1.
Mar Drugs
; 13(1): 444-59, 2015 Jan 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25603342
RESUMO
The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.