[Features of lipid peroxidation-antioxidant protection in adolescent girls in different groups of health].

UNLABELLED: Among the metabolic processes involved in the formation of physical and sexual development of adolescents recently the system of lipid peroxidation and antioxidant protection (LPO-AOP) supporting the redox state of organism and its adaptive response under the influence of different factors is highlighted. BACKGROUND: The aim of this work is an analysis LPO-AOP-parameters in adolescent girls of different groups of health depending on where they live. PATIENTS AND METHODS: We examined 143 girls aged 15-17 years who had the second and the third groups of health and lived in the village and the city. For assessment of LPO-AOP parameters spectrophotometric, spectrofluorometric and statistical methods were used. RESULTS: The combination of high concentration of unsaturated lipids with primary accumulation of lipid peroxidation products and the stable level of the end products of lipid peroxidation were found in girls rural both groups of health. State of the antioxidant defense system in girls of the village was characterized by a high content of its components, except for alpha-tocopherol. It concentration was reduced in girls of the third group of health. The levels of lipid peroxidation secondary intermediats were elevated and oxidized glutathione level was reduced in city girls of the third groups of health. CONCLUSION: The usage of oxidized glutathione for the prevention of exacerbations of chronic diseases in city girls of the third group of health is recommended.

[Development of medical and biological research in Eastern Siberia]. / Razvitie mediko-biologicheskikh issledovanii v Vostochnoi Sibiri.

The impact of the North conditions on the human body has been studied. There are high morbidity and mortality rates, abnormal pregnancy, premature and abnormal labors, and congenital malformations in the newborn. A complex of medical and prophylactic measures has been worked out to protect human health as a result of the studies of the regularities of general and occupational diseases at some enterprises in the Far North, Yakutia, and Buryatia.