Financial Incentives for Physical Activity and Sports Participation in Young People.

Physical inactivity is a global health problem. Childhood is an opportune time to establish healthy physical activity behaviors, including the participation in organized physical activity, such as sports. We hypothesize that financial incentives can improve young people's participation in physical activity and sports. The design of the incentive and the context in which it operates are crucial to its success.

A novel approach to perioperative risk assessment for patients with pulmonary hypertension.

RATIONALE: Pulmonary hypertension (PH) is associated with significant perioperative morbidity and mortality. We hypothesised that pulmonary arterial hypertension (PAH) composite risk assessment scores could estimate perioperative risk for PH patients when adjusted for inherent procedural risk. METHODS: We identified patients in the Johns Hopkins PH Center Registry that had noncardiac surgery (including endoscopies) between September 2015 and January 2020. We collected information on preoperative patient-level and procedural variables and used logistic regression to evaluate associations with a composite outcome of death within 30 days or serious postoperative complication. We generated composite patient-level risk assessment scores for each subject and used logistic regression to estimate the association with adverse surgical outcomes. We adjusted multivariable models for inherent procedural risk of major cardiovascular events and used these models to generate a numerical PH perioperative risk (PHPR) score. RESULTS: Among 150 subjects, 19 (12.7%) reached the primary outcome, including 7 deaths (4.7%). Individual patient-level and procedural variables were associated with the primary outcome (all p<0.05). A composite patient-level risk assessment score built on three noninvasive parameters was strongly associated with reduced risk for poor outcomes (OR=0.4, p=0.03). This association was strengthened after adjusting the model for procedural risk. A PHPR score derived from the multivariable model stratified patients into low (0%), intermediate (≤10%), or high (>10%) risk of reaching the primary outcome. CONCLUSION: Composite PAH risk assessment scores can predict perioperative risk for PH patients after accounting for inherent procedural risk. Validation of the PHPR score in a multicentre, prospective cohort is warranted.

Why do patients self-present to Middlemore Hospital Emergency Department?

AIM: To determine the drivers for acute (Australasian Triage Scale Category 3-5) demand in patients who self-present to New Zealand's Middlemore Hospital Emergency Department (MMH ED), we sought to establish a demographic profile of a sample of self-presenting patients and explore their reasons for presenting to ED rather than attending a primary care centre. METHOD: A prospective, observational study was undertaken of patients in Australasian Triage Scale Categories 3-5 (ATS 3-5) who self-presented to MMH ED over a 7 day period from 14 April 2011 to 21 April 2011. We studied two time periods, 0900-1200 and 1800-2200, to compare drivers for attendance to MMH ED during primary care service open hours and closed hours. A structured questionnaire was used to collect demographic data and outcomes. The cumulative 2011 demographic data for self-presentations to MMH was compared to the study data. RESULTS: 500 patients were approached to participate and 421 met the inclusion criteria. The mean age of presenters was 37.6 years (SD of 24.6) with 48.2% (95%CI 44-53%) being male and 23% (95%CI 19-27%) employed. Of those who indicated they had a general practitioner (GP), 23% (95%CI 21-30%) had contacted their GP prior to presentation to MMH ED, with 73% (n=73) advised to attend ED. Of the 73 patients told by their GP to attend ED, 30 (41.1%; 95%CI 31-53%) were admitted, with two patients being transferred to another district health board (DHB), and the remainder discharged home. Thirty-two percent of the self-presenting patients came to ED because they felt sick enough to require emergency care. Comparison of the data for the two time periods indicated only one significant difference: 14% of patients presented to ED in the morning because their GP was closed, whereas 28.7% of those who presented after hours did so for this reason. CONCLUSION: Almost 25% of self-presenting patients had contacted their GP or a health professional prior to their ED presentation and were advised to attend ED. The most common reason for patients to self-present at MMH ED is the belief that a hospital emergency department is the appropriate service to treat acute sickness. Neither cost nor knowledge of the Shorter Stays in Emergency Departments Health Target featured as a reason for attendance.

An assessment of the biotechnological use of hemoglobin modulation in cereals.

Non-symbiotic hemoglobin (nsHb) genes are ubiquitous in plants, but their biological functions have mostly been studied in model plant species rather than in crops. nsHb influences cell signaling and metabolism by modulating the levels of nitric oxide (NO). Class 1 nsHb is upregulated under hypoxia and is involved in various biotic and abiotic stress responses. Ectopic overexpression of nsHb in Arabidopsis thaliana accelerates development, whilst targeted overexpression in seeds can increase seed yield. Such observations suggest that manipulating nsHb could be a valid biotechnological target. We studied the effects of overexpression of class 1 nsHb in the monocotyledonous crop plant barley (Hordeum vulgare cv. Golden Promise). nsHb was shown to be involved in NO metabolism in barley, as ectopic overexpression reduced the amount of NO released during hypoxia. Further, as in Arabidopsis, nsHb overexpression compromised basal resistance toward pathogens in barley. However, unlike Arabidopsis, nsHb ectopic overexpression delayed growth and development in barley, and seed specific overexpression reduced seed yield. Thus, nsHb overexpression in barley does not seem to be an efficient strategy for increasing yield in cereal crops. These findings highlight the necessity for using actual crop plants rather than laboratory model plants when assessing the effects of biotechnological approaches to crop improvement.

Aiming for zero: decreasing central line associated bacteraemia in the intensive care unit.

AIM: To eliminate Central Line Associated Bacteraemia (CLAB) in the Critical Care Complex (CCC)-Intensive Care Unit (ICU) and High Dependency Unit (HDU)-Middlemore Hospital. METHOD: Multifaceted quality improvement programme that included: engagement with ICU leadership and education of ICU staff; the introduction of a CLAB prevention bundle of care through standardised checklists for central line insertion (December 2008) and line maintenance (July 2009); the development of a central line pack; and rapid, visual feedback of results. RESULTS: Absolute numbers of CLAB in the CCC decreased from 14 in 2008, to 4 in 2009 and 1 in the first 6 months of 2010 (despite increase in bed census and a doubling of admissions). The CLAB rate per 1,000 line days decreased from 6.6 to 0.9. The days between CLAB increased from a median of 30 to >100 days, with zero CLAB for 5 of the last 6 months. Mortality for patients with CLAB was 37%, compared with mortality of 13% for all other ICU patients. The conservative cost savings were $200,000 in 2009 and $260,000 in 2010. CONCLUSION: Using an evidenced-based quality improvement approach, it is possible to significantly decrease Central Line Associated Bacteraemia in the Critical Care Complex. In doing so patient morbidity and mortality are reduced and money is saved for other healthcare needs.