Economic assessment of the secondary prevention of ischaemic stroke with dipyridamole plus aspirin (Aggrenox/Asasantin) in France.

OBJECTIVE: To assess the cost effectiveness of aspirin 25 mg plus dipyridamole 200 mg twice daily in the secondary prevention of ischaemic stroke, according to the French social security perspective, using efficacy data from the second European Stroke Prevention Study (ESPS-2). The ESPS-2 was a double-blind, placebo-controlled clinical trial which assessed the efficacy of four secondary prevention strategies: (i) placebo; (ii) aspirin (acetylsalicylic acid) 25 mg twice daily; (iii) dipyridamole 200 mg twice daily; and (iv) aspirin 25 mg plus dipyridamole 200 mg twice daily. METHOD: We performed a cost-effectiveness analysis with Monte Carlo simulations to compute confidence intervals. We combined data from various sources including the Dijon Stroke Registry, Institut National de la Statistique et des Etudes Economiques, Etude du Coût de l'Infarctus Cérébral (Study of the Cost of Cerebral Infarction [ECIC]) study and the ESPS-2 trial. RESULTS: According to our findings, a preventive strategy with aspirin 25 mg plus dipyridamole 200 mg twice daily is associated with net benefits per avoided stroke recurrence amounting to USD 23,932 (95% CI -USD 32,609, USD 35,772) compared with aspirin 25 mg twice daily alone, and USD 31,555 (95% CI USD 4921, USD 74,515) compared with dipyridamole alone (1997 values). Sensitivity analysis demonstrated that dipyridamole plus aspirin was still cost effective when the average cost of adverse effects per episode (ignored in the original estimation of the cost-effectiveness ratios due to a lack of data) was assumed to be USD 8600 (50,000 French francs); this cost is unlikely as most of the adverse effects associated with aspirin plus dipyridamole are only slight to moderate in severity. CONCLUSIONS: In the secondary prevention of stroke in France, this study suggests, given its underlying assumptions and data, that aspirin 25 mg plus dipyridamole 200 mg twice daily is likely to be a cost-effective strategy from the social security perspective, when compared with other relevant strategies that were evaluated in the ESPS-2 trial.

[Economic assessment of adjuvant and palliative chemotherapy in colorectal cancer: a review]. / Evaluation économique des chimiothérapies adjuvante et palliative dans le traitement du cancer colorectal: enseignements de la littérature.

The aim of this study is to perform a review of the literature on economic (or medico-economic) studies in the area of chemotherapy for colorectal cancer. French and international literature has been reviewed on this topic. Colorectal cancer represents a major public health problem due to high mortality, prevalence and costs. Up to now chemotherapy can be used at the adjuvant stage or at the palliative one. This work provides a synthesis of the main results of economic publications devoted to adjuvant and palliative chemotherapies, as well as a reflection on the limits frequently associated with such studies.

[Cost of colorectal cancer in France in 1999]. / Coût du cancer colorectal en France en 1999.

AIM: Due to high incidence and disease severity, colorectal cancer is a major public health concern in western countries. Few studies have been devoted to estimating its cost in France. The aim of this study was to analyze the direct (medical) and indirect (short-term disability, long-term disability, premature death) costs of colorectal cancer in France. METHODS: This cost-of-illness study was based on data available for 1999. Two evaluation perspectives were considered: French social security system (medical care + daily allowances + disability allowances) and the society (medical care + production losses). Sources of data used in this analysis were: PMSI (hospital care), EPPM-IMS study (ambulatory care) and the GAZEL cohort (short-term disability). RESULTS: Direct costs of colorectal cancer in France amounted in 1999 to more than 469.7 million euros, of which 98% were induced by hospitalisation (on an outpatient or an inpatient basis). Indirect costs represented in 1999 for the French social security system an amount of 85.9 million, of which 71% were due to disability allowances. Taking into account the society's point of view, indirect costs corresponded to production losses of 528.1 million. Total costs of colorectal cancer amounted 555.5 million for the social security system and 997 million for the society. CONCLUSION: These results confirm the high economic burden of colorectal cancer for the French social security system and for the society in general.