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2.
Environ Sci Pollut Res Int ; 31(11): 17275-17288, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38340303

RESUMO

Minimal research exists on polychlorinated biphenyl (PCB) exposure from traditional Chinese medicines (TCMs), despite their significant contributions to domestic and international health protection. This study is the first to investigate the levels, profiles, and health risks of PCB residue in Pheretima, a typical TCM produced from earthworm. Seventy-seven Pheretima samples from different regions of China were analyzed for 45 PCB congeners. PCBs were found in all samples exhibiting species-dependent discrepancies. ∑45PCBs was ranging from 0.532 to 25.2 µg/kg (mean 4.46 µg/kg), with CB-11 being the most abundant congener contributing 71.8% ± 10.8% to ∑45PCBs, followed by CB-47, which were all non-Aroclor congeners called unintentionally produced PCBs (UP-PCBs). The average estimated daily intake of ∑45PCBs, ∑7ID-PCBs (indicative polychlorinated biphenyls), and CB-11 were 0.71, 0.04, and 0.51 ng/kg bw/d, respectively. The ∑HQ of PCBs in Pheretima samples was 2.97 × 10-4-2.46 × 10-2 (mean 2.77 × 10-3, 95th 4.21 × 10-3), while the ∑RQ ranged from 1.19 × 10-8 to 2.88 × 10-6 (mean 4.87 × 10-7, 95th 2.31 × 10-6). These findings indicate that Pheretima ingestion does not pose significant non-carcinogenic risks. However, certain individual samples exhibit an acceptable level of potential risks, particularly when considering that PCBs are recognized as endocrine disruptors and classified as probable carcinogens. These results contribute to the safety evaluation of traditional medicines and suggest the potential use of Pheretima as a bioindicator for PCB pollution. It is advisable to monitor UP-PCBs as indicator congeners and gather additional toxicological data.


Assuntos
Oligoquetos , Bifenilos Policlorados , Animais , Bifenilos Policlorados/análise , Carcinógenos , Medição de Risco , China , Medicina Tradicional Chinesa
3.
Curr Opin Psychiatry ; 37(3): 225-236, 2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38415715

RESUMO

PURPOSE OF REVIEW: Economic development and urbanisation have prompted many Chinese parents to move from rural to urban regions for better job opportunities. Their children, who remain behind in rural regions, become left-behind children (LBC). With absent parents, children and adolescents are unable to maintain the secure attachment required for healthy social and emotional development, increasing the risk of mental illness. This study aimed to compare risk of self-harm and suicidal ideation in LBC and non-LBC in China. RECENT FINDINGS: Greater risks for poor mental health outcomes including worse depression, loneliness and anxiety have been identified in LBC in cross-sectional studies. Previous studies have also identified higher prevalence of bullying victimization, poorer school performance and worse school attendance amongst LBC. SUMMARY: Findings indicate that prolonged separation from parents put LBC at greater risks of poor mental health. Policy changes to allow children to migrate with their parents and policies to reduce inequalities in job opportunities between urban and rural regions are needed.


Assuntos
Ideação Suicida , Urbanização , Criança , Humanos , Adolescente , Estudos Transversais , Saúde Mental , China/epidemiologia
4.
Huan Jing Ke Xue ; 45(1): 396-406, 2024 Jan 08.
Artigo em Chinês | MEDLINE | ID: mdl-38216489

RESUMO

To analyze the source apportionment and health risk of heavy metals in agricultural soils of major producing areas of agricultural products in Chongqing, a positive matrix factorization (PMF) model and health risk assessment (HRA) model based on Monte Carlo simulation were used. Meanwhile, both the PMF and HRA model were combined to explore health risks of heavy metals in agricultural soils by different pollution sources in order to determine the priority control factors. The results showed that the average values of Cd concentration were higher than its corresponding background value; the average values of Cr concentration were lower than its corresponding background value; and the average values of As, Pb, Cu, Ni, and Zn concentration were basically consistent with their corresponding background values. Using PMF model analysis, natural sources, industrial sources, and agricultural sources were identified as the determinants for the accumulation of heavy metals in agricultural soils, with the contribution rates of 35%, 24%, and 41%, respectively. Using the HRA model based on Monte Carlo simulation analysis, carcinogenic risks of adult and children were tolerable (1.00E-6 < TCR ≤ 1.00E-4), whereas non-carcinogenic risks were acceptable (HI ≤ 1). Oral ingestion was the main exposure pathway. The analysis results of the relationship among heavy metals, pollution sources, and health risks showed that industrial pollution and As were identified as priority control factors, and agricultural pollution and Cd were identified as secondary control factors. Our findings provide scientific support for decision makers to control soil pollution and reduce the management costs of soil pollution.


Assuntos
Metais Pesados , Poluentes do Solo , Adulto , Criança , Humanos , Solo , Monitoramento Ambiental , Cádmio/análise , Poluentes do Solo/análise , Metais Pesados/análise , Medição de Risco , China
5.
Am J Med Sci ; 367(3): 181-189, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37989441

RESUMO

BACKGROUND: With increasing mortality and incidence, hepatocellular carcinoma (HCC) has become a major public health problem. The early diagnosis of HCC can improve its prognosis. The aim of this study was to identify potential risk factors related to HCC development and to establish a high-risk population rating scale. METHODS: A total of 853 patients with chronic hepatitis B (CHB) were enrolled in this study, including 403 patients with HCC as the case group and others as the control group. Their demographic and clinical characteristics were compared and the independent risk factors for HCC were assessed. Then, the optimal cutoff levels of these factors were analyzed by the receiver operating characteristic (ROC) method. A high-risk population rating scale was constructed based on the factors and then evaluated in the modeling population. RESULTS: The factors that presented statistically significant differences between the two groups included age, smoking, alcohol abuse, body mass index, triglyceride, high‒density lipoprotein cholesterol, aspartate transaminase, alanine transaminase, fasting plasma glucose, creatinine and uric acid. The ROC curve showed that the cutoff score for the HCC high risk population was 5 (AUC=0.74, P<0.001) and the Hosmer‒Lemeshow analysis showed that the fitting effect of this rating scale was good (P = 0.294). CONCLUSIONS: The integration of these factors can contribute to a prognostic score for the risk of HCC development, which offered certain clinical practicability.


Assuntos
Carcinoma Hepatocelular , Hepatite B Crônica , Neoplasias Hepáticas , Humanos , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/epidemiologia , Carcinoma Hepatocelular/etiologia , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/epidemiologia , Neoplasias Hepáticas/etiologia , Hepatite B Crônica/complicações , Hepatite B Crônica/epidemiologia , Fatores de Risco , Incidência , Curva ROC
6.
Environ Sci Pollut Res Int ; 30(57): 120576-120589, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37945947

RESUMO

A promising approach forfacilitating China's shift towards renewable energy sources entails combining digital finance and green financing. The present research investigates the supply chains and reverse logistics of significant financial indices, including the S&P Green Bond Index, the MSCI Global Markets Index, and the S&P Global Renewable Energy Index. The analysis encompasses the period from the creation of these indices on September 28, 2008, through January 12, 2022. To minimize risk, portfolios have increasingly adopted diverse indices, such as the S&P Global Clean Energy Index and the S&P Green Bond Index. This study investigates the intricate relationship between green financing and digital finance, shedding light on their combined impact on the uptake of renewable energy in China. This study examines the role of digital financial technologies, including blockchain, mobile payment systems, and big data analytics, in enhancing the accessibility of green financing choices for renewable energy projects. A comprehensive analysis of existing literature and empirical research is conducted to achieve this objective. The results emphasize the significant progress in improving financial inclusion, risk management, and transparency by integrating green financing and digital finance. As mentioned earlier, the enhancements have significantly enhanced the level of trust and assurance among investors operating within the renewable energy industry. Moreover, the report highlights the crucial need for continuous governmental backing and financial investments in digital financial infrastructure to drive China towards a more environmentally friendly and sustainable energy framework.


Assuntos
Governo , Energia Renovável , China , Transporte Biológico , Pesquisa Empírica , Desenvolvimento Econômico
7.
J Glob Health ; 13: 04096, 2023 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-37824177

RESUMO

Background: Due to their known variation by geography and economic development, we aimed to evaluate the incidence and mortality of colorectal cancer (CRC) in China over the past decades and identify factors associated with CRC among the Chinese population to provide targeted information on disease prevention. Methods: We conducted a systemic review and meta-analysis of epidemiolocal studies on the incidence, mortality, and associated factors of CRC among the Chinese population, extracting and synthesising data from eligible studies retrieved from seven global and Chinese databases. We pooled age-standardised incidence rates (ASIRs) and mortality rates (ASMRs) for each province, subregion, and the whole of China, and applied a joinpoint regression model and annual per cent changes (APCs) to estimate the trends of CRC incidence and mortality. We conducted random-effects meta-analyses to assess the effect estimates of identified associated risk factors. Results: We included 493 articles; 271 provided data on CRC incidence or mortality, and 222 on associated risk factors. Overall, the ASIR of CRC in China increased from 2.75 to 19.39 (per 100 000 person-years) between 1972 and 2019 with a slowed-down growth rate (APC1 = 5.75, APC2 = 0.42), while the ASMR of CRC decreased from 12.00 to 7.95 (per 100 000 person-years) between 1974 and 2020 with a slight downward trend (APC = -0.89). We analysed 62 risk factors with synthesized data; 16 belonging to the categories of anthropometrics factors, lifestyle factors, dietary factors, personal histories and mental health conditions were graded to be associated with CRC risk among the Chinese population in the meta-analysis limited to the high-quality studies. Conclusions: We found substantial variation of CRC burden across regions and provinces of China and identified several associated risk factors for CRC, which could help to guide the formulation of targeted disease prevention and control strategies. Registration: PROSPERO: CRD42022346558.


Assuntos
Neoplasias Colorretais , Humanos , Incidência , Fatores de Risco , China/epidemiologia , Neoplasias Colorretais/epidemiologia , Neoplasias Colorretais/prevenção & controle
8.
Huan Jing Ke Xue ; 44(10): 5666-5678, 2023 Oct 08.
Artigo em Chinês | MEDLINE | ID: mdl-37827783

RESUMO

To analyze the pollution characteristics of heavy metals in the soil of farmland surrounding the gangue heap of a coal mine in Chongqing, the Nemerow, Muller, and Hakanson indices were used. Meanwhile, to investigate the health risks of heavy metals in soil, a health risk assessment model was employed using Monte Carlo simulation. The results revealed that the average contents of Cd, Hg, As, Pb, Cr, Cu, Ni, and Zn were higher than their soil background values, and the Muller index (Igeo) from high to low was as follows:Cd>Hg>Cu>As>Ni>Zn>Cr>Pb. The Nemerow index (PN) demonstrated that the results of the assessment indicated mainly light pollution (1Cu>Ni>Cr>Zn>As>Pb>Hg. The Hakanson index (RI) demonstrated that the results of the assessment indicated mainly moderate ecological risk (150 ≤ RI<300). The single ecological risk index (Eri) from high to low was as follows:Cd>Hg>As>Cu>Ni>Pb>Cr>Zn. The health risk assessment of heavy metals revealed that the non-carcinogenic health risks of children and adults could be ignored, but carcinogenic health risks existed, with an average total carcinogenic risk index (TCR) of 1.04E-5 and 3.94E-6, respectively. The major carcinogenic factors were As and Cd. Sensitivity analysis of non-carcinogenic health risks revealed that the ingestion rate of soil (Ringest) was the most sensitive, followed by the contents of As. Meanwhile, sensitivity analysis of carcinogenic health risks indicated that the content of As was the most sensitive, followed by the ingestion rate of soil (Ringest). In general, the health risks of children, including non-carcinogenic and carcinogenic risks, were higher than those of adults.


Assuntos
Mercúrio , Metais Pesados , Poluentes do Solo , Adulto , Criança , Humanos , Solo , Monitoramento Ambiental/métodos , Cádmio , Chumbo , Método de Monte Carlo , Poluentes do Solo/análise , Medição de Risco , Metais Pesados/análise , Carcinógenos/análise , Carvão Mineral , China
9.
Am J Primatol ; 85(11): e23548, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37661600

RESUMO

Provisioning can significantly affect the ranging patterns, foraging strategies, and time budget of wild primates. In this study, we document for the first time, the effects of provisioning on the activity budget and foraging effort in an Asian colobine. Over 3-years, we used an instantaneous scanning method at 10-min intervals to collect data on the activity budget of a semiprovisioned breeding band (SPB) of black-and-white snub-nosed monkeys (Rhinopithecus bieti) (42-70 individuals) at Xiangguqing (Tacheng), Yunnan, China. We then compared the effects of provisioning in our study band with published data on a sympatric wild nonprovisioned breeding band (NPB) of R. bieti (ca. 360 monkeys) at the same field site. The SPB spent 25.6% of their daytime feeding, 17.1% traveling, 46.9% resting, and 10.3% socializing. In comparison, the NPB devoted more time to feeding (34.9%) and socializing (14.1%), less time to resting (31.3%), and was characterized by a greater foraging effort (1.74 versus 0.96, foraging effort = (feeding + traveling)/resting; see Methods). There was no difference between bands in the proportion of their activity budget devoted to traveling (15.7% vs. 17.1%). In addition, the SPB exhibited a more consistent activity budget and foraging effort across all seasons of the year compared to the NPB. These findings suggest that the distribution, availability, and productivity of naturally occurring feeding sites is a major determinant of the behavioral strategies and activity budget of R. bieti. Finally, a comparison of our results with data on six nonprovisioned R. bieti bands indicates that caution must be raised in meta-analyses or intraspecific comparisons of primate behavioral ecology that contain data generated from both provisioned and nonprovisioned groups.

10.
Asian J Psychiatr ; 89: 103771, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37757537

RESUMO

OBJECTIVES: Health literacy (HL) is associated with early prevention of mild cognitive impairment (MCI), but a targeted comprehensive assessment tool is lacking. This study aims to psychometrically evaluate the MCI-HLA scale. METHODS: This observational study was conducted in a tertiary-level hospital's physical examination center from October to December 2020. The middle-aged and older adults (N = 550, aged 41-80 years) completed the MCI-HLA questionnaire online. The validity of the MCI-HLA scale was assessed through content validity, exploratory factor analysis, confirmatory factor analysis (CFA), convergent validity, and discriminant validity. The internal reliability was measured using Cronbach's alpha, McDonald's Omega coefficient, and split-half reliability. RESULTS: 5 factors emerged, naming: Function (7 items), Knowledge (8 items), Practice (8 items), Attitude (4 items), and Motivation (3 items), explaining 72.42% of variance. The CFA revealed that five factors of the MCI-HLA scale fit well (χ2/df=4.076, RMSEA=0.078, SRMR=0.057, CFI=0.904, TLI=0.894). Good convergent validity was suggested by the Average Variance Extracted (AVE) values exceeding 0.50. Discriminant validity was demonstrated for all the square root AVE were higher than the correlation between the two factors. Internal consistency was high (Cronbach's alpha=0.875, McDonald's Omega coefficient=0.910, split-half reliability=0.949). CONCLUSIONS: The MCI-HLA scale takes on high reliability and validity, suitable for assessing MCI-related health literacy in middle-aged and older adults. The MCI-HLA scale could enhance MCI health literacy assessment and supports tailored interventions for improved outcomes.


Assuntos
Disfunção Cognitiva , Letramento em Saúde , Pessoa de Meia-Idade , Humanos , Idoso , Reprodutibilidade dos Testes , Psicometria , Inquéritos e Questionários , Disfunção Cognitiva/diagnóstico
11.
Huan Jing Ke Xue ; 44(9): 5264-5274, 2023 Sep 08.
Artigo em Chinês | MEDLINE | ID: mdl-37699844

RESUMO

To analyze the health risk assessment and environmental benchmark of cadmium in farmland soils surrounding the gangue heap of a coal mine in Chongqing, Hakanson, the ecological risk index and health risk assessment were used. Meanwhile, the soil environmental reference value of the regional cultivated land was inverted based on the species sensitive distribution model (SSD). The results showed that the dryland soil was polluted by Cd, with an over-standard rate of 55.8%, and the paddy field soil was polluted by Cd, with an over-standard rate of 31.6%. The corn was polluted by Cd, with an over-standard rate of 4.4%, and the rice was not polluted by Cd. The Hakanson ecological risk index showed that Cd was mainly characterized in soils by high ecological risk and considerable ecological risk. The health risk assessment indicated that Cd presented low non-carcinogenic risk by corn and rice; however, it showed acceptable carcinogenic risk by corn and unacceptable carcinogenic risk by rice in this study. The sensitivity analysis of health risks showed that the content of Cd was the most sensitive. The SSD inversion showed that the reference values for Cd in dryland soil of pH ≤ 5.5, 5.57.5 had HC5 values of 0.491, 0.382, 0.376, and 0.588 mg·kg-1, respectively, and that for Cd in paddy soil had an HC5 value of 0.807 mg·kg-1. The reverse analysis showed that the HC5 of Cd in dryland soil (pH ≤ 7.5) and paddy soil was relatively relaxed and was higher than the soil risk screening values, which showed that the current standard was relatively loose. However, the HC5 of Cd in dryland soil (pH>7.5) was lower than the soil risk screening values, which showed that the current standard was relatively strict. It is suggested that the current soil standard could be adjusted in this area.


Assuntos
Benchmarking , Cádmio , Fazendas , Medição de Risco , Solo , Zea mays , Carvão Mineral
12.
Adv Sci (Weinh) ; 10(29): e2302974, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-37610561

RESUMO

Intrinsically stretchable gas sensors possess outstanding advantages in seamless conformability and high-comfort wearability for real-time detection toward skin/respiration gases, making them promising candidates for health monitoring and non-invasive disease diagnosis and therapy. However, the strain-induced deformation of the sensitive semiconductor layers possibly causes the sensing signal drift, resulting in failure in achievement of the reliable gas detection. Herein, a surprising result that the stretchable organic polymers present a universal strain-insensitive gas sensing property is shown. All the stretchable polymers with different degrees of crystallinity, including indacenodithiophene-benzothiadiazole (PIDTBT), diketo-pyrrolo-pyrrole bithiophene thienothiophene (DPPT-TT) and poly[4-(4,4-dihexadecyl-4H-cyclopenta[1,2-b:5,4-b']dithiophen-2-yl)-alt-[1,2,5]thiad-iazolo [3,4-c] pyridine] (PCDTPT), show almost unchanged gas response signals in the different stretching states. This outstanding advantage enables the intrinsically stretchable devices to imperceptibly adhere on human skin and well conform to the versatile deformations such as bending, twisting, and stretching, with the highly strain-stable gas sensing property. The intrinsically stretchable PIDTBT sensor also demonstrates the excellent selectivity toward the skin-emitted trimethylamine (TMA) gas, with a theoretical limit of detection as low as 0.3 ppb. The work provides new insights into the preparation of the reliable skin-like gas sensors and highlights the potential applications in the real-time detection of skin gas and respiration gas for non-invasive medical treatment and disease diagnosis.


Assuntos
Semicondutores , Pele , Humanos , Polímeros , Dispositivos Eletrônicos Vestíveis
13.
J Glob Health ; 13: 04077, 2023 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-37539855

RESUMO

Background: Past studies have identified determinants of growth failure (GF) such as socio-economic, nutritional, parenting, and inequality factors. However, few studies investigate the numerous causes of GF across multiple countries. By analysing the data of children under five in 25 low and middle-income countries, this study aims to examine the correlations of determinants with GF to identify the strongest modifiable risk factors. Methods: Cross-sectional study design was used, and data were collected across 25 LMICs by the United Nations Children's Fund in 2019. Regions and households were randomly selected in participating LMICs. The four outcome measures were stunting, wasting, underweight and low body mass index (BMI). Results: Multilevel analysis was performed to identify the impact of country, suburb, and household levels on the variance of outcome variables. GF measures were significantly correlated with low gross domestic product (GDP) per capita (odds ratio (OR) = 2.482), rural areas (OR = 1.223), lack of health insurance (OR = 1.474), low maternal education (OR = 2.260), lack of plain water (OR = 1.402), poor maternal physical caregiving ability (OR = 1.112), low carbohydrate consumption (OR = 1.470), and continued breastfeeding in children >12 months old (OR = 0.802). Conclusions: By identifying key GF risk factors, this study may provide valuable insights for policymaking and interventions. This may allow the prioritisation of resources within countries for preventative measures to be developed.


Assuntos
Aleitamento Materno , Países em Desenvolvimento , Feminino , Criança , Humanos , Lactente , Estudos Transversais , Magreza , Transtornos do Crescimento/epidemiologia
14.
Ann Gen Psychiatry ; 22(1): 30, 2023 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-37573334

RESUMO

BACKGROUND: In China, patients with somatoform disorders (SFD) often seek medical treatment repeatedly in outpatient clinics of general hospitals, which increases unreasonable medical expenses. It is imperative to provide early screening to these patients and specialized treatment to reduce the unnecessary cost. This study aimed to screen patients with SFD in general hospitals using a new Chinese questionnaire and explore the characteristics and economic burden of these patients. METHODS: Patients (n = 1497) from the outpatient department of neurology, cardiology and gastroenterology of three large general hospitals were included. Participants were screened using a newly developed questionnaire, the Self-screening Questionnaire for Somatic Symptoms (SQSS), to identify the patients with SFD (total SQSS score ≥ 29 points). We compared the demographics and clinical information of patients with and without SFD. Logistic regression was used to explore potential factors related to medical expenses, visits to doctors and sick leave days taken. RESULTS: The frequency of detection of patients with SFD was 17.03%. There were significant differences in employment, doctor visits, symptom duration, medical expenses, sick leave days, PHQ-15 scores, and PHQ-9 scores between patients with SFD and without SFD. General nonspecific somatic symptoms were frequently present in patients with SFD. Several potential factors were associated with higher medical expenses, repeated doctor visits, and sick leave days taken in the regression analysis. CONCLUSION: The findings indicate that patients with SFD are common in general hospitals, and their direct and indirect economic burden is higher than that of non-SFD patients, which indicates that more screening effort should be made to this group to early identify their problems. Certain characteristics were identified among patients with SFD and several factors were associated with negative consequences of SFD, all of which might be prevented by developing a preventive intervention program to reduce the economic burden of the patients.

15.
Chin Med Sci J ; 38(3): 235-241, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37643872

RESUMO

This data article presents data from the China Migrants Dynamic Survey (CMDS), a multi-wave, large-scale national cross-sectional survey of China's internal migrants from 2009 to 2018. The CMDS is an annual questionnaire survey conducted by the former National Health and Family Planning Commission (NHFPC) of the People's Republic of China. The respondents included in this survey are internal migrants over 15 years old. The sample was drawn from the China Migrant Population Information System, using multi-stage stratified sampling method and the probability proportional-to-size (PPS) cluster sampling strategy. Between 2009 and 2018, there were 1,527,650 internal migrants from 23 provinces, 5 autonomous regions and 4 municipalities participated in the surveys. The survey tools were a series of self-designed questionnaires with high inheritance and consistency designed and implemented by the NHFPC. The questionnaires mainly contain basic information of the respondents and their family members, migration status, healthcare or health behaviors, public health service utilization, social insurance, social integration, and family planning. The dataset is currently the most widely used survey data on China's internal migrants, offering information on migration patterns, healthcare and health behaviors, use of public health services, access to social security, social integration, and family planning, which are valuable for health planning, health decision-making, and health equity research.


Assuntos
Serviços de Planejamento Familiar , Migrantes , Estados Unidos , Humanos , Adolescente , Estudos Transversais , China/epidemiologia , Inquéritos e Questionários
16.
Wei Sheng Yan Jiu ; 52(3): 429-433, 2023 May.
Artigo em Chinês | MEDLINE | ID: mdl-37500523

RESUMO

OBJECTIVE: To make a cost-benefit analysis on anemia intervention with iron-fortified soy sauce in 15-54 years old women. METHODS: The study was conducted in Deqing county, Zhejiang province in 2012-2013. A total 585 women as sampling size were estimated with statistical model and randomly selected by probability proportionate to size sampling. Hemoglobin were measured before intervention and after 15 months. The cost of the intervention project were collected with manpower, communication and other invest. The benefit was estimated with profiling model. RESULTS: After the intervention, the anemia prevalence of sampled women decreased from 31.1% to 21.9%(P<0.01). The major cost of the project was 156 400 RMB, and total benefits result ing from projects were 1 448 485 RMB. The cost-benefit ratio of the project is 1∶9.49. If investing one yuan can produce economic benefits of nearly 9.49 yuan, therefore, the intervention projectis worth to be scaling up. Sensitivity analysis showed the result of this study was stable. CONCLUSION: The intervention can significantly reduce the prevalence of anemia in women, and reduce the economic burden of the diseases. .


Assuntos
Anemia Ferropriva , Anemia , Alimentos de Soja , Humanos , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Ferro , Anemia Ferropriva/epidemiologia , Anemia Ferropriva/prevenção & controle , Análise Custo-Benefício , Alimentos Fortificados , Ácido Edético , Anemia/epidemiologia , Anemia/prevenção & controle
17.
Front Surg ; 10: 1023329, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37035572

RESUMO

This was an initial effort to treat hemophiliac hematoma by ultrasound-guided intratumoral drainage and lavage with urokinase after adequate supplementation of coagulation factors. Two patients with severe hemophilia underwent ultrasound-guided percutaneous drainage in combination with lavage using urokinase. After 5-day and 3-day treatments, respectively, intramuscular hematomas in both patients disappeared, compression symptom was relieved, and no obvious adverse reactions or serious complications were observed during the treatment or follow-up. These findings suggest that ultrasound-guided drainage combined with lavage using urokinase is an immediate, safe, effective, and minimally invasive treatment for intramuscular hematomas in hemophiliacs, avoiding potential complications by surgical resection with relatively low treatment cost.

18.
Mol Genet Genomics ; 298(4): 823-836, 2023 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-37059908

RESUMO

Coronavirus 2019 (COVID-19) is a complex disease that affects billions of people worldwide. Currently, effective etiological treatment of COVID-19 is still lacking; COVID-19 also causes damages to various organs that affects therapeutics and mortality of the patients. Surveillance of the treatment responses and organ injury assessment of COVID-19 patients are of high clinical value. In this study, we investigated the characteristic fragmentation patterns and explored the potential in tissue injury assessment of plasma cell-free DNA in COVID-19 patients. Through recruitment of 37 COVID-19 patients, 32 controls and analysis of 208 blood samples upon diagnosis and during treatment, we report gross abnormalities in cfDNA of COVID-19 patients, including elevated GC content, altered molecule size and end motif patterns. More importantly, such cfDNA fragmentation characteristics reflect patient-specific physiological changes during treatment. Further analysis on cfDNA tissue-of-origin tracing reveals frequent tissue injuries in COVID-19 patients, which is supported by clinical diagnoses. Hence, our work demonstrates and extends the translational merit of cfDNA fragmentation pattern as valuable analyte for effective treatment monitoring, as well as tissue injury assessment in COVID-19.


Assuntos
COVID-19 , Ácidos Nucleicos Livres , Humanos , COVID-19/diagnóstico , Ácidos Nucleicos Livres/genética
19.
J Nutr ; 153(6): 1730-1741, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-37003507

RESUMO

BACKGROUND: Although dietary factors play a crucial role in the incidence of cardiovascular disease (CVD), the specific dietary risk factors vary across regions and require further investigation. OBJECTIVE: We aimed to analyze the burden of CVD due to different dietary factors by sex, age, and sociodemographic index (SDI) for 204 countries and territories between 1990 and 2019. METHODS: Data were extracted from the Global Burden of Disease 2019 and analyzed to determine population attributable fractions (PAFs), mortality, disability-adjusted life years (DALYs), and trends thereof, for CVDs attributable to dietary risk factors from 1990 to 2019. We used a generalized linear model with a Gaussian distribution to calculate the estimated annual percentage changes (EAPCs) in CVD mortality and DALY rates attributable to dietary risk factors. We also used a comparative risk-assessment framework to estimate CVD mortality and DALYs attributable to dietary risk factors. RESULTS: Approximately 40% of CVD mortality and DALY rates were attributable to dietary risk factors, with high-sodium intake, low whole grain intake, and low legume intake being the greatest dietary risk factors globally. Moreover, high SDI regions had the highest PAFs for CVD mortality and DALYs associated with high red and processed meat intake, middle SDI regions had the highest PAFs with high-sodium intake, and low SDI regions had the highest PAFs with low fruit and vegetable intake. The highest PAFs for CVD mortality and DALYs were associated with low whole grain intake in 13 and 9 regions, respectively. CONCLUSION: Reducing sodium intake and increasing whole grain and legume intake should be the top priority worldwide for improving regional diets and thereby decreasing CVD burdens. Other priorities should be set for regions with different SDIs, depending on the predominant dietary risk factors for CVDs in the respective regions.


Assuntos
Doenças Cardiovasculares , Fabaceae , Sódio na Dieta , Humanos , Doenças Cardiovasculares/epidemiologia , Anos de Vida Ajustados por Qualidade de Vida , Carga Global da Doença , Fatores de Risco , Verduras , Saúde Global
20.
Medicine (Baltimore) ; 102(17): e33684, 2023 Apr 25.
Artigo em Inglês | MEDLINE | ID: mdl-37115045

RESUMO

Few studies have explored the association between organizational justice and mental health, particularly in collectivist countries. Hence, the aim of the present study was to evaluate the impact of organizational justice on psychological distress and to discuss the findings in collectivist culture. A cross-sectional survey was conducted among nurses from public hospitals in western of China, July 2022, which followed the STROBE guidelines. This study used Chinese versions of the Organizational Justice Scale and Kesseler Psychological Distress Scale to assess the perceptions of organizational justice and mental health levels, respectively. A total of 663 nurses completed the questionnaires. The psychological distress of university-educated and low-income nurses was poor. There was a moderately positive relationship between organizational justice and psychological distress (R = 0.508, P < .01), indicating that the greater level of organizational injustice, the poorer mental health. Hierarchical regression analysis showed that organizational justice was an strong predictor of psychological distress, accounting for approximately 20.5% of the psychological distress. The findings of this study highlight the importance of interpersonal injustice and distributive injustice on psychological distress specific in Chinese culture, suggesting that nursing management or leaders should notice that the most being taken seriously by nurses is their recognition and respect for subordinate, meanwhile, alerting nurses, in some sense, a negative relationship with leaders as a kind of workplace bullying could harm their mental health. The promulgation of organizational justice policy to protect employees from the government and the real role of employee labor union organizations are urgently needed.


Assuntos
Enfermeiras e Enfermeiros , Cultura Organizacional , Humanos , Estudos Transversais , Justiça Social/psicologia , Inquéritos e Questionários , Hospitais Públicos , Local de Trabalho/psicologia
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