Secular trends and attributable risk factors of esophageal cancer deaths among non-elderly adults based on Global Burden of Disease Study.

OBJECTIVE: Esophageal cancer (EC) poses a persistent threat to the health of non-elderly adults. This study aims to elucidate the temporal trends of EC-related mortality and investigate the impact of various risk factors on such deaths in the age group of 20-59 years, spanning 3 decades. METHODS: Data on EC deaths were acquired from the Global Burden of Disease, Injuries, and Risk Factors (GBD) study. We employed estimated average percentage change (EAPC) and linear mixed-effects (LME) models to analyze mortality trends and pertinent risk factors for EC. RESULTS: Between 1990 and 2019, EC mortality showed a downward trend, and the global number of deaths from EC among non-elderly adults surged by 24.37%. During this period, mortality rates saw an increase in only two regions-the Caribbean and Western Sub-Saharan Africa (EAPCs > 0). For male deaths, smoking and alcohol use emerged as the primary risk factors, while high body mass index (BMI) stood out as the main risk factor for female deaths. Furthermore, the LME model identified male sex, advancing age, alcohol use, smoking, and chewing tobacco as factors associated with an additional rise in EC deaths. CONCLUSION: EC continues to exert a substantial toll on mortality among young and middle-aged adults globally. Implementing targeted interventions are significant in alleviating the burden of this disease within this population.

Applying stress and coping models to ethnic/racial identity, discrimination, and adjustment among diverse adolescents.

Adopting the constructs of exposure, reactivity, and recovery, from stress and coping frameworks, this study investigated three models of discrimination, adjustment, and ethnic/racial identity among 76 African American, 145 Asian American, and 129 Latinx adolescents who were majority United States-born. The sample includes adolescents sampled from public schools in a large urban area in the northeastern United States, 62% female and with an average age of 14.3 years. Multilevel analyses support an exposure effect (Model 1) where a higher level of ethnic/racial identity (ERI) commitment was associated with a 28% reduction in experiencing discrimination stress. The negative effects of discrimination were attenuated by ERI commitment and centrality/private regard, while effects were exacerbated by ERI exploration (Model 2). Two approaches investigated next-day and longer-term recovery from discrimination (Model 3). With the exception of positive mood and anxiety, the data support recovery from discrimination stress. Discrimination is discussed in the development and maintenance of health disparities. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

A Novel Fire Risk Assessment Approach for Large-Scale Commercial and High-Rise Buildings Based on Fuzzy Analytic Hierarchy Process (FAHP) and Coupling Revision.

In recent years, much more emphasis than before has been placed on fire safety regulations by the local and central authorities of China, which makes fire risk assessments more important. In this paper we propose a new fire risk assessment approach for large-scale commercial and high-rise buildings that aims to evaluate the performances of their fire safety systems; this should improve the fire risk management and public safety in those buildings. According to the features of large-scale commercial and high-rise buildings, a fire-risk indexing system was built, and based on it we established a scientific fire risk evaluation system. To this end, the fuzzy analytic hierarchy process (FAHP) was used to assign a reasonable weight to each fire risk factor in the evaluation system. In addition, we revised the original scores by analyzing the coupling relationships among the fire risk factors. To validate our system, we selected 11 buildings in Shandong province and collected their fire safety data. Then, we calculated the final scores for the fire safety management of those buildings, and the results show that: (1) our fire risk evaluation system can assign reasonable weights; (2) the proposed evaluation system is comprehensive and has strong interpretability, since it exploits the coupling relationships among the risk factors. The novelty of the proposed approach lies in that it integrates opinions from multiple experts and utilizes coupling relationships among the factors. Further, the feedback from the approach can find not only the weaknesses in fire risk management, but also the potential causes of fires. As a result, the feedback from our assessment can assist the safety chiefs and inspectors with improving fire risk management.

Exploring microbial communities, assessment methodologies and applications of animal's carcass decomposition: a review.

Animals are an essential part of the ecosystem, and their carcasses are the nutrient patches or hotspots where nutrients accumulate for a long time. After death, the physical and chemical properties undergo alterations inside the carcass. The animal carcass is decomposed by many decomposers such as bacteria, fungi, microeukaryotes and insects. The role of microbial symbionts in living organisms is well explored and studied, but there is a scarcity of knowledge and research related to their role in decomposing animal carcasses. Microbes play an important role in carcass decomposition. The origins of microbial communities associated with a carcass, including the internal and external microbiome, are discussed in this review. The succession and methods used for the detection and exploration of decomposition-associated microbial communities have been briefly described. Also, the applications of carcass-associated microbial taxa have been outlined. This review is intended to understand the dynamics of microbial communities associated with the carcass and pave the way to estimate postmortem interval and its role in recycling nutrients.

Global patterns in vision loss burden due to vitamin A deficiency from 1990 to 2017.

OBJECTIVE: To investigate the vision loss burden due to vitamin A deficiency (VAD) at the global, regional and national levels by year, age, sex and socio-economic status using prevalence and years lived with disability (YLD). DESIGN: International, retrospective, comparative burden-of-disease study. SETTING: Prevalence and YLD data were extracted from the Global Burden of Disease (GBD) Study 2017. The association of age-standardised YLD rates and human development index (HDI) was tested by Pearson correlation and linear regression analyses. The Gini coefficient and concentration index (CI) were calculated to demonstrate the trends in between-country inequality in vision loss burden due to VAD. PARTICIPANTS: All participants met the GBD inclusion criteria. RESULTS: The age-standardised prevalence rate increased by 9·2 %, while the age-standardised YLD rates rose by 10·8 % from 1990 to 2017. Notably, the vision loss burden caused by VAD showed a declining trend since 2014. The vision loss burden was more concentrated in the post-neonatal age group and decreased with increasing age. The age-standardised YLD rates were inversely correlated with HDI (r = -0·2417, P = 0·0084). The CI and Gini coefficients indicated that socio-economic-related and between-country inequality declined from 2000 to 2017. VAD was the eighth leading cause of the age-standardised prevalence rate and ninth leading cause of age-standardised YLD rate among fifteen causes of vision loss in 2017. CONCLUSION: VAD has become one of the significant leading causes of vision loss globally. Efforts to control vision impairment related to VAD are needed, especially for children in countries with lower socio-economic status.

Burden of vision loss due to diabetic retinopathy in China from 1990 to 2017: findings from the global burden of disease study.

PURPOSE: To conduct a detailed analysis on the burden of vision loss due to diabetic retinopathy (DR) by year, age and gender in China from 1990 to 2017. METHODS: This is a between-country, retrospective, comparative burden-of-disease study. Prevalence and Years Lived with Disability (YLDs) data caused by DR in China and relative territories were extracted from the Global Burden of Disease (GBD) study 2017 to observe the changing trends of vision loss. RESULTS: Prevalence and YLDs of DR in China increased significantly from 1990 to 2017. The age-standardized prevalence and YLDs rate witnessed a slowly declining trend recently. Higher prevalence and YLDs were observed in female subjects in the past three decades. Middle-aged and elderly people suffered from a higher burden of DR-induced vision loss. The total age-standardized prevalence rate of China in 1990 (17.68) and 2017 (21.88) was lower than that of other seven neighbouring countries. In 2017, moderate vision loss (MVL) (17.19) accounted for the largest proportion in China. The all-age YLDs of DR showed the second-highest increase (150.26%) while the age-standardized YLDs rate showed the third-highest increase (14.91%) among fifteen common causes of vision impairment (VI) from 1990 to 2017. China ranked 3rd among G20 countries in terms of all-age YLDs while ranked 18th in age-standardized YLDs rate in 2017. CONCLUSIONS: In the past three decades, the prevalence and YLDs due to DR in China have improved in both genders. This study highlights the importance of prevention for DR, especially for women and the elderly.

The pattern and gender disparity in global burden of age-related macular degeneration.

PURPOSE: To explore the trend patterns and gender disparity in global burden of age-related macular degeneration (AMD) by year, age, and socioeconomic status using disability-adjusted life-years (DALYs) from Global Burden of Disease (GBD) study 2017. METHODS: DALYs and impairment data caused by AMD were extracted from GBD Study 2017. World Bank income level (WBIL) and human development index (HDI) in 2017 were cited as indicators of socioeconomic status. The Gini coefficients and the concentration indexes were calculated to unveil trends in between-country inequality. The association between gender inequality and socioeconomic levels was analyzed by Pearson correlation. RESULTS: Total age-standardized DALYs of AMD showed a slightly descending pattern in recent years. However, gender disparity has existed since 1990 for almost three decades, with female being more heavily impacted. This pattern became more obvious with aging and varied among different WHO and WBIL regions. Meanwhile, female subjects tended to have higher vision impairments. Gini coefficients of AMD burden increased from 0.423 to 0.448, while the ones of female-to-male ratio fluctuated around 0.11 between 1990 and 2017, with concentration indexes changing from 0.024 to -0.057 and 0.046 to 0.029 respectively. Female-minus-male difference (r = 0.1721, p = 0.0195) and female-to-male ratio (r = 0.2072, p = 0.0048) of age-standardized DALYs rates were positively related to HDI. CONCLUSIONS: Though global AMD health care is progressing, gender imbalance in disease burden of AMD distribution barely improved. Gender sensitive health policy should be emphasized for the increasing elder population and relieving the higher AMD burden of females.

Sociodemographic and environmental factors associated with childhood sleep duration.

OBJECTIVES: This study investigates sociodemographic and environmental correlates of sleep duration among school-aged children. DESIGN & SETTING: The New York City 2009 Child Community Health Survey was analyzed using weighted regression analyses. PARTICIPANTS: 1293 Asian, Black, Latino and White children ages 6-12 years, 999 children in Pre-K - 5th grade and 294 children in the 6th-8th grades. MEASUREMENTS: Parents/guardians completed a survey about the target child's sleep duration on a typical school night/day, and sociodemographic and household characteristics. RESULTS: Most children (89.3%) met the National Sleep Foundation's (NSF) recommendation of 9-11 h of sleep per night. Pre-K-5th grade children who were born in the United States were less likely than children born outside of the United States to sleep 9-11 h. When sleep duration was examined continuously, children slept an average of 9 h 44 min. On average, with each additional year of age, children slept 7.2 min less than children who were one year younger. Although there were no differences among ethnic/racial groups in sleeping the recommended 9-11 h/night, when sleep duration was measured as a continuous variable, Asian, Latino, and Black children slept an average of 23, 14, and 17 min fewer, respectively, than White children, adjusting for sociodemographic and environmental factors. CONCLUSIONS: Sleep duration varied across sociodemographic groups of children in New York City in 2009. Future studies should determine causal influences and whether these differences persist.

Socio-economic disparity in global burden of near vision loss: an analysis for 2017 with time trends since 1990.

PURPOSE: To investigate the socio-economic disparity in global burden of near vision loss by disability-adjusted life-years (DALYs). METHODS: The DALY numbers of country income groups by World Bank classification and the national age-standardized DALY rates caused by near vision loss were obtained from Global Burden of Disease Study 2017. Human development index (HDI) was collected from the Human Development Report. The association between age-standardized DALY rates and HDI was analysed. Additionally, the concentration index (CI) and the relative index of inequality (RII) were employed to assess the trends of socio-economic disparity in the global burden of near vision loss from 1990 to 2017. RESULTS: The global burden of near vision loss increased from 5.3 million DALYs in 1990 to 9.8 million DALYs in 2017, corresponding to an increase of 82.4%. The highest rate of increase for 1990-2017 occurred in low-income country group (97.7%). Age-standardized DALY rates were inversely correlated with HDI (Standardized ß = -0.679, P < 0.001). Lower HDI countries displayed higher age-standardized DALY rates caused by near vision loss. From 1990 to 2017, CI declined from -0.233 to -0.209, and RII increased from 0.149 to 0.247. CONCLUSION: The total global burden of near vision loss increased greatly in the past few decades, with low-income countries showing the highest growth. The age-standardized burden was higher in countries with lower socio-economic status. Although a declining trend of socio-economic inequalities was observed, the persistence of disparities still highlights the need to provide more eye care services for developing countries.

Racial discrimination, the superwoman schema, and allostatic load: exploring an integrative stress-coping model among African American women.

Racial discrimination has been linked to allostatic load (i.e., cumulative biological stress) among African American women. However, limited attention has been given to psychosocial processes involved in the stress response-critical for understanding biological pathways to health-in studies examining racial discrimination as a social determinant of health. We examined whether the superwoman schema (SWS), a multidimensional culture-specific framework characterizing psychosocial responses to stress among African American women, modifies the association between racial discrimination and allostatic load. We used purposive sampling to recruit a community sample of African American women ages 30-50 from five San Francisco Bay Area counties (n = 208). Path analysis was used to test for interactions while accounting for the covariance among SWS subscales using both linear and quadratic models. Significant interactions were observed between racial discrimination and four of the five SWS subscales. Feeling obligated to present an image of strength and an obligation to suppress emotions were each protective whereas feeling an intense motivation to succeed and feeling an obligation to help others exacerbated the independent health risk associated with experiencing racial discrimination. Our findings affirm the need to consider individual variability in coping and potentially other psychosocial processes involved in the stress response process, and offer several insights that may help elucidate the mechanisms by which racial discrimination gets "under the skin."

Moderating the association between discrimination and adjustment: A meta-analysis of ethnic/racial identity.

The detrimental effects of discrimination are well documented; however, the influence of ethnic/racial identity (ERI) on this association is equivocal. There is theoretical and empirical support for both protective and detrimental effects of ERI. This meta-analysis includes 53 effect sizes from 51 studies and 18,545 participants spanning early adolescence to adulthood to synthesize the interaction of ERI and discrimination for adjustment outcomes. Consistent with existing meta-analyses, discrimination was associated with compromised adjustment; further, this effect was buffered by overall ERI particularly for academic and physical health outcomes. Different ERI dimensions and adjustment outcomes revealed important patterns. ERI exploration increased vulnerabilities associated with discrimination, particularly for negative mental health and risky health behaviors. The exacerbating influence of ERI exploration was strongest at age 24, and more recent publications reported weaker exacerbating effects. In contrast, ERI commitment conferred protection. A composite score of ERI exploration and commitment also conferred protection against discrimination. Sample demographics mattered. The buffering effect of ERI commitment was stronger for Latinx (compared with Asian heritage) individuals. The buffering effect of public regard was stronger for Asian heritage (compared with African heritage) individuals. For positive mental health outcomes, a composite score of ERI exploration and commitment had a stronger buffering effect for Latinx (compared with African heritage) individuals. For risky health behaviors, Latinx individuals reported a stronger buffering effect of ERI (compared with African heritage and Asian heritage) individuals. The current meta-analysis identifies gaps in the literature and offers suggestions for future research. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Adolescents' Social Norms across Family, Peer, and School Settings: Linking Social Norm Profiles to Adolescent Risky Health Behaviors.

Social norms around adolescent risky health behaviors have been often studied in separate developmental settings (e.g., family norms, peer norms), and little is known regarding the overall patterns of social norms across contexts and how they influence adolescent risky health behaviors. This study explored profiles of social norms around risky health behaviors across family, peer, and school settings, using data from 11,086 adolescents (50% female; 49% White, 22% Black, 18% Latinx, 8% Asian American, 3% other race/ethnicities) in the National Longitudinal Study of Adolescent to Adult Health. Five profiles of social norms around risky health behaviors emerged. Only a small portion of the sample experienced either congruent-restrictive (6%) or congruent-permissive (10%) social norms across settings. The majority experienced incongruent social norms, including the developmentally normative-low risk (39%), developmentally normative-high risk (40%), and resilient (5%) profiles. Adolescents with the congruent-restrictive profile and developmentally normative-low risk profiles exhibited the least risky health behaviors over time, followed by those with the resilient profile, and adolescents with the developmentally normative-high risk and the congruent-permissive profile exhibited the greatest risky health behaviors over time. Each profile was associated with unique developmental, socio-demographic, and psychosocial characteristics. The findings highlighted the complexity of social norms across contexts and the developmental versus risky natures of these social norm profiles.

Racial/ethnic discrimination and well-being during adolescence: A meta-analytic review.

This meta-analytic study systematically investigates the relations between perceived racial/ethnic discrimination and socioemotional distress, academics, and risky health behaviors during adolescence, and potential variation in these relations. The study included 214 peer-reviewed articles, theses, and dissertations, with 489 unique effect sizes on 91,338 unique adolescents. Random-effects meta-analyses across 11 separate indicators of well-being identified significant detrimental effects. Greater perceptions of racial/ethnic discrimination were linked to more depressive and internalizing symptoms; greater psychological distress; poorer self-esteem; lower academic achievement and engagement; less academic motivation; greater engagement in externalizing behaviors, risky sexual behaviors, and substance use; and more associations with deviant peers. Metaregression and subgroup analyses indicated differences by race/ethnicity, Gender × Race/Ethnicity interactions, developmental stage, timing of retrospective measurement of discrimination, and country. Overall, this study highlights the pernicious effects of racial/ethnic discrimination for adolescents across developmental domains and suggests who is potentially at greater risk. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Intergenerational Transmission of Educational Attitudes in Chinese American Families: Interplay of Socioeconomic Status and Acculturation.

This longitudinal study examined the influence of parents' educational attitudes on adolescents' educational attitudes and identified antecedents (i.e., parent education, family income, and parent acculturation), consequences (i.e., academic achievement and engagement), and a potential moderator (i.e., adolescent acculturation) of the transmission process. The sample was 444 Chinese American mothers, fathers, and adolescents (12-15 at W1). Using path analysis, this study found significant two-way interactions among parent education, income, and acculturation in predicting parents' concurrent positive educational attitudes, which, in turn, predicted adolescents' attitudes at W2. The latter link was further moderated by W1 and W2 adolescent acculturation for mother-adolescent and father-adolescent dyads. Adolescents' positive educational attitudes at W2, in turn, were positively associated with their concurrent academic achievement and engagement.

Development of an Asian American parental racial-ethnic socialization scale.

OBJECTIVE: To develop a measure of parental racial-ethnic socialization that is appropriate for Asian American families. METHOD: To test the reliability and validity of this new measure, we surveyed 575 Asian American emerging adults (49% female, 79% U.S. born). RESULTS: Using exploratory and confirmatory factor analyses, the results show 7 reliable subscales: maintenance of heritage culture, becoming American, awareness of discrimination, avoidance of other groups, minimization of race, promotion of equality, and cultural pluralism. Tests of factorial invariance show that overall, the subscales demonstrate, at minimum, partial metric invariance across gender, age, nativity, educational attainment, parent educational attainment, geographic region of residence, and Asian-heritage region. Thus, the relations among the subscales with other variables can be compared across these different subgroups. The subscales also correlated with ethnic identity, ethnic centrality, perceptions of discrimination, and pluralistic orientation, demonstrating construct validity. CONCLUSION: In an increasingly complex and diverse social world, our scale will be useful for gaining a better understanding of how Asian American parents socialize their children regarding issues of race, discrimination, culture, and diversity. (PsycINFO Database Record

Adolescent substance use: The role of demographic marginalization and socioemotional distress.

We investigated the links between racial/ethnic marginalization (i.e., having few same-race/ethnic peers at school) and adolescents' socioemotional distress and subsequent initiation of substance use (alcohol and marijuana) and substance use levels. Data from 7,731 adolescents (52% female; 55% White, 21% African American, 16% Latino, 8% Asian American) were drawn from the National Longitudinal Study of Adolescent to Adult Health. In our path analysis model, we found that adolescents who were racially/ethnically marginalized at school (i.e., who had less than 15% same-ethnicity peers) reported poorer school attachment, which was linked to more depressive symptoms. More depressive symptoms were associated with higher levels of subsequent marijuana and alcohol use. These relationships showed some variation by students' gender, race/ethnicity, and age. Findings suggest that the influence of school demographics extends beyond the academic domain into the health and well-being of young people.

Parent-child acculturation profiles as predictors of Chinese American adolescents' academic trajectories.

Acculturation plays a critical role in the adjustment of Asian Americans, as a large proportion of them are immigrants in the US. However, little is known about how acculturation influences Asian American adolescents' academic trajectories over time. Using a longitudinal sample of 444 Chinese American families (54% female children), the current study explored the effect of mothers', fathers', and adolescents' individual acculturation profiles and parent-child acculturation dissonance on adolescents' academic trajectories from 8th to 12th grade. Academic performance was measured by grade point average (GPA), and by standardized test scores in English language arts (ELA) and Math every year. Latent growth modeling analyses showed that adolescents with a Chinese-oriented father showed faster decline in GPA, and Chinese-oriented adolescents had lower initial ELA scores. Adolescents whose parents had American-oriented acculturation profiles tended to have lower initial Math scores. These results suggest that Chinese and American profiles may be disadvantageous for certain aspects of academic performance, and bicultural adolescents and/or adolescents with bicultural parents are best positioned to achieve across multiple domains. In terms of the role of parent-child acculturation dissonance on academic trajectories, the current study highlighted the importance of distinguishing among different types of dissonance. Adolescents who were more Chinese-oriented than their parents tended to have the lowest initial ELA scores, and adolescents experiencing more normative acculturation dissonance (i.e., who were more American-oriented than their parents) had the highest initial ELA scores. No effects of parent-child acculturation dissonance were observed for GPAs or standardized Math scores. Altogether, the current findings add nuances to the current understanding of acculturation and adolescent adjustment.

Demographic marginalization, social integration, and adolescents' educational success.

Links between schools' demographic composition and students' achievement have been a major policy interest for decades. Using a racially/ethnically diverse sample from the National Longitudinal Study of Adolescent Health (N = 6,302; 54% females; 53% White, 21% African American, 15% Latino, 8% Asian American, 2% other race/ethnicity), we examined the associations between demographic marginalization, students' later social integration (loneliness at school, school attachment), and educational performance and attainment. Adolescents who were socioeconomically marginalized at school [i.e., having <15% same-socioeconomic status (SES) peers] had lower cumulative grade point averages across high school and lower educational attainment. A similar disadvantage was observed among students who were both socioeconomically and racially/ethnically marginalized at school (i.e., having <15% same-SES peers and <15% same-racial/ethnic peers). Indirect effects were also observed, such that demographic marginalization was linked to poorer school attachment, and poorer school attachment, in turn, was related to poorer academic performance. These results highlight the educational barriers associated with demographic marginalization and suggest potential targets for future intervention efforts.

Joint clustering of protein interaction networks through Markov random walk.

Biological networks obtained by high-throughput profiling or human curation are typically noisy. For functional module identification, single network clustering algorithms may not yield accurate and robust results. In order to borrow information across multiple sources to alleviate such problems due to data quality, we propose a new joint network clustering algorithm ASModel in this paper. We construct an integrated network to combine network topological information based on protein-protein interaction (PPI) datasets and homological information introduced by constituent similarity between proteins across networks. A novel random walk strategy on the integrated network is developed for joint network clustering and an optimization problem is formulated by searching for low conductance sets defined on the derived transition matrix of the random walk, which fuses both topology and homology information. The optimization problem of joint clustering is solved by a derived spectral clustering algorithm. Network clustering using several state-of-the-art algorithms has been implemented to both PPI networks within the same species (two yeast PPI networks and two human PPI networks) and those from different species (a yeast PPI network and a human PPI network). Experimental results demonstrate that ASModel outperforms the existing single network clustering algorithms as well as another recent joint clustering algorithm in terms of complex prediction and Gene Ontology (GO) enrichment analysis.

Shifting attendance trajectories from middle to high school: influences of school transitions and changing school contexts.

In the current study, we examine patterns of school attendance across middle and high school with a diverse sample of 8,908 students (48% female; 54% Latino, 31% White, 13% African American, 2% Asian American). Attendance declined from middle through high school, but this overall pattern masked important variations. In total, 44% of students maintained their attendance trajectories from middle to high school (11% stable high, 19% high-decreasing, 10% mid-decreasing, 4% low-decreasing), and shifting attendance trajectories often signaled greater school disengagement (38% shifted to poorer attendance trajectories, 18% experienced improved attendance trajectories). Transition experiences, school structural characteristics, and the divergence between students' middle and high schools provided insights into which students recovered, becoming more engaged in high school versus those who became more disconnected. Implications for identifying and intervening with disengaged youth are discussed.