1.
Antimicrob Agents Chemother
; 48(5): 1908-11, 2004 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15105158
RESUMO
We developed a novel model of invasive aspergillosis (IA) that recapitulates human disease. Mice were immunosuppressed with cyclophosphamide and cortisone acetate and then infected in an aerosol chamber. This procedure reproducibly delivered 1 x 10(3) to 3 x 10(3) conidia to the lungs. Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B.