Assessment of eight insulin resistance surrogate indexes for predicting metabolic syndrome and hypertension in Thai law enforcement officers.

Police officers in Thailand have an increased risk of heart disease, stroke, and type 2 diabetes, possibly due to a high prevalence of hypertension and metabolic syndrome (MetS). In this study, the researchers aimed to understand the relationship between surrogate markers of insulin resistance (IR) and the prevalence of MetS and hypertension in Thai police officers. The study included 7,852 police officer participants, of which 91.8% were men with an average age of 48.56 years. The prevalence of hypertension and MetS were found to be 51.1% and 30.8%, respectively, and the participants with MetS and hypertension were older compared to the regular group. The study looked at eight IR indices, including markers such as atherogenic index of plasma (AIP), lipid accumulation product (LAP), metabolic score for insulin resistance (METS-IR), triglyceride glucose (TyG) index, TyG index with body mass index (TyG-BMI), TyG index with waist circumference (TyG-WC), the ratio of triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-c), and visceral obesity index (VAI). These indices were found to be positively correlated with waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), and triglycerides (TG), while being negatively correlated with high-density lipoprotein cholesterol (HDL-c). In addition, the multiple regression analysis showed that higher quartiles of all IR indices were significantly associated with increased risks of MetS and hypertension. Interestingly, the IR indices were more accurate in predicting MetS (ranges 0.848 to 0.892) than traditional obesity indices, with the AUC difference at p < 0.001. Among the IR indices, TyG-WC performed the best in predicting MetS (AUC value 0.892 and Youden index 0.620). At the same time, TyG-BMI had the highest accuracy in predicting hypertension (AUC value of 0.659 and Youden index of 0.236). In addition, this study found that when two markers were combined for diagnosing metabolic syndrome, a significantly improved predictive value for disease risk was observed, as evidenced by higher AUC and Yoden index. Moreover, the IR indices were found to have higher predictive power for MetS and hypertension in younger police personnel (age < 48 years) than older personnel. In conclusion, this study highlights the importance of reducing cardiovascular disease risks among law enforcement personnel as a strategic goal to improve their health and wellness. The findings suggest that IR indices may be valuable tools in predicting MetS and hypertension in law enforcement personnel and could potentially aid in the early identification and prevention of law enforcement personnel health conditions.

Spatial distribution and risk assessment of fluorine and cadmium in rice, corn, and wheat grains in most karst regions of Guizhou province, China.

The pollution status of crops planted in Guizhou province of Southwestern China with high background values of Fluorine (F) and Cadmium (Cd) has attracted people's concern. The present study aimed to investigate the spatial distributions of F and Cd in rice, corn and wheat grains, and further evaluate their health risks to residents in Guizhou province. The contents of F and Cd were measured by fluoride ion-selective electrode and inductively coupled plasma mass spectrometry (ICP-MS) methods, respectively. Additionally, the inverse distance weighted (IDW) technique was conducted to analyze spatial distribution, and the health risk was estimated by target hazard quotient (THQ) and hazardous index (HI). The results indicate that Cd contents in samples varied from 0.000 to 0.463 for rice, 0.000 to 0.307 for corn, and 0.012 to 0.537 (mg/kg) for wheat, while F contents ranged from 0.825 to 5.193 (rice), 0.946 to 8.485 (corn), and 0.271 to 9.143 (wheat) mg/kg. The Cd exceeding ratios were 11.600% for rice, 13.500% for corn, and 45.100% for wheat grains, respectively. In terms of spatial distribution, high levels of F and Cd in rice were found in the northern and central in Guizhou, while Cd in corn was distributed in the eastern and F in corn were distributed in the west area of Guizhou. Moreover, the high levels of F and Cd in wheat were distributed in the western and eastern areas. The mean carcinogenic risks (R) of Cd in rice, corn, and wheat in children were 4.150 × 10-4, 1.670 × 10-4 and 3.470 × 10-4, respectively, and that in adults were 3.430 × 10-4, 0.471 × 10-4, and 2.190 × 10-4, respectively. The HI for adults in rice, corn and wheat grains were 0.756, 0.154, and 0.514, respectively, and that for children were 0.913, 0.549, and 0.814, respectively. Collectively, the potential risks produced by F and Cd to the local residents should not be ignored.

Accumulation and risk assessment of heavy metals in rice: a case study for five areas of Guizhou Province, China.

In the present study, the concentration and accumulation abilities of five heavy metals (Cd, Hg, As, Pb, Cr) in rice were assessed and their human health risk to local citizens had been evaluated. Soil and rice samples (125 samples) were collected from Guiyang (GY), Qiannan (QN), Bijie (BJ), Tongren (TR), and Zunyi (ZY) in Guizhou Province. Heavy metals were measured by inductively coupled plasma-mass spectrometry (ICP-MS) after microwave digestion. The mean concentrations of Cd, Hg, As, Pb, and Cr were 0.58, 0.65, 12.31, 38.70, and 87.30 mg/kg in soil and were 0.05, 0.005, 0.11, 0.07, and 0.34 mg/kg in rice, respectively. The bioconcentration factors (BCF) decreased with the order Cd > Hg > As > Cr > Pb. Non-carcinogenic risk in this study was evaluated using the method of the hazard quotient (HQ) and hazard index (HI). The mean HQ values for Cd, Hg, Pb, and Cr were all lower than the standard limit (1.0) for children and adults, except As with the mean HQ for children of 2.79. The mean HI values for children and adults were 4.22 and 1.42, which exceeded 1.0. The mean carcinogenic risk (CR) values of As and Pb for children and adults were higher than the upper limit of the acceptable range (1 × 10-4) established by the United States Environmental Protection Agency (USEPA). In a conclusion, the non-carcinogenic and carcinogenic risks induced by heavy metals for children were higher than that for adults. This study revealed that consumption of rice in study areas may pose potential non-carcinogenic and carcinogenic risks to humans, and As was the largest contributor.

Distributions of Heavy Metals in Rice and Corn and Their Health Risk Assessment in Guizhou Province.

Long-term exposure to heavy metals from high geological background area may lead to varieties of diseases. Therefore, risk assessment from agricultural products in these areas was crucial to ensure the health of customers. However, the effects of geological background on distributions of heavy metals and their accumulation in plant remain unclear. This study aimed to determine the distributions of mercury (Hg), cadmium (Cd), arsenic (As), lead (Pb), chromium (Cr) and copper (Cu) in 1036 corn and rice samples collected from 9 locations in Guizhou province and to evaluate their health risks. The concentrations of Hg, Cd, As, Pb, Cr and Cu in these two crops were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS), and their health risk were estimated by the target risk quotient approaches. Results showed that the mean concentrations of Hg, Cd, As, Pb, Cr and Cu in corn and rice were 0.01, 0.07, 0.06, 0.27, 0.56 and 1.86 mg/kg which were lower than their respective maximum allowable concentrations (MAC) of 0.02, 0.20, 0.70, 0.20, 0.50 and 10.00 mg/kg except Pb and Cr. The concentrations of Cr and Cu in corn were higher than in rice while Cd, As and Pb in rice were higher than in corn. Moreover, the distributions of Hg, Cd and Cu in corn and rice samples were mainly observed from QDN located at southeast of Guizhou province while Pb, As and Cr were most detected at ZY, QXN and BJ areas, southwest zone. The hazard indices (HIs) values for corn and rice were 0.20 and 2.61. The high HIs (> 1) in rice indicated that the health risk of heavy metals in rice was relatively high and Pb was the major component that attributed to the risk, followed by Cd. These results could provide a reference for the distributions of heavy metals in agricultural products in Guizhou province under crop cultivation conditions, and to provide scientific basis for health risk assessment and ensure food safety.

Determination of etoxazole in different parts of citrus fruit and its potential dietary exposure risk assessment.

In this study, the profile of etoxazole in whole citrus, peel and pulp samples collected from Chongqing, Guangdong and Anhui provinces was monitored and their dietary risk to human had also been assessed. The final residual levels and distributions of etoxazole in citrus samples were detected by using an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS). The results showed that final concentrations of etoxazole in whole citrus, peel, and pulp were ranged at 0.012-0.174, 0.010-0.637, and 0.010-0.011 mg kg-1, respectively. The assessment of dietary risk suggested that chronic dietary risk of etoxazole in whole fruit and peel were 0.010-0.197% and 0.035-0.951%, respectively. Our findings indicated that the chronic risk of daily consumption of citrus fruit is acceptable at recommended dosage.

Quality assessment of the guidelines for the management of malignant pleural effusions and ascites.

OBJECTIVES: To fully assess the quality of the guidelines for the management of malignant pleural effusions (MPE) and ascites and reveal the heterogeneity of recommendations and possible reasons among guidelines. METHODS: A systematic search was performed in the database to obtain guidelines for the management of MPE and ascites. The AGREE IIGtool was used to assess the quality of these guidelines. The Measurement Scale of Rate of Agreement (MSRA) was introduced to assess the scientific agreement of formulated recommendations for the management of MPE and ascites among guidelines, and evidence supporting these recommendations was extracted and analyzed. RESULTS: Nine guidelines were identified. Only 4 guidelines scored more than 60% and are worth recommending. Recommendations were also heterogeneous among guidelines for the management of MPE, and the main reasons were the different emphases of the recommendations for the treatment of MPE, the contradictions in recommendations, and the unreasonably cited evidence for MPE. CONCLUSIONS: The quality of the management guidelines for patients with MPE and malignant ascites was highly variable. Specific improvement of the factors leading to the heterogeneity of recommendations will be a reasonable and effective way for developers to upgrade the recommendations in the guidelines for MPE.

A low cost mobile phone dark-field microscope for nanoparticle-based quantitative studies.

Dark-field microscope (DFM) analysis of nanoparticle binding signal is highly useful for a variety of research and biomedical applications, but current applications for nanoparticle quantification rely on expensive DFM systems. The cost, size, limited robustness of these DFMs limits their utility for non-laboratory settings. Most nanoparticle analyses use high-magnification DFM images, which are labor intensive to acquire and subject to operator bias. Low-magnification DFM image capture is faster, but is subject to background from surface artifacts and debris, although image processing can partially compensate for background signal. We thus mated an LED light source, a dark-field condenser and a 20× objective lens with a mobile phone camera to create an inexpensive, portable and robust DFM system suitable for use in non-laboratory conditions. This proof-of-concept mobile DFM device weighs less than 400g and costs less than $2000, but analysis of images captured with this device reveal similar nanoparticle quantitation results to those acquired with a much larger and more expensive desktop DFMM system. Our results suggest that similar devices may be useful for quantification of stable, nanoparticle-based activity and quantitation assays in resource-limited areas where conventional assay approaches are not practical.

Comparison of multi-modal early oral nutrition for the tolerance of oral nutrition with conventional care after major abdominal surgery: a prospective, randomized, single-blind trial.

BACKGROUND & AIMS: Early oral nutrition (EON) has been shown to improve recovery of gastrointestinal function, length of stay and mortality after abdominal surgery; however, early oral nutrition often fails during the first week after surgery. Here, a multi-modal early oral nutrition program is introduced to promote recovery of gastrointestinal function and tolerance of oral nutrition. METHODS: Consecutive patients scheduled for abdominal surgery were randomized to the multimodal EON group or a group receiving conventional care. The primary endpoint was the time of first defecation. The secondary endpoints were outcomes and the cost-effectiveness ratio in treating infectious complications. The rate of infectious-free patients was regarded as the index of effectiveness. RESULTS: One hundred seven patients were randomly assigned to groups. Baseline characteristics were similar for both groups. In intention-to-treat analysis, the success rate of oral nutrition during the first week after surgery in the multimodal EON group was 44 (83.0%) versus 31 (57.4%) in the conventional care group (P = 0.004). Time to first defecation, time to flatus, recovery time of bowel sounds, and prolonged postoperative ileus were all less in the multimodal EON group (P < 0.05). The median postoperative length of stay in the multimodal EON group was 8 days (6, 12) versus 10 days (7, 18) in the conventional care group (P < 0.001). The total cost of treatment and nutritional support were also less in the multi-modal early oral nutrition group (P < 0.001). The effectiveness was 84.9 and 79.9% in the multimodal EON and conventional care group, respectively (P = 0.475). However, the cost-effectiveness ratio was USD 537.6 (506.1, 589.3) and USD 637.8 (593.9, 710.3), respectively (P < 0.001). CONCLUSION: The multi-modal early oral nutrition program was an effective way to improve tolerance of oral nutrition during the first week after surgery, decrease the length of stay and improve cost-effectiveness after abdominal surgery. TRIAL REGISTRATION: Registration number: ChiCTR-TRC-14004395 . Registered 15 March 2014.