Animal Welfare Assessment and Meat Quality through Assessment of Stress Biomarkers in Fattening Pigs with and without Visible Damage during Slaughter.

The study aimed to investigate the physiological and meat quality differences between Non-Ambulatory, Non-Injured (NANI), and without apparent abnormalities (non-NANI) pigs in a commercial slaughterhouse setting, focusing on the impact of stress and health conditions on the overall well-being and meat quality of the animals. A total of 241 surgically castrated crossbred male pigs from Southern Brazil were analyzed, with 131 non-NANI pigs and 110 NANI pigs. Infrared orbital temperature, rectal temperature, hematological parameters, and meat quality measurements were collected. Statistical analysis included ANOVA tests and principal component analysis (PCA). NANI pigs exhibited significantly higher infrared orbital temperatures and rectal temperature (p < 0.01). Hematological analysis revealed higher levels of hemoglobin, hematocrit, and red blood cells in NANI pigs (p < 0.05). White blood cell count and lactate dehydrogenase were significantly elevated in NANI pigs (p < 0.01), indicating potential infections or inflammatory responses. Meat quality parameters showed that NANI pigs had lower pH values, higher luminosity, and increased drip loss (p < 0.01), reflecting poorer water retention and potential muscle glycogen depletion. The study highlights the physiological and meat quality differences between NANI and non-NANI pigs, emphasizing the impact of stress, health conditions, and handling procedures on the animals. Blood biomarkers proved valuable in assessing physiological stress, immune response, and potential health issues in pigs, correlating with meat quality abnormalities. Utilizing these biomarkers as predictive tools can enhance animal welfare practices and contribute to improving meat quality in the swine industry.

The Free Radical Scavenging Property of the Leaves, Branches, and Roots of Mansoa hirsuta DC: In Vitro Assessment, 3D Pharmacophore, and Molecular Docking Study.

In this work, a metabolic profile of Mansoa hirsuta was investigated, and in vitro assays and theoretical approaches were carried out to evaluate its antioxidant potential. The phytochemical screening detected saponins, organic acids, phenols, tannins, flavonoids, and alkaloids in extracts of leaves, branches, and roots. Through LC-MS analysis, the triterpenes oleanolic acid (m/z 455 [M-H]-) and ursolic acid (m/z 455 [M-H]-) were identified as the main bioactive components. The extracts of the leaves, branches, and roots revealed moderate antioxidant potential in the DPPH test and all extracts were more active in the ABTS test. The leaf extracts showed better antioxidant capacity, displaying IC50 values of 43.5 ± 0.14, 63.6 ± 0.54, and 56.1 ± 0.05 µg mL-1 for DPPH, ABTS, and kinetics assays, respectively. The leaf extract showed higher total flavonoid content (TFC) (5.12 ± 1.02 mg QR/g), followed by branches (3.16 ± 0.88 QR/g) and roots (2.04 ± 0.52 QR/g/g). The extract of the branches exhibited higher total phenolic content (TPC) (1.07 ± 0.77 GAE/g), followed by leaves (0.58 ± 0.30 GAE/g) and roots (0.19 ± 0.47 GAE/g). Pharmacophore and molecular docking analysis were performed in order to better understand the potential mechanism of the antioxidant activity of its major metabolites.

Psychosocial rehabilitation in the west network of the municipality of São Paulo: potentialities and challenges. / A reabilitação psicossocial na rede oeste do município de São Paulo: potencialidades e desafios.

OBJECTIVE: To describe the strategies of the Psychosocial Rehabilitation conducted in the Network of Psychosocial Care of the western region of the municipality of São Paulo. METHODOLOGY: Descriptive qualitative study, carried out with 123 professionals, from September 2015 to July 2016. Data processed by the software Alceste and analyzed in light of the analytical category Psychosocial Rehabilitation of Benedetto Saraceno and complementary literature. RESULTS: Three classes emerged that address the potential and scarcity of therapeutic residential services as a space to resume the daily life; importance of cultural activities for the exchange of identities and care beyond the scope of health; the potential of projects to generate work and income to regain the contractual power. CONCLUSION: The strategies contribute to the construction of subjectivity and the resumption of the citizenship. In order to sustain the Psychosocial Rehabilitation it is necessary to overcome the weaknesses of human, physical and structural resources. Still, there is potential in the collaborative work and accountability of the teams.

A reabilitação psicossocial na rede oeste do município de São Paulo: potencialidades e desafios / La rehabilitación psicosocial en la red oeste del municipio de São Paulo: potencialidades y desafíos / Psychosocial rehabilitation in the west network of the municipality of São Paulo: potentialities and challenges

Resumo OBJETIVO Descrever as estratégias de Reabilitação Psicossocial conduzidas na Rede de Atenção Psicossocial da região Oeste do munícipio de São Paulo. METODOLOGIA estudo qualitativo descritivo, realizado com 123 profissionais, de setembro de 2015 a julho de 2016. Dados processados pelo software Alceste e analisados a luz da categoria analítica Reabilitação Psicossocial de Benedetto Saraceno e literatura complementar. RESULTADOS Emergiram três classes que tratam do potencial e escassez dos serviços residenciais terapêuticos enquanto espaço de retomada da vida cotidiana; importância das atividades culturais para troca de identidades e cuidado para além do âmbito da saúde e; a potencialidade dos projetos de geração de trabalho e renda para retomada do poder contratual. CONCLUSÃO As estratégias contribuem para construção da subjetividade e retomada da cidadania. Para sustentar a Reabilitação Psicossocial é necessário superar as fragilidades de recursos humanos, físicos e estruturais. Ainda assim, há potencialidade no trabalho colaborativo e de responsabilização das equipes.

Resumen OBJETIVO Describir las estrategias de Rehabilitación Psicosocial conducidas en la Red de Atención Psicosocial de la región Oeste del municipio de São Paulo. METODOLOGÍA Estudio cualitativo y descriptivo, realizado con 123 profesionales, de septiembre de 2015 a julio de 2016. Datos procesados ​​por el software Alceste y analizados a la luz de la categoría analítica Rehabilitación Psicosocial de Benedetto Saraceno y literatura complementaria. RESULTADOS Emergieron tres clases que tratan del potencial y de la escasez de los servicios residenciales terapéuticos como espacio de retomada a la vida cotidiana; la importancia de las actividades culturales para el intercambio de identidades y del cuidado más allá del ámbito de la salud; y la potencialidad de los proyectos de generación de trabajo y renta para reanudación del poder contractual. CONCLUSIÓN Las estrategias contribuyen a construir la subjetividad y a reanudar la ciudadanía. Para sostener la Rehabilitación Psicosocial, es necesario superar las debilidades de los recursos humanos, físicos y estructurales. Sin embargo, hay potencialidad en el trabajo colaborativo y de responsabilidad de los equipos.

Abstract OBJECTIVE To describe the strategies of the Psychosocial Rehabilitation conducted in the Network of Psychosocial Care of the western region of the municipality of São Paulo. METHODOLOGY Descriptive qualitative study, carried out with 123 professionals, from September 2015 to July 2016. Data processed by the software Alceste and analyzed in light of the analytical category Psychosocial Rehabilitation of Benedetto Saraceno and complementary literature. RESULTS Three classes emerged that address the potential and scarcity of therapeutic residential services as a space to resume the daily life; importance of cultural activities for the exchange of identities and care beyond the scope of health; the potential of projects to generate work and income to regain the contractual power. CONCLUSION The strategies contribute to the construction of subjectivity and the resumption of the citizenship. In order to sustain the Psychosocial Rehabilitation it is necessary to overcome the weaknesses of human, physical and structural resources. Still, there is potential in the collaborative work and accountability of the teams.

Burden and related factors in caregivers of young adults presenting bipolar and unipolar mood disorder.

BACKGROUND: Caregiver burden has been associated with caregivers' mental disorders and need for support and information. However, the lack of quantitative studies and formal interventions aiming to lower burden levels in this population reflect the current negligence regarding this important issue. AIM: To identify burden levels and associated factors in caregivers of young adults with bipolar and unipolar mood disorder. METHOD: This is a cross-sectional study nested within a population-based cross-sectional study with young adults. Caregiver burden was assessed through the Burden Interview. Information about caregiver mental disorders (Axis I) and alcohol abuse were obtained through the Mini International Neuropsychiatric Interview (MINI) and the Cut-Down, Annoyed, Guilty and Eye-Opener (CAGE) questionnaire, respectively. RESULTS: Caregiver burden was associated to caregiver's mood and anxiety disorders, suicide risk and being the caregiver of young adults with depression disorder and bipolar disorder. Also, burden was higher among caregivers of bipolar individuals. When excluding the control group from the analysis, only mood and anxiety disorders remained associated to caregiver burden. CONCLUSIONS: Caregivers are affected by the young adult's disorder even before a diagnosis has been given, with serious impairments in their lives. Thus, this is a subject in need of designing relevant strategies aiming to provide them with care.