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1.
Biotechnol Adv ; 69: 108265, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-37783293

RESUMO

Urbanization has driven the demand for fossil fuels, however, the overly exploited resource has caused severe damage on environmental pollution. Biorefining using abundant lignocellulosic biomass is an emerging strategy to replace traditional fossil fuels. Value-added lignin biomass reduces the waste pollution in the environment and provides a green path of conversion to obtain renewable resources. The technology is designed to produce biofuels, biomaterials and value-added products from lignocellulosic biomass. In the biorefinery process, the pretreatment step is required to reduce the recalcitrant structure of lignocellulose biomass and improve the enzymatic digestion. There is still a gap in the full and deep understanding of the biorefinery process including the pretreatment process, thus it is necessary to provide optimized and adapted biorefinery solutions to cope with the conversion process in different biorefineries to further provide efficiency in industrial applications. Current research progress on value-added applications of lignocellulosic biomass still stagnates at the biofuel phase, and there is a lack of comprehensive discussion of emerging potential applications. This review article explores the advantages, disadvantages and properties of pretreatment methods including physical, chemical, physico-chemical and biological pretreatment methods. Value-added bioproducts produced from lignocellulosic biomass were comprehensively evaluated in terms of encompassing biochemical products , cosmetics, pharmaceuticals, potent functional materials from cellulose and lignin, waste management alternatives, multifunctional carbon materials and eco-friendly products. This review article critically identifies research-related to sustainability of lignocellulosic biomass to promote the development of green chemistry and to facilitate the refinement of high-value, environmentally-friendly materials. In addition, to align commercialized practice of lignocellulosic biomass application towards the 21st century, this paper provides a comprehensive analysis of lignocellulosic biomass biorefining and the utilization of biorefinery green technologies is further analyzed as being considered sustainable, including having potential benefits in terms of environmental, economic and social impacts. This facilitates sustainability options for biorefinery processes by providing policy makers with intuitive evaluation and guidance.


Assuntos
Celulose , Lignina , Lignina/química , Biomassa , Biocombustíveis , Combustíveis Fósseis
2.
Bioresour Technol ; 380: 129094, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37100295

RESUMO

Microalgae are promising alternatives to mitigate atmospheric CO2 owing to their fast growth rates, resilience in the face of adversity and ability to produce a wide range of products, including food, feed supplements, chemicals, and biofuels. However, to fully harness the potential of microalgae-based carbon capture technology, further advancements are required to overcome the associated challenges and limitations, particularly with regards to enhancing CO2 solubility in the culture medium. This review provides an in-depth analysis of the biological carbon concentrating mechanism and highlights the current approaches, including species selection, optimization of hydrodynamics, and abiotic components, aimed at improving the efficacy of CO2 solubility and biofixation. Moreover, cutting-edge strategies such as gene mutation, bubble dynamics and nanotechnology are systematically outlined to elevate the CO2 biofixation capacity of microalgal cells. The review also evaluates the energy and economic feasibility of using microalgae for CO2 bio-mitigation, including challenges and prospects for future development.


Assuntos
Dióxido de Carbono , Microalgas , Hidrodinâmica , Biocombustíveis , Biomassa
3.
Carbohydr Polym ; 306: 120599, 2023 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-36746569

RESUMO

Pretreatment with pure, mixed, and diluted deep eutectic solvents (DESs) was evaluated for its effect on Napier grass through compositional and characterization studies. The morphological changes of biomass caused by pretreatment were analyzed by FTIR and XRD. The cellulose and hemicellulose content after pretreatment using mixed DES increased and decreased 1.29- and 4.25-fold, respectively, when compared to untreated Napier grass. The crystallinity index (CrI. %) of mixed DES sample increased due to the maximum removal of hemicellulose (76 %) and delignification of 62 %. The material costs of ChCl/FA and ChCl/LA for a single run are ≈2.16 USD and ≈1.65 USD, respectively. Pure DES showed that ChCl/LA pretreatment enhanced delignification efficiency and that ChCl/FA increased hemicellulose removal. It was estimated that a single run using ChCl/LA:ChCl/FA to achieve maximum hemicellulose and lignin removal would cost approximately ≈1.89 USD. Future work will evaluate the effect of DES mixture on enzyme digestibility and ethanol production from Napier grass. HYPOTHESES: Deep eutectic solvent (DES) pretreatment studies on the fractionation of lignocellulosic biomass have grown exponentially. The use of pure and diluted DES has been reported to improve saccharification efficiency, delignification, and cellulose retention (Gundupalli et al., 2022). These studies have reported maximum lignin removal but also a lower effect on hemicellulose removal from lignocellulosic biomass. It was hypothesized that mixing two pure DESs could result in maximum removal of hemicellulose and lignin after pretreatment. To our knowledge, no studies have been performed to investigate the efficiency of pretreatment using a DES mixture and compared the outcome with pure and diluted DESs. Furthermore, it was hypothesized that using two pure DESs in a mixed form could lower the material cost for each experimental run. Process efficiency was determined by compositional, XRD, and FTIR analysis. Avenues for future research include determining glucose and ethanol yields during the enzymatic saccharification and fermentation processes.


Assuntos
Celulose , Cenchrus , Lignina , Solventes Eutéticos Profundos , Solventes , Etanol , Biomassa , Hidrólise
4.
Bioresour Technol ; 372: 128661, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36690215

RESUMO

Microalgae are photoautotrophic microorganisms which comprise of species from several phyla. Microalgae are promising in producing a varieties of products, including food, feed supplements, chemicals, and biofuels. Medicinal supplements derived from microalgae are of a significant market in which compounds such as -carotene, astaxanthin, polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and polysaccharides such as -glucan, are prominent. Microalgae species which are commonly applied for commercial productions include Isochrysis sp., Chaetoceros (Chlorella sp.), Arthrospira sp. (Spirulina Bioactive) and many more. In this present review, microalgae species which are feasible in metabolites production are being summarized. Metabolites produced by microalgae as well as their prospective applications in the healthcare and pharmaceutical industries, are comprehensively discussed. This evaluation is greatly assisting industrial stakeholders, investors, and researchers in making business decisions, investing in ventures, and moving the production of microalgae-based metabolites forward.


Assuntos
Chlorella , Microalgas , Microalgas/metabolismo , Ácido Eicosapentaenoico , Indústria Farmacêutica , Atenção à Saúde
5.
Bioresour Technol ; 369: 128256, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36343780

RESUMO

The increase in worldwide demand for energy is driven by the rapid increase in population and exponential economic development. This resulted in the fast depletion of fossil fuel supplies and unprecedented levels of greenhouse gas in the atmosphere. To valorize biomass into different bioproducts, one of the popular and carbon-neutral alternatives is biorefineries. This system is an appropriate technology in the circular economy model. Various research highlighted the role of biorefineries as a centerpiece in the carbon-neutral ecosystem of technologies of the circular economy model. To fully realize this, various improvements and challenges need to be addressed. This paper presents a critical and timely review of the challenges and future direction of biorefineries as an alternative carbon-neutral energy source.


Assuntos
Ecossistema , Gases de Efeito Estufa , Biomassa , Tecnologia , Combustíveis Fósseis , Biocombustíveis , Carbono
6.
Bioresour Technol ; 367: 128257, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36343781

RESUMO

Phycoremediation is gaining attention not only as a pollutant mitigation approach but also as one of the most cost-effective paths to achieve carbon neutrality. When compared to conventional treatment methods, phycoremediation is highly effective in removing noxious substances from wastewater and is inexpensive, eco-friendly, abundantly available, and has many other advantages. The process results in valuable bioproducts and bioenergy sources combined with pollutants capture, sequestration, and utilization. In this review, microalgae-based phycoremediation of various wastewaters for carbon neutrality and circular economy is analyzed scientometrically. Different mechanisms for pollutants removal and resource recovery from wastewaters are explained. Further, critical parameters that influence the engineering design and phycoremediation performance are described. A comprehensive knowledge map highlighting the microalgae potential to treat a variety of industrial effluents is also presented. Finally, challenges and future prospects for industrial implementation of phycoremediation towards carbon neutrality coupled with circular economy are discussed.


Assuntos
Poluentes Ambientais , Microalgas , Águas Residuárias , Carbono , Biomassa
7.
Bioresour Technol ; 364: 128085, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36220529

RESUMO

Microalgae are known for containing high value compounds and its significant role in sequestering carbon dioxide. This review mainly focuses on the emerging microalgae cultivation technologies such as nanomaterials technology that can improve light distribution during microalgae cultivation, attached cultivation and co-cultivation approaches that can improve growth and proliferation of algal cells, biomass yield and lipid accumulation in microalgal. This review includes a comprehensive discussion on the use of microbubbles technology to enhance aerated bubble capacity in photobioreactor to improve microalgal growth. This is followed by discussion on the role of microalgae as phycoremediation agent in removal of contaminants from wastewater, leading to better water quality and high productivity of shellfish. The review also includes techno-economic assessment of microalgae biorefinery technology, which is useful for scaling up the microalgal biofuel production system or integrated microalgae-shellfish cultivation system to support circular economy.

8.
J Biotechnol ; 357: 18-27, 2022 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-35970361

RESUMO

Sustainable Development Goals (SDGs) have been part of much worldwide cooperation in engineering design, nutrients production that contributes towards a better and more sustainable future. This review intends to uncover a potential renewable source that could significantly contribute to various goals under the SDGs. The prospects of algae tackling the socio-ecological, economic, and environmental issues faced globally are discussed, along with approaches of algae that can be utilized to achieve many of the SDGs are reviewed and discussed. Moreover, the recent trends in terms of engineering application that co-relate to novel algae-based technology has also been included. Apart from that, algae have high oil content which is suitable for producing affordable and clean energy, which can be used for biofuels or electricity generation. The promising characteristics of algae will lead to its global acceptance and utilization for sustainability to help create a better world.


Assuntos
Microalgas , Biocombustíveis
9.
Environ Res ; 215(Pt 1): 114120, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36029837

RESUMO

Cytotoxicity in freshwater fishes induced by industrial effluents and dyes is a global issue. Trypan blue dye has many applications in different sectors, including laboratories and industries. This study determines to detect the cytotoxic effects of trypan blue dye in vivo. The objective of this study was to estimate the sub-lethal effects of azodye in fish. Cirrhinus mrigala, a freshwater fish, was exposed to three different grading concentrations of dye 5 mg/L, 10 mg/L, and 20 mg/L in a glass aquarium. Significant (p < 0.05) decrease in the weight of fish was observed as 0.728 ± 0.14 g and 2.232 ± 0.24 g, respectively, in the trial groups exposed to 10 and 20 mg/L of dye in a week. After exposure to trypan blue dye, fishes were dissected to remove liver and kidney tissues. Histopathological assessments determined hepatotoxicity and nephrotoxicity induced by trypan blue through the paraffin wax method. This dye induces mild alterations in the liver such as congestion, hemolysis, dilated sinusoids, ruptured hepatocytes, vacuolization, edema of hepatocytes, necrosis, degeneration, aggregation, and inflammation. This dye not only alters liver tissue, also induces an acute level of tissue alterations in the kidneys, such as degeneration of epithelial cells of renal tubules, shrinkage of the glomerulus, congestion, reduced lumen, degeneration of glomerulus, absence of space of bowmen, glomerulonephritis, necrosis in hematopoietic interstitial tissues and glomerulus, reduced lumen, vacuolar degeneration of renal tubules, increased per tubular space. The current study concludes that trypan blue dye released even in small amounts is found to be associated with a high incidence of cytotoxicity. Such tissue alterations in this species could be used as biomarkers for azo dyes.


Assuntos
Doença Hepática Induzida por Substâncias e Drogas , Cyprinidae , Animais , Compostos Azo/toxicidade , Biomarcadores , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Corantes/toxicidade , Necrose , Parafina , Azul Tripano/toxicidade
10.
Environ Res ; 213: 113619, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-35700763

RESUMO

The Industrial Revolution 4.0 (IR 4.0) holds the opportunity to improve the efficiency of managing solid waste through digital and machinery applications, effectively eliminating, recovering, and repurposing waste. This research aims to discover and review the potential of current technologies encompassing innovative Industry 4.0 designs for solid waste management. Machinery and processes emphasizing on circular economy were summarized and evaluated. The application of IR 4.0 technologies shows promising opportunities in improving the management and efficiency in view of solid waste. Machine learning (ML), artificial intelligence (AI), and image recognition can be used to automate the segregation of waste, reducing the risk of exposing labour workers to harmful waste. Radio Frequency Identification (RFID) and wireless communications enable the traceability in materials to better understand the opportunities in circular economy. Additionally, the interconnectivity of systems and automatic transfer of data enable the creation of more complex system that houses a larger solution space that was previously not possible such as centralised cloud computing to reduce the cost by eliminating the need for individual computing systems. Through this comprehensive review-based work, innovative Industry 4.0 components of machinery and processes involving waste management which focuses on circular economy are identified with the critical ones evaluated briefly. It was found that the current research and work done is based on applying Industry 4.0 technologies on individual waste management systems, which lacks the coherency needed to capitalise on technologies such as cloud computing, interconnectivity, big data, etc on a larger scale. Therefore, a real world comprehensive end-to-end integration aimed to optimize every process within the solid waste management chain should be explored.


Assuntos
Resíduos Sólidos , Gerenciamento de Resíduos , Inteligência Artificial , Humanos , Indústrias , Aprendizado de Máquina , Resíduos Sólidos/análise
11.
Environ Res ; 212(Pt A): 113171, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35364042

RESUMO

Groundwater is considered as the primary source of water for the majority of the world's population. The preponderance of the nation's drinking water, as well as agricultural and industrial water, comes from groundwater. Groundwater level is becoming increasingly challenging to replenish due to climate change. Fertilizer application and improper processing of industrial waste are the two major anthropogenic drivers of groundwater pollution. Arsenic and cadmium are two of the principal heavy metal pollutants that have affected groundwater quality by human activity. When people are exposed to both non-carcinogenic and carcinogenic contaminants for an extended period, toxic effects might occur. It can have detrimental health effects from long-term exposure to contaminants, even in low amounts. As a result, metal contamination concentrations and fractions can be used to determine potential health concerns. At the same time, contaminants also need to be removed or converted to harmless products by groundwater remediation. Remediation of groundwater quality can be accomplished in several ways, including natural and artificial means. The purpose of this review is to explore a wide range of factors that affect groundwater quality, including their possible health effects. This communication provides state-of-the-art information about remediation approaches for groundwater contamination including hindrances and perspectives in this area of research. The in-depth information provided in different sections of this communication would expand the scope of interdisciplinary research.


Assuntos
Água Potável , Água Subterrânea , Metais Pesados , Poluentes Químicos da Água , Monitoramento Ambiental , Humanos , Metais Pesados/análise , Metais Pesados/toxicidade , Medição de Risco , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/toxicidade , Qualidade da Água
12.
Environ Res ; 205: 112458, 2022 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-34863687

RESUMO

This study explores the role of renewable energy (RE) penetration in Malaysia's energy security (ES) and its implications for the country's target of 20% capacity in the energy mix by 2025. Renewable energy (RE) is a critical driver of long-term energy security. In 2018, the share of renewable energy in Malaysia's energy mix was 9%, falling far short of the national target of 20% penetration by 2025. This study employs a system dynamics approach to investigate the relationship between RE penetration and correlated indicators from energy security (ES) dimensions: energy availability, environmental sustainability, and socio-economics. The causal relationships between the three-dimensional indicators of ES have been established using causal and stock and flow logic. Simulated results show that energy consumption has increased sharply, while energy efficiency and economic growth have only increased by a small margin with an increase in RE from 2015 to 2020. The energy intensity is expected to rise slightly by the end of the fifth year. As a result, the overall impact is positive for Malaysia's environmental sustainability while reducing its reliance on energy imports and meeting national economic growth demands.


Assuntos
Dióxido de Carbono , Recuperação e Remediação Ambiental , Dióxido de Carbono/análise , Desenvolvimento Econômico , Energia Renovável
13.
Sci Total Environ ; 803: 150070, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-34525689

RESUMO

To suffice the escalating global energy demand, microalgae are deemed as high potential surrogate feedstocks for liquid fuels. The major encumbrance for the commercialization of microalgae cultivation is due to the high costs of nutrients such as carbon, phosphorous, and nitrogen. Meanwhile, the organic-rich anaerobic digestate which is difficult to be purified by conventional techniques is appropriate to be used as a low-cost nutrient source for the economic viability and sustainability of microalgae production. This option is also beneficial in terms of reutilize the organic fraction of solid waste instead of discarded as zero-value waste. Anaerobic digestate is the side product of biogas production during anaerobic digestion process, where optimum nutrients are needed to satisfy the physiological needs to grow microalgae. Besides, the turbidity, competing biological contaminants, ammonia and metal toxicity of the digestate are also potentially contributing to the inhibition of microalgae growth. Thus, this review is aimed to explicate the feasibility of utilizing the anaerobic digestate to cultivate microalgae by evaluating their potential challenges and solutions. The proposed potential solutions (digestate dilution and pre-treatment, microalgae strain selection, extra organics addition, nitrification and desulfurization) corresponding to the state-of-the-art challenges are applicable as future directions of the research.


Assuntos
Microalgas , Anaerobiose , Biocombustíveis , Nutrientes , Fósforo
14.
Bioresour Technol ; 337: 125461, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34198241

RESUMO

Industrial effluents such as pharmaceutical residues, pesticides, dyes, and metal processes holds abundant value-added products (VAPs), where its recovery has become essential. The purpose of such recovery is for sustainable treatment, which is an approach that considers the economic, social, and environmental aspects. Microalgae with its potential in the recovery process from effluents, can reduce energy usage of waste management strategies and regenerate nutrients such as carbon, phosphorus, and nitrogen. Microalgae cultures offer the use of inorganic materials by microalgae for their growth and the help of bacteria to produce biomass, thus, resulting in the absence of secondary emissions due to its ability to eliminate volatile organic compounds. Moreover, recovered bioactive compounds are transformed into bioethanol, bio-fertilizers, biopolymer, health supplements and animal feed. Therefore, it is significant to focus on an economical and efficient utilization of microalgae in recovering nutrients that can be further used in various commercial applications.


Assuntos
Microalgas , Animais , Biomassa , Carbono , Nitrogênio , Fósforo , Águas Residuárias
15.
J Hazard Mater ; 415: 125364, 2021 08 05.
Artigo em Inglês | MEDLINE | ID: mdl-33740721

RESUMO

In the present research work, a comprehensive tool for cumulative ecotoxicological impact assessment of ionic liquids (ILs) to aquatic life has been constructed. Using the probabilistic tool, impact of individual ILs to a group of aquatic species is assessed by chemical toxicity distributions (CTDs). The impact of group of ILs to individual aquatic species is assessed by species sensitivity distributions (SSDs). Acute toxicity data of imidazolium ILs with chloride (Cl-), bromide (Br-), tetrafluoroborate (BF4-), and hexafluorophosphate (PF6-) anions are used in CTD and SSD. Allowable concentrations for a group of Imidazolium ILs with the same mode of action (SMOA) to five aquatic species; Daphnia magna, Vibrio fischeri, Algae, Zebrafish, and Escherichia coli are estimated by CTDs. It has been concluded that 1-Butyl-3-methylimidazolium chloride (BMIMCl) possess the lowest risk at an acceptable risk value of 750 × 10-5 mmol/L which is 12% less than that of OMIMCl. Furthermore, the sensitivities towards the aquatic species reveal that from the studied ILs, BMIMBF4 with an acceptable risk value of 3200 × 10-5 mmol/L is the most suitable IL towards the selected aquatic species. Hence, current work provides cumulative allowable concentrations and acceptable risk values for ILs which release to aquatic compartment of ecosystem.


Assuntos
Líquidos Iônicos , Aliivibrio fischeri , Animais , Ecossistema , Líquidos Iônicos/toxicidade , Medição de Risco , Peixe-Zebra
16.
Environ Res ; 195: 110857, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33581088

RESUMO

The nature of micro- and nanoplastics and their harmful consequences has drawn significant attention in recent years in the context of environmental protection. Therefore, this paper aims to provide an overview of the existing literature related to this evolving subject, focusing on the documented human health and marine environment impacts of micro- and nanoplastics and including a discussion of the economic challenges and strategies to mitigate this waste problem. The study highlights the micro- and nanoplastics distribution across various trophic levels of the food web, and in different organs in infected animals which is possible due to their reduced size and their lightweight, multi-coloured and abundant features. Consequently, micro- and nanoplastics pose significant risks to marine organisms and human health in the form of cytotoxicity, acute reactions, and undesirable immune responses. They affect several sectors including aquaculture, agriculture, fisheries, transportation, industrial sectors, power generation, tourism, and local authorities causing considerable economic losses. This can be minimised by identifying key sources of environmental plastic contamination and educating the public, thus reducing the transfer of micro- and nanoplastics into the environment. Furthermore, the exploitation of the potential of microorganisms, particularly those from marine origins that can degrade plastics, could offer an enhanced and environmentally sound approach to mitigate micro- and nanoplastics pollution.


Assuntos
Organismos Aquáticos , Poluentes Químicos da Água , Animais , Humanos , Microplásticos , Plásticos/toxicidade , Fatores Socioeconômicos , Poluentes Químicos da Água/análise
17.
Bioresour Technol ; 325: 124702, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33487515

RESUMO

The accumulation of conventional petroleum-based polymers has increased exponentially over the years. Therefore, algae-based biopolymer has gained interest among researchers as one of the alternative approaches in achieving a sustainable circular economy around the world. The benefits of microalgae biopolymer over other feedstock is its autotrophic complex to reduce the greenhouse gases emission, rapid growing ability with flexibility in diverse environments and its ability to compost that gives greenhouse gas credits. In contrast, this review provides a comprehensive understanding of algae-based biopolymer in the evaluation of microalgae strains, bioplastic characterization and bioplastic blending technologies. The future prospects and challenges on the algae circular bioeconomy which includes the challenges faced in circular economy, issues regard to the scale-up and operating cost of microalgae cultivation and the life cycle assessment on algal-based biopolymer were highlighted. The aim of this review is to provide insights of algae-based biopolymer towards a sustainable circular bioeconomy.


Assuntos
Compostagem , Gases de Efeito Estufa , Microalgas , Biocombustíveis , Biopolímeros
18.
Acta Neurol Belg ; 120(1): 99-105, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31679149

RESUMO

Mechanical thrombectomy (MT) has been demonstrated as an effective treatment for acute ischemic stroke (AIS), thanks to large vessel occlusion (LVO), especially in case of anterior cerebral artery with many randomized clinical trials (RCTs) every year. On the other hand, there is a limited number of basilar artery occlusion (BAO)-related studies which have been conducted. The fact prompts our range of case studies, which furnish BAO understanding with our experience, results and some prognosis factors of MT. This retrospective and single-center study was conducted on 22 patients who were diagnosed with BAO and underwent the treatment of MT from October 2012 to January 2018. Clinical feature such as radiological imaging, procedure complications, and intracranial hemorrhage were all documented and evaluated. All the studies' results based on performance using modified Rankin scale score (mRS) and mortality at 90 days. The results from these BAO patients study indicated that the posterior circulation Acute Stroke Prognosis Early CT Score (pcASPECTS) recorded before the intervention was 7.7 ± 1.6, while the admission National Institutes of Health Stroke Scale (NIHSS) was 17.5 ± 5.4. 15/22 cases achieved successful recanalization (TICI, Thrombolysis in Cerebral Infarction scale, of 2b-3), accounting for 68.2%. The results highlighted 50% of the favorable outcome (mRS 0-2) occupying 11 out of 22 patients in total and the overall mortality was 36.4%. The intracranial hemorrhagic complication was detected in three cases (13.6%). Placing in juxtaposition the poor-outcome group and the favorable-outcome group, we could witness statistically significant difference (P < 0.05) suggesting both good baseline image (pc-ASPECTS ≥ 7) and recanalization (TICI 2b-3) were two good prognosis factors. Our case series showed that MT would be an effective and feasible treatment for BAO. The pre-procedural pcASPECTS ≥ 7 and post-procedural good recanalization (TICI 2b-3) were two important prognosis factors for predicting good clinical outcome.


Assuntos
Infarto Encefálico/terapia , Trombólise Mecânica/estatística & dados numéricos , Avaliação de Resultados em Cuidados de Saúde/estatística & dados numéricos , Insuficiência Vertebrobasilar/terapia , Idoso , Idoso de 80 Anos ou mais , Infarto Encefálico/complicações , Infarto Encefálico/mortalidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Insuficiência Vertebrobasilar/complicações , Insuficiência Vertebrobasilar/mortalidade
19.
Front Chem ; 7: 201, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31001522

RESUMO

Nowadays, downstream bioprocessing industries inclines towards the development of a green and high efficient bioseparation technology. Betacyanins are presently gaining higher interest in the food science as driven by their high tinctorial strength and health promoting functional properties. In this study, a novel green integration process of liquid biphasic electric partitioning system (LBEPS) was proposed for betacyanins extraction from peel and flesh of red-purple pitaya. Initially, the betacyanins extraction using LBEPS with initial settings was compared with that of liquid biphasic partitioning system (LBPS), and the results revealed that both systems demonstrated a comparable betacyanins extraction. This was followed by further optimizing the LBEPS for better betacyanins extraction. Several operating parameters including operation time, voltage applied, and position of graphitic electrodes in the system were investigated. Moreover, comparison between optimized LBEPS and LBPS with optimized conditions of electric system (as post-treatment) as well as color characterization and antioxidant properties assessment were conducted. Overall, the betacyanins extraction employing the optimized LBEPS showed the significant highest values of betacyanins concentration in alcohol-rich top phase (C t ) and partition coefficient (K) of betacyanins from peel (99.256 ± 0.014% and 133.433 ± 2.566) and flesh (97.189 ± 0.172% and 34.665 ± 2.253) of red-purple pitaya. These results inferred that an optimal betacyanins extraction was successfully achieved by this approach. Also, the LBEPS with the peel and flesh showed phase volume ratio (V r ) values of 1.667 and 2.167, respectively, and this indicated that they have a clear biphasic separation. In addition, the peel and flesh extract obtained from the optimized LBEPS demonstrated different variations of red color as well as their antioxidant properties were well-retained. This article introduces a new, reliable, and effective bioseparation approach for the extraction of biomolecules, which is definitely worth to explore further as a bioseparation tool in the downstream bioprocessing.

20.
Biotechnol J ; 13(6): e1700618, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29356369

RESUMO

Microalgae are considered promising feedstock for the production of biofuels and other bioactive compounds, yet there are still challenges on commercial applications of microalgae-based products. This review focuses on the economic analysis, environmental impact, and industrial potential of biofuels production from microalgae. The cost of biofuels production remains higher compared to conventional fuel sources. However, integration of biorefinery pathways with biofuels production for the recovery of value-added products (such as antioxidants, natural dyes, cosmetics, nutritional supplements, polyunsaturated fatty acids, and so forth) could substantially reduce the production costs. It also paves the way for sustainable energy resources by significantly reducing the emissions of CO2 , NOx , SOx , and heavy metals. Large-scale biofuels production has yet to be successfully commercialized with many roadblocks ahead and heavy competition with conventional fuel feedstock as well as technological aspects. One of the prominent challenges is to develop a cost-effective method to achieve high-density microalgal cultivation on an industrial scale. The biofuels industry should be boosted by Government's support in the form of subsidies and incentives, for addressing the pressing climate change issues, achieving sustainability, and energy security.


Assuntos
Biocombustíveis/economia , Biotecnologia , Microalgas , Biotecnologia/economia , Biotecnologia/métodos , Meio Ambiente
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