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1.
iScience ; 27(6): 109924, 2024 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-38827403

RESUMO

Since the Russia-Ukraine war in February 2022, European electricity prices have experienced considerable turbulence, primarily attributed to a shortage in the natural gas supply. We investigate the relationship between natural gas prices in the European continent and electricity prices in Nordic countries before and after the outbreak of war. Despite the low proportion of natural gas electricity generation, the empirical analysis reveals both direct and indirect transmission paths for natural gas prices in Nordic countries. Meanwhile, the theoretical analysis demonstrates how Nordic renewable (wind and solar) and other non-gas generators exercise market power through price bidding in the anticipation of an increase in gas prices or a shortage of gas supply, which results in higher electricity prices. Understanding the underlying factors and dynamics driving substantial price fluctuations in the Nordic electricity market is essential for comprehending the intricate interconnections within the European energy landscape.

2.
Front Psychol ; 15: 1361158, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38746924

RESUMO

Introduction: Why do some people show more corruption when facing uncertain environment? The present study aimed to give a plausible answer from an evolutionary perspective: this might be rooted in people's different life history strategies (slow vs. fast). Methods: The present study measured the participants' corrupt intentions by a hypothetical scenario and primed the feeling of economic environmental uncertainty by requiring the participants to read economic uncertainty (vs. neutral) materials. Results: It is revealed that the participants with fast life history strategies had stronger corrupt intentions after reading materials about economic uncertainty than reading neutral materials. In addition, the desire for power mediated the interactive effect between life history strategy and economic uncertainty on corrupt intentions for fast life history strategists. Discussion: This finding was discussed for its theoretical and practical implications from the perspective of life history theory.

3.
PLoS One ; 19(5): e0303997, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38781252

RESUMO

BACKGROUND: The Chinese government has been promoting commercial medical insurance (CMI) in recent decades as it plays an increasingly important role in addressing disease burden, health inequities, and other healthcare challenges. However, compared with developed countries, the CMI is still less fledged with low coverage. OBJECTIVE: This study aims to explore the factors associated with enrollment in CMI, with regards to explicit characteristics (including sociodemographic characteristics and family economic status), latent characteristics (including social security status), and the global incentive compatibility index (including health status), to inform the design of CMI to improve its coverage in China. METHODS: Based on the principal-agent model, we summarized and classified the factors associated with the enrollment in CMI, and then analyzed the data generated from the Chinese General Social Survey in 2015,2018 and 2021 respectively. A comparison of factors regarding sociodemographic characteristics, family economic status, social security status, and health status was conducted between individuals enrolled and unenrolled in CMI using Mann-Whitney U test and Chi-square test. Binary logistic regression analysis was used to explore factors influencing the enrollment status of CMI. RESULTS: Of all individuals, the proportion of enrolled individuals shows an increasing trend year by year, with 8.7%,11.8% and 14.1% enrolled in CMI in 2015,2018 and 2021, respectively. The binary regression analysis further suggested that the factors associated with the enrollment in CMI were consistent in 2015,2018 and 2021.We found that individuals divorced, obese, who had a higher level of education, had non-agricultural household registration, perceived themselves as the upper social status, conducted daily exercise, had more family houses, had a car, had investment activities, or did not have basic health insurance were more likely to be enrolled in CMI. CONCLUSIONS: We identified multidimensional factors associated with the enrollment of CMI, which help inform the government and insurance industry to improve the coverage of CMI.


Assuntos
Seguro Saúde , Humanos , China , Seguro Saúde/economia , Feminino , Masculino , Adulto , Pessoa de Meia-Idade , Inquéritos e Questionários , Fatores Socioeconômicos , Adulto Jovem , Adolescente , Idoso , Nível de Saúde
4.
Front Med (Lausanne) ; 10: 1240253, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38131042

RESUMO

Objectives: This study aims to explore the relationship between the severity of asthma and neutrophils and related oxidative stress-associated molecules in peripheral blood and induced sputum. Methods: A total of 67 subjects were included in this study, namely, 25 patients with severe asthma and 42 patients with non-severe asthma. Clinical data, induced sputum and peripheral blood were collected. Lung function and molecules related to oxidative stress in induced sputum and peripheral blood of asthma patients were detected. The relationship between neutrophils and asthma severity was analyzed. HDAC2 mRNA and protein expression levels and HDAC2 activity were also analyzed. Multivariate logistic regression was performed to select statistically significant variables. Results: The absolute value of neutrophils and percentage of neutrophils were higher in the severe asthma patients. These two values were used to predict the severity of asthma by ROC analysis, with the best cutoff values being 4.55 × 109/L (sensitivity 83.3%, specificity 64.0%) and 55.15% (sensitivity 54.8%, specificity 88.0%). The ROS concentration of neutrophils in the induced sputum samples and the 8-iso-PGF2α concentration in the peripheral blood samples were higher in the severe asthma group (P = 0.012; P = 0.044), whereas there was reduced HDAC2 protein activity in PBMCs (P < 0.001). A logistic equation and a nomogram were created to give a precise prediction of disease severity. Conclusion: Oxidative stress is increased in severe asthma patients. Peripheral blood neutrophils and 8-iso-PGF2α can be used as biomarkers to predict the severity of asthma. A prediction model was created for evaluating asthma severity.

5.
BMC Ophthalmol ; 23(1): 460, 2023 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-37968622

RESUMO

OBJECTIVE: To quantify corneal nerve fiber parameters in a Mongolian population with diabetic peripheral neuropathy (DPN) by corneal confocal microscopy. METHODS: This study conducted a comprehensive evaluation of 114 participants from Hulunbuir between January 2020 and December 2021. The participants included healthy controls, Mongolian and Han patients with type 2 diabetes mellitus. Demographic, medical, and laboratory data were collected, and neuropathy was evaluated by confocal corneal microscopy. And compare various parameters between Han and Mongolian were performed using SPSS software. RESULTS: The average waist circumference of Mongolian diabetic patients was larger than that of Han diabetic patients (P < 0.05). The mean HbA1c of Mongolian was 9.30 (8.15, 10.30) %, and that of Han was 8.30 (7.20, 9.40) % (P = 0.023). The average values of Corneal Nerve Fiber Density (CNFD), Corneal Nerve Fiber Length (CNFL) and corneal nerve branch density (CNBD) in Mongolian diabetic patients were significantly lower than those in Han diabetic patients (P < 0.05). The correlation coefficient between CNFL and age was - 0.368. ROC results show that CNBD has a certain diagnostic value for DPN in Mongolian patients with type 2 diabetes and the optimal cut-off point value is 24.99(no./mm2), the sensitivity is 80.0%, and the specificity is 77.8%. CONCLUSION: The corneal confocal microscopy could possibly represent a promising adjuvant technique for the early diagnosis and assessment of PDN in Mongolian T2DM patients.


Assuntos
Diabetes Mellitus Tipo 2 , Neuropatias Diabéticas , Humanos , Diabetes Mellitus Tipo 2/complicações , Neuropatias Diabéticas/diagnóstico , Neuropatias Diabéticas/epidemiologia , Córnea , Microscopia Confocal/métodos , China/epidemiologia
6.
J Agric Food Chem ; 71(48): 19045-19053, 2023 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-37982559

RESUMO

Pyrrolizidine alkaloids (PAs) have been detected in tea and can threaten human health. However, the specific source of PAs in tea is still unclear. Here, 88 dried tea products collected from six major tea-producing areas in Anhui Province, China, were analyzed. The detection frequency was 76%. The content of total PAs in dried tea was between 1.1 and 90.5 µg/kg, which was all below the MRL recommended by the European Union (150 µg/kg). In the Shexian tea garden, PAs in the weeds and weed rhizospheric soil around tea plants and the fresh tea leaves were analyzed. Intermedine (Im), intermedine-N-oxide (ImNO), and jacobine-N-oxide (JbNO) were transferred through the weed-to-soil-to-tea route into the fresh tea leaves; only Im and ImNO were detected in dried tea samples. Potential risk of the total PAs in the tea infusion was assessed according to the margin of exposure method, and it might be a low concern for public health.


Assuntos
Camellia sinensis , Alcaloides de Pirrolizidina , Humanos , Alcaloides de Pirrolizidina/análise , Plantas Daninhas , Chá , Medição de Risco , Óxidos
8.
Sci Rep ; 13(1): 17794, 2023 10 18.
Artigo em Inglês | MEDLINE | ID: mdl-37852992

RESUMO

Currently, the precise and detailed anatomical data of the normal uterus, especially the myometrium thickness in various parts of the uterus, are lacking. This study aims to provide normal references for uterine size in healthy reproductive-aged Chinese women to facilitate the application of hysteroscopic surgery. A total of 298 women of reproductive age with normal uterine were included. Parity was significantly correlated with uterine measurements (P < 0.05), and age impacted several measurements (P < 0.05). At each uterine site examined, the myometrium was thinner in nulliparous women than in parous or primiparous women (P < 0.001). Similarly, the extrauterine measurements for parous or primiparous women were larger than those for nulliparous women. Weight affected some external measurements but not myometrial thicknesses, while height did not affect uterine measurements (P > 0.05). There was a positive correlation between body mass index (BMI) and extrauterine measurements as well as myometrial thickness (P < 0.05). The mathematical model of the uterine size for women of reproductive age was constructed stratified by parity. The study is the first to provide a detailed statistical description of the accurate anatomical parameters of the uterus in Chinese reproductive-aged women and has great significance for improving the safety and effectiveness of hysteroscopic surgery for patients.


Assuntos
Miométrio , Útero , Gravidez , Humanos , Feminino , Adulto , Reprodução , Paridade , Índice de Massa Corporal
9.
Environ Sci Technol ; 57(23): 8467-8475, 2023 06 13.
Artigo em Inglês | MEDLINE | ID: mdl-37256786

RESUMO

Residential emissions significantly contribute to air pollution. To address this issue, a clean heating campaign was implemented to replace coal with electricity or natural gas among 13.9 million rural households in northern China. Despite great success, the cost-benefits and environmental equity of this campaign have never been fully investigated. Here, we modeled the environmental and health benefits, as well as the total costs of the campaign, and analyzed the inequality and inequity. We found that even though the campaign decreased only 1.1% of the total energy consumption, PM2.5 emissions and PM2.5 exposure experienced 20% and 36% reduction, respectively, revealing the amplification effects along the causal pathway. Furthermore, the number of premature deaths attributable to residential emissions reduced by 32%, suggesting that the campaign was highly beneficial. Governments and residents shared the cost of 2,520 RMB/household. However, the benefits and the costs were unevenly distributed, as the residents in mountainous areas were not only less benefited from the campaign but also paid more because of the higher costs, resulting in a notably lower cost-effectiveness. Moreover, villages in less developed areas tended to choose natural gas with a lower initial investment but a higher total cost (2,720 RMB/household) over electricity (2,190 RMB/household). With targeted investment and subsidies in less developed areas and the promotion of electricity and other less expensive alternatives, the multidevelopment goals of improved air quality, reduced health impacts, and reduced inequity in future clean heating interventions could be achieved.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Humanos , Análise Custo-Benefício , Material Particulado/análise , Calefação , Gás Natural , Poluição do Ar/análise , China , Poluentes Atmosféricos/análise
10.
Front Oncol ; 13: 1151073, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37213273

RESUMO

Introduction: Metastatic spinal cord compression (MSCC) is a disastrous complication of advanced malignancy. A deep learning (DL) algorithm for MSCC classification on CT could expedite timely diagnosis. In this study, we externally test a DL algorithm for MSCC classification on CT and compare with radiologist assessment. Methods: Retrospective collection of CT and corresponding MRI from patients with suspected MSCC was conducted from September 2007 to September 2020. Exclusion criteria were scans with instrumentation, no intravenous contrast, motion artefacts and non-thoracic coverage. Internal CT dataset split was 84% for training/validation and 16% for testing. An external test set was also utilised. Internal training/validation sets were labelled by radiologists with spine imaging specialization (6 and 11-years post-board certification) and were used to further develop a DL algorithm for MSCC classification. The spine imaging specialist (11-years expertise) labelled the test sets (reference standard). For evaluation of DL algorithm performance, internal and external test data were independently reviewed by four radiologists: two spine specialists (Rad1 and Rad2, 7 and 5-years post-board certification, respectively) and two oncological imaging specialists (Rad3 and Rad4, 3 and 5-years post-board certification, respectively). DL model performance was also compared against the CT report issued by the radiologist in a real clinical setting. Inter-rater agreement (Gwet's kappa) and sensitivity/specificity/AUCs were calculated. Results: Overall, 420 CT scans were evaluated (225 patients, mean age=60 ± 11.9[SD]); 354(84%) CTs for training/validation and 66(16%) CTs for internal testing. The DL algorithm showed high inter-rater agreement for three-class MSCC grading with kappas of 0.872 (p<0.001) and 0.844 (p<0.001) on internal and external testing, respectively. On internal testing DL algorithm inter-rater agreement (κ=0.872) was superior to Rad 2 (κ=0.795) and Rad 3 (κ=0.724) (both p<0.001). DL algorithm kappa of 0.844 on external testing was superior to Rad 3 (κ=0.721) (p<0.001). CT report classification of high-grade MSCC disease was poor with only slight inter-rater agreement (κ=0.027) and low sensitivity (44.0), relative to the DL algorithm with almost-perfect inter-rater agreement (κ=0.813) and high sensitivity (94.0) (p<0.001). Conclusion: Deep learning algorithm for metastatic spinal cord compression on CT showed superior performance to the CT report issued by experienced radiologists and could aid earlier diagnosis.

11.
Sci Total Environ ; 875: 162654, 2023 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-36894103

RESUMO

Municipal solid waste (MSW) without proper managements could be a significant source of greenhouse gas (GHG) emissions. MSW incineration with electricity recovery (MSW-IER) is recognized as a sustainable way to utilize waste, but its effectiveness on reducing GHG emissions at the city scale in China remain unclear due to limited data of MSW compositions. The aim of the study is to investigate reduction potential of GHG from MSW-IER in China. Based on the MSW compositions covering 106 Chinese prefecture-level cities during the period of 1985 to 2016, random forest models were built to predict MSW compositions in Chinese cities. MSW compositions in 297 cities of China from 2002 to 2017 were predicted using the model trained by a combination of socio-economic, climate and spatiotemporal factors. Spatiotemporal and climatic factors (such as economic development level, precipitation) accounted for 6.5 %-20.7 % and 20.1 %-37.6 % to total contributions on MSW composition, respectively. The GHG emissions from MSW-IER in each Chinese city were further calculated based on the predicted MSW compositions. The plastic is the main GHG emission source, accounting for over 91 % of the total emission during 2002-2017. Compared to baseline (landfill) emission, the GHG emission reduction from MSW-IER was 12.5 × 107 kg CO2-eq in 2002 and 415 × 107 kg CO2-eq in 2017, with an average annual growth rate of 26.3 %. The results provide basic data for estimating GHG emission in MSW management in China.

12.
Environ Sci Pollut Res Int ; 30(15): 45455-45471, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36707476

RESUMO

Significant challenges confronting China include reducing carbon emissions, dealing with the resulting problems, and meeting various requirements for long-term economic growth. As a result, the shift in industrial structure best reflects how human society utilizes resources and impacts the environment. To meet China's 2050 net-zero emissions target, we look at how technological innovations, financial development, renewable energy investment, population age, and the economic complexity index all play a role in environmental sustainability in China. Analyzing short- and long-term relationships using auto-regressive distributive lag (ARDL) bounds testing, we used historical data spanning 1990 to 2018. According to the study's findings, the cointegration between CO2 emissions and their underlying factors was found. The deterioration of the environment directly results from the financial development, increasing economic complexity, and population aging. Technical advancements, investments in renewable energy sources, and changes to the industrial structure all contribute to lower CO2 emissions. Granger causality results were also reliably obtained in this study. According to our findings in the fight against environmental problems, a key tool for meeting long-term sustainability goals is policy prescriptions that use technological innovations, renewable energy investment, and industrial structure.


Assuntos
Dióxido de Carbono , Energia Renovável , Humanos , Desenvolvimento Econômico , Investimentos em Saúde , Pesquisa
13.
Environ Manage ; 71(4): 867-884, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36318286

RESUMO

Changes in land-use patterns may increase the ecological risks faced by Eco-Fragile regions. It is vital for regional ecological restoration and management of Eco-Fragile regions to reasonably assess ecological risk and study its response to typical land-use patterns. Existing study on regional ecological risk largely ignored the internal representation of ecosystem health and ecosystem services to ecological risk, and also ignored the internal relationship between ecological risk and land use patterns. This study developed a regional ecological assessment model by describing the relationship between ecosystem health, ecosystem services and ecological risks. Among them, the ecosystem health assessment used the Net Primary Productivity, landscape index and ecosystem elasticity coefficient based on different land use patterns to build Vigor-Organization-Resilience (VOR) model, and the improved equivalent factor method was used to calculate the ecosystem service value. Taking the Fen River Basin (FRB), a typical Eco-Fragile region of the Loess Plateau, as a study region, spatial auto-correlation analysis was used to reveal the temporal and spatial changes and spatial clustering characteristics of regional ecological risk, and regression analysis was used to study the relationship between typical land use patterns and ecological risks, which was included in the consideration of ecological and environmental risk management strategies. The results show that the regions with high ecological risk are mainly distributed in the middle and southwest of the FRB; the regions with low ecological risk are mainly distributed in the north, east and west of the FRB. Both high-risk and low-risk areas show significant spatial clustering effects. The change of ecological risk in FRB is related to the land use patterns. The ecological risk is negatively related to the expansion of construction land and cultivated land at the county and patch scales. On this basis, the environmental management strategies at different scales are discussed. This study can helpful deepen the understanding of the impact of land use patterns on ecological risk, and can also provide important reference for regional ecological risk management and land use policies.


Assuntos
Ecossistema , Modelos Teóricos , Análise Espacial , China , Gestão de Riscos , Conservação dos Recursos Naturais
14.
J Hazard Mater ; 445: 130407, 2023 03 05.
Artigo em Inglês | MEDLINE | ID: mdl-36444813

RESUMO

A comparison was performed on various methods detecting the volatile contaminants (VCs) in recycled poly(ethylene terephthalate) (rPET) flakes, the results demonstrated that head-space solid phase micro-extraction combined with comprehensive two-dimensional gas chromatograph-tandem quadrupole-time-of-flight mass spectrometry (HS-SPME-GC×GC-QTOF-MS) was a sensitive, effective, accurate method, and successfully applied to analyze 57 rPET flakes collected from different recycling plants in China. A total of 212 VCs were tentatively identified, and the possible source were associated with plastic, food, and cosmetics. 45 VCs are classified as high-priority compounds with toxicity level IV or V and may pose a risk to human health. Combined chemometrics for further analysis revealed that significant differences among these three geographical recycling regions. 6, 7, and 6 volatile markers were chosen based on VIP values and S-plot among plant1 plant 2 and plant 3, respectively. The markers differed significantly between recycled rPET samples in three geographical recycling regions based on chemometrics analysis. The initial classification rate and cross-validation accuracy were 100% on the identified VCs. These significant differences demonstrate that a systematic study is needed to obtain a comprehensive data on the contamination of rPET for food contact applications in China.


Assuntos
Polietilenotereftalatos , Compostos Orgânicos Voláteis , Humanos , Cromatografia Gasosa-Espectrometria de Massas/métodos , Polietilenotereftalatos/química , Quimiometria , Microextração em Fase Sólida/métodos , Etilenos , Compostos Orgânicos Voláteis/análise
15.
Plant Dis ; 107(6): 1920-1924, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-36471473

RESUMO

Trichothecium roseum is widely distributed throughout the world and forms pink powdery molds on various fruits and vegetables, lowering their quality and leading to great economic losses. Due to the limited availability of high-quality genomic and annotation resources, little is known about the pathogenesis of T. roseum at the molecular level. In this study, we reported a high-quality genome assembly of strain YXFP-22015 using Oxford Nanopore Technologies (ONT) for long read sequencing and MGISEQ-2000 for short read sequencing. The genome was also well-annotated based on the combination of RNA-seq by MGISEQ-2000 and in silico prediction. Further analysis on this will contribute to a better understanding of T. roseum infection mechanisms.


Assuntos
Hypocreales , Genômica , Frutas , China
16.
Front Genet ; 13: 1031557, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36531242

RESUMO

Genetic selection for resilience is essential to improve the long-term sustainability of the dairy cattle industry, especially the ability of cows to maintain their level of production when exposed to environmental disturbances. Recording of daily milk yield provides an opportunity to develop resilience indicators based on milk losses and fluctuations in daily milk yield caused by environmental disturbances. In this context, our study aimed to explore milk loss traits and measures of variability in daily milk yield, including log-transformed standard deviation of milk deviations (Lnsd), lag-1 autocorrelation (Ra), and skewness of the deviations (Ske), as indicators of general resilience in dairy cows. The unperturbed dynamics of milk yield as well as milk loss were predicted using an iterative procedure of lactation curve modeling. Milk fluctuations were defined as a period of at least 10 successive days of negative deviations in which milk yield dropped at least once below 90% of the expected values. Genetic parameters of these indicators and their genetic correlation with economically important traits were estimated using single-trait and bivariate animal models and 8,935 lactations (after quality control) from 6,816 Chinese Holstein cows. In general, cows experienced an average of 3.73 environmental disturbances with a milk loss of 267 kg of milk per lactation. Each fluctuation lasted for 19.80 ± 11.46 days. Milk loss traits are heritable with heritability estimates ranging from 0.004 to 0.061. The heritabilities differed between Lnsd (0.135-0.250), Ra (0.008-0.058), and Ske (0.001-0.075), with the highest heritability estimate of 0.250 ± 0.020 for Lnsd when removing the first and last 10 days in milk in a lactation (Lnsd2). Based on moderate to high genetic correlations, lower Lnsd2 is associated with less milk losses, better reproductive performance, and lower disease incidence. These findings indicate that among the variables evaluated, Lnsd2 is the most promising indicator for breeding for improved resilience in Holstein cattle.

17.
Sci Rep ; 12(1): 22365, 2022 12 26.
Artigo em Inglês | MEDLINE | ID: mdl-36572762

RESUMO

The fusion of X-ray fluorescence spectroscopy (XRF) and visible near infrared spectroscopy (visNIR) has been widely used in geological exploration. The outer product analysis (OPA) has a good effect in the fusion. The dimension of the spectral matrix obtained by OPA is large, and the Competitive Adaptive Reweighted Sampling (CARS) cannot cover the whole spectrum. As a result, the selected variables by the method are inconsistent each time. In this paper, a new feature variable screening method is proposed, which uses the Least Angle Regression (LAR) to select the high dimensional spectral matrix first, and then uses CARS to complete the secondary selection of the spectral matrix, forming the LAR-CARS algorithm. The purpose is to make the sampling method cover all the spectral data. XRF and visNIR tests were carried out on three cores in two boreholes, and a cross-validation set, validation set and a test set were established by combining the results of wavelength dispersion X-ray fluorescence spectrometer and ITRAX Core scanner in the laboratory. The quantitative model was established with the Extreme Gradient Boosting (XGBoost) and LAR-CARS was compared to these other algorithms (LAR, Successive Projections Algorithm, Monte Carlo uninformative variables elimination and CARS). The results showed that the RMSEP values of the models established by the LAR-CARS for six rock-forming elements (Si, Al, K, Ca, Fe, Ti) were relatively small, and the RPD ranges from 1.424 to 2.514. All these results show that the high-dimensional matrix formed by XRF and visNIR integration combined with LAR-CARS can be used for quantitative analysis of rock forming elements in in-situ coal seam cores, and the analysis results can be used as the basis for judging lithology. The research will provide necessary technical support for digital mine construction.


Assuntos
Algoritmos , Espectroscopia de Luz Próxima ao Infravermelho , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Análise dos Mínimos Quadrados , Método de Monte Carlo
18.
Vaccine ; 40(40): 5781-5790, 2022 09 22.
Artigo em Inglês | MEDLINE | ID: mdl-36055874

RESUMO

The global burden of malaria remains substantial. Circumsporozoite protein (CSP) has been demonstrated to be an effective target antigen, however, improvements that offer more efficacious and more durable protection are still needed. In support of research and development of next-generation malaria vaccines, Walter Reed Army Institute of Research (WRAIR) has developed a CSP-based antigen (FMP013) and a novel adjuvant ALFQ (Army Liposome Formulation containing QS-21). We present a single center, open-label, dose-escalation Phase 1 clinical trial to evaluate the safety and immunogenicity of the FMP013/ALFQ malaria vaccine candidate. In this first-in-human evaluation of both the antigen and adjuvant, we enrolled ten subjects; five received 20 µg FMP013 / 0.5 mL ALFQ (Low dose group), and five received 40 µg FMP013 / 1.0 mL ALFQ (High dose group) on study days 1, 29, and 57. Adverse events and immune responses were assessed during the study period. The clinical safety profile was acceptable and there were no serious adverse events. Both groups exhibited robust humoral and cellular immunological responses, and compared favorably with historical responses reported for RTS,S/AS01. Based on a lower reactogenicity profile, the 20 µg FMP013 / 0.5 mL ALFQ (Low dose) was selected for follow-on efficacy testing by controlled human malaria infection (CHMI) with a separate cohort. Trial Registration:Clinicaltrials.gov Identifier NCT04268420 (Registered February 13, 2020).


Assuntos
Vacinas Antimaláricas , Malária Falciparum , Adjuvantes Imunológicos/efeitos adversos , Adulto , Anticorpos Antiprotozoários , Humanos , Malária Falciparum/prevenção & controle , Plasmodium falciparum , Proteínas de Protozoários
19.
Front Psychol ; 13: 913672, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36092033

RESUMO

How to improve the development quality of state-owned enterprises is of great significance to the economic and social development in the transition period. And promoting the reform of mixed ownership is an important path for state-owned enterprises to achieve high-quality development. Based on the micro-data of China's A-share listed state-owned companies, the paper explores the impact of mixed ownership reform on the high-quality development of state-owned enterprises. It clarifies the importance and moderation of equity reform and the heterogeneity of impact effects from the theoretical mechanism analysis and empirical test. It also analyzes the reasons of inverted U-shape from the perspective of the transmission mechanism of the internal competition atmosphere and non-state-owned capital speculation motivation. It is found that the relationship between equity reform and state-owned enterprises' high-quality development is inverted U-shaped with multi-dimensional heterogeneity. From the analysis of conduction mechanism, on the one hand, the equity reform can enhance the internal competitive atmosphere, stimulate the vitality of enterprises and improve the development quality for state-owned enterprises. On the other hand, it enhances the speculation motivation of enterprises and slows down the high-quality development process.

20.
Environ Sci Pollut Res Int ; 29(56): 84690-84701, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35781667

RESUMO

The thermal power industry takes the important social responsibility of energy conservation and environmental protection. The carbon emissions made by the thermal power industry are affected by the industrial structure. In this paper, the carbon emission of thermal power generation is divided into three links: energy combustion, desulfurization process, and power transportation. The total carbon emission of thermal power in 11 provinces in western China from 2000 to 2017 is calculated. Combined with industrial reform, this paper constructs a panel data fixed effect model to systematically analyze the interactive response relationship between thermal power carbon emission and industrial structure in the western region. The research shows that due to the continuous expansion of hydropower, wind power, and other new energy power generation scale and the improvement of energy efficiency in the western region, the growth trend of thermal power carbon emission has slowed down since 2010. The industrial development pattern is the main driving force of regional economic development, and the secondary industry in the western region is the main driving factor of thermal power carbon emission. High quality economic development in the western region can be promoted through technological upgrading, new energy development, and industrial multi-mode operation.


Assuntos
Carbono , Desenvolvimento Econômico , Carbono/análise , Indústrias , Desenvolvimento Industrial , Dióxido de Carbono/análise , China
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