidade dos Testes , Ultrassonografia
3.
NMR Biomed ; 25(4): 514-22, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21874657

RESUMO

The aim of this study was to determine the value of different magnetic resonance (MR) protocols to assess early tumor response to chemotherapy. We used a murine tumor model (TLT) presenting different degrees of response to three different cytotoxic agents. As shown in survival curves, cyclophosphamide (CP) was the most efficient drug followed by 5-fluorouracil (5-FU), whereas the etoposide treatment had little impact on TLT tumors. Three different MR protocols were used at 9.4 Tesla 24 h post-treatment: diffusion-weighted (DW)-MRI, choline measurement by (1) H MRS, and contrast-enhanced MRI using ultrasmall iron oxide nanoparticles (USPIO) targeted at phosphatidylserine. Accumulation of contrast agent in apoptotic tumors was monitored by T(2) -weighted images and quantified by EPR spectroscopy. Necrosis and apoptosis were assessed by histology. Large variations were observed in the measurement of choline peak areas and could not be directly correlated to tumor response. Although the targeted USPIO particles were able to significantly differentiate between the efficiency of each cytotoxic agent and best correlated with survival endpoint, they present the main disadvantage of non-specific tumor accumulation, which could be problematic when transferring the method to the clinic. DW-MRI presents a better compromise by combining longitudinal studies with a high dynamic range; however, DW-MRI was unable to show any significant effect for 5-FU. This study illustrates the need for multimodal imaging in assessing tumor response to treatment to compensate for individual limitations.


Assuntos
Antineoplásicos/uso terapêutico , Colina/análise , Dextranos , Imagem de Difusão por Ressonância Magnética/métodos , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/tratamento farmacológico , Espectroscopia de Ressonância Magnética/métodos , Nanopartículas de Magnetita , Animais , Apoptose/efeitos dos fármacos , Biomarcadores Tumorais/análise , Linhagem Celular Tumoral , Neoplasias Hepáticas/metabolismo , Camundongos , Prótons , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Resultado do Tratamento
4.
Z Orthop Unfall ; 146(3): 357-63, 2008.
Artigo em Alemão | MEDLINE | ID: mdl-18561082

RESUMO

INTRODUCTION: Resurfacing arthroplasty represents an alternative method to total hip replacement especially for the young and active patient. The main reasons for early implant failure are mal-positioning of the femoral component and notching of the femoral neck during femoral head preparation. MATERIAL AND METHODS: In the context of a cadaver study of formalin-fixed cadaveric full body specimens 6 DUROM -Hip-Resurfacing prosthesis have been implanted under navigation control. The aim of the study was an evaluation of the functionality and accuracy of the computer-assisted planning and navigation system on the basis of a navigation module library from Surgitaix AG Aachen, Germany. RESULTS: The main angulation error between planning (135.2 +/- 3.6 degrees ) and navigation (136.2 +/- 2.8 degrees ) was 1.9 +/- 1.1 degrees , the main anterior offset error between planning (2.2 +/- 1.3 mm) and navigation (2.7 +/- 2.3 mm) was 1.2 +/- 1.9 mm. The main distance error between planning and navigation was 2.7 +/- 1.3 mm. The mean time for all five planning and navigation steps was 20.2 +/- 2.5 min. Against the background of a acetabular bone-saving approach in all 6 cases the smallest possible femoral component could be implanted. CONCLUSION: The computer-assisted fluoroscopic planning and navigation system for hip resurfacing showed within the scope of this cadaver study first promising results. The system approaches a practicable intraoperative planning with a high accuracy in operative implementation. Nevertheless, the potential benefit has to be evaluated in further clinical studies, especially from the perspective of a possible integration of this navigation system into the clinical work-flow. Further studies should consider a fluoroscopic-assisted range of motion assessment under consideration of an additional cup-module to enhance the postoperative range of motion after hip resurfacing procedures.


Assuntos
Artroplastia de Quadril/instrumentação , Fluoroscopia/instrumentação , Processamento de Imagem Assistida por Computador/instrumentação , Imageamento Tridimensional/instrumentação , Cirurgia Assistida por Computador/instrumentação , Feminino , Humanos , Masculino , Desenho de Prótese , Ajuste de Prótese , Avaliação da Tecnologia Biomédica
5.
Clin Orthop Relat Res ; (354): 28-38, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9755761

RESUMO

Recent developments in computer assisted surgery offer promising solutions for the translation of the high accuracy of the preoperative imaging and planning into precise intraoperative surgery. Broad clinical application is hindered by high costs, additional time during intervention, problems of intraoperative man and machine interaction, and the spatially constrained arrangement of additional equipment within the operating theater. An alternative technique for computerized tomographic image based preoperative three-dimensional planning and precise surgery on bone structures using individual templates has been developed. For the preoperative customization of these mechanical tool guides, a desktop computer controlled milling device is used as a three-dimensional printer to mold the shape of small reference areas of the bone surface automatically into the body of the template. Thus, the planned position and orientation of the tool guide in spatial relation to bone is stored in a structural way and can be reproduced intraoperatively by adjusting the position of the customized contact faces of the template until the location of exact fit to the bone is found. No additional computerized equipment or time is needed during surgery. The feasibility of this approach has been shown in spine, hip, and knee surgery, and it has been applied clinically for pelvic repositioning osteotomies in acetabular dysplasia therapy.


Assuntos
Osso e Ossos/cirurgia , Equipamentos Ortopédicos , Terapia Assistida por Computador/instrumentação , Acetábulo/cirurgia , Osso e Ossos/anatomia & histologia , Osso e Ossos/diagnóstico por imagem , Desenho Assistido por Computador , Diagnóstico por Imagem , Desenho de Equipamento , Estudos de Viabilidade , Custos de Cuidados de Saúde , Luxação do Quadril/cirurgia , Articulação do Quadril/cirurgia , Humanos , Cuidados Intraoperatórios , Articulação do Joelho/cirurgia , Microcomputadores , Osteotomia/instrumentação , Osteotomia/métodos , Planejamento de Assistência ao Paciente , Coluna Vertebral/cirurgia , Propriedades de Superfície , Terapia Assistida por Computador/métodos , Fatores de Tempo , Tomografia Computadorizada por Raios X , Interface Usuário-Computador
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