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Neurotoxicology ; 81: 347-352, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33742601

RESUMO

The Seychelles Child Development Study is a longitudinal cohort study following a group of 779 children exposed prenatally to methyl mercury (MeHg) through a maternal diet high in fish. The cohort has been examined six times beginning in infancy with no consistent evidence of adverse effects. In fact, their performance resembles what would be expected from normal children of comparable ages growing up in western cultures. During a neurodevelopment assessment at 66 months, the children were tested for scholastic achievement using the Woodcock Johnson Tests of Achievement. Their reading scores were depressed relative to US norms while arithmetic scores were within normal limits. This disparity was not evident at 107 months; in fact, reading achievement scores far exceeded expected performance relative to US norms, with over 75% of the cohort obtaining scores at or above the 90th percentile. This study reports a secondary analysis of the scholastic achievement data to test the hypothesis that the results obtained in the primary analysis were probably due to the onset of the primary school curriculum between the first and second testing, and not to inherent cognitive deficits among the children at 66 months. The results suggest that a combination of reading instruction and characteristically consistent letter-sound relationships in Creole, the language spoken at home by the majority of Seychellois families, probably accounted for the high achievement scores at 107 months.


Assuntos
Comportamento Infantil , Desenvolvimento Infantil , Exposição Dietética/efeitos adversos , Escolaridade , Contaminação de Alimentos , Exposição Materna/efeitos adversos , Compostos de Metilmercúrio/efeitos adversos , Sistema Nervoso/efeitos dos fármacos , Alimentos Marinhos/efeitos adversos , Fatores Etários , Pré-Escolar , Cognição , Feminino , Humanos , Estudos Longitudinais , Masculino , Conceitos Matemáticos , Sistema Nervoso/crescimento & desenvolvimento , Gravidez , Efeitos Tardios da Exposição Pré-Natal , Leitura , Seicheles
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