LRFNet: A deep learning model for the assessment of liver reserve function based on Child-Pugh score and CT image.

BACKGROUND AND OBJECTIVE: Liver reserve function should be accurately evaluated in patients with hepatic cellular cancer before surgery to evaluate the degree of liver tolerance to surgical methods. Meanwhile, liver reserve function is also an important indicator for disease analysis and prognosis of patients. Child-Pugh score is the most widely used liver reserve function evaluation and scoring system. However, this method also has many shortcomings such as poor accuracy and subjective factors. To achieve comprehensive evaluation of liver reserve function, we developed a deep learning model to fuse bimodal features of Child-Pugh score and computed tomography (CT) image. METHODS: 1022 enhanced abdomen CT images of 121 patients with hepatocellular carcinoma and impaired liver reserve function were retrospectively collected. Firstly, CT images were pre-processed by de-noising, data amplification and normalization. Then, new branches were added between the dense blocks of the DenseNet structure, and the center clipping operation was introduced to obtain a lightweight deep learning model liver reserve function network (LRFNet) with rich liver scale features. LRFNet extracted depth features related to liver reserve function from CT images. Finally, the extracted features are input into a deep learning classifier composed of fully connected layers to classify CT images into Child-Pugh A, B and C. Precision, Specificity, Sensitivity, and Area Under Curve are used to evaluate the performance of the model. RESULTS: The AUC by our LRFNet model based on CT image for Child-Pugh A, B and C classification of liver reserve function was 0.834, 0.649 and 0.876, respectively, and with an average AUC of 0.774, which was better than the traditional clinical subjective Child-Pugh classification method. CONCLUSION: Deep learning model based on CT images can accurately classify Child-Pugh grade of liver reserve function in hepatocellular carcinoma patients, provide a comprehensive method for clinicians to assess liver reserve function before surgery.

Technological Requirements and Challenges in Wireless Body Area Networks for Health Monitoring: A Comprehensive Survey.

With the rapid growth in healthcare demand, an emergent, novel technology called wireless body area networks (WBANs) have become promising and have been widely used in the field of human health monitoring. A WBAN can collect human physical parameters through the medical sensors in or around the patient's body to realize real-time continuous remote monitoring. Compared to other wireless transmission technologies, a WBAN has more stringent technical requirements and challenges in terms of power efficiency, security and privacy, quality of service and other specifications. In this paper, we review the recent WBAN medical applications, existing requirements and challenges and their solutions. We conducted a comprehensive investigation of WBANs, from the sensor technology for the collection to the wireless transmission technology for the transmission process, such as frequency bands, channel models, medium access control (MAC) and networking protocols. Then we reviewed its unique safety and energy consumption issues. In particular, an application-specific integrated circuit (ASIC)-based WBAN scheme is presented to improve its security and privacy and achieve ultra-low energy consumption.

[Research on biometric method of heart sound signal based on GMM].

OBJECTIVE: Extraction of cepstral coefficients combined with Gaussian Mixture Model (GMM) is used to propose a biometric method based on heart sound signal. METHODS: Firstly, the original heart sounds signal was preprocessed by wavelet denoising. Then, Linear Prediction Cepstral Coefficients (LPCC) and Mel Frequency Cepstral Coefficients (MFCC) are compared to extract representative features and develops hidden Markov model (HMM) for signal classification. At last, the experiment collects 100 heart sounds from 50 people to test the proposed algorithm. RESULTS: The comparative experiments prove that LPCC is more suitable than MFCC for heart sound biometric, and by wavelet denoising in each piece of heart sound signal, the system achieves higher recognition rate than traditional GMM. CONCLUSION: Those results show that this method can effectively improve the recognition performance of the system and achieve a satisfactory effect.