The Design and Validation of a Self-Assessment Questionnaire of Critical Appraisal of Medical Literature Skills in Medical Students.

Introduction: Critical appraisal of medical literature is a challenging step of the evidence-based medicine practice. Many assessment questionnaires have been published in the literature, but they have mainly focused on all the evidence-based medicine practice process. The authors aimed to develop and validate a questionnaire assessing the critical appraisal skills of medical students from the same Faculty. Methods: The questionnaire was developed by item generation through a review of the literature and an expert committee. The questionnaire was validated in terms of content validity and construct validity. Fitness of data for analysis was checked through Kaiser-Meyer-Olkin (KMO) and Bartlett's sphericity. Construct validity was carried out using a principal axis exploratory factor analysis (EFA) with 'varimax' rotation to study the internal structure of the questionnaire and to extract the test major factors. The questionnaire was administrated to a cohort of under and postgraduate medical students (n=84) to evaluate the test reliability and select the best items. The reliability of the questionnaire was assessed by Cronbach's alpha coefficient to evaluate the internal consistency. The correlations between the self-confidence and satisfaction dimension score, the critical thinking dimension score, the learning style dimension score, the Fresno-adapted test scores and the total score were assessed using the Spearman's correlation test. Results: The questionnaire consisted of 31 items. A factorial analysis grouped the items into 3 dimensions that consisted of the self-confidence and satisfaction dimension, the critical thinking dimension and the learning style dimension. Cronbach's alpha accounted for 0.95, CI95% [0.9-1] for the entire questionnaire. The factor analysis explained 79.51% of the variance. The external validity assessment based on a Spearman's correlation study highlighted a weak correlation between the total scores and the critical thinking dimension and the self-perception and satisfaction dimension. Conclusion: In spite of the limitations of this study, mainly the small number of the students recruited, the questionnaire seems to measure with adequate reliability the competences of under and postgraduate medical students.

Assessment of debriefing in high-fidelity mannequin simulation: study among students in cardiology.

INTRODUCTION: Debriefing is the fundamental step in the learning process when teaching by simulation. The Debriefing Assessment for Simulation in Healthcare (DASH) guide is a tool designed to assess and develop the debriefing skills of trainers using healthcare simulation. AIM: To evaluate the debriefing in high-fidelity mannequin simulation in the management of cardiological emergency by the DASH tool, student version. METHODS: This was a bicentric, prospective, cross-sectional and evaluative study including five groups of students in the first year of the second cycle of medical studies completing their internship in the cardiology departments of the Habib Thameur hospital and the Internal Security Forces Hospital of Marsa during the first semester of the 2021-2022 academic year. The simulation scenario included the diagnosis and emergency management of degenerative syncopal atrioventricular block. RESULTS: Forty-four students completed the DASH assessment form (28 female, 16 male). According to the students, the trainers had maintained a climate conducive to learning (6.51±0.74). They had conducted the debriefing in a structured way (6.35±0.75). They had aroused engagement in the exchange leading the learner to analyze his performance (6.01±1.03). They had effectively identified the learner's strengths and areas for improvement as well as their reasons (6.39±1.04). The trainers had helped the learners to consider how to improve or maintain a good level of performance (6.57±0.77). The mean DASH score evaluating the trainers was 6.36±0.88. CONCLUSION: The DASH tool allows trainers to highlight the strengths and areas for improvement in the debriefing, which is the key step in the simulation to optimize the clinical reasoning process and improve the quality of care.

Epidemiological characteristics, management, and outcomes of atrial fibrillation in TUNISIA: Results from the National Tunisian Registry of Atrial Fibrillation (NATURE-AF).

BACKGROUND: Contemporary registries on atrial fibrillation (AF) are scare in North African countries. HYPOTHESIS: In the context of the epidemiological transition, prevalence of valvular AF in Tunisia has decreased and the quality of management is still suboptimal. METHODS: NATURE-AF is a prospective Tunisian registry, involving consecutive patients with AF from March 1, 2017 to May 31, 2017, with a one-year follow-up period. All the patients with an Electrocardiogram-documented AF, confirmed in the year prior to enrolment were eligible. The epidemiological characteristics and outcomes were described. RESULTS: A total of 915 patients were included in this study, with a mean age of 64.3 ± 22 years and a male/female sex ratio of 0.93. Valvular AF was identified in 22.4% of the patients. The mean CHA2 DS2 VASC score in nonvalvular AF was 2.4 ± 1.6. Monotherapy with antiplatelet agents was prescribed for 13.8% of the patients. However, 21.7% of the subjects did not receive any antithrombotic agent. Oral anticoagulants were prescribed for half of the patients with a low embolic risk score. In 341 patients, the mean time in therapeutic range was 48.87 ± 28.69%. Amiodarone was the most common antiarrhythmic agent used (52.6%). During a 12-month follow-up period, 15 patients (1.64%) had thromboembolism, 53 patients (5.8%) had major hemorrhage, and 52 patients (5.7%) died. CONCLUSIONS: NATURE-AF has provided systematic collection of contemporary data regarding the epidemiological and clinical characteristics as well as the management of AF by cardiologists in Tunisia. Valvular AF is still prevalent and the quality of anticoagulation was suboptimal.

Assessment of atrial conduction time by Doppler tissue imaging in hypertensive patients.

BACKGROUND: Hypertension is the first cause of atrial fibrillation. Its onset is explained by intricate mechanisms such as atrial conduction impairment. AIM: To evaluate atrial conduction by tissue Doppler imaging in hypertensive patients compared to a control group. METHODS: This is a comparative prospective study performed in the cardiology department of the FSI hospital   enrolling 55 patients with hypertension and 55 controls. All of them underwent a complete echocardiocardiography exam with Doppler tissue imaging. We measured intraatrial and interatrial electromechanical delay by Pulsed Tissue Doppler. Statical analysis was conducted using SPSS version 22.0. Comparison of means was made with t student test. RESULTS: Left ventricular mass and septal thikness were more important in the hypertensive group. Mitral A wave was greater in hypertensive group compared to controls (7,1cm/s vs 5,6cm/s; p<0,0001; respectively). Left atrial volume was of 32,7±6,8mL/m² in hypertensives vs 29,5±4,3 mL/m² in controls (p=0,006). Doppler Tissue study showed homogeneous statistically significant elongation of atrial conduction times in hypertensive patients compared to controls: interatrial time (16.8±7.8ms vs 12.4±4,2ms, p<0.0003) and left intraatrial (27.6±8.6ms vs 19.0±4.3ms, p<0.0001) and right intraatrial time (10.8±6.0ms vs 6.6±2.9ms, p<0.0001; respectively for hypertensive and control subjects. There was a significant correlation between measured intraatrial and interatrial electromechanical delays and duration of hypertension, indexed left atrial volume ans indexed left ventricular mass (r 0.27-0.41, p<0.001). CONCLUSION: Atrial conduction time is significantly longer in hypertensive patients. Impairment of atrial conduction may be predictive of atrial fibrillation and should prompt closer surveillance to detect this arrhythmia in these patients.

Assessment of left atrial mechanical function by two-dimensional echocardiography in hypertensive patients.

INTRODUCTION: The left atrium (LA) have an important role in the normal functioning of the heart thanks to its three functions: reservoir, conduct and pump. Several pathologies lead directly or indirectly to morphological and functional modifications of the LA. AIM:   Investigate the effect of arterial hypertension on LA size and function. METHODS:   Prospective study including 50 hypertensive patients compared to 50 healthy controls. LA Volumes were measured using transthoracic echocardiography by biplane Simpson  method  at different times of cardiac cycle: at the end of systole (maximum LA volume (Vmax)), at mitral valve  closure (minimum LA volume (Vmin)) and immediately before LA contraction (Vp)). LA reservoir function (total emptying volume and expansion index), conduct function (passive emptying volume and passive emptying fraction) and pumping function (active emptying volume and active emptying fraction) have been calculated. RESULTS:   Hypertension was associated with an increase of all LA volumes: Vmax (p<0.001),  Vmin (p=0.001) and Vp (p<0.001). LA reservoir function evaluated by LA total emptying volume was higher in hypertensives than in control group (p=0.032). LA conduct function was impaired in hypertensive patients with a significantly lower passive emptying fraction in hypertensive group compared to control group (22 ± 12% versus 32 ± 11%, p <0.001, respectively). This decrease was greater in the presence of left ventricular hypertrophy (p = 0.02). LA pumping function was significantly higher in hypertensive patients than in controls with an increase of LA active emptying fraction (35±12% versus 30±12%respectively; p=0.037). The increase of LA pumping function was found to be higher in hypertensive patients with impaired diastolic function (p=0.029). CONCLUSION:   Hypertension was associated with an increase of pumping and reservoir functions and a decrease in left atrial passive emptying function. These changes appear to be related to left ventricular hypertrophy and the degree of left ventricular diastolic dysfunction.

Echocardiographic assessment of left ventricular dyssynchrony and correlation with QRS width in chronic heart failure.

BACKGROUND: Echocardiographic parameters of mechanical dyssynchrony may improve patients selection for cardiac resynchronisation therapy in chronic heart failure. AIM: This study aimed to define the prevalence of inter, intra and atrio-ventricular dyssynchrony in heart failure patients with different QRS duration and to evaluate inter and intra-observer variability in collecting different echocardiographic dyssynchony parameters. METHODS: Twenty patients with chronic heart failure of any origin, NYHA functional class II-III with LVEF < 40%, were evaluated by complete echocardiographic examination including tissue Doppler imaging (DTI) and Tissue Tracking. RESULTS: Three patients had an atrio-ventricular dyssynchrony with a mean left ventricular filling time to cardiac cycle of 33 +/- 5%. Six patients had an interventricular mechanical delay (IVMD) > or = 40 milliseconds, all of them had a QRS duration > or = 120 milliseconds. Overall, no statistically significant correlation was found between IVMD and QRS duration (r = 0.35, p = 0.4). The mean septal to posterior wall-motion delay (SPWMD) was 83 +/- 64 ms. 7 patients had SPWMD > or = 130 ms. The baseline QRS duration did not correlate with SPWMD (p = 0.7). The mean LV dyssynchrony determined by deltaS-peak was 74 +/- 42 ms. Seven patients had LV dyssynchrony. Linear regression did not demonstrate a relation between QRS width and intraventricular dyssynchrony (p = 0.34). There was no concordance between intra-ventricular spatial or longitudinal dyssynchrony determined by DTI method and by Tissue Tracking (p = 0.3 and 0.6 respectively). The intraobserver reproducibility of LVFT/RR, IVMD and deltaS-peak (ICC = 0.99, 0.98 and 0.99, respectively), as well as the interobserver reproducibility (ICC: 0.96, 0.94 and 0.92, respectively), were very high. However, we observed a high variability for SPWMD measure (ICC = 0.27, p = 0.31). CONCLUSION: Mechanical dyssynchrony did not correlate with QRS duration, despite the poor variability in collecting different echocardiographic parameters.