Assessment of gustatory function in aging people using event-related potentials.

Gustatory dysfunctions are more frequent than other chemosensory dysfunctions in aging people. Gustatory event-related potentials (ERPs) has been suggested as a reliable and effective approach for assessing gustatory functions in young and middle subjects, but has rarely been investigated in aging people, leaving influencing factors of ERPs in that population not completely understood. In this study, we analyzed gustatory ERPs results of aging participants and characterized potential impacting factors, including age, sex, BMI, drinking, smoking, hypertension, diabetes, cognition and psychophysical test scores of gustation and olfaction. Our results revealed three components (P1, N1 and P2) in gustatory ERPs upon salty stimulation. Significant differences between responses collected from different recording electrodes were observed: minimum latencies and maximum amplitudes of P1 were detected at frontal electrode, and maximum amplitudes of N1 and P2 were detected at central and centro-parietal electrodes, respectively. Major cortical sources of components P1, N1 and P2 were located at bilateral insula, frontal operculum, and orbitofrontal cortex. Diabetes was positively associated with latencies of P1. Sex was positively associated with amplitudes of P1, N1 and P2. Hypertension was negatively associated with amplitudes of P1 and P2. In conclusion, gustatory ERPs in aging people exhibited a specific topographical distribution, represented by sex-related differences and negative impacts of diabetes and hypertension.

Validation of a simple diet self-assessment tool (SDSAT) in head and neck cancer patients undergoing radiotherapy.

PURPOSE: The simple diet self-assessment tool (SDSAT) is a simple instrument for estimating the cancer patients' dietary intake. This study aimed to evaluate its reliability and validity among head and neck (HNC) cancer patients undergoing radiotherapy (RT). METHODS: Two studies were conducted at the department of radiation oncology of a University-affiliated hospital, where HNC patients were assessed at baseline, mid-treatment and post-treatment of RT. In the first study, 25 patients (a total of 60 cases) were recruited by convenience sample method to estimate the interrater reliability of SDSAT. Then, 304 patients (a total of 912 cases) were involved in a prospective, longitudinal observational study. The criterion validity was confirmed by the agreement rate between SDSAT and 24-h dietary recall (24HR). The predictive validity was established by exploring the impact of the score of SDSAT on weight loss among HNC patients during RT. RESULTS: The estimation of interrater reliability of SDSAT showed that weighted kappa was 0.82 (95%CI = 0.74-0.90, p < 0.001), suggesting a high level of agreement between two raters. The overall agreement rate between SDSAT and 24HR was 62.9% (574/912) and weighted kappa was 0.66 (95%CI = 0.63-0.70, p < 0.001), which indicated good criterion validity. Generalized estimating equation (GEE) showed that the score of SDSAT had a significant impact on weight loss (ß = 1.40, 95%CI = 1.21-1.59, p < 0.001), which demonstrated good predictive validity. CONCLUSIONS: The SDSAT demonstrated favorable reliability and validity. It is appropriate for estimation of dietary intake among HNC patients.