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1.
Int J Law Psychiatry ; 91: 101924, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37690361

RESUMO

BACKGROUND: Adults with co-occurring opioid use and mental health disorder (COD) recently released from incarceration have many social and health needs that place them at the most significant risk for overdose and poor reentry outcomes. Little is known about racial/ethnic differences in this population. METHODS: To examine racial/ethnic differences in social and health needs, data were analyzed for 293 adults with COD within two weeks of release, a high-risk period for overdose, from six Massachusetts jails. RESULTS: Overall, participants (62.6% non-Hispanic White, 23.1% Hispanic, 14.3% non-Hispanic Black, and 73.5% male) reported multiple health and social needs across groups. Chi-square tests and Kruskal-Wallis one-way ANOVAs were used to compare social and health needs among racial/ethnic groups. Non-Hispanic Black participants reported more problems with crack/cocaine, whereas Non-Hispanic White and Hispanic participants reported more problems with opioids (p < .001). Despite similar lifetime rates of illicit substance use, non-Hispanic Black and Hispanic participants received less treatment (p < .001). Non-Hispanic White participants reported more opioid and alcohol use (p < .006), trauma symptoms (p = .020), utilization of behavioral health treatment (p = .008), and more medical needs than Hispanic and/or non-Hispanic Black participants (p = .001). Non-Hispanic Black and Hispanic participants reported more needs related to social determinants of health (p = .008). CONCLUSIONS: While re-entry is a vulnerable period for all adults with COD, this paper identifies specific needs by race/ethnicity and proposes strategies to advance equity and improve care for all formerly incarcerated adults with a COD.


Assuntos
Transtornos Mentais , Transtornos Relacionados ao Uso de Opioides , Adulto , Feminino , Humanos , Masculino , Analgésicos Opioides , Etnicidade , Hispânico ou Latino , Saúde Mental , Estados Unidos , Grupos Raciais , Negro ou Afro-Americano , Transtornos Mentais/epidemiologia , Transtornos Relacionados ao Uso de Opioides/epidemiologia
2.
J Clin Transl Sci ; 7(1): e80, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37125066

RESUMO

Introduction: Behavioral health treatment disparities by race and ethnicity are well documented across the criminal legal system. Despite criminal legal settings such as drug treatment courts (DTCs) increasingly adopting evidence-based programs (EBPs) to improve care, there is a dearth of research identifying strategies to advance equitable implementation of EBPs and reduce racial/ethnic treatment disparities. This paper describes an innovative approach to identify community- and provider-generated strategies to support equitable implementation of an evidence-based co-occurring mental health and substance use disorder intervention, called Maintaining Independence and Sobriety through Systems Integration, Outreach and Networking-Criminal Justice (MISSION-CJ), in DTCs. Methods/design: Guided by the Health Equity Implementation Framework, qualitative interviews and surveys will assess factors facilitating and hindering equitable implementation of MISSION-CJ in DTCs among 30 Black/African American and/or Hispanic/Latino persons served and providers. Concept mapping with sixty Black/African American and/or Hispanic/Latino persons served and providers will gather community- and provider-generated strategies to address identified barriers. Finally, an advisory board will offer iterative feedback on the data to guide toolkit development and inform equitable implementation of MISSION-CJ within DTCs. Conclusions: The paper illustrates a protocol of a study based in community-engaged research and implementation science to understand multilevel drivers of racial/ethnic disparities in co-occurring disorder treatment and identify opportunities for intervention and improvements within criminal legal settings.

3.
BMC Prim Care ; 23(1): 331, 2022 12 19.
Artigo em Inglês | MEDLINE | ID: mdl-36529718

RESUMO

BACKGROUND: Homelessness is a robust social determinant of acute care service utilization among veterans. Although intensive outpatient programs have been developed for homeless veterans who are high utilizers of acute care ("super utilizers"), few scalable programs have been implemented to address their needs. OBJECTIVE: Describe the development and pilot testing of a novel intervention that integrates the roles of a peer and whole health coach ("Peer-WHC") in coordination with primary care teams to reduce homeless veterans' frequent use of acute care. DESIGN: Single-arm trial in three outpatient primary care clinics at a Veterans Health Administration (VHA) medical center; pre/post design using mixed-methods. PARTICIPANTS: Twenty veterans from VHA's homeless registry who were super-utilizers of acute care and enrolled in primary care. INTERVENTION: Weekly health coaching sessions with a peer over 12 weeks, including discussions of patients' health care utilization patterns and coordination with primary care. MAIN MEASURES: Rates of session attendance and intervention fidelity, patient-reported satisfaction and changes in patient engagement and perceptions of health, pre/post utilization of acute and supportive care services, and qualitative interviews with multiple stakeholders to identify barriers and facilitators to implementation. KEY RESULTS: On average, patients attended 6.35 sessions (SD = 3.5, Median = 7). Satisfaction scores (M = 28.75 out of 32; SD = 2.79) exceeded a priori benchmarks. Patients' perceptions of health improved from pre to post [t(df)=-2.26(14), p = 0.04]. In the 3-months pre/post, 45% (n = 9) and 15% (n = 3) of patients, respectively, were hospitalized. Qualitative feedback from patients, providers, and peers and fidelity metrics suggested value in increasing the length of the intervention to facilitate goal-setting with patients and coordination with primary care. CONCLUSION: Findings support the feasibility, acceptability, and utility of Peer-WHC to address the healthcare needs of homeless veterans. A future trial is warranted to test the impact of Peer-WHC on reducing these patients' frequent use of acute care.


Assuntos
Pessoas Mal Alojadas , Tutoria , Veteranos , Estados Unidos , Humanos , United States Department of Veterans Affairs , Projetos Piloto , Aceitação pelo Paciente de Cuidados de Saúde
4.
Psychol Serv ; 19(4): 637-647, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-35549301

RESUMO

Mental Health Courts (MHCs), an alternative to incarceration, aim to address behavioral health, social needs, and criminal recidivism and serve many adults with co-occurring mental health and substance use disorder (COD). Despite the growth in MHCs, little research has examined ethnic/racial differences in behavioral health and service needs of individuals with COD. This study used data from behavioral health and social assessments administered to 146 adults with COD entering a Massachusetts MHC. Multivariate linear and logistic regression controlling for key demographics tested differences between racial/ethnic groups on current and lifetime substance use, mental health symptoms, and history of criminal legal system involvement. Hispanic participants were more likely than non-Hispanic White participants to report current and lifetime serious mental illness and lifetime Emergency Department (ED) mental health treatment. Non-Hispanic White participants were more likely to report current and lifetime use of illicit substances, more recent outpatient and overall lifetime treatment attempts for substance use, and higher number of lifetime arrests compared to non-Hispanic Black participants. Lastly, non-Hispanic White participants also reported more recent outpatient and overall lifetime treatment attempts for substance use compared to Hispanic participants. Racial/ethnic differences in behavioral health and social needs of MHC enrollees with COD exist and should be considered in the planning and delivery of psychological and social services. Understanding the diverse population of new MHC enrollees is an important first step in identifying and addressing racial and ethnic disparities. (PsycInfo Database Record (c) 2022 APA, all rights reserved).


Assuntos
Criminosos , Transtornos Relacionados ao Uso de Substâncias , Adulto , Humanos , Estados Unidos , População Branca , Saúde Mental , Hispânico ou Latino , Transtornos Relacionados ao Uso de Substâncias/terapia
5.
J Addict Med ; 14(6): 446-450, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32032211

RESUMO

: Vaping, the inhalation of a nicotine or tetrahydrocannabinol (THC), cannabidiol (CBD), or non-drug infused solution delivered by vaping devices, is a growing phenomenon across many segments of the US population. Complications associated with vaping are newly emerging and relatively unstudied; little guidance exists on how clinicians may best elicit information related to vaping practices and associated medical problems. This publication, therefore, provides physicians and other treatment clinicians with direction for obtaining the medical history that can guide clinical decision-making for patients at risk for adverse effects associated with vaping.


Assuntos
Canabidiol , Sistemas Eletrônicos de Liberação de Nicotina , Vaping , Canabidiol/efeitos adversos , Dronabinol , Humanos , Nicotina , Vaping/efeitos adversos
6.
J Health Care Poor Underserved ; 31(3): 1440-1456, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33416704

RESUMO

Legal clinics housed by the Department of Veterans Affairs (VA) help veterans eliminate service access barriers. In this survey of 95 VA-housed legal clinics (70% of clinics), clients' legal problems were mainly estate planning, family, obtaining VA benefits, and housing (14-17% of clients). Most clinics rarely interacted with VA health care providers, did not have access to clients' VA health care records, and did not track clients' VA health care access (58-81% of clinics); 32% did not have dedicated and adequate space. Most clinic staff members were unpaid. Survey findings-that most VA-housed legal clinics do not interact with VA health care or directly address clients' mental health and substance use needs, and lack funds to serve fully all veterans seeking services-suggest that VA and community agencies should enact policies that expand and fund veterans' legal services and health system interactions to address health inequities and improve health outcomes.


Assuntos
Serviços de Saúde Mental , Veteranos , Acessibilidade aos Serviços de Saúde , Habitação , Humanos , Seguridade Social , Estados Unidos , United States Department of Veterans Affairs
7.
J Subst Abuse Treat ; 108: 104-114, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31285078

RESUMO

Given the interrelated nature of opioid use, criminal justice interaction, and mental health issues, the current opioid crisis has created an urgent need for treatment, including medication assisted treatment, among justice-involved populations. Implementation research plays an important role in improving systems of care and integration of evidence-based practices within and outside of criminal justice institutions. The current study is a formative qualitative evaluation of the implementation of a cross-system (corrections and community-based) opioid use treatment initiative supported by Opioid State Targeted Response (STR) funding. The purpose of the study is to assess the fit of the Consolidated Framework for Implementation Research (CFIR) to a cross-system initiative, and to identify key barriers and facilitators to implementation. The process evaluation showed that adaptability of the clinical model and staff flexibility were critical to implementation. Cultural and procedural differences across correctional facilities and community-based treatment programs required frequent and structured forums for cross-system communication. Challenges related to recruitment and enrollment, staffing, MAT, and data collection were addressed through the collaborative development and continuous review of policies and procedures. This study found CFIR to be a useful framework for understanding implementation uptake and barriers. The framework was particularly valuable in reinforcing the use of implementation research as a means for continuous process improvement. CFIR is a comprehensive and flexible framework that may be adopted in future cross-system evaluations.


Assuntos
Centros Comunitários de Saúde/organização & administração , Acessibilidade aos Serviços de Saúde/organização & administração , Ciência da Implementação , Transtornos Relacionados ao Uso de Opioides/reabilitação , Prisioneiros/psicologia , Prisões , Direito Penal , Humanos , Transtornos Mentais/terapia , Pesquisa Qualitativa
8.
Community Ment Health J ; 55(8): 1305-1312, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31236735

RESUMO

This study explored patterns of clinical need among homeless individuals with dual diagnoses, and explored whether certain profiles are characteristic of different demographic groups. Data were drawn from two larger studies conducted with dually diagnosed, homeless individuals (n = 373). Hierarchical cluster analysis identified four subgroups: (1) Clinically least severe, characterized by less frequent psychological symptoms and no history of physical or sexual abuse; (2) Moderate clinical needs, including shorter history of substance use and less frequent psychological symptoms, but symptoms consistent with severe mental illness; (3) Clinically severe, with frequent anxiety, depression, past and recent physical or sexual abuse, and long history of substance use; (4) Least frequent psychological symptoms, but frequent history of physical or sexual abuse and long history of drug use. Women veterans were mostly likely to be classified in cluster 3, and male civilians in cluster 2. Subgroups of homeless individuals with dual diagnoses demonstrated different clusters of clinical needs, having implications for service delivery to the population.


Assuntos
Diagnóstico Duplo (Psiquiatria)/estatística & dados numéricos , Necessidades e Demandas de Serviços de Saúde/estatística & dados numéricos , Pessoas Mal Alojadas/psicologia , Análise por Conglomerados , Diagnóstico Duplo (Psiquiatria)/psicologia , Feminino , Pessoas Mal Alojadas/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Estados Unidos
9.
BMC Health Serv Res ; 17(1): 647, 2017 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-28899394

RESUMO

BACKGROUND: Approximately 600,000 persons are released from prison annually in the United States. Relatively few receive sufficient re-entry services and are at risk for unemployment, homelessness, poverty, substance abuse relapse and recidivism. Persons leaving prison who have a mental illness and/or a substance use disorder are particularly challenged. This project aims to create a peer mentor program to extend the reach and effectiveness of reentry services provided by the Department of Veterans' Affairs (VA). We will implement a peer support for reentry veterans sequentially in two states. Our outcome measures are 1) fidelity of the intervention, 2) linkage to VA health care and, 3) continued engagement in health care. The aims for this project are as follows: (1) Conduct contextual analysis to identify VA and community reentry resources, and describe how reentry veterans use them. (2) Implement peer-support, in one state, to link reentry veterans to Veterans' Health Administration (VHA) primary care, mental health, and SUD services. (3) Port the peer-support intervention to another, geographically, and contextually different state. DESIGN: This intervention involves a 2-state sequential implementation study (Massachusetts, followed by Pennsylvania) using a Facilitation Implementation strategy. We will conduct formative and summative analyses, including assessment of fidelity, and a matched comparison group to evaluate the intervention's outcomes of veteran linkage and engagement in VHA health care (using health care utilization measures). The study proceeds in 3 phases. DISCUSSION: We anticipate that a peer support program will be effective at improving the reentry process for veterans, particularly in linking them to health, mental health, and SUD services and helping them to stay engaged in those services. It will fill a gap by providing veterans with access to a trusted individual, who understands their experience as a veteran and who has experienced justice involvement. The outputs from this project, including training materials, peer guidebooks, and implementation strategies can be adapted by other states and regions that wish to enhance services for veterans (or other populations) leaving incarceration. A larger cluster-randomized implementation-effectiveness study is planned. TRIAL REGISTRATION: This protocol is registered with clinicaltrials.gov on November 4, 2016 and was assigned the number NCT02964897 .


Assuntos
Serviços de Saúde Mental , Grupo Associado , Veteranos/psicologia , Feminino , Acessibilidade aos Serviços de Saúde , Pessoas Mal Alojadas , Humanos , Entrevistas como Assunto , Massachusetts , Aceitação pelo Paciente de Cuidados de Saúde , Pennsylvania , Atenção Primária à Saúde , Pesquisa Qualitativa , Transtornos Relacionados ao Uso de Substâncias , Estados Unidos , United States Department of Veterans Affairs/organização & administração , Populações Vulneráveis
10.
PeerJ ; 3: e1096, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26246964

RESUMO

Background. Homeless veterans have complex healthcare needs, but experience many barriers to treatment engagement. While information technologies (IT), especially mobile phones, are used to engage patients in care, little is known about homeless veterans' IT use. This study examines homeless veterans' access to and use of IT, attitudes toward health-related IT use, and barriers to IT in the context of homelessness. Methods. Qualitative interviews were conducted with 30 homeless veterans in different housing programs in Boston, MA, ranging from emergency shelters to supportive transitional housing that allow stays of up to 2 years. Interviews were conducted in person, audio recorded and then transcribed. Three researchers coded transcripts. Inductive thematic analysis was used. Results. Most participants (90%) had a mobile phone and were receptive to IT use for health-related communications. A common difficulty communicating with providers was the lack of a stable mailing address. Some participants were using mobile phones to stay in touch with providers. Participants felt mobile-phone calls or text messages could be used to remind patients of appointments, prescription refills, medication taking, and returning for laboratory results. Mobile phone text messaging was seen as convenient, and helped participants stay organized because necessary information was saved in text messages. Some reported concerns about the costs associated with mobile phone use (calls and texting), the potential to be annoyed by too many text messages, and not knowing how to use text messaging. Conclusion. Homeless veterans use IT and welcome its use for health-related purposes. Technology-assisted outreach among this population may lead to improved engagement in care.

11.
Addict Sci Clin Pract ; 8: 7, 2013 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-23497630

RESUMO

BACKGROUND: This paper describes an innovative protocol for a type-II hybrid effectiveness-implementation trial that is evaluating a smoking cessation telephone care coordination program for Veterans Health Administration (VA) mental-health clinic patients. As a hybrid trial, the protocol combines implementation science and clinical trial methods and outcomes that can inform future cessation studies and the implementation of tobacco cessation programs into routine care. The primary objectives of the trial are (1) to evaluate the process of adapting, implementing, and sustaining a smoking cessation telephone care coordination program in VA mental health clinics, (2) to determine the effectiveness of the program in promoting long-term abstinence from smoking among mental health patients, and (3) to compare the effectiveness of telephone counseling delivered by VA staff with that delivered by state quitlines. METHODS/DESIGN: The care coordination program is being implemented at six VA facilities. VA mental health providers refer patients to the program via an electronic medical record consult. Program staff call referred patients to offer enrollment. All patients who enroll receive a self-help booklet, mailed smoking cessation medications, and proactive multi-call telephone counseling. Participants are randomized to receive this counseling from VA staff or their state's quitline. Four primary implementation strategies are being used to optimize program implementation and sustainability: blended facilitation, provider training, informatics support, and provider feedback. A three-phase formative evaluation is being conducted to identify barriers to, and facilitators for, program implementation and sustainability. A mixed-methods approach is being used to collect quantitative clinical effectiveness data (e.g., self-reported abstinence at six months) and both quantitative and qualitative implementation data (e.g., provider referral rates, coded interviews with providers). Summative data will be analyzed using the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) framework. DISCUSSION: This paper describes the rationale and methods of a trial designed to simultaneously study the clinical effectiveness and implementation of a telephone smoking cessation program for smokers using VA mental health clinics. Such hybrid designs are an important methodological design that can shorten the time between the development of an intervention and its translation into routine clinical care.


Assuntos
Aconselhamento/métodos , Abandono do Hábito de Fumar/métodos , Prevenção do Hábito de Fumar , Telefone/estatística & dados numéricos , Tabagismo/reabilitação , United States Department of Veterans Affairs/organização & administração , Veteranos/estatística & dados numéricos , Adulto , Feminino , Implementação de Plano de Saúde , Humanos , Masculino , Serviços de Saúde Mental/estatística & dados numéricos , Pessoa de Meia-Idade , Equipe de Assistência ao Paciente/organização & administração , Cooperação do Paciente/estatística & dados numéricos , Inquéritos e Questionários , Resultado do Tratamento , Estados Unidos , Veteranos/psicologia , Adulto Jovem
12.
Psychiatr Rehabil J ; 35(3): 209-17, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22246119

RESUMO

PURPOSE: The influx of young adult veterans with mental health challenges from recent wars combined with newly expanded veteran education benefits has highlighted the need for a supported education service within the Veterans Administration. However, it is unknown how such a service should be designed to best respond to these needs. This study undertook a qualitative needs assessment for education supports among veterans with post-9/11 service with self-reported PTSD symptoms. METHODS: Focus groups were held with 31 veterans, 54% of whom were under age 30. Transcripts were analyzed and interpreted using a thematic approach and a Participatory Action Research team. RESULTS: Findings indicate a need for age relevant services that assist with: education planning and access, counseling for the G.I. Bill, accommodations for PTSD symptoms, community and family re-integration, and outreach and support. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: The veterans recommended that supported education be integrated with the delivery of mental health services, that services have varied intensity, and there be linkages between colleges and the Veterans Health Administration.


Assuntos
Escolaridade , Avaliação das Necessidades , Transtornos de Estresse Pós-Traumáticos , Apoio ao Desenvolvimento de Recursos Humanos/organização & administração , Veteranos , Adulto , Serviços Comunitários de Saúde Mental/métodos , Serviços Comunitários de Saúde Mental/organização & administração , Aconselhamento , Feminino , Pesquisa sobre Serviços de Saúde , Humanos , Masculino , Saúde Mental , Transtornos de Estresse Pós-Traumáticos/psicologia , Transtornos de Estresse Pós-Traumáticos/reabilitação , Estados Unidos , United States Department of Veterans Affairs , Veteranos/educação , Veteranos/psicologia , Saúde dos Veteranos , Orientação Vocacional
13.
Womens Health Issues ; 19(6): 446-56, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19879456

RESUMO

OBJECTIVES: We sought to estimate the prevalence of mental illness (MI) and substance use disorders (SUD) and determine the predictors of MI/SUD categories among veteran women with diabetes. METHODS: We evaluated a cross-sectional analysis of 16,368 women veterans with diabetes in fiscal 1999 and 2000. SUD, MI, and diabetes were identified using validated algorithms based on diagnosis codes. Chi-square and multinomial logistic regressions were used to examine associations between SUD, MI, demographic, socioeconomic, and health status variables. RESULTS: Overall, 45% of women had a MI, SUD, or both. SUD rates were high among those with serious MI. The associations between MI/SUD and independent variables were not uniformly significant, except for macrovascular conditions; women veterans were more likely to have combinations of MI/SUD. CONCLUSION: A high rate of MI/SUD suggests that care for mental and physical illness needs to be integrated into health care planning and delivery of services to veteran women with diabetes.


Assuntos
Diabetes Mellitus/epidemiologia , Transtornos Mentais/complicações , Transtornos Relacionados ao Uso de Substâncias/complicações , Veteranos/psicologia , Adulto , Idoso , Estudos Transversais , Diagnóstico Duplo (Psiquiatria) , Feminino , Humanos , Medicare/estatística & dados numéricos , Transtornos Mentais/epidemiologia , Pessoa de Meia-Idade , Prevalência , Fatores Socioeconômicos , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Estados Unidos/epidemiologia , United States Department of Veterans Affairs , Veteranos/estatística & dados numéricos
14.
J Behav Health Serv Res ; 35(3): 290-303, 2008 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-18512155

RESUMO

Few studies have looked at the health-care expenditures of diabetes patients based on the type of co-occurring conditions of mental illness (MI) or substance use disorders (SUD). Our study analyzes the health-care expenditures associated with various diagnostic clusters of co-occurring drug, alcohol, tobacco use, and mental illness in veterans with diabetes. We merged Veteran Health Administration and Medicare fee-for-service claims database (fiscal years 1999 and 2000) for analysis (N = 390,253) using generalized linear models; SUD/MI were identified using International Classification of Diseases, 9th edition codes. The total average expenditures (fiscal year 2000) were lowest ($6,185) in the "No MI and No SUD" and highest ($19,801) for individuals with schizophrenia/other psychoses and alcohol/drug use. High expenditures were associated with both SUD and MI conditions in diabetes patients, and veterans with alcohol/drug use had the highest expenditures across all groups of MI. These findings reinforce the need to target groups with multiple comorbidities specifically those with serious mental illnesses and alcohol/drug use for interventions to reduce health-care expenditures.


Assuntos
Diabetes Mellitus/economia , Transtornos Mentais/economia , Transtornos Relacionados ao Uso de Substâncias/economia , Veteranos , Comorbidade , Feminino , Humanos , Masculino , Estados Unidos
15.
Am J Drug Alcohol Abuse ; 33(6): 807-21, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17994477

RESUMO

OBJECTIVE: Create a taxonomy and examine the predictors of the often co-occurring conditions of substance use disorders and mental illness in veterans with diabetes. DESIGN: Merged Veteran Health Administration and Medicare fee-for-service claims data (N = 485,893). RESULTS: Thirty-one percent of patients with diabetes were diagnosed with either mental illness or substance use and had higher rates of diabetes-related complications. Women were more likely to have serious mental illness; African Americans and Latinos more likely to have drug and/or alcohol use. CONCLUSION: Prevalence of substance use disorder and mental illness differed by socio-demographics, suggesting the need for tailored diabetes management interventions.


Assuntos
Diabetes Mellitus/epidemiologia , Transtornos Mentais/complicações , Transtornos Relacionados ao Uso de Substâncias/complicações , Veteranos/estatística & dados numéricos , Adulto , Negro ou Afro-Americano/estatística & dados numéricos , Idoso , Doença Crônica , Classificação , Comorbidade , Diagnóstico Duplo (Psiquiatria) , Etnicidade , Feminino , Hispânico ou Latino/estatística & dados numéricos , Humanos , Masculino , Medicare/estatística & dados numéricos , Transtornos Mentais/classificação , Transtornos Mentais/epidemiologia , Pessoa de Meia-Idade , População , Fatores Sexuais , Fatores Socioeconômicos , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Estados Unidos , United States Department of Veterans Affairs
16.
JAMA ; 290(20): 2693-702, 2003 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-14645311

RESUMO

CONTEXT: Although olanzapine has been widely adopted as a treatment of choice for schizophrenia, its long-term effectiveness and costs have not been evaluated in a controlled trial in comparison with a standard antipsychotic drug. OBJECTIVE: To evaluate the effectiveness and cost impact of olanzapine compared with haloperidol in the treatment of schizophrenia. DESIGN AND SETTING: Double-blind, randomized controlled trial with randomization conducted between June 1998 and June 2000 at 17 US Department of Veterans Affairs medical centers. PARTICIPANTS: Three hundred nine patients with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of schizophrenia or schizoaffective disorder, serious symptoms, and serious dysfunction for the previous 2 years. Fifty-nine percent fully completed and 36% partially completed follow-up assessments. INTERVENTIONS: Patients were randomly assigned to receive flexibly dosed olanzapine, 5 to 20 mg/d, with prophylactic benztropine, 1 to 4 mg/d (n = 159); or haloperidol, 5 to 20 mg/d (n = 150), for 12 months. MAIN OUTCOME MEASURES: Standardized measures of symptoms, quality of life, neurocognitive status, and adverse effects of medication. Veterans Affairs administrative data and interviews concerning non-VA service use were used to estimate costs from the perspective of the VA health care system and society as a whole (ie, consumption of all resources on behalf of these patients). RESULTS: There were no significant differences between groups in study retention; positive, negative, or total symptoms of schizophrenia; quality of life; or extrapyramidal symptoms. Olanzapine was associated with reduced akathisia in the intention-to-treat analysis (P<.001) and with lower symptoms of tardive dyskinesia in a secondary analysis including only observations during blinded treatment with study drug. Small but significant advantages were also observed on measures of memory and motor function. Olanzapine was also associated with more frequent reports of weight gain and significantly greater VA costs, ranging from 3000 dollars to 9000 dollars annually. Differences in societal costs were somewhat smaller and were not significant. CONCLUSION: Olanzapine does not demonstrate advantages compared with haloperidol (in combination with prophylactic benztropine) in compliance, symptoms, extrapyramidal symptoms, or overall quality of life, and its benefits in reducing akathisia and improving cognition must be balanced with the problems of weight gain and higher cost.


Assuntos
Antipsicóticos/economia , Antipsicóticos/uso terapêutico , Haloperidol/economia , Haloperidol/uso terapêutico , Pirenzepina/análogos & derivados , Pirenzepina/economia , Pirenzepina/uso terapêutico , Esquizofrenia/tratamento farmacológico , Esquizofrenia/economia , Adulto , Acatisia Induzida por Medicamentos , Antipsicóticos/efeitos adversos , Benzodiazepinas , Benzotropina/uso terapêutico , Método Duplo-Cego , Feminino , Haloperidol/efeitos adversos , Custos de Cuidados de Saúde , Serviços de Saúde/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Antagonistas Muscarínicos/uso terapêutico , Testes Neuropsicológicos , Olanzapina , Pirenzepina/efeitos adversos , Qualidade de Vida , Resultado do Tratamento , Estados Unidos
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