Hepatic Encephalopathy Challenges, Burden, and Diagnostic and Therapeutic Approach.

Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with cirrhosis. The impact of HE on the health care system is similarly profound. The number of hospital admissions for HE has increased in the last 10-year period. HE is a huge burden to the patients, care givers, and the health care system. HE represents a "revolving door" with readmission, severely affects care givers, and has effects on cognition that can persists after liver transplant. This article reviews the current literature to discuss the challenges and diagnostic and therapeutic approaches to HE.

A review of the use of transient elastography in the assessment of fibrosis and steatosis in the post-liver transplant patient.

Liver biopsy is considered the gold standard method for diagnosing and staging liver disease, particularly in the post-liver transplant setting. Given the invasive nature of biopsy, alternate means for accurately assessing liver fibrosis and steatosis are preferred especially as the number of patients with fatty liver disease is increasing. Transient elastography has been validated as a useful tool for evaluation of liver fibrosis, as has controlled attenuation parameter index as a tool for assessing steatosis. It is a non-invasive, rapid, and highly reproducible approach to demonstrate the presence of fibrosis among non-transplant patients with chronic liver disease of various etiologies. However, it has not yet found wide acceptance in liver transplant recipients. There are few published studies evaluating the merits and applicability of transient elastography to assess allografts after liver transplantation. We review the published data on the use of transient elastography with concurrent controlled attenuation parameter in liver transplant recipients and recommend its greater use to follow allograft function over time.

Assessment of the mechanically ventilated patient: an advanced practice approach.

Multiple perspectives must be considered when assessing the mechanically ventilated patient. Assessment begins before the advance practice nurse (APN) encounters the patient. Important information about the patient can be gleaned from the history, medications, and social history. The APN then observes the patient to determine if patient-ventilator synchrony has been achieved. Physical findings are gathered and correlated with the chest radiogram. Data from the ventilator are evaluated to assess compliance, minute ventilation, tidal volume, and other parameters that will assist in the evaluation of the patient's needs. Electrolytes, acid-base state, and nutrition must all be considered to obtain a complete assessment of these patients. From all these data points, the APN can develop a detailed plan of care that will enhance positive patient outcomes.