Network Diversity and Health Change among International Migrants in China: Evidence from Foreigners in Changchun.

OBJECTIVE: Is the migration process likely to lead to sustained changes in individual social networks and health status? There are many controversies about the relationship between migrants' networks and migrants' health. An important reason may be that the constraints of specific social contexts on immigrant networks and health consequences are neglected. This study distinguished two types of social networks of international immigrants to China-their Chinese networks (Chinese-Net) and home-country networks (Motherland-Net). In addition, the study investigated the construction basis of immigrant social networks and health effects based on the Chinese context. METHOD: A cross-sectional survey was conducted in 2017, 2018, and 2019. The survey was carried out by an on-site questionnaire survey of foreigners in China in the entry-exit hall of the National Immigration Administration. The survey asked foreigners about their immigration experience, labor and employment, social networks, and access to health care. RESULTS AND CONCLUSIONS: Immigrants from more developed countries are more likely to succeed in establishing Chinese-Net and reduce the dependence on Motherland-Net. The Japanese and South Korean immigrants tended to be associated with their home-country compatriots, excluding the Chinese from social contacts and immigration networks. The mixed residence of non-home-country immigrants reduces both the Motherland-Net and Chinese-Net of international immigrants. From the perspective of the health effect, the establishment and expansion of Chinese-Net did not present the "bright side" of encouraging immigrants to reach a better health status. In contrast, Motherland-Net has a stronger explanatory power for the health changes in immigrants.

Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients.

Gastric cancer is one of the most common cancers and the efficient therapeutic methods are limited. Further study of the exact molecular mechanism of gastric cancer to develop novel targeted therapies is necessary and urgent. We herein systematically examined that miR-204 suppressed both proliferation and metastasis of gastric cancer AGS cells. miR-204 directly targeted SOX4. In clinical tissue research, we determined that miR-204 was expressed much lower and SOX4 expressed much higher in gastric cancer tissues compared with normal gastric tissues. Associated analysis with clinicopathological parameters in gastric cancer patients showed miR-204 was associated with no lymph node metastasis and early tumor stages whereas SOX4 was associated with lymph node metastasis and advanced tumor stages. In addition, miR-204 and SOX4 were negatively correlated in tissues from gastric cancer patients. Our findings examined the important role of miR-204 and SOX4 played in gastric cancer, and they could be used as candidate therapeutic targets for gastric cancer therapy.

Assessment of adult neurogenesis in mice.

Adult neurogenesis is a lifelong developmental process that occurs in two discrete regions in the adult mammalian brain: the subgranular zone of the dentate gyrus (DG) and the subventricular zone (SVZ) along the lateral ventricles. Despite immense interest in the therapeutic potential of adult neural stem cells (aNSCs) residing along these two neurogenic regions, molecular and cellular mechanisms regulating this process are not fully defined. Defining the regulatory mechanisms responsible for the genesis of new neurons in the adult brain is integral to understanding the basic biology of aNSCs. The techniques described here provide a basic blueprint to isolate, culture, and perform experiments using aNSCs in vitro as well as providing methods to perform immunohistochemistry on brain sections. Curr. Protoc. Toxicol. 56:12.20.1-12.20.16. © 2013 by John Wiley & Sons, Inc.