Untangling interactions and prioritizations among Sustainable Development Goals in the Asian Water Tower region.

Understanding the interactions among Sustainable Development Goals (SDGs) is critical for prioritizing SDGs and accelerating the overall SDGs progress. However, SDG interactions and prioritizations at the regional scale have rarely been researched (e.g., Asia), and more importantly, their spatial differences and temporal variations remain elusive. Here, we focused on the Asian Water Tower region (16 countries), which represents major challenges for Asian and even global SDG progress, and we assessed the spatiotemporal variations in SDG interactions and prioritizations in the region from 2000 to 2020 based on correlation coefficients calculations and network analyses. We observed a striking spatial difference in the SDG interactions, which may be minimized by promoting balanced progress toward SDGs 1 (no poverty), 5 (gender equality), and 11 (sustainable cities and communities) across countries. The prioritization differences of the same SDG across countries ranged from 8 to 16 places. Temporally, the SDG trade-offs in the region have declined, implying a possible shift to synergies. However, such success has faced several obstacles, mainly climate change and a lack of partnerships. The prioritizations of SDGs 1 and 12 (responsible consumption and production) have shown the largest increase and decrease, respectively, over time. Overall, to accelerate the regional SDG progress, we highlight the importance of enhancing top prioritized SDGs 3 (good health and well-being), 4 (quality education), 6 (clean water and sanitation), 11, and 13 (climate actions). Related complex actions are also provided (e.g., across-scaled cooperation, interdisciplinary research, and sectoral transformation).

Does global positioning system-based navigation dependency make your sense of direction poor? A psychological assessment and eye-tracking study.

Background: Global positioning system (GPS)-based navigation apps are very useful in our lives. However, whether and how the usage of these apps affects spatial cognition and the sense of direction is still unclear. Methods: A total of 108 individuals were recruited and completed the GPS dependence, internet gaming behavior, and impulsivity test using scales. The eye-tracking-based general mental rotation (MR) task and target finding (TF; require individuals to find a target specified in a 3D street map in a rotated version of top 2D view map) task were used to assess their spatial cognition and the sense of direction. The correlation was used to relate GPS navigation usage, spatial cognition ability, and impulsivity. Subgroup analyses stratifying by gaming hours of individuals (< 2 h or ≥ 2 h) or maps (countryside or city) in TF task were performed. The moderating and mediating effect analyses were conducted to verify these relationships. Results: The GPS dependency score was nominal positively correlated with fixations in the TF task in the entire cohort (r = 0.202, unadjusted p = 0.036); it was significant in city (r = 0.254, p = 0.008) and gaming time of < 2 h (r = 0.459, p = 0.001) subgroups. The high-score (upper 30%) group of GPS dependency had more fixations on the original target building in the training area and indicative building in the test area than the low-score (lower 30%) group. GPS dependency was not associated with the correct rate and reaction time in the TF task or any of the indicators in the MR task (p > 0.05). The GPS dependency mediated the indirect effect of impulsivity on the fixations on TF. The internet gaming time moderated the association between GPS dependency and fixations on TF. Conclusion: The dependency on GPS-based navigation apps was associated with impaired spatial cognition but may not significantly affect the sense of direction.

[Distribution Characteristics and Risk Assessment of Accumulated Heavy Metals in Bioretention Systems].

Topsoil samples (0-10 cm) from four bioretention systems with different land-use types were collected, including parking lot, roadside, residential area, and industrial park systems. The accumulation contents of As, Hg, Cd, Cr, Pb, Cu, Ni, and Zn were analyzed and evaluated, as were the influencing factors, pollution level, potential ecological risk, and human health risk. The results showed that there were significant differences in the accumulated contents of eight heavy metals. The average ω(As), ω(Hg), ω(Cd), ω(Cr), ω(Pb), ω(Cu), ω(Ni), and ω(Zn) were 8.92, 0.25, 0.10, 31.56, 14.81, 21.27, 23.69, and 62.75 mg·kg-1, respectively, and the average contents of As and Hg were 1.26 and 5.21 times the soil background values, respectively. Correlation analysis showed that the contents of the eight heavy metals were positively correlated with soil organic matter, pH value (except Hg), and phosphorus content (except As). The results of the Nemerow Comprehensive Pollution Index and Hakanson Potential Ecological Index showed that the pollution level and ecological risk of the other seven heavy metals were relatively low, whereas the pollution level and ecological risk of Hg reached the level of severe pollution and strong ecological risk, respectively. Affected by Hg, the comprehensive pollution level and ecological risk were relatively high; thus, Hg was a potential threat to the soil environment. The non-carcinogenic risks of heavy metals in the four systems were acceptable, but the carcinogenic risks were all beyond 10-6 though lower than 10-4, which indicated that these four systems had a certain carcinogenic risk, in which As was the main risk factor. Among these four land-use types, the accumulated pollutant contents, pollution levels, ecological risk, and human health risk of parking lots and roadside bioretention systems were much higher than those of residential areas and industrial parks.

An Assessment of Temporal and Spatial Dynamics of Regional Water Resources Security in the DPSIR Framework in Jiangxi Province, China.

Water resources are critical for the survival and prosperity of both natural and socioeconomic systems. A good and informational water resources evaluation system is substantial in monitoring and maintaining sustainable use of water. The Driver-Pressure-State-Impact-Response (DPSIR) framework is a widely used general framework that enabled the measurement of water resources security in five different environmental and socioeconomic subsystems: driver, pressure, state, impact, and response. Methodologically, outcomes of water resources evaluation based on such framework and using fuzzy set pair analysis method and confidence interval rating method depend critically on a confidence threshold parameter which was often subjectively chosen in previous studies. In this work, we demonstrated that the subjectivity in the choice of this critical parameter can lead to contradicting conclusions about water resources security, and we addressed this caveat of subjectivity by proposing a simple modification in which we sample a range of thresholds and pool them to make more objective evaluations. We applied our modified method and used DPSIR framework to evaluate the regional water resource security in Jiangxi Province, China. The spatial-temporal analysis of water resources security level was carried out in the study area, despite the improvement in Pressure, Impact, and Response factors, the Driver factor is found to become less safe over the years. Significant variation of water security across cities are found notably in Pressure and Response factors. Furthermore, we assessed both cross-sectionally and longitudinally the inter-correlations among the DPSIR nodes in the DPSIR framework. The region-specific associations among the DPSIR nodes showed important deviances from the general DPSIR framework, and our analysis showed that in our study region, although Responses of regional government work effectively in improving Pressure and State security, more attention should be paid to improving Driver security in future regional water resources planning and management in Jiangxi Province, China.

Cost-effectiveness of prophylactic cranial irradiation in stage III non-small cell lung cancer.

INTRODUCTION: In stage III non-small cell lung cancer (NSCLC), prophylactic cranial irradiation (PCI) reduces the brain metastases incidence and prolongs the progression-free survival without improving overall survival. PCI increases the risk of toxicity and is currently not adopted in routine care. Our objective was to assess the cost-effectiveness of PCI compared with no PCI in stage III NSCLC from a Dutch societal perspective. METHODS: A cohort partitioned survival model was developed based on individual patient data from three randomized phase III trials (N = 670). Quality-adjusted life years (QALYs) and costs were estimated over a lifetime time horizon. A willingness-to-pay (WTP) threshold of €80,000 per QALY was adopted. Sensitivity and scenario analyses were performed to address parameter uncertainty and to explore what parameters had the greatest impact on the cost-effectiveness results. RESULTS: PCI was more effective and costly (0.443 QALYs, €10,123) than no PCI, resulting in an incremental cost-effectiveness ratio (ICER) of €22,843 per QALY gained. The probability of PCI being cost-effective at a WTP threshold of €80,000 per QALY was 93%. The probability of PCI gaining three and six additional months of life were 76% and 56%. The scenario analysis adding durvalumab increased the ICER to €35,159 per QALY gained. Using alternative survival distributions had little impact on the ICER. Assuming fewer PCI fractions and excluding indirect costs decreased the ICER to €18,263 and €5554 per QALY gained. CONCLUSION: PCI is cost-effective compared to no PCI in stage III NSCLC, and could therefore, from a cost-effectiveness perspective, be considered in routine care.

Concentrations, spatial distribution, sources and environmental health risks of potentially toxic elements in urban road dust across China.

Potentially toxic element (PTE) pollution is widespread in road dust across China, and the effects of PTEs in road dust on health cannot be ignored. In this study, the concentrations of six PTEs (Pb, Cd, Cr, Cu, Zn and Ni) in 4336 road dust samples from 58 cities in 31 provincial regions of China taken after 2000 were obtained from the literatures. Based on these data, the spatial distribution, pollution sources, and ecological and human health risks of PTEs in road dust were comprehensively assessed and the main pollution factors and areas of high risk were identified. The results revealed that PTE levels are generally higher in eastern cities than western cities in China. The key driving factors are socioeconomic factors, including those related to transportation, industry, and population, for which the contribution rates are 57.80%, 55.39% and 37.19%, respectively. PTEs in the road dust with high ecological risks are mainly distributed in the southeastern coastal areas and the Beijing-Tianjin-Hebei region. No obvious noncarcinogenic risk was found for PTEs in road dust, but Cd and Pb may have potential noncarcinogenic risk, mainly distributed in cities in western China. Therefore, regions and pollution sources contributing to Pb and Cd levels should be monitored. The control of PTE pollution in China is a priority for ecological and environmental protection.

Thermodynamic properties and hysteresis loops in a hexagonal core-shell nanoparticle.

We applied Monte Carlo simulation to investigate the thermodynamic properties and hysteresis loops of the hexagonal core-shell nanoparticle described by a ferrimagnetic mixed-spin (3/2, 5/2) Ising model. The results revealed the significance of the single-ion anisotropy, exchange coupling, external magnetic field in dominating various thermodynamic quantities and hysteresis loops. We obtained the variation of the critical temperature with various parameters. Under certain parameter conditions, the system may exhibit rich multiple-loop hysteresis behaviors, depending on the competition among the physical parameters.

How Serious is the Economic Burden of Diabetes Mellitus in Hainan Province? A Study Based on "System of Health Account 2011".

INTRODUCTION: The treatment of diabetes requires extensive use of healthcare resources, resulting in high medical costs, which in turn places a heavy economic burden on society, patients and their families. METHODS: A multi-stage stratified random sampling method was used to investigate 283 medical and health institutions in Hainan Province. The total medical expenses relating to diabetes in Hainan Province in 2016, institutional flow directions, the composition of service functions and the distribution of the healthcare costs to beneficiaries were analyzed based on the System of Health Account 2011. The STATA version 12.0 statistical software package was used to collate operation data, and SPSS software was used to carry out regression analysis on the factors affecting hospitalization costs. RESULTS: In 2016, the total medical expenses for the treatment of diabetes in Hainan Province was 242.17 billion renminbi (RMB), of which 81.95% was spent in high-level hospitals and 14.71% was spent in medical institutions providing primary care. There was little difference between outpatient and hospitalization expenses (53.01 and 46.99%, respectively). Hospitalization accounted for 77.62% of the expenses of medical institutions providing primary care. Older patients were found to spend more on medical and drug expenditure. CONCLUSION: The economic burden of healthcare expenses for the treatment of diabetes in Hainan Province is massive, and patient treatment is concentrated in large hospitals. It is necessary to inform patients to focus more on medical institutions that provide primary care, adjust the proportion of medical insurance reimbursement, control the cost of hospitalization and strengthen the healthcare management of middle-aged and elderly diabetic patients. Only in this way can costs be reduced and the economic burden be eased.

Development of an oligonucleotide dye solution facilitates high throughput and cost-efficient chromosome identification in peanut.

BACKGROUND: Development of oligonucleotide probes facilitates chromosome identification via fluorescence in situ hybridization (FISH) in many organisms. RESULTS: We report a high throughput and economical method of chromosome identification based on the development of a dye solution containing 2 × saline-sodium citrate (SSC) and oligonucleotide probes. Based on the concentration, staining time, and sequence effects of oligonucleotides, an efficient probe dye of peanut was developed for chromosome identification. To validate the effects of this solution, 200 slides derived from 21 accessions of the cultivated peanut and 30 wild Arachis species were painted to identify Arachis genomes and establish karyotypes. The results showed that one jar of dye could be used to paint 10 chromosome preparations and recycled at least 10 times to efficiently dye more than 100 slides. The A, B, K, F, E, and H genomes showed unique staining karyotype patterns and signal colors. CONCLUSIONS: Based on the karyotype patterns of Arachis genomes, we revealed the relationships among the A, B, K, F, E, and H genomes in genus Arachis, and demonstrated the potential for adoption of this oligonucleotide dye solution in practice.

Assessment of the Geographical Detector Method for investigating heavy metal source apportionment in an urban watershed of Eastern China.

Assessing heavy metal pollution in river sediments and identifying the key factors contributing to metal pollution are critical components for devising river environmental protection and remediation strategies to protect human and ecological health. This is especially important in urban areas where metals from a wide range of sources contribute to sediment pollution. In this study, the metal enrichment factor (EF) was used to measure the watershed distribution of Cu, Zn, Pb and Cd in sediments in the Wen-Rui Tang urban river system in Wenzhou, Eastern China. The Geographical Detector Method (GDM) was specifically evaluated for its ability to analyze spatial relationships between metal EFs and their anthropogenic and natural control factors, including densities of industry (DI), livestock (DL), service industries (DS), population (DP), and roads (DR), along with agricultural area (AG), sediment total organic carbon (TOC), and soil types (ST). Results showed that the watershed was highly contaminated by all metals with an EF trend of Cd ≫ Zn > Cu > Pb. The spatial distribution of EFs demonstrated high contamination of all metals in the southwestern region of the watershed where industrial activities were concentrated, and higher Cu and Zn concentrations in the northeastern region having a high density of livestock production. GDM results identified DI as the dominant determinant for all metals, while TOC and ST were determined to have a moderate secondary influence for Zn, Pb and Cd. Additionally, GDM revealed several additive and nonlinear interactions between anthropogenic and natural factors influencing metal concentrations. Compared to other correlation, multiple linear regression and geographically weighted regression, GDM demonstrated distinct advantages of being able to assess both categorical and continuous variables and determine both single and multiple factor interactions. These attributes provide a more comprehensive understanding of metal spatial distributions while avoiding multicollinearity issues when identifying significant contributing factors at the watershed scale.

Rationale and study design for one-stop assessment of renal artery stenosis and renal microvascular perfusion with contrast-enhanced ultrasound for patients with suspected renovascular hypertension.

BACKGROUND: Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP). However, few imaging methods can simultaneously evaluate the degree of luminal stenosis and RMP. Thus, this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for assessing both RAS and RMP to achieve a one-stop assessment of patients with suspected renovascular hypertension. METHODS: This will be a single-center diagnostic study with a sample size of 440. Patients with chronic kidney disease (CKD) and suspected of having resistant hypertension will be eligible. Patients with Stages 1-3 CKD will undergo CEUS and computed tomography (CT) angiography (CTA). Values obtained by CEUS and CTA for diagnosing low-grade (lumen reduced by <60%) and high-grade (lumen reduced by ≥60%) RAS will be compared. Moreover, all patients will also undergo radionuclide imaging. The diagnostic value for RAS will be assessed by the receiver operating characteristic curve, including the accuracy, sensitivity, specificity, positive predictive values, negative predictive values, and area under the ROC. Pearson correlation analysis will be performed to assess the association between CEUS findings for RMP and glomerular filtration rate measured by a radionuclide imaging method. CONCLUSION: The data gathered from this study will be used to evaluate the feasibility of expanding clinical applications of CEUS for evaluation of patients with suspected renovascular hypertension. TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR1800016252; https://www.chictr.org.cn.