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1.
J Environ Manage ; 365: 121505, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38908156

RESUMO

Selecting the optimal monitoring points in a water distribution network is challenging due to the complex spatiotemporal variability of water quality degradation. The lack of a standardized methodology for monitoring point selection forces operators to rely on general recommendations, historical data and professional experience, which can mask water quality problems and increase the risk to consumers. This study proposes a new methodology to optimize the selection of monitoring points in distribution networks. The method considers the spatiotemporal degradation of water quality, the definition of representative zones and two selection criteria: global representativeness and potential health risk. Representative zones were determined for each node of the network based on hydraulic paths and their water quality spatial variability. Part of the distribution network in Quebec City, Canada was used as the case study, in which four water quality parameters were investigated: free chlorine residual (FRC), heterotrophic plate counts (HPC), trihalomethanes (THMs) and haloacetic acids (HAAs). Seasonal variabilities (summer and winter) were also analyzed. The results obtained for the two criteria and for both seasons were compared, and methodological and practical recommendations were established for dynamic monitoring programs that respond to the needs of operators.


Assuntos
Monitoramento Ambiental , Qualidade da Água , Monitoramento Ambiental/métodos , Quebeque , Abastecimento de Água , Humanos
2.
J Clin Med ; 12(3)2023 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-36769762

RESUMO

This study sought to examine the correlation between left ventricular (LV) myocardial feature tracking (FT) and deep learning-based strain (DLS) analysis in the diagnostic (CMRd) and follow-up (CMRf) cardiac magnetic resonance imaging of patients with acute myocarditis. The retrospective study included 17 patients with acute myocarditis and 20 healthy controls. The CMRd took place within 14 days of symptom onset, while the CMRf took place at least 2 months after the event. The global-circumferential FT (FTc) and global-circumferential DLS (DLSc) were analyzed. The continuous variables were compared using paired t-tests or the Wilcoxon test, whereas Pearson's test or Spearman's test was used to evaluate the correlation between the continuous variables. The time between the CMRd and CMRf was 5 months [3-11]. The LV ejection fraction (LVEF) was 55 ± 6 and 59 ± 4%, p = 0.008, respectively, and 94.1% of the patients showed late gadolinium enhancement (LGE) and myocardial edema on the CMRd. Significantly lower FTc (-16.1 ± 2.2% vs. -18.9 ± 1.9%, p = 0.001) and DLSc (-38.1 ± 5.2% vs. -41.3 ± 4.5%, p = 0.015) were observed with respect to the controls. Significant increases in the FTc (-16.1 ± 2.2 vs. -17.5 ± 1.9%, p = 0.016) and DLSc (-38.1 ± 5.2 vs. -39.8 ± 3.9%, p = 0.049) were found between the CMRd and CMRf, which were unrelated to the LGE. The LVEF correlated well with the FTc (r = 0.840) and DLSc (r = 0.760). Both techniques had excellent reproducibility, with high intra- (FTc = 0.980, DLSc = 1.000) and inter-observer (FTc = 0.970, DLSc = 0.980) correlation. There was correlation between the LV DLSc/FTc and LVEF in the patients with acute myocarditis according to the CMRd and CMRf.

3.
Sci Total Environ ; 866: 161085, 2023 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-36586684

RESUMO

Heavy rainfall events can lead to the runoff of large amounts of dissolved and particulate matter into surface water sources that may represents challenges for drinking water treatment, such as membrane fouling, increases in chemical demands, and formation of various disinfection by products (DBPs) after disinfection, such as trihalomethanes (THM) and haloacetic acids (HAA). In this study, a framework is defined for analyzing water quality data in relation to climatic variables (rainfalls). The effects of 22 different rain events were assessed on an organic matter proxy (UV absorbance), and on different key water quality parameters for the coagulation step in a drinking water treatment plant. Extended impacts of rewetting events after long term dry period on source water quality were identified, with significant increases in raw water UV 254 nm that last almost 3 weeks. A significant effect on filtered water quality was also noticed and the potential impacts on finished waters quality was confirmed by HAA modelling results. Future studies could focus on the monitoring and modelling of other regulated DBPs such as THM as well as simulations of different scenarios of climate change to estimate the variability of DBPs and its precursors such as organic matter.

4.
J Environ Manage ; 325(Pt B): 116537, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36334449

RESUMO

Due to rapid population growth, urbanization, water contamination, and climate change, global water resources are under increasing pressure. Water utilities apply drinking water management strategies (DWMS) to ensure that water is safe for drinking. However, in recent years, due to increased inclination towards climate change, environmental emissions, and sustainable development goals; the environmental and economic performance of DWMSs is getting attention. An integrated framework combining life cycle thinking and water quality assessment techniques was developed in this study to evaluate the DWMSs' performance in terms of water quality, environment, and economics. Six DWMSs were assessed using the integrated framework as a case study. The environmental impacts in terms of human health, ecosystem, and resource use ranged from 1.46E-06 to 4.01E-06 DALY, 9.35E-10 to 3.80E-09 species.yr, and 0.0025-0.0071 USD-$, respectively. Pollution water index (PWI) and cost-benefit analysis (CBA) were used as decision-making techniques to assess the overall performance and suitability of DWMSs under given settings. The DWMSs with surface water as a source or ones providing relatively more degree of treatment have a relatively high PWI score (i.e., ≈0.31), reflective of high environmental impacts and water pollution compared to other alternatives. The CBA scores of selected alternatives ranged between 0.22 and 1.0. Furthermore, it was identified that DWMSs applied on relatively bigger water distribution systems can outweigh their costs (i.e., environmental and economic impacts). The proposed framework and approaches are flexible as they can incorporate different criteria in evaluating the performance and applicability of DWMSs.


Assuntos
Água Potável , Ecossistema , Humanos , Meio Ambiente , Recursos Hídricos , Abastecimento de Água
5.
J Environ Manage ; 290: 112588, 2021 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-33901833

RESUMO

Water security represents ecological security and a policy priority for sustainable development; however, un-gridded assessment results cannot be used to support urban environmental management decisions. This study proposes a systematic framework to obtain a gridded regional water security assessment, which reflects the regional natural resource, based on the index system derived from the Pressure-State-Response (PSR) model and the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model. The results were applied to sustainable water management. Using 15 key cities in the Yangtze River Delta (YRD) region as a case study to apply the methodology, we found that the comprehensive water security was relatively high and high-value areas were widely distributed, accounting for about two-thirds of the study area. Low-value areas were mainly distributed in central and eastern regions, such as Shanghai, Suzhou, and Nanjing. There was evidence of a water resource shortage during the twelve-month period studied, particularly in August. The proportions of comprehensive water security in each administrative unit and the differences between simulated and target water quality could be used in the spatial planning and the exploration of payments for ecosystem services (PES) mechanism in county-level or smaller administrative units. Despite the premise requirement and the grid resolution problems of the InVEST model, it can be concluded that our assessment method proves capable of matching spatial and temporal differences in water supply and demand at a fine scale, and results can be used to supply useful information for urban management decision making.


Assuntos
Ecossistema , Rios , China , Cidades , Conservação dos Recursos Naturais , Água , Abastecimento de Água
6.
Int. j. morphol ; 38(4): 933-939, Aug. 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1124879

RESUMO

Sexual dimorphism is one of the most important ways to identify bone remains in mass disasters. Many of them have been used for this purpose; mainly skull, pelvis and long bones. However, only a few studies using the patella have been done and, to our knowledge, there are no assessments of previous results in the literature. Meta-analysis provides a useful strong tool to test, in a systematic way, the most relevant information about a given research field. The aim of this study is to apply the meta-analytic technique to assess the major studies concerning sexual dimorphism in the patella by measuring classical metric traits: maximum height and maximum width, with different techniques, such as caliper, radiography, tomography and magnetic resonance. The 17 papers found, involving a total sample size higher than 2600 patellae, showed a very high heterogeneity- around 93 % of I2 value, for height and width measurements when all the studies were analyzed together. Homogeneity increased when each study was classified according to the techniques used. In this case, a statistical difference appeared, among the several subgroups of techniques for the two measurements, suggesting the importance of the methodology used. Maximum height and maximum width were all showed to be statistically relevant in distinguishing both sexes.


El dimorfismo sexual es una de las formas más importantes para identificar restos óseos en desastres masivos. Se han utilizado huesos como cráneo, pelvis y huesos largos para la diferenciación sexual. Sin embargo, solo se han realizado unos pocos estudios con la patela y, hasta donde sabemos, no hay evaluaciones de resultados anteriores en la literatura. El meta-análisis proporciona una herramienta sólida y útil para probar, de manera sistemática, la información más relevante sobre un cierto campo de investigación. El objetivo de este estudio consiste en aplicar la técnica metaanalítica para evaluar los principales estudios sobre dimorfismo sexual en la patela midiendo los rasgos métricos clásicos: altura máxima y anchura máxima, con diferentes técnicas: calibre, radiografía, tomografía y resonancia magnética. Los 17 de documentos encontrados, con un tamaño de muestra total superior a 2600 patelas, mostraron una heterogeneidad muy alta, alrededor del 93 % del valor de I2, para mediciones de altura y anchura cuando todos los estudios se analizaron juntos. La homogeneidad aumentó cuando cada estudio se clasificó de acuerdo con las técnicas utilizadas. En este caso, se observó diferencias estadísticas, entre los subgrupos de técnicas para las dos mediciones, lo que sugiere la importancia de la metodología utilizada. La altura máxima y la anchura máxima mostraron ser estadísticamente relevantes para distinguir ambos sexos.


Assuntos
Humanos , Patela/anatomia & histologia , Análise para Determinação do Sexo/métodos , Caracteres Sexuais
7.
Anim Reprod Sci ; 215: 106315, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32216928

RESUMO

The study was conducted to compare the effect of four commercially available extenders (Triladyl®- egg yolk-based; Andromed® and Bioxcell®-plant based and Optixcell®-liposome-based) on post-thaw sperm quality and functionality variables evaluated using computer-assisted sperm analysis and flow cytometry. A total of 30 ejaculates from five bulls were analysed. With use of Triladyl®, sperm had a greater post-thaw total motility than with use of Bioxell® and Optixcell® but there was no difference as compared with use of Andromed® with the greatest (P < 0.05) percentage of progressively motile cells. With use of Optixcell®, there was a greater (P < 0.05) percentage of sperm with an intact membrane than with use of Triladyl® and Bioxcell®, but values were similar with use of Andromed®. Acrosome damage in semen preserved with use of Optixcell® was less than with use of Bioxcell® and Andromed®. With use of Optixcell®, there was a greater percentage of viable spermatozoa with a lesser lipid disruption (P < 0.05) when compared with the other extenders. Production of peroxides was greater for sperm cryopreserved with use of Triladyl® and Optixcell® while less superoxide was produced in the samples cryopreserved with the egg yolk-based extender. Optixcell® appears to be a promising alternative to replace traditional egg yolk extenders. With use of Optixcell®, however, there were greater peroxide concentrations after thawing. With use of Andromed®, there were similar results as with use of Optixcell®, therefore, it could be an effective substitute for egg-yolk based media due to the greater proportion of highly and progressively motile spermatozoa at thawing.


Assuntos
Criopreservação/veterinária , Gema de Ovo , Glycine max , Lecitinas/farmacologia , Lipossomos/farmacologia , Preservação do Sêmen/veterinária , Animais , Bovinos , Crioprotetores/farmacologia , Lecitinas/química , Lipossomos/química , Masculino , Análise do Sêmen/veterinária , Motilidade dos Espermatozoides/efeitos dos fármacos
8.
Sci Total Environ ; 722: 137786, 2020 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-32208246

RESUMO

Perception of tap water is subject to a wide range of factors and interactions. These include risk perception, tap water quality and organoleptic perceptions, microbiological and chemical quality, prior experiences, information sources, trust in water companies and other groups, and perceived control and contextual factors, among others. The objective of this study is to assess the factors that influence and determine citizen behavior regarding drinking water. A phone survey was conducted among 1014 citizens living in the city of Québec, Canada. Five different domestic water consumption profiles were elaborated according to the citizens' preferences and behavior. Descriptive statistics and mediation analyses were carried out to analyse the survey results and assess the factors modifying the links between satisfaction and water consumption behavior. Results show that drinking water quality could be loosely linked with overall satisfaction with tap water. The water consumption profile was strongly linked with satisfaction levels related to the taste, odor and color of tap water. We observed that the association between an individual's tap water satisfaction and water consumption behavior was mediated by the water treatment strategies applied at home (filtering, cooling), knowledge about drinking water quality and its production, and risk perception. The mediating effects were shown to be significant mainly among bottled-water-only and tap-water-only consumers. Future interventions that aim to encourage the population's use of tap water as a primary source should prioritize cooling and filtering tap water in their messaging, in order to improve population satisfaction. The reduction of risk perception through targeted information campaigns is also of primary importance for decreasing the number of citizens who exclusively drink bottled water.


Assuntos
Água Potável , Qualidade da Água , Comportamento , Cidades , Ingestão de Líquidos , Humanos , Satisfação Pessoal , Quebeque , Abastecimento de Água
9.
Nat Commun ; 11(1): 994, 2020 02 24.
Artigo em Inglês | MEDLINE | ID: mdl-32094329

RESUMO

Conservation strategies based on charismatic flagship species, such as tigers, lions, and elephants, successfully attract funding from individuals and corporate donors. However, critics of this species-focused approach argue it wastes resources and often does not benefit broader biodiversity. If true, then the best way of raising conservation funds excludes the best way of spending it. Here we show that this conundrum can be resolved, and that the flagship species approach does not impede cost-effective conservation. Through a tailored prioritization approach, we identify places containing flagship species while also maximizing global biodiversity representation (based on 19,616 terrestrial and freshwater species). We then compare these results to scenarios that only maximized biodiversity representation, and demonstrate that our flagship-based approach achieves 79-89% of our objective. This provides strong evidence that prudently selected flagships can both raise funds for conservation and help target where these resources are best spent to conserve biodiversity.


Assuntos
Biodiversidade , Conservação dos Recursos Naturais/métodos , Análise Custo-Benefício , Obtenção de Fundos , Animais , Conservação dos Recursos Naturais/economia , Elefantes , Leões , Tigres
10.
Stud Health Technol Inform ; 264: 1801-1802, 2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31438351

RESUMO

The univocal identification of people is fundamental for the longitudinal monitoring of health status. The impossibility of all people to credit their identity via their identity document generates temporary records that make it difficult to record the continuity of care. This paper analyzes the Patient Index of the Ministry of Health of the Buenos Aires City and describes how the age and nationality variables influence the creation of temporary records.


Assuntos
Etnicidade , Programas Governamentais , Argentina , Cidades , Humanos
11.
Rev Esp Salud Publica ; 932019 Jun 24.
Artigo em Espanhol | MEDLINE | ID: mdl-31258153

RESUMO

In this paper the current regulations on cadaveric preservation practices required for the transfer of corpses in the different Autonomous Communities -Reglamentos de Policía Sanitaria Mortuoria- and national legislation are compared. The criteria taken into account have been: a) which sanitary practices are included in the regulations, b) which ones can be carried out in corpses posing a health risk, c) when they are compulsory to be carried out, d) when they can be carried out after death, and e) what professionals can carry them out and/or take responsibility for them. At the time of finishing the paper, a new mortuary regulation is being passed in Andalusia, as well as a decree from the Ministry of Health on technical and sanitary requirements concerning international transfer of corpses and human remains.


Se comparan las normativas vigentes sobre prácticas sanitarias de conservación cadavérica requeridas para el traslado de cadáveres, en las diferentes Comunidades autónomas y la legislación estatal. Los criterios tenidos en cuenta han sido: qué prácticas sanitarias se incluyen en la normativa, cuáles pueden llevarse a cabo en cadáveres de riesgo sanitario, cuándo se requiere su realización, en qué momento tras el fallecimiento pueden realizarse y qué profesionales las pueden llevarlas a cabo y/o responsabilizarse de las mismas. En el momento de finalizar el artículo se está tramitando la publicación del nuevo decreto de sanidad mortuoria de Andalucía, así mismo se está elaborando, por parte del Ministerio de Sanidad, Consumo y Bienestar Social, un Real Decreto sobre "Condiciones técnico sanitarias básicas en materia de traslado internacional de cadáveres, restos humanos y restos cadavéricos".


Assuntos
Cadáver , Embalsamamento/legislação & jurisprudência , Regulamentação Governamental , Práticas Mortuárias/legislação & jurisprudência , Preservação de Tecido , Embalsamamento/métodos , Embalsamamento/normas , Humanos , Práticas Mortuárias/métodos , Espanha , Preservação de Tecido/métodos , Preservação de Tecido/normas
12.
Environ Sci Pollut Res Int ; 26(35): 35399-35410, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31001783

RESUMO

The marble industry generates enormous amounts of waste every year, whose incorrect management can lead to environmental problems. The Circular Economy model can provide an effective solution to this issue, an aspect that has been addressed in this research. The suitability of a marble sludge generated in the ornamental rock industry of Andalusia (Spain) has been assessed as raw material in ceramic bricks. Mixtures containing a clayey base and 0, 2.5, 5, 7.5, and 10 wt% of marble powder have been shaped into 60 × 30 × 10-mm3 prismatic specimens and sintered at 950 °C in a muffle. The main technological properties of the bricks related to color, shrinkage, porosity, water absorption, suction, and compressive strength have been determined. The addition of marble sludge has fostered the development of a lighter color, together with a significant increase of the open porosity. This aspect has implied, on the one hand, higher water absorption and suction results and, on the other hand, a decrease of the density and the mechanical strength. The correlations obtained after applying Shapiro-Wilk normality tests and r Pearson coefficients endorse the clear relationship between the addition of marble powder and the abovementioned effects on the technological properties of the sintered bricks. All the measured properties fully meet the brick standardized requirements, which would indicate that the recycling of marble wastes could be a promising alternative to obtain eco-friendly lightweight ceramic materials.


Assuntos
Resíduos Industriais/análise , Esgotos/análise , Carbonato de Cálcio , Cerâmica , Argila , Força Compressiva , Indústrias , Porosidade , Reciclagem , Espanha
13.
Rev. colomb. radiol ; 30(1): 5098-5101, 2019. ilus, graf
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-1008294

RESUMO

El bocio congénito es una patología infrecuente, que se genera por alteración de la función tiroidea fetal de causa endógena o exógena: disfunción tiroidea materna, déficit de aporte de yodo en la dieta o secundario a la toma de medicación. La repercusión en la maduración del feto, la compresión de estructuras adyacentes debido al aumento de tamaño, lo cual puede ser un factor de riesgo de obstrucción de la vía aérea y de lesiones hipóxico-isquémicas, hacen que el diagnóstico y tratamiento de esta patología sea de vital importancia. Habitualmente, se diagnostica por ecografía en el segundo o tercer trimestre de embarazo, pero la resonancia magnética (RM) se ha convertido en una técnica diagnóstica complementaria e importante ante un eventual tratamiento intraparto


Congenital goiter is an uncommon condition caused by altered fetal thyroid function of endogenous or exogenous cause (maternal thyroid dysfunction, iodine deficiency in the diet or secondary to taking medication). The impact on the mature development of the fetus, as well as the compression of adjacent structures due to increased size, which may be a risk factor for airway obstruction and hypoxic-ischemic lesions, make the diagnosis and treatment of this pathology of vital importance. It is usually diagnosed by ultrasound in the second or third trimester of pregnancy, but magnetic resonance imaging (MRI) has become a complementary and important diagnostic technique in the event of an intrapartum treatment procedure


Assuntos
Humanos , Bócio , Recém-Nascido , Imageamento por Ressonância Magnética , Ultrassonografia
14.
Toxicol Sci ; 163(2): 364-373, 2018 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-29514332

RESUMO

Human health risk assessment (HHRA) must be adapted to the challenges of the 21st century, and the use of toxicogenomics data in HHRA is among the changes that regulatory agencies worldwide are trying to implement. However, the use of toxicogenomics data in HHRA is still limited. The purpose of this study was to explore the availability, quality, and relevance to HHRA of toxicogenomics publications as potential barriers to their use in HHRA. We conducted a scoping review of available toxicogenomics literature, using trihalomethanes as a case study. Four bibliographic databases (including the Comparative Toxicogenomics Database) were assessed. An evaluation table was developed to characterize quality and relevance of studies included on the basis of criteria proposed in the literature. Studies were selected and analyzed by 2 independent reviewers. Only 9 studies, published between 1997 and 2015, were included in the analysis. Based on the selected criteria, critical methodological details were often missing; in fact, only 3 out of 9 studies were considered to be of adequate quality for HHRA. No studies met >3 (out of 7) criteria of relevance to HHRA (eg, adequate number of doses and sample size). This first scoping review of toxicogenomics publications on trihalomethanes shows that low availability, quality, and relevance to HHRA of toxicogenomics publications presents potential barriers to their use in HHRA. Improved reporting of methodological details and study design is needed in the future so that toxicogenomics studies can be appropriately assessed regarding their quality and value for HHRA.


Assuntos
Expressão Gênica/efeitos dos fármacos , Medição de Risco , Toxicogenética , Trialometanos/toxicidade , Acesso à Informação , Bases de Dados Bibliográficas , Bases de Dados Genéticas , Humanos , Medição de Risco/métodos , Medição de Risco/normas , Toxicogenética/métodos , Toxicogenética/normas
15.
World J Gastroenterol ; 23(41): 7459-7469, 2017 11 07.
Artigo em Inglês | MEDLINE | ID: mdl-29151700

RESUMO

AIM: To demonstrate the non-inferiority (15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate (TDF) vs the combination of lamivudine (LAM) plus adefovir dipivoxil (ADV) in the maintenance of virologic response in patients with chronic hepatitis B (CHB) and prior failure with LAM. METHODS: This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups (TDF and LAM+ADV) of adult patients with hepatitis B e antigen (HBeAg)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed. RESULTS: Forty-six patients were evaluated [median age: 55.4 years (30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA (HBV-DNA) remained undetectable, all patients remained HBeAg negative, and hepatitis B surface antigen (HBsAg) positive. Alanine aminotransferase (ALT) values at the end of the study were similar in the 2 groups (25.1 ± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects (AEs) (53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively (P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment (€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001). CONCLUSION: TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs.


Assuntos
Adenina/análogos & derivados , Antivirais/uso terapêutico , Hepatite B Crônica/tratamento farmacológico , Lamivudina/uso terapêutico , Organofosfonatos/uso terapêutico , Tenofovir/uso terapêutico , Adenina/economia , Adenina/farmacologia , Adenina/uso terapêutico , Adulto , Idoso , Alanina Transaminase/sangue , Antivirais/economia , Antivirais/farmacologia , DNA Viral/isolamento & purificação , Farmacorresistência Viral , Quimioterapia Combinada/efeitos adversos , Quimioterapia Combinada/economia , Quimioterapia Combinada/métodos , Feminino , Antígenos de Superfície da Hepatite B/imunologia , Antígenos E da Hepatite B/imunologia , Vírus da Hepatite B/efeitos dos fármacos , Vírus da Hepatite B/fisiologia , Hepatite B Crônica/sangue , Hepatite B Crônica/imunologia , Custos Hospitalares/estatística & dados numéricos , Humanos , Lamivudina/economia , Lamivudina/farmacologia , Masculino , Pessoa de Meia-Idade , Organofosfonatos/economia , Organofosfonatos/farmacologia , Estudos Prospectivos , Tenofovir/economia , Tenofovir/farmacologia , Falha de Tratamento , Carga Viral/efeitos dos fármacos
16.
Regul Toxicol Pharmacol ; 85: 119-123, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28137640

RESUMO

Regulatory agencies worldwide need to modernize human health risk assessment (HHRA) to meet challenges of the 21st century. Toxicogenomics is at the core of this improvement. Today, however, the use of toxicogenomics data in HHRA is very limited. The purpose of this survey was to identify barriers to the application of toxicogenomics data in HHRA by human health risk assessors. An online survey targeting Canadian risk assessors gathered information on their knowledge and perception of toxicogenomics, their current and future inclusion of toxicogenomics data in HHRA, and barriers to the use of such data. Twenty-nine (29) participants completed a questionnaire after 2 months of solicitation. The results show that the application of toxicogenomics data in Canada is marginal, with 85% of respondents reporting that they never or rarely used such data. Knowledge of toxicogenomics by Canadian risk assessors is also limited: about two-thirds of respondents (68%) were not at all or only slightly familiar with the concept. Lack of guidelines for toxicogenomics data interpretation, data quality assessment and on their use in HHRA, were found to be major barriers. In conclusion, there is a need for interventions aimed at facilitating the use of toxicogenomics data in HHRA, when available.


Assuntos
Medição de Risco , Toxicogenética , Adulto , Canadá , Humanos , Pessoa de Meia-Idade , Inquéritos e Questionários
17.
Environ Res ; 148: 411-420, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-27131795

RESUMO

This study was aimed at assessing the profiles (occurrence and speciation) of disinfection by-product (DBP) contamination in air and water of a group of 41 public indoor swimming pools in Québec (Canada). The contaminants measured in the water included the traditional DBPs [i.e., four trihalomethanes (THMs), six haloacetic acids (HAAs)] but also several emergent DBPs [i.e., halonitriles, halonitromethanes, haloketones and nitrosodimethylamine (NDMA)]. Those measured in the air comprised THMs and chloramines (CAMs). Overall, extremely variable DBP levels were found from one pool to another (both quantitatively and in terms of speciation). For instance, in water, among the four THMs, chloroform was usually the most abundant compound (37.9±25.7µg/L). Nevertheless, the sum of the three other brominated THMs represented more than 25% of total THMs at almost half the facilities visited (19 cases). In 13 of them, the levels of brominated THMs (66±24.2µg/L) even greatly outweighed the levels of chloroform (15.2±6.31µg/L). Much higher levels of HAAs (294.8±157.6µg/L) were observed, with a consistent preponderance of brominated HAAs in the swimming pools with more brominated THMs. NDMA levels which were measured in a subset of 8 pools ranged between 2.8ng/L and 105ng/L. With respect to air, chloroform was still the most abundant THM globally (119.4±74.2µg/m(3)) but significant levels of brominated THMs were also observed in various cases, particularly in the previously evoked group of 13 swimming pools with preponderant levels of brominated THMs in water. CAM levels (0.23±0.15mg/m(3)) varied highly, ranging from not detected to 0.56mg/m(3). Overall, the levels were generally relatively high compared to current guidelines or reference values from several countries, and they point to a relatively atypical presence of brominated compounds, and to significant levels of emergent DBPs for which health risk is less documented.


Assuntos
Acetatos/análise , Poluentes Atmosféricos/análise , Cloraminas/análise , Hidrocarbonetos Halogenados/análise , Piscinas , Poluentes Químicos da Água/análise , Acetatos/química , Poluentes Atmosféricos/química , Cloraminas/química , Cloro/química , Desinfecção , Monitoramento Ambiental , Hidrocarbonetos Halogenados/química , Quebeque , Poluentes Químicos da Água/química
18.
Ambio ; 45(2): 146-60, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26224563

RESUMO

Climate change effects are expected to be more severe for some segments of society than others. In Mexico, climate variability associated with climate change has important socio-economic and environmental impacts. From the central mountainous region of eastern Veracruz, Mexico, we analyzed data of total annual precipitation and mean annual temperature from 26 meteorological stations (1922-2008) and from General Circulation Models. We developed climate change scenarios based on the observed trends with projections to 2025, 2050, 2075, and 2100, finding considerable local climate changes with reductions in precipitation of over 700 mm and increases in temperature of ~9°C for the year 2100. Deforested areas located at windward were considered more vulnerable, representing potential risk for natural environments, local communities, and the main crops cultivated (sugarcane, coffee, and corn). Socio-economic vulnerability is exacerbated in areas where temperature increases and precipitation decreases.


Assuntos
Mudança Climática , Conservação dos Recursos Naturais , Altitude , Humanos , México , Modelos Teóricos , Fatores Socioeconômicos
19.
Environ Pollut ; 207: 88-96, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26367702

RESUMO

Few studies have assessed social inequalities in exposure to drinking water contaminants. This study explores this issue in 593 rural municipalities of Québec, Canada. Quartiles of an ecological composite deprivation index were used as a proxy of socioeconomic status. Total trihalomethanes (TTHMs) and lead were chosen as proxies of chemical drinking water quality. The results show that the majority of deprived rural municipalities apply no treatment to their water (26%) or use a basic treatment (51%), whereas a relative majority of the wealthiest municipalities (40%) use advanced treatment. The proportion of municipalities having important lead (>5 µg/L) levels is highest in most deprived municipalities. Moreover, most deprived municipalities have a higher risk of high tap lead levels (RR = 1.33; 95%CI: 1.30, 1.36). Conversely, most deprived municipalities have a lower risk of high TTHMs levels (RR = 0.78; 95%CI: 0.69, 0.86). These findings suggest an environmental inequality in drinking water contaminants distribution in rural municipalities.


Assuntos
Água Potável/análise , Chumbo/análise , Trialometanos/análise , Poluentes Químicos da Água/análise , Cidades , Monitoramento Ambiental , Humanos , Quebeque , População Rural , Fatores Socioeconômicos , Qualidade da Água , Abastecimento de Água
20.
J Environ Manage ; 154: 358-71, 2015 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-25768713

RESUMO

Generally, groundwater is naturally of good quality for human consumption and represents an essential source of drinking water. In Canada, small municipalities and individuals are particularly reliant on groundwater, since they cannot afford complex water treatment installations. However, groundwater is a vulnerable resource that, depending on its characteristics, can be contaminated by almost any land use. In recent decades, governments have launched programs to acquire more information on groundwater, in order to better protect it. Nevertheless, the data produced are rarely adequate to be understood and used by land planners. The aim of this study was to develop a method that helps planners interpret hydrogeological data in the Province of Quebec, Canada. Based on the requests and needs of planners during semi-directed interviews, a methodology was developed to qualitatively evaluate groundwater contamination risk by land uses. The method combines land planning data and hydrogeological data through the MACBETH multicriteria analysis method, to obtain maps of groundwater contamination risk. The method was developed through group and individual meetings with numerous hydrogeology, land planning, water's economics and drinking water specialists. The resulting maps allow planners to understand the dynamics of groundwater within their territory, identify problem areas where groundwater is threatened and analyse the potential impact of planning scenarios on the risk of groundwater contamination.


Assuntos
Conservação dos Recursos Naturais , Água Subterrânea/química , Abastecimento de Água , Cidades , Humanos , Quebeque , Medição de Risco
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