Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment.

Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 µm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platform measures volumetric water content (up to ~1 mm in depth) and wirelessly transmits data to any near-field communication-compatible smartphone. The SHS is readily manufacturable, comprises unique powering and encapsulation strategies, and achieves high measurement precision (±5% volumetric water content) and resolution (±0.015°C skin surface temperature). Validation on n = 16 healthy/normal human participants reveals an average skin water content of ~63% across multiple body locations. Pilot studies on patients with atopic dermatitis (AD), psoriasis, urticaria, xerosis cutis, and rosacea highlight the diagnostic capability of the SHS (P AD = 0.0034) and its ability to study impact of topical treatments on skin diseases.

Spatial distribution, risk assessment and source identification of heavy metals in sediments of the Yangtze River Estuary, China.

The aim of this study was to determine the spatial distribution, potential risks and sources of seven heavy metals in sediments of the Yangtze River Estuary. Analyses of 55 sediment samples revealed that the distributions of metals within the YRE were determined by the combined effects of their sources, hydrodynamic conditions, pH and Eh. According to the geoaccumulation index (Igeo) and sediment quality guidelines, Pb, Cd and Cr were present at low levels of pollution, with Cd posing the largest ecological risk. Positive Factor Matrix (PMF) results indicated that Hg, Zn, As, Pb and Cr mainly originated from natural geological background sources, while Cu originated from anthropogenic activities and atmospheric deposition was the source of Cd. These three sources contributed to 53.0%, 32.8% and 14.2%, respectively of total heavy metal concentrations. These results suggest that reducing the emission of Cd would promote a reduction of potential risks in sediments of the YRE.