RESUMO
Both academics and policymakers regard publicly planned logistics nodes (PPLN) as a potential measure to promote logistics agglomeration and mitigate environmental damage caused by logistics activities. However, such measure may lead to non-linear carbon emission effect from the perspective of agglomeration economy, and empirical evidences are yet to be found to verify this inference. This paper uses DID method and mediating effect models to explore the effects and mechanisms of PPLN on CO2 emissions with panel data from 2000 to 2017 in Chengdu, China. Our findings show that PPLN promotes the agglomeration of both small and large-scale logistics enterprises and increases carbon emissions. In addition, the agglomeration of large-scale logistics enterprises can reduce carbon emissions; the opposite is true for smaller ones. Despite the continuous diminishing of the carbon emission increase, the emission-reduction effect has not been achieved through PPLN operations. Based on the results, the study recommends that the government should appropriately determine the location and scale of PPLN, advocate green construction and industrial upgrading, and adopt differentiated regulatory and incentive measures for enterprises. Logistics enterprises can increase their investment in green technologies and strengthen cooperation with their customers.
Assuntos
Carbono , Indústrias , Carbono/análise , China , Investimentos em Saúde , Dióxido de Carbono/análise , Desenvolvimento EconômicoRESUMO
OBJECTIVE: The aim of this study was to investigate the role of nutritional factors in predicting radiotherapy-associated toxicities for gastric cancer patients. METHODS: A total of 285 gastric cancer patients who underwent radiotherapy in our hospital (Fudan University Shanghai Cancer Center) between 2010 and 2017 were included in this retrospective study. Nutritional status assessment included body weight loss (BWL), body mass index (BMI), serum albumin, nutrition risk screening 2002(NRS-2002), patient-generated subjective global assessment(PG-SGA) and nutritional risk index (NRI). RESULTS: Of all patients, 19.6% were underweight (BMI<18.5 kg/m2), 25.6% were hypoalbuminemia (<35 g l-1) and 48.8% lost ≥10% of body weight in the 6-month interval before radiotherapy(BWL). Meanwhile, 73.3%, 78.6 and 47.2% of the patients were diagnosed as malnutrition based on NRS-2002, PG-SGA and NRI, respectively. Hematological adverse events were present in 91.2% (≥Grade 1) and 20.4% (≥Grade 3) of the patients. Non-hematological adverse events occurred in 89.8% (≥Grade1) and 14.4% (≥Grade 3) of the patients. Multivariate analyses indicated that only hypoalbuminemia(<35 g l-1) was independent predictor for Grade 3/4 hematological and non-hematological adverse events. Meanwhile, higher BWL(≥10%) was also independent predictor for Grade 3/4 non-hematological adverse events. NRS-2002, PG-SGA and NRI score were not associated with treatment-induced adverse events. CONCLUSION: BWL and serum albumin are useful factors for predicting severe adverse events in gastric cancer patients who undergo radiotherapy. ADVANCES IN KNOWLEDGE: The use of nutritional factors in predicting severe adverse events enables implementation of individualized treatment strategies for early and intensive nutritional interventions in high-risk patients.
Assuntos
Desnutrição/diagnóstico , Avaliação Nutricional , Radioterapia de Intensidade Modulada/efeitos adversos , Neoplasias Gástricas/radioterapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Antineoplásicos/uso terapêutico , Índice de Massa Corporal , Feminino , Humanos , Hipoalbuminemia/complicações , Leucopenia/etiologia , Masculino , Desnutrição/complicações , Pessoa de Meia-Idade , Neutropenia/etiologia , Radioterapia Adjuvante/efeitos adversos , Estudos Retrospectivos , Medição de Risco/métodos , Albumina Sérica/análise , Neoplasias Gástricas/complicações , Neoplasias Gástricas/tratamento farmacológico , Magreza/complicações , Redução de Peso , Adulto JovemRESUMO
Pain is a significant burden among different communities, but little is known regarding the epidemiology of pain, particularly with respect to socioeconomic status (SES).The aim of the study was to estimate the prevalence of body pain and to identify risk factors of pain in middle-aged and older Chinese.The data were extracted from the 2008 Chinese Suboptimal Health Study that consisted of 18,316 Chinese subjects aged 18 to 65 years. Information on SES including occupation and education levels and body pain were collected. A Likert scale was used to evaluate reported body pain. We used the multiple logistic regression model to examine the association between SES and body pain.Overall, 65.34% reported body pain (male: 60.93%; female: 69.73%). After adjustments based on sex, age, education, area of residence, marital status, smoking, drinking and health status, the results showed that students (odds ratio [OR]â=â1.51; 95% confidence interval [CI]: 1.32-1.74) and professionals (ORâ=â1.22; 95% CI: 1.08-1.37) had significant high risk for body pain, compared with civil servants and farmers (ORâ=â0.64; 95% CI: 0.55-0.75) who significantly lower risk of body pain. The study demonstrates there is a significant negative association between education and reported body pain.The results indicated an association between SES and body pain within the Chinese community. Body pain varied among different Chinese occupation-related population and people with higher education level are less like to have body pain.
Assuntos
Dor/epidemiologia , Fatores Socioeconômicos , Adolescente , Adulto , Fatores Etários , Idoso , Consumo de Bebidas Alcoólicas/epidemiologia , Feminino , Nível de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Características de Residência , Fatores Sexuais , Fumar/epidemiologia , Adulto JovemRESUMO
To investigate whether socioeconomic status is associated with the self-rated health (SRH) status among Chinese.A cross sectional study including a national sample was conducted among Chinese adults in 2008. In total, 3225 participants were selected by a multistage cluster sampling method. Both general self-rated health and time-comparative self-rated health were measured by a standardized questionnaire. Logistic regression models were used to estimate the odds ratios (ORs) (95% confidence intervals, CIs) of occupation with SRH by occupation, and adjusted for age, sex, education, area, marriage, smoking, drinking, and health status.Overall, 34.4% of study participants reported "good" on the general SRH (male: 35.8%; female: 32.9%) and 26.2% reported "good" on the time-comparative SRH (male: 27.2%; female: 25.3%). The prevalence of "good" general SRH varied from 28.8% to 52.8% and the prevalence of time-comparative SHR varied from 21.7% to 33.9% in different occupations. The adjusted OR (Odd Ratio) for "good" on the general SRH was 1.35 (95% CI: 1.20-1.52) for the occupation of civil servants, 2.23 (95% CI: 1.96-2.54) for farmers, and 1.15 (95%CI: 1.01-1.31) for businessmen. The full adjusted OR of "good" on the time-comparative SRH was 1.36 (95% CI: 1.17-1.58) for students and was 1.25 (95% CI: 1.10-1.42) for civil servants.In presented study, 34.4% of the participants reported "good" on the general SRH, and 26.2% participants reported "good" on the time-comparative SRH. The prevalence of "good" general SRH and "good" time-comparative SRH varied among occupations.
Assuntos
Escolaridade , Nível de Saúde , Renda/estatística & dados numéricos , Ocupações/estatística & dados numéricos , Adulto , Fatores Etários , Consumo de Bebidas Alcoólicas/epidemiologia , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Autorrelato , Fatores Sexuais , Fumar/epidemiologia , Fatores SocioeconômicosAssuntos
Comunismo , Desenvolvimento Econômico , Política de Planejamento Familiar , Controle da População , Direitos da Mulher , Coeficiente de Natalidade , China/epidemiologia , Comunismo/economia , Comunismo/tendências , Países Desenvolvidos , Desenvolvimento Econômico/tendências , Família/etnologia , Política de Planejamento Familiar/economia , Política de Planejamento Familiar/tendências , Feminino , Humanos , Masculino , Controle da População/economia , Controle da População/ética , Controle da População/tendências , Crescimento Demográfico , Direitos da Mulher/economia , Direitos da Mulher/tendênciasRESUMO
There has been a lack of socioeconomic status (SES) disparity analysis on women in China with only one child, the family planning target population. In 2008, the National Research Institute for Family Planning of China conducted a study investigating the relationship between SES and fertility intentions among 17,093 women in China who already had one child. A questionnaire was used to collect information on SES and fertility intentions, and logistic regression models were used to estimate the odds ratios and 95% CIs of fertility intentions according to SES. Compared with female farmers, women in other occupations intended to have fewer children (p < 0.05). Additionally, compared with women with low educational level (illiterate/primary), women with secondary and postsecondary education intended to have fewer children (p < 0.05) (OR = 0.70; 95% CI: 0.61-0.81 and OR = 0.56; 95% CI 0.47-0.66). A mother's education level was significantly and negatively associated with fertility intentions after adjustment for potential confounders (p < 0.05). Among Chinese women who had one child, the women with higher SES (e.g. higher educational level) had lower fertility intentions. There is an SES disparity in the fertility intention among Chinese women who already have one child. China's policy-makers should consider increasing high SES women's fertility intention.
Assuntos
Escolaridade , Características da Família , Serviços de Planejamento Familiar , Ocupações , Comportamento Reprodutivo , Classe Social , Adolescente , Adulto , Comunismo , Fatores de Confusão Epidemiológicos , Características da Família/etnologia , Política de Planejamento Familiar , Serviços de Planejamento Familiar/economia , Fazendeiros , Feminino , Humanos , Modelos Logísticos , Ocupações/economia , Paridade , Comportamento Reprodutivo/etnologia , Autorrelato , Fatores Socioeconômicos , Adulto JovemRESUMO
Gastric cancer (GC) is one of the most common cancers, with high incidences in East Asia countries. Most GC patients have been reported with low early diagnosis rate and show extremely poor prognosis. Therefore, it is necessary to develop novel and more sensitive biomarkers to improve early diagnosis and therapy in order to provide longer survival and better quality of life for gastric cancer patients. MicroRNAs (miRNAs) play crucial roles in GC development and progression. miRNAs have emerged as a novel molecular biomarker for cancer diagnosis, prognosis and therapy with surprising stability in tissues, serum or other body fluids. This review summarizes major advances in our current knowledge about potential miRNA biomarkers for GC that have been reported in the past two years.
Assuntos
Biomarcadores Tumorais/genética , Regulação Neoplásica da Expressão Gênica , MicroRNAs/genética , Terapia de Alvo Molecular , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/terapia , Progressão da Doença , Humanos , Prognóstico , Neoplasias Gástricas/genéticaRESUMO
BACKGROUND: Increasingly, researchers have begun to explore the association between depression and mortality. The current study examined the association between depressive symptoms and all-cause and cause-specific mortality in Chinese older people. Further to examine whether any associations were similar by sex and health status. METHODS: We used the Chinese version of the 15-item Geriatric Depression Scale to measure depressive symptoms (Geriatric Depression Scale score ≥ 8) and Cox regression to examine the association with all-cause and cause-specific mortality in a population-based cohort study of all 56,088 enrollees, aged 65 years or older, from July 1998 to December 2000 at all 18 Elderly Health Centers of Department of Health of Hong Kong. The cohort was followed up for mortality till December 31, 2005. RESULTS: Depressive symptoms were associated with all-cause mortality (hazard ratio 1.21, 95% confidence interval: 1.08-1.37) in men only (p value for sex interaction <.05) and with suicide mortality in men (hazard ratio 2.81, 95% confidence interval: 1.13-7.01) and women (hazard ratio 2.40, 95% confidence interval: 1.18-4.82) but not with other major causes of death after adjusting for age, education, monthly expenditure, smoking, alcohol drinking, physical activity, body mass index, health status, and self-rated health. The associations did not vary with health status. CONCLUSIONS: Depressive symptoms were associated with all-cause mortality in men and with suicide in both sexes. Randomized controlled trials concerning the effects of treatment of depression on mortality are needed to clarify the causal pathways.