Assessment of Neuromuscular Fatigue 24 hours After a Futsal Simulated Protocol in University Female Athletes.

The purpose of this study was to identify changes in neuromuscular performance variables evaluated through the countermovement jump test before and after (0 hours, after session and 24h post) of a simulated futsal protocol in young university female athletes. Fourteen eumenorrheic, healthy and experienced female futsal players were randomly assigned to an intervention group n = 7) or a control group (n = 7). Both groups performed three countermovement jumps before and after the protocol using an inertial system device. The intervention group completed a short-term functional agility and fatigue protocol that simulated the characteristics of futsal, while the control group did not perform any exercise. The results showed a reduction in peak flight time (p = 0.049; d = 0.586), peak concentric work (p = 0.03; d = 1.819) and peak maximum force (p = 0.02; d = 0.782) comparing experimental and control group. No changes in other variables examined were noted between conditions (p > 0.05). These findings indicate that the changes in neuromuscular performance variables, evaluated through a simulated protocol, are established as determinants in the definition of peripheral fatigue in futsal practitioners until 24 h after a demanding intervention.

Las luchas indígenas por el derecho fundamental a la salud propio e intercultural en Colombia / Indigenous struggles for an own and intercultural fundamental right to health in Colombia

RESUMEN El presente artículo hace una aproximación a las luchas de los pueblos indígenas en Colombia, particularmente aquellos pertenecientes al Consejo Regional Indígena del Cauca (Cric), por la materialización del derecho fundamental a la salud, a lo largo de cinco períodos históricos entre 1971 y 2019. Este artículo presenta las características de la disputa política con el Estado, la transformación contenciosa de la política de salud indígena, direccionada desde el estado, y de la política indígena de salud, promovida desde las luchas de los pueblos indígenas. Ambas políticasse expresan en enfoques, normas e instituciones en un contexto de violencia, discriminación y racismo; en la permanente tensión entre un Sistema General de Seguridad Social en Salud (SGSSS) oficial, con una lógica de mercado y rentabilidad económica, y un Sistema de Salud Indígena, Propio e Intercultural (Sispi) de carácter colectivo y público, que desafía las asimetrías de poderes y saberes entre el modelo hegemónico de desarrollo, la medicina occidental y democracia restringida, orientado hacia el buen vivir, la sabiduría ancestral y la acción política colectiva basada en la ley de origen, el derecho mayor y el derecho propio de los pueblos indígenas.

ABSTRACT This article provides an approximation to the struggles of indigenous peoples in Colombia for the materialization of the fundamental right to health. The study emphasizes the case of the Regional Indigenous Cauca´s Council (Cric). It reviews five historical periods between 1971 and 2019. While doing so, the paper presents the characteristics of the political dispute between Cric and the State, the contentious transformation of the indigenous health policy, and the indigenous health policy expressed in approaches, norms, and institutions in a context of violence, discrimination, and racism. It highlights the permanent tension between a General System of Social Security (SGSSS), embodying the logic of a market and economic profit ability and an indigenous Health System Integrating Own and Intercultural (Sispi) of collective and public nature that challenges the asymmetries of power and knowledge among the hegemonic model of development, western medicine, and restricted democracy. In contrast to this latter, the indigenous health system is one oriented towards the good living, the ancestral wisdom, and the collective political action based on the law of origin, the greater right and the own right of the indigenous peoples.

Las luchas indígenas por el derecho fundamental a la salud propio e intercultural en Colombia / Indigenous struggles for an own and intercultural fundamental right to health in Colombia

RESUMEN El presente artículo hace una aproximación a las luchas de los pueblos indígenas en Colombia, particularmente aquellos pertenecientes al Consejo Regional Indígena del Cauca (Cric), por la materialización del derecho fundamental a la salud, a lo largo de cinco períodos históricos entre 1971 y 2019. Este artículo presenta las características de la disputa política con el Estado, la transformación contenciosa de la política de salud indígena, direccionada desde el estado, y de la política indígena de salud, promovida desde las luchas de los pueblos indígenas. Ambas políticasse expresan en enfoques, normas e instituciones en un contexto de violencia, discriminación y racismo; en la permanente tensión entre un Sistema General de Seguridad Social en Salud (SGSSS) oficial, con una lógica de mercado y rentabilidad económica, y un Sistema de Salud Indígena, Propio e Intercultural (Sispi) de carácter colectivo y público, que desafía las asimetrías de poderes y saberes entre el modelo hegemónico de desarrollo, la medicina occidental y democracia restringida, orientado hacia el buen vivir, la sabiduría ancestral y la acción política colectiva basada en la ley de origen, el derecho mayor y el derecho propio de los pueblos indígenas.

ABSTRACT This article provides an approximation to the struggles of indigenous peoples in Colombia for the materialization of the fundamental right to health. The study emphasizes the case of the Regional Indigenous Cauca´s Council (Cric). It reviews five historical periods between 1971 and 2019. While doing so, the paper presents the characteristics of the political dispute between Cric and the State, the contentious transformation of the indigenous health policy, and the indigenous health policy expressed in approaches, norms, and institutions in a context of violence, discrimination, and racism. It highlights the permanent tension between a General System of Social Security (SGSSS), embodying the logic of a market and economic profit ability and an indigenous Health System Integrating Own and Intercultural (Sispi) of collective and public nature that challenges the asymmetries of power and knowledge among the hegemonic model of development, western medicine, and restricted democracy. In contrast to this latter, the indigenous health system is one oriented towards the good living, the ancestral wisdom, and the collective political action based on the law of origin, the greater right and the own right of the indigenous peoples.

In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa.

The pyrrole-imidazoles, a group of alkaloids commonly found in marine sponges belonging to the genus Agelas, display a wide range of biological activities. Herein, we report the first chemical study of the secondary metabolites of the sponge A. dilatata from the coastal area of the Yucatan Peninsula (Mexico). In this study, we isolated eight known alkaloids from an organic extract of the sponge. We used NMR and MS analysis and comparison with existing databases to characterize the alkaloids: ageliferin (1), bromoageliferin (2), dibromoageliferin (3), sceptrin (4), nakamuric acid (5), 4-bromo-1H-pyrrole-2-carboxylic acid (6), 4,5-dibromopyrrole-2-carboxylic acid (7) and 3,7-dimethylisoguanine (8). We also evaluated, for the first time, the activity of these alkaloids against the most problematic multidrug-resistant (MDR) pathogens, i.e., the Gram-negative bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Bromoageliferin (2) displayed significant activity against P. aeruginosa. Comparison of the antibacterial activity of ageliferins 1-3 (of similar structure) against P. aeruginosa revealed some relationship between structure and activity. Furthermore, in in vitro assays, 2 inhibited growth and biofilm production in clinical strains of P. aeruginosa. Moreover, 2 increased the survival time in an in vivo Galleria mellonella model of infection. The findings confirm bromoageliferin (2) as a potential lead for designing new antibacterial drugs.

Chile's National Advisory Committee on Immunization (CAVEI): Evidence-based recommendations for public policy decision-making on vaccines and immunization.

A National Immunization Technical Advisory Group (NITAG) provides independent, evidence-based recommendations to the Ministry of Health for immunization programmes and policy formulation. In this article, we describe the structure, functioning and work processes of Chile's NITAG (CAVEI) and assess its functionality, quality of work processes and outputs, and integration of the committee into the Ministry of Health policy process using the Assessment tool for National Immunization Technical Advisory Groups. Among its strengths, CAVEI's administrative and work plasticity allows it to respond in a timely manner to the Ministry of Health's requests and proactively raise subjects for review. Representation of multiple areas of expertise within the committee makes CAVEI a robust and balanced entity for the development of evidence-based comprehensive recommendations. High ranking profile of the Secretariat structure furthers CAVEI's competences in policymaking and serves as a bridge between the committee and international initiatives in the field of immunizations.

[Implementation of intraoperative neurophysiologic monitoring in children and adults in secondary and tertiary health care facilities]. / Implementación del monitoreo neurofisiológico intraoperatorio en niños y adultos en el segundo y tercer nivel de atención.

INTRODUCTION: Intraoperative neurophysiological monitoring (IONM) is a procedure that uses neurophysiological techniques in order to evaluate the motor and sensitive systems during surgeries that endanger the nervous system. METHOD: The approach, scope, target population, and clinical questions to be answered were defined. A systematic search of the evidence was conducted step by step; during the first stage, clinical practice guidelines were collected, during the second stage systematic reviews were obtained, and during the third stage, clinical trials and observational studies were procured. The MeSH nomenclature and free related terminology were used, with no language restrictions and a 5-10 years frame. The quality of the evidence was graded using the CEPD and SIGN scales. RESULTS: Obtained using the search algorrhythms of 892 documents. Fifty-eight were chosen to be included in the qualitative synthesis. A meta-analysis was not possible due to the heterogeneity of the studies. CONCLUSIONS: Eighteen recommendations were issued and will support the adequate use of the IONM.

INTRODUCCIÓN: El monitoreo neurofisiológico intraoperatorio (MNIO) es un procedimiento que emplea técnicas neurofisiológicas con la finalidad de evaluar los sistemas motor y sensitivo durante cirugías que ponen en riesgo al sistema nervioso. MÉTODO: Se definieron el enfoque, los alcances, la población diana y las preguntas clínicas por resolver. Se realizó una búsqueda sistematizada de la evidencia por etapas. En la primera, se buscaron guías de práctica clínica; en la segunda, revisiones sistemáticas; y en la tercera, ensayos clínicos y estudios observacionales. Se utilizaron los términos MeSH y libres correspondientes, sin restricciones de lenguaje y con una temporalidad de 5 a 10 años. Se graduó la calidad de la evidencia utilizando las escalas CEPD y SIGN. RESULTADOS: Mediante los algoritmos de búsqueda se obtuvieron 892 documentos, y se seleccionaron 58 para la inclusión de la síntesis cualitativa. Debido a la heterogeneidad entre los estudios, no fue posible realizar metaanálisis. CONCLUSIONES: Se emitieron 18 recomendaciones, las cuales servirán como apoyo para la adecuada utilización del MNIO.

Gastroprotective and ulcer healing effect of ferruginol in mice and rats: assessment of its mechanism of action using in vitro models.

The gastroprotective activity of the diterpene ferruginol isolated from Prumnopitys andina wood and bark was determined on HCl/EtOH-induced gastric lesions in mice. The effect of the compound on the healing of subacute gastric lesions in rats was also studied. The mode of action of the diterpene was assessed using human gastric epithelial cells (AGS) and MRC-5 fibroblasts. The effect of ferruginol on the prostaglandin E2 content, protection against sodium taurocholate induced-damage and reduced glutathione content was evaluated on AGS cells as well as on the growth of AGS and fibroblast cultures. The free radical scavenging effect of ferruginol was assessed by the 1,1-diphenyl-2-picryl-hydrazil radical and superoxide anion assays. The effect of ferruginol on human erythrocyte membrane lipoperoxidation was determined. The cytotoxicity of the compound was assessed by means of the neutral red uptake. At 25 mg/kg, ferruginol inhibited the appearance of gastric lesions by 60% showing similar effects than lansoprazole at 20 mg/kg. Additionally, the compound displayed a significant ulcer healing activity in rats at 25 and 50 mg/kg with curative ratios of 36.0% and 92.5%, respectively, while the reference compound ranitidine at 50 mg/kg showed a curative ratio of 79.6%. At 6 and 12 microM, ferruginol increased significantly the prostaglandin E2 content. A strong inhibition of lipoperoxidation was found (IC50: 1.4 microM), but no effect was observed on the sodium taurocholate induced-damage or reduced glutathione content. Ferruginol stimulated cell proliferation at 1-2 microM in AGS cells and at 4-8 microM in fibroblasts, with cytotoxicities (IC50) of 24 and 26 microM, respectively. Our results support that ferruginol acts as gastroprotective increasing the PGs content, protecting the cells against lipid peroxidation and improving the gastric ulcer healing by a stimulating effect on the cell proliferation. These findings encourage further pharmacological studies of ferruginol as a potential new anti-ulcerogenic drug.

Curso de Gerencia y Epidemiogía 1993. Módulo: Investigación y Epidemilogía / Managament and Epidemiology the Course 1993; Recearch and epidemiology

El propósito de este Curso: que la formación de Recursos Humanos en Investigación, Epidemiología y Gerencia se traduzcan en la optimozación de los recursos existentes en sus servicios y se mejore la calidad en la prestación de los Servicios en Salud, en Areas, Distritos y Unidades Sanitarias.

Valoración de la función ventricular izquierda con ecocardiografía bi-dimensional en el infarto agudo del miocardio pre y posterapia trombolítica

Se estudian 26 pacientes que ingresan cursando infarto agudo del miocardio (IAM). Se compara la fracción de eyección ventricular (FEV) medida por ventriculografía invasiva y ecocardiografía 2-D y se hacen mediciones de le FEV antes de iniciar la terapia, a las 72 horas, 8 días, y 6 semanas. En los pacientes que son tratados en forma médica convencional la FEV inicial de 37.7+-7 por ciento no se modifica durante el estudio permaneciendo en 37.2+-2 por ciento a las 6 semanas. En los 11 pacientes tratados en Estreptoquinasa intracoronaria la FEV inicial de 36.8+-4.04 por ciento no varía a las 72 horas paro se eleva desde los 8 días a 42,2+-5.8 por ciento y se mantiene a las 6 semanas (P<0.05). En pacientes tratados con estreptoquinasa endovenosa la FEV inicial de 42.5+-3.53 por ceinto no varía a las 72 horas y aumenta a 45.5+-2.5 por ciento desde el 8 día manteniendose a las 6 semanas (P<0.05). 5 pacientes tratados con estreptoquinasa y angioplastia no evidencian cambio a las 72 horas de la FEV inicial, por pérdida en el seguimiento no hay datos posteriores. Concluimos que la evaluación por ecocardiografía 2-D de la FEV en forma cualitativa se correlaciona adecuadamente con el ventriculograma (P<0.05) y el tratamiento con estreptoquinasa resulta en mejoría de la FEV, la cual se evidencia solo después de 72 horas y permanece en le tiempo