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1.
Spine (Phila Pa 1976) ; 49(10): 694-700, 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38655789

RESUMO

STUDY DESIGN: A retrospective cohort study using prospectively collected data. OBJECTIVE: The aim of this study was to investigate preoperative differences in racial and socioeconomic factors in patients undergoing laminoplasty (LP) versus laminectomy and fusion (LF) for degenerative cervical myelopathy (DCM). SUMMARY OF BACKGROUND DATA: DCM is prevalent in the United States, requiring surgical intervention to prevent neurological degeneration. While LF is utilized more frequently, LP is an emerging alternative. Previous studies have demonstrated similar neurological outcomes for both procedures. However, treatment selection is primarily at the discretion of the surgeon and may be influenced by social determinants of health that impact surgical outcomes. MATERIALS AND METHODS: The Quality Outcome Database (QOD), a national spine registry, was queried for adult patients who underwent either LP or LF for the management of DCM. Covariates associated with socioeconomic status, pain and disability, and demographic and medical history were collected. Multivariate logistic regression was performed to assess patient factors associated with undergoing LP versus LF. RESULTS: Of 1673 DCM patients, 157 (9.4%) underwent LP and 1516 (90.6%) underwent LF. A significantly greater proportion of LP patients had private insurance (P<0.001), a greater than high school level education (P<0.001), were employed (P<0.001), and underwent primary surgery (P<0.001). LP patients reported significantly lower baseline neck/arm pain and Neck Disability Index (P<0.001). In the multivariate regression model, lower baseline neck pain [odds ratio (OR)=0.915, P=0.001], identifying as non-Caucasian (OR=2.082, P<0.032), being employed (OR=1.592, P=0.023), and having a greater than high school level education (OR=1.845, P<0.001) were associated with undergoing LP rather than LF. CONCLUSIONS: In DCM patients undergoing surgery, factors associated with patients undergoing LP versus LF included lower baseline neck pain, non-Caucasian race, higher education, and employment. While symptomatology may influence the decision to choose LP over LF, there may also be socioeconomic factors at play. The trend of more educated and employed patients undergoing LP warrants further investigation.


Assuntos
Vértebras Cervicais , Laminectomia , Laminoplastia , Fatores Socioeconômicos , Fusão Vertebral , Espondilose , Humanos , Masculino , Feminino , Laminoplastia/métodos , Laminectomia/métodos , Pessoa de Meia-Idade , Espondilose/cirurgia , Vértebras Cervicais/cirurgia , Fusão Vertebral/métodos , Estudos Retrospectivos , Idoso , Adulto , Resultado do Tratamento , Disparidades em Assistência à Saúde/etnologia , Disparidades Socioeconômicas em Saúde
2.
World Neurosurg ; 168: e354-e368, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36216246

RESUMO

BACKGROUND: Private insurers use the calendar deductible system, placing pressure on patients and medical personnel to perform medical services before the end of the year to maximize patient savings. The impact of the deductible calendar on patient-reported outcomes (PROs) after spine surgery is poorly understood. The objective of our study was to investigate if patients undergoing surgery in December had different PROs and demographics compared with all other months. METHODS: The Quality Outcome Database, a national spine registry, was queried for patients who underwent elective spine surgery between January 2012 and January 2021 for degenerative spine conditions. PROs and demographics were compared between the December and non-December groups using various statistical tests. RESULTS: A total of 978 patients (9.3%) underwent anterior cervical discectomy and fusion in December versus 9548 (90.7%) in other months. There was a significantly higher percentage of patients in December who had private insurance and were employed. A total of 1104 patients (8.5%) underwent lumbar fusion in December versus 11,826 (91.5%) in other months. There was a significantly greater chance of undergoing surgery in December if patients had private insurance and were employed. Although some PROs were statistically significant for the lumbar and cervical cohorts between December and non-December patients, none were clinically significant. CONCLUSIONS: Patients undergoing elective spine surgery in December were more likely to have private insurance and be employed. PROs for ACDF and lumbar fusions were not affected by surgical timing (December yes/no). Other spinal procedures directed at more chronic diseases might be more susceptible to external influence of insurance deductibles.


Assuntos
Fusão Vertebral , Humanos , Fusão Vertebral/métodos , Vértebras Lombares/cirurgia , Dedutíveis e Cosseguros , Discotomia/métodos , Procedimentos Cirúrgicos Eletivos/efeitos adversos , Complicações Pós-Operatórias/etiologia , Resultado do Tratamento , Vértebras Cervicais/cirurgia , Estudos Retrospectivos
3.
Public Health ; 190: 152-159, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33419526

RESUMO

OBJECTIVE: The objective of the study is to identify the barriers to UK Black, Asian and Minority Ethnic (BAME) women attending breast screening and subsequently, support the growing evidence base providing solutions to the public health problem of ethnic variation within screening attendance. STUDY DESIGN: A systematic review and thematic analysis of UK-based, qualitative studies concerning BAME women. METHODS: The methodology of this review is based on Cochrane guidelines. A search strategy was applied to Embase, PubMed and Medline. Predefined inclusion and exclusion criteria yielded 8 final articles which were appraised and thematically analysed. RESULTS: The main findings of the review revealed three overarching themes: knowledge-related, access-related and cultural-related factors. The emphasis of the importance of knowledge was highlighted by all studies identifying a lack of knowledge as a key barrier to screening attendance. CONCLUSIONS: BAME women have disproportionally lower breast screening attendance and a lack of knowledge is an essential barrier to overcome when addressing this health inequality.


Assuntos
Neoplasias da Mama/psicologia , Assistência à Saúde Culturalmente Competente , Etnicidade/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Promoção da Saúde/métodos , Acessibilidade aos Serviços de Saúde , Disparidades nos Níveis de Saúde , Mamografia/psicologia , Adulto , Negro ou Afro-Americano , Povo Asiático , População Negra , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/etnologia , Cultura , Detecção Precoce de Câncer , Etnicidade/psicologia , Feminino , Humanos , Aceitação pelo Paciente de Cuidados de Saúde/etnologia
4.
Contemp Nurse ; 56(4): 297-308, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32799620

RESUMO

Nurses and midwives of Australia now is the time for change! As powerfully placed, Indigenous and non-Indigenous nursing and midwifery professionals, together we can ensure an effective and robust Indigenous curriculum in our nursing and midwifery schools of education. Today, Australia finds itself in a shifting tide of social change, where the voices for better and safer health care ring out loud. Voices for justice, equity and equality reverberate across our cities, our streets, homes, and institutions of learning. It is a call for new songlines of reform. The need to embed meaningful Indigenous health curricula is stronger now than it ever was for Australian nursing and midwifery. It is essential that nursing and midwifery leadership continue to build an authentic collaborative environment for Indigenous curriculum development. Bipartisan alliance is imperative for all academic staff to be confident in their teaching and learning experiences with Indigenous health syllabus. This paper is a call out. Now is the time for Indigenous and non-Indigenous nurses and midwives to make a stand together, for justice and equity in our teaching, learning, and practice. Together we will dismantle systems, policy, and practices in health that oppress. The Black Lives Matter movement provides us with a 'now window' of accepted dialogue to build a better, culturally safe Australian nursing and midwifery workforce, ensuring that Black Lives Matter in all aspects of health care.


Assuntos
Pessoal Administrativo/psicologia , Negro ou Afro-Americano/psicologia , Assistência à Saúde Culturalmente Competente/organização & administração , Tocologia/educação , Cuidados de Enfermagem/psicologia , Recursos Humanos de Enfermagem Hospitalar/psicologia , Racismo/prevenção & controle , Estudantes de Enfermagem/psicologia , Adulto , Austrália , Currículo , Bacharelado em Enfermagem , Feminino , Humanos , Liderança , Masculino , Pessoa de Meia-Idade , Recursos Humanos de Enfermagem Hospitalar/educação , Gravidez , Racismo/psicologia
5.
Br J Surg ; 106(13): 1775-1783, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31747071

RESUMO

BACKGROUND: This study evaluated public preferences for the treatment processes for abdominal aortic aneurysm repair in order to allow them to be incorporated into a cost-effectiveness analysis. METHODS: This was a telephone survey using a trade-off method in UK resident adults (aged at least 18 years) with no previous diagnosis of a vascular condition. RESULTS: Some 167 of 209 participants (79·9 per cent) stated that they would prefer endovascular aneurysm repair (EVAR), 40 (19·1 per cent) preferred open surgery and two (1·0 per cent) stated no preference. Participants preferred EVAR because of the less invasive nature of the intervention and quicker recovery. Participants preferring open surgery cited reasons such as having a single follow-up appointment, and a procedure that felt more permanent. When participants were asked to make a sacrifice in order to have their preferred treatment, 122 (58·4 per cent) favoured EVAR, 18 (8·6 per cent) favoured open surgery and 69 (33·0 per cent) had no preference. Those preferring EVAR were willing to give up a mean of 0·135 expected quality-adjusted life-years (QALYs) to have EVAR, compared with a willingness to give up 0·033 expected QALYs among those preferring open repair. CONCLUSION: These results indicate a clear preference for EVAR over open surgery for aortic aneurysm.


ANTECEDENTES: Este estudio evaluó las preferencias de la opinion pública en relación a las opciones de tratamiento para la reparación del aneurisma de aorta abdominal, con el objetivo de que dichas preferencias se puedan incorporar en un análisis de coste-efectividad. MÉTODOS: Se realizó una encuesta telefónica utilizando el método trade-off (solución de intercambio) en adultos residentes en el Reino Unido (mayores de 18 años) sin diagnóstico previo de enfermedad vascular. RESULTADOS: Un total de 167 (79,9%) de 209 participantes declararon que preferirían la reparación endovascular del aneurisma (endovascular aneurysm repair, EVAR), 40 (19,1%) prefirieron cirugía abierta y dos (1,0%) no tenían preferencia. Los participantes prefirieron el EVAR debido a la naturaleza menos invasiva de la intervención y a tiempos de recuperación más rápidos. Los participantes que preferían la cirugía abierta mencionaron como razones tener una única visita de seguimiento y consideraron que se trataba de un procedimiento más permanente. Cuando se pidió a los participantes que para recibir su tratamiento preferido hicieran un intercambio, 122 (58,4%) se decantaron por la EVAR, 18 (8,6%) por la cirugía abierta y 69 (33%) no tuvieron preferencia. Los que prefirieron EVAR estaban dispuestos a renunciar a una media de 0,135 años de vida ajustados por calidad (QALYs) esperados con tal de recibir una EVAR en comparación con la renuncia de 0,033 QALYs esperada entre quienes preferían la reparación abierta. CONCLUSIÓN: Estos resultados indican una clara preferencia por la EVAR sobre la cirugía abierta, lo que está en desacuerdo con la reciente recomendación de NICE de que la EVAR no debe recomendarse como una opción de tratamiento. Los hallazgos sugieren que se debe prestar mayor atención a las características del proceso de tratamiento. Al no incorporar explícitamente tales preferencias en el proceso de toma de decisiones, NICE corre el riesgo de recomendar opciones de tratamiento que son contrarias a las preferencias de la población del Reino Unido.


Assuntos
Aneurisma da Aorta Abdominal/cirurgia , Comportamento do Consumidor/estatística & dados numéricos , Procedimentos Endovasculares , Procedimentos Cirúrgicos Vasculares , Adulto , Idoso , Idoso de 80 Anos ou mais , Aneurisma da Aorta Abdominal/psicologia , Análise Custo-Benefício , Procedimentos Endovasculares/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Procedimentos Cirúrgicos Vasculares/psicologia , Adulto Jovem
6.
Cardiovasc J Afr ; 28(1): 54-59, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-27701490

RESUMO

BACKGROUND: Paediatric cardiac services in Nigeria have been perceived to be inadequate but no formal documentation of availability and distribution of facilities and services has been done. OBJECTIVE: To evaluate and document the currently available paediatric cardiac services in Nigeria. METHODS: In this questionnaire-based, cross-sectional descriptive study, an audit was undertaken from January 2010 to December 2014, of the personnel and infrastructure, with their distributions according to geopolitical zones of Nigeria. RESULTS: Forty-eight centres participated in the study, with 33 paediatric cardiologists and 31 cardiac surgeons. Echocardiography, electrocardiography and pulse oximetry were available in 45 (93.8%) centres while paediatric intensive care units were in 23 (47.9%). Open-heart surgery was performed in six (12.5%) centres. South-West zone had the majority of centres (20; 41.7%). CONCLUSIONS: Available paediatric cardiac services in Nigeria are grossly inadequate and poorly distributed. Efforts should be intensified to upgrade existing facilities, establish new and functional centres, and train personnel.


Assuntos
Cardiologia/organização & administração , Auditoria Clínica , Acessibilidade aos Serviços de Saúde/organização & administração , Pediatria/organização & administração , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Nigéria , Inquéritos e Questionários
7.
Diabet Med ; 32(7): 907-19, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25661661

RESUMO

AIMS: To examine the short- and long-term cost-effectiveness of intensive multifactorial treatment compared with routine care among people with screen-detected Type 2 diabetes. METHODS: Cost-utility analysis in ADDITION-UK, a cluster-randomized controlled trial of early intensive treatment in people with screen-detected diabetes in 69 UK general practices. Unit treatment costs and utility decrement data were taken from published literature. Accumulated costs and quality-adjusted life years (QALYs) were calculated using ADDITION-UK data from 1 to 5 years (short-term analysis, n = 1024); trial data were extrapolated to 30 years using the UKPDS outcomes model (version 1.3) (long-term analysis; n = 999). All costs were transformed to the UK 2009/10 price level. RESULTS: Adjusted incremental costs to the NHS were £285, £935, £1190 and £1745 over a 1-, 5-, 10- and 30-year time horizon, respectively (discounted at 3.5%). Adjusted incremental QALYs were 0.0000, - 0.0040, 0.0140 and 0.0465 over the same time horizons. Point estimate incremental cost-effectiveness ratios (ICERs) suggested that the intervention was not cost-effective although the ratio improved over time: the ICER over 10 years was £82,250, falling to £37,500 over 30 years. The ICER fell below £30 000 only when the intervention cost was below £631 per patient: we estimated the cost at £981. CONCLUSION: Given conventional thresholds of cost-effectiveness, the intensive treatment delivered in ADDITION was not cost-effective compared with routine care for individuals with screen-detected diabetes in the UK. The intervention may be cost-effective if it can be delivered at reduced cost.


Assuntos
Complicações do Diabetes/prevenção & controle , Diabetes Mellitus Tipo 2/economia , Diabetes Mellitus Tipo 2/terapia , Assistência Centrada no Paciente , Idoso , Análise por Conglomerados , Estudos de Coortes , Terapia Combinada/economia , Análise Custo-Benefício , Complicações do Diabetes/economia , Complicações do Diabetes/epidemiologia , Complicações do Diabetes/terapia , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/diagnóstico , Feminino , Custos de Cuidados de Saúde , Humanos , Incidência , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Educação de Pacientes como Assunto/economia , Assistência Centrada no Paciente/economia , Anos de Vida Ajustados por Qualidade de Vida , Fatores de Risco , Fatores de Tempo , Reino Unido/epidemiologia
8.
Niger Med J ; 56(4): 268-71, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26759512

RESUMO

BACKGROUND: The rising prevalence of cardiovascular diseases in the population has increased the demand for cardiovascular imaging procedures (specifically echocardiography) in our center. AIM: To determine the percentage of appropriate indications for echocardiography. MATERIALS AND METHODS: This was a prospective study conducted over a period of 1 year in the Department of Medicine of a Tertiary Health Care Center. The clinical diagnoses by the referring clinician and the indications (specific reasons for the study) for the echocardiography were consecutively recorded. The age and gender of the patients were also recorded. The indications were given a score of one to nine according to the revised appropriate use criteria of the American College of Cardiology Foundation and the American Society of Echocardiography (ASE). These indications were then classified into appropriate, inappropriate or uncertain based on the score. (1-3)-inappropriate use, (4-6) were derived. RESULTS: There were 25 indications, 16 (64%) were appropriate, 6 (24%) were inappropriate and three (12%) were rated as uncertain. CONCLUSION: Sixty-four percent of the indications for echocardiography are appropriate for the procedure. This implies that the criteria for echocardiography are yet to be fully implemented resulting in overutilization of the procedure.

11.
Br J Surg ; 97(2): 210-9, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20035545

RESUMO

BACKGROUND: : A recent systematic review found early laparoscopic cholecystectomy (ELC) to be safe and to shorten total hospital stay compared with delayed laparoscopic cholecystectomy (DLC) for acute cholecystitis. The cost-effectiveness of ELC versus DLC for acute cholecystitis is unknown. METHODS: : A decision tree model estimating and comparing costs to the UK National Health Service (NHS) and quality-adjusted life years (QALYs) gained following a policy of either ELC or DLC was developed with a time horizon of 1 year. Uncertainty was investigated with probabilistic sensitivity analysis, and value-of-information analysis estimated the likely return from further investment in research in this area. RESULTS: : ELC is less costly (approximately - pound820 per patient) and results in better quality of life (+0.05 QALYs per patient) than DLC. Given a willingness-to-pay threshold of pound20 000 per QALY gained, there is a 70.9 per cent probability that ELC is cost effective compared with DLC. Full implementation of ELC could save the NHS pound8.5 million per annum. CONCLUSION: : The results of this decision analytic modelling study suggest that on average ELC is less expensive and results in better quality of life than DLC. Future research should focus on quality-of-life measures alone.


Assuntos
Colecistectomia Laparoscópica/economia , Colecistite Aguda/cirurgia , Colecistite Aguda/economia , Análise Custo-Benefício , Humanos , Tempo de Internação , Anos de Vida Ajustados por Qualidade de Vida , Fatores de Tempo , Resultado do Tratamento
12.
BMJ ; 339: b3723, 2009 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-19837741

RESUMO

OBJECTIVES: To test the hypothesis that nurse led follow-up programmes are effective and cost effective in improving quality of life after discharge from intensive care. DESIGN: A pragmatic, non-blinded, multicentre, randomised controlled trial. SETTING: Three UK hospitals (two teaching hospitals and one district general hospital). PARTICIPANTS: 286 patients aged >or=18 years were recruited after discharge from intensive care between September 2006 and October 2007. INTERVENTION: Nurse led intensive care follow-up programmes versus standard care. Main outcome measure(s) Health related quality of life (measured with the SF-36 questionnaire) at 12 months after randomisation. A cost effectiveness analysis was also performed. RESULTS: 286 patients were recruited and 192 completed one year follow-up. At 12 months, there was no evidence of a difference in the SF-36 physical component score (mean 42.0 (SD 10.6) v 40.8 (SD 11.9), effect size 1.1 (95% CI -1.9 to 4.2), P=0.46) or the SF-36 mental component score (effect size 0.4 (-3.0 to 3.7), P=0.83). There were no statistically significant differences in secondary outcomes or subgroup analyses. Follow-up programmes were significantly more costly than standard care and are unlikely to be considered cost effective. CONCLUSIONS: A nurse led intensive care follow-up programme showed no evidence of being effective or cost effective in improving patients' quality of life in the year after discharge from intensive care. Further work should focus on the roles of early physical rehabilitation, delirium, cognitive dysfunction, and relatives in recovery from critical illness. Intensive care units should review their follow-up programmes in light of these results. TRIAL REGISTRATION: ISRCTN 24294750.


Assuntos
Cuidados Críticos/organização & administração , Estado Terminal/enfermagem , Adulto , Idoso , Análise Custo-Benefício , Cuidados Críticos/economia , Estado Terminal/economia , Seguimentos , Hospitais de Distrito , Hospitais de Ensino , Humanos , Assistência de Longa Duração/economia , Pessoa de Meia-Idade , Qualidade de Vida , Anos de Vida Ajustados por Qualidade de Vida , Resultado do Tratamento , Adulto Jovem
13.
Health Technol Assess ; 13(9): iii, ix-xi, 1-73, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19208305

RESUMO

OBJECTIVES: To assess the effects of acute pressor and depressor blood pressure (BP) manipulation on 2-week death and dependency following acute stroke and investigate the safety and efficacy of such treatments. DESIGN: A multicentre, prospective, randomised, double-blind, placebo-controlled titrated-dose trial. SETTING: Five hospitals in England. PARTICIPANTS: Patients over 18 years admitted to hospital with a clinical diagnosis of suspected stroke and either (1) symptom onset < 36 hours and hypertension, defined as systolic BP (SBP) < 160 mmHg (depressor arm), or (2) symptom onset < 12 hours and hypotension, defined as SBP < or = 140 mmHg (pressor arm). INTERVENTIONS: Patients were allocated to either the pressor or the depressor arm depending on blood pressure at randomisation. The ratio of allocation to active intervention versus matched placebo was 2:1 for the depressor arm and 1:1 for the pressor arm. MAIN OUTCOME MEASURES: The primary end point was death and dependency at 2 weeks, with dependency defined as a modified Rankin score < 3. Secondary end points were the safety of acute pressor (0-12 hours post stroke) and depressor (0-36 hours post stroke) BP manipulation in stroke patients; whether effects of BP reduction are influenced by stroke type (ischaemic versus haemorrhagic); whether alternative routes for administration of antihypertensive therapy (including sublingual and intravenous) are effective in dysphagic stroke patients; whether effects of BP manipulation are influenced by the time to treatment; and the short- and medium-term cost-effectiveness of such therapy in the acute post-stroke period on subsequent disability or death. RESULTS: 180 patients were recruited over the 36-month trial period, 179 in the depressor arm and one in the pressor arm (who received placebo). No significant difference was found in death or dependency at 2 weeks between those receiving active depressor treatment with lisinopril or labetalol and those receiving placebo, although numbers recruited to the trial were lower than projected. Active treatment was not associated with an increase in early neurological deterioration despite significantly greater reductions in BP at 24 hours and 2 weeks with active therapy compared with placebo. Active treatment was generally well tolerated and treatment discontinuation rates were similar in active and placebo groups. Survival analysis showed that the active treatment group had a lower mortality at 3 months than the placebo group (p = 0.05). The pressor arm was closed early because of problems with recruitment, so no conclusions can be drawn regarding this therapy. CONCLUSIONS: Oral and sublingual lisinopril and oral and intravenous labetalol are effective BP-lowering agents in acute cerebral infarction and haemorrhage and do not increase the likelihood of early neurological deterioration. The study was not sufficiently powered to detect a difference in disability or death at 2 weeks. However, the 3-month difference in mortality in favour of active treatment is of interest, although care must be taken in interpretation of the results. Further work is needed to confirm this and to assess whether there are differences in the effectiveness of labetalol compared with lisinopril in terms of reducing death or dependency after acute stroke, and whether the introduction of treatment post stroke earlier than was achieved here would be of greater benefit.


Assuntos
Anti-Hipertensivos/farmacologia , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea/efeitos dos fármacos , Cardiotônicos/uso terapêutico , Hipertensão/tratamento farmacológico , Hipotensão/tratamento farmacológico , Labetalol/farmacologia , Labetalol/uso terapêutico , Lisinopril/farmacologia , Lisinopril/uso terapêutico , Fenilefrina/farmacologia , Fenilefrina/uso terapêutico , Acidente Vascular Cerebral/tratamento farmacológico , Adulto , Idoso , Anti-Hipertensivos/economia , Cardiotônicos/economia , Cardiotônicos/farmacologia , Análise Custo-Benefício , Transtornos de Deglutição/tratamento farmacológico , Transtornos de Deglutição/etiologia , Método Duplo-Cego , Feminino , Hospitais , Humanos , Hipertensão/etiologia , Hipotensão/etiologia , Infusões Intravenosas , Labetalol/economia , Lisinopril/economia , Masculino , Pessoa de Meia-Idade , Fenilefrina/economia , Placebos , Acidente Vascular Cerebral/mortalidade , Acidente Vascular Cerebral/fisiopatologia , Análise de Sobrevida , Fatores de Tempo , Resultado do Tratamento
14.
Health Technol Assess ; 12(4): iii, v-ix, 1-78, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18284895

RESUMO

OBJECTIVES: To determine whether a social support intervention (access to an employed befriending facilitator in addition to usual care) is effective compared with usual care alone. Also to document direct and indirect costs, and establish incremental cost-effectiveness. DESIGN: The Befriending and Costs of Caring (BECCA) trial was a cost-effectiveness randomised controlled trial. Data on well-being and resource use were collected through interviews with participants at baseline and at 6, 15 and 24 months. SETTING: This research was carried out in the English counties of Norfolk and Suffolk, and the London Borough of Havering. It was a community-based study. PARTICIPANTS: Participants were family carers who were cohabiting with, or providing at least 20 hours' care per week for, a community-dwelling relative with a primary progressive dementia. INTERVENTIONS: The intervention was 'access to a befriender facilitator' (BF). BFs, based with charitable/voluntary-sector organisations, were responsible for local befriending schemes, including recruitment, screening, training and ongoing support of befriending volunteers, and for matching carers with befrienders. The role of befrienders was to provide emotional support for carers. The target duration for befriending relationships was 6 months or more. MAIN OUTCOME MEASURES: Depression was measured by the Hospital Anxiety and Depression Scale (HADS) at 15 months postrandomisation. The health-related quality of life scale EQ-5D (EuroQol 5 Dimensions) was used to derive utilities for the calculation of quality-adjusted life-years (QALYs). RESULTS: A total of 236 carers were randomised into the trial (116 intervention; 120 control). At final follow-up, 190 carers (93 intervention; 97 control) were still involved in the trial (19% attrition). There was no evidence of effectiveness or cost-effectiveness from the primary analyses on the intention-to-treat population. The mean incremental cost per incremental QALY gained was in excess of 100,000 pounds, with only a 42.2% probability of being below 30,000 pounds per QALY gained. Where care-recipient QALYs were included, mean incremental cost per incremental QALY gained was 26,848 pounds, with a 51.4% probability of being below 30,000 pounds per QALY gained. Only 60 carers (52%) took up the offer of being matched with a trained lay befriender, and of these only 37 (32%) were befriended for 6 months or more. A subgroup analysis of controls versus those befriended for 6 months or more found a reduction in HADS-depression scores that approached statistical significance (95% CI -0.09 to 2.84). CONCLUSIONS: 'Access to a befriender facilitator' is neither an effective nor a cost-effective intervention in the support of carers of people with dementia, although there is a suggestion of cost-effectiveness for the care dyad (carer and care recipient). In common with many services for carers of people with dementia, uptake of befriending services was not high. However, the small number of carers who engaged with befrienders for 6 months or more reported a reduction in scores on HADS depression that approached statistical significance compared with controls (95% CI -0.09 to 2.84). While providing only weak evidence of any beneficial effect, further research into befriending interventions for carers is warranted.


Assuntos
Cuidadores/psicologia , Demência/economia , Qualidade de Vida , Idoso , Cuidadores/economia , Análise Custo-Benefício , Demência/psicologia , Feminino , Amigos , Nível de Saúde , Humanos , Masculino , Testes Psicológicos , Psicometria
15.
J Natl Med Assoc ; 99(6): 627-31, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17595931

RESUMO

INTRODUCTION: The high cost of antiretroviral (ARV) drugs has led to the initiation of subsidized HIV treatment programs in developing countries. The care of tuberculosis (TB), a common opportunistic infection, is not built into the subsidized program. The current study was done to evaluate the cost burden of HIV/AIDS, TB, and TB and HIV/AIDS coinfections to the family. SUBJECTS AND METHODS: The study was carried out in the consultant outpatient department of the University of Benin Teaching Hospital in Nigeria. Consecutive families with 21 family member managed for HIV and or TB were recruited into three cohorts of HIV only, TB only and HIV/TB cohorts. The average monthly costs of treatment, transportation family income and percentage of income spent on care were computed for each family. The average monthly man-hours per family spent on clinic visitation were determined. RESULTS: A total of 61 families consisting of 128 family members met the study criteria. The mean cost of treatment per month was significantly higher in families in the HIV/TB cohort than in other cohorts, P = 0.0001. The mean percentage of income spent on treatment was significantly higher in the HIV/TB cohort compared to other cohorts, P = 0.0001. CONCLUSION: The cost of managing TB/HIV coinfection significantly increased the costs to the families in the subsidized HIV treatment program. It is recommended that a comprehensive package of subsidized HIV care that is inclusive of TB treatment and care for other comorbidities be initiated in developing countries.


Assuntos
Infecções Oportunistas Relacionadas com a AIDS/economia , Efeitos Psicossociais da Doença , Família , Tuberculose/economia , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Adolescente , Fármacos Anti-HIV/economia , Criança , Pré-Escolar , Comorbidade , Países em Desenvolvimento , Feminino , Custos de Cuidados de Saúde , Humanos , Lactente , Masculino , Nigéria , Tuberculose/tratamento farmacológico
16.
Rheumatology (Oxford) ; 46(7): 1096-101, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17409128

RESUMO

OBJECTIVES: Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect any system of the body. Involvement of the kidneys, lupus nephritis (LN), affects up to 50% of SLE patients during the course of their disease, and is characterized by periods of active disease (flares) and remission. For more severe nephritis, an induction course of immunosuppressive therapy is recommended. Options include intravenous cyclophosphamide (IVC) or mycophenolate mofetil (MMF), followed by a maintenance course, typically of azathioprine. The objective of this study is to determine which therapy results in better quality of life (QoL) for patients and which represents best value for money for finite health service resources. METHODS: A patient-level simulation model is developed to estimate the costs and quality-adjusted life-years (QALYs) of a patient treated with IVC or MMF for an induction period of six months. Efficacy, QoL, resource use and cost data are extracted from the literature and standard databases and supplemented with expert opinion where necessary. RESULTS: On average, the model predicts MMF to result in improved QoL compared with IVC. MMF is also less expensive than IVC, costing pound 1600 (euro 2400; US$ 3100) less over the period, based on 2005 NHS prices. The major determinant and cost driver of this result is the requirement for a day-case procedure to administer IVC. Sensitivity analysis shows an 81% probability that MMF will be cost-effective compared with IVC at a willingness to pay of pound 30,000 (euro 44,700; US$ 58,500) per QALY gained. CONCLUSION: MMF is likely to result in better QoL and be less expensive than IVC as induction therapy for LN.


Assuntos
Simulação por Computador , Imunossupressores/economia , Nefrite Lúpica/tratamento farmacológico , Modelos Econômicos , Ácido Micofenólico/análogos & derivados , Prednisolona/economia , Doença Aguda , Análise Custo-Benefício , Ciclofosfamida/administração & dosagem , Ciclofosfamida/economia , Ciclofosfamida/uso terapêutico , Hospital Dia/economia , Custos de Medicamentos , Humanos , Imunossupressores/uso terapêutico , Infusões Intravenosas , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Ácido Micofenólico/economia , Ácido Micofenólico/uso terapêutico , Prednisolona/uso terapêutico , Anos de Vida Ajustados por Qualidade de Vida , Medicina Estatal/economia
17.
Eur J Cancer Care (Engl) ; 16(2): 109-21, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17371419

RESUMO

There is growing evidence of inequalities in access to high-quality cancer services between minority and majority ethnic groups. However, little research has been carried out from the perspective of users from minority ethnic groups themselves. This paper reports a review of the British literature exploring the views and experiences of cancer service users from minority ethnic groups. We reviewed 25 qualitative studies that reported the experiences of people from minority ethnic groups. The studies highlighted significant issues and challenges, including comprehension and communication barriers, a lack of awareness of the existence of services and a perceived failure by providers to accommodate religious and cultural diversity. This paper critically discusses some of the explanations commonly invoked for ethnic inequalities in access to high-quality care, such as the belief that the lack of use of services reflects a lack of need. Despite positive initiatives to respond better to the needs of minority groups, we suggest the impact of these remains highly variable. Institutional racism within services is still much in evidence.


Assuntos
Institutos de Câncer , Atenção à Saúde/normas , Acessibilidade aos Serviços de Saúde/normas , Grupos Minoritários , Neoplasias/terapia , Atitude Frente a Saúde , Institutos de Câncer/estatística & dados numéricos , Institutos de Câncer/provisão & distribuição , Barreiras de Comunicação , Diversidade Cultural , Feminino , Necessidades e Demandas de Serviços de Saúde , Humanos , Masculino , Neoplasias/etnologia , Enfermagem Oncológica/organização & administração , Enfermagem Oncológica/normas
18.
Diabet Med ; 20(5): 394-8, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12752489

RESUMO

AIMS: To assess the process of clinical care and outcomes of young patients with diabetes attending clinics at a large district general hospital. METHODS: Retrospective analysis of data obtained from 106 case notes of patients aged 12-22 years attending the paediatric, combined adolescent or adult diabetes clinics between 1998 and 2000. The frequency of follow-up, rate of admission, glycaemic control, systolic blood pressure, weight change and screening for complications were assessed. RESULTS: The mean attendance rate was 78%. The admission rate was 91 admissions per 1000 patient years. Overall, the mean HbA1c was 9.1% with only 15% of paediatric and adolescent patients having mean HbA1c

Assuntos
Continuidade da Assistência ao Paciente , Diabetes Mellitus/enfermagem , Hemoglobinas Glicadas/análise , Hospitais de Distrito/normas , Qualidade da Assistência à Saúde/normas , Adolescente , Adulto , Glicemia/análise , Pressão Sanguínea , Pesos e Medidas Corporais , Criança , Complicações do Diabetes , Feminino , Humanos , Masculino , Transferência de Pacientes/organização & administração , Estudos Retrospectivos
19.
Aviat Space Environ Med ; 73(9): 851-8, 2002 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12234034

RESUMO

BACKGROUND: There have been few well-designed studies which estimate the costs inflicted on society from injuries, fatalities, and property damage caused by aviation crashes. Furthermore, indirect cost estimates from the human capital (HC) approach tend to be substantially smaller than those obtained from the willingness-to-pay (WTP) approach. OBJECTIVES: To estimate the direct and indirect costs of general aviation crashes in New Zealand, and to contrast the HC and WTP approaches used to estimate indirect costs. METHODS: The incidence, morbidity, and mortality from aviation crashes between 1988 and 1997 were estimated from national health and aviation records. Direct costs included medical treatment, damage to aircraft and property, and the cost of crash investigation. For the HC approach, we valued losses to society as the value of lost production from both employed work and household activity. For the WTP approach, we used the Land Transport Safety Authority's estimated values of society's willingness to pay to avoid a fatality or injury. RESULTS: The annual average direct cost of aviation crashes was $9.1 m (range: $8.0 m to $11.4 m). The annual average indirect cost using the HC approach was $13.6 m ($5.6 m to $32.2 m). Using the WTP approach the annual average indirect costs was $49.3 m ($20.6 m to $106.5 m). Indirect costs from premature deaths were the key cost drivers. A sensitivity analysis showed that these values were relatively robust to changes in parameters. CONCLUSION: The annual average cost of general aviation crashes in New Zealand was between $22.6 m and $58.4 m. Indirect costs using the WTP approach were 3.5 times greater than those estimated using the HC approach.


Assuntos
Acidentes Aeronáuticos/economia , Custos e Análise de Custo/estatística & dados numéricos , Acidentes Aeronáuticos/mortalidade , Efeitos Psicossociais da Doença , Eficiência , Emprego/economia , Financiamento Pessoal , Custos de Cuidados de Saúde/estatística & dados numéricos , Hospitalização/economia , Humanos , Nova Zelândia/epidemiologia , Valor da Vida/economia
20.
Waste Manag Res ; 20(1): 16-22, 2002 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-12020091

RESUMO

Evaluating the environmental performance of municipal solid waste management options is a complex task. Part 1 of this study presents the municipal solid waste management program of the Pamplona Region in Spain, exploring the institutional, operational and economic factors of the program. In Part 2, alternative waste management scenarios that include the selective collection of organic material and composting are illustrated. The use of a Life Cycle Inventory model for waste management allows for the comparison of the environmental burdens of the different scenarios. This use of a Life Cycle Inventory model for solid waste management lets program managers and decision makers include energy use, final solid waste, and Greenhouse gas emissions in the decision making process. Additionally, the different management scenarios are evaluated on their ability to fulfil Pamplona regional objectives and meet European Packaging and Landfill Directive targets.


Assuntos
Conservação dos Recursos Naturais , Meio Ambiente , Modelos Teóricos , Eliminação de Resíduos , Cidades , Custos e Análise de Custo , Tomada de Decisões , Fontes Geradoras de Energia , Espanha
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