Assessment and analysis of the balance between economic development and ecological environment protection and its implementation strategy derived from spatial planning-Take three heterogeneous and representative provinces in China as an example.

Balancing ecological environment protection (EEP) and economic development (ED) (balance for short) is a difficult problem that must be solved in the development of modern society, particularly important for realizing UN Sustainable Development Goals. How to assess the regional balance situation and reveal the spatial and temporal heterogeneous characteristics of the balance (especially for the vast China) and its influencing factors are the primary scientific problems and realistic needs. Taking Zhejiang, Hunan and Gansu Provinces in the eastern, central and western region of China as a regional representative, an index system characterizing EEP and ED were established, which were processed by extreme difference method and entropy weight method. The coupling characteristics, stress factors and coordination type from 2010 to 2019 in the 3 provinces were assessed and analyzed by means of the coupling coordination model and the grey correlation degree model. Balance is the mission and responsibility of the spatial planning system for spatial planning is of the source, whole-region and comprehensiveness of public strategy, therefore, the balance strategies and its integration approaches are constructed in the 3 provincial spatial planning based on the assessment and analysis of balance characteristics. Research results show that: (1) the 3 provinces' coupling coordination degree is rising year by year, coordination type is more and more better indicating that the balance of EEP and ED is getting better and better, but coordination type differentiates at one level between 3 provinces at the east, central, western region of China, Zhejiang province is from nearby imbalance to primary coordination, Hunan Province is from nearby imbalance to narrow coordination, and Gansu Province is from medium imbalance to nearby imbalance. (2) The ED have same strong stress on EEP in the 3 provinces, and the constraints of EEP on ED are different, the current balance characteristics of Zhejiang, Hunan and Gansu province are the types of ecological environment pressure constraints primary coordination, ecological environment pressure constraints narrow coordination, and ecological environment condition constraints nearby imbalance. (3) The coordination types are the co-environmental pressure constraints primary coordination (Zhejiang Province), eco-environmental pressure constraints narrow coordination (Hunan Province) and eco-environmental condition constraints nearby imbalance (Gansu Province), and corresponding balanced planning strategy system are to promote ecological modernization, implement ecological industrialization and adhere to the ecological fundamentalization.

Risk assessment and stratification of mild cognitive impairment among the Chinese elderly: attention to modifiable risk factors.

BACKGROUND: The early identification of individuals at risk of mild cognitive impairment (MCI) has major public health implications for Alzheimer's disease prevention. OBJECTIVE: This study aims to develop and validate a risk assessment tool for MCI with a focus on modifiable factors and a suggested risk stratification strategy. METHODS: Modifiable risk factors were selected from recent reviews, and risk scores were obtained from the literature or calculated based on the Rothman-Keller model. Simulated data of 10 000 subjects with the exposure rates of the selected factors were generated, and the risk stratifications were determined by the theoretical incidences of MCI. The performance of the tool was verified using cross-sectional and longitudinal datasets from a population-based Chinese elderly cohort. RESULTS: Nine modifiable risk factors (social isolation, less education, hypertension, hyperlipidaemia, diabetes, smoking, drinking, physical inactivity and depression) were selected for the predictive model. The area under the curve (AUC) was 0.71 in the training set and 0.72 in the validation set for the cross-sectional dataset. The AUCs were 0.70 and 0.64 in the training and validation sets, respectively, for the longitudinal dataset. A combined risk score of 0.95 and 1.86 was used as the threshold to categorise MCI risk as 'low', 'moderate' and 'high'. CONCLUSION: A risk assessment tool for MCI with appropriate accuracy was developed in this study, and risk stratification thresholds were also suggested. The tool might have significant public health implications for the primary prevention of MCI in elderly individuals in China.

Global burden of female breast cancer and its association with socioeconomic development status, 1990-2044.

BACKGROUND: Breast cancer is a widespread disease in women worldwide. AIM: We aimed to explore the global epidemiological trends of female breast cancer (FBC) between 1990 and 2044. METHODS AND RESULTS: Disease burden, population, and socio-demographic index (SDI) data were obtained from the Global Health Data Exchange (GHDx) database. We analyzed temporal trends, age differences, risk factors, and geographic patterns of FBC disease burden globally and explored the association between age-standardized incidence rate (ASIR) of FBC and SDI. Bayesian age-period-cohort model was also performed to predict the changes in FBC incidence worldwide from 2020 to 2044. First, the global ASIR of FBC increased by 14.31% from 1990 to 2019 (95% Uncertainty Interval 4.75% to 23.98%). The death rate presented a falling trend. Second, alcohol use is the most-highlighted risk factor for FBC in some high-income regions such as Europe. A high fasting plasma glucose levels is the most prominent risk factor for FBC in Latin America and Africa. Third, the ASIR of the FBC increases with the SDI. Fourth, the incidence is expected to increase faster among women aged 35-60 years and fastest for those aged 50-54 years from 2020 to 2044. Countries with a high incidence of FBC that is expected to increase significantly include Barbados, Burkina Faso, Senegal, Monaco, Lebanon, Togo, and Uganda. CONCLUSION: The disease burden of FBC varies worldwide; the findings suggest attaching importance to the control of middle and low-middle SDI regions. Public health as well as cancer prevention experts should pay more attention to regions and populations at an increased risk of developing FBC, focusing on their prevention and rehabilitation while conducting further epidemiological studies to investigate the risk factors of their increase.