RESUMO
Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.
Assuntos
COVID-19/diagnóstico , Teste em Amostras de Sangue Seco/métodos , Anticorpos Antivirais/imunologia , Teste Sorológico para COVID-19/métodos , Estudos de Casos e Controles , Teste em Amostras de Sangue Seco/economia , Humanos , Valor Preditivo dos Testes , SARS-CoV-2/imunologia , Glicoproteína da Espícula de Coronavírus/imunologia , Glicoproteína da Espícula de Coronavírus/isolamento & purificaçãoRESUMO
UNLABELLED: The gold standard treatment for Dupuytren's contracture is surgical excision of the cord. A non-surgical treatment with collagenase clostridium histolyticum injection is available but appears costly. OBJECTIVES: To provide data on resource consumption related to surgical and non-surgical treatment for Dupuytren's contracture. DESIGN AND PARTICIPANTS: Twenty patients with a single digit Dupuytren's contracture, 10 treated with surgical excision, and 10 treated with a single injection of collagenase. MEASUREMENTS: Minutes spent in theatre, number of follow-up appointments, time to skin healing, and patients return to normal activities of daily living. RESULTS: The injection group was significantly better regarding theatre time (p < 0.0001), follow-up appointments (p = 0.048), skin healing time (p < 0.001), and return to normal activities of daily living (p = 0.02) than the operated group. CONCLUSIONS: There are significant personal and health economic differences between the two methods of treatment which may influence local choice.