Assuntos
Atitude Frente a Saúde , COVID-19 , Diagnóstico Tardio/psicologia , Pandemias , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Pacientes/psicologia , SARS-CoV-2 , Neoplasias Cutâneas/psicologia , Idoso , Idoso de 80 Anos ou mais , Agendamento de Consultas , Carcinoma/diagnóstico , Carcinoma/psicologia , Estudos Transversais , Progressão da Doença , Detecção Precoce de Câncer , Serviço Hospitalar de Emergência/estatística & dados numéricos , Medo , Feminino , Acessibilidade aos Serviços de Saúde , Humanos , Ceratoacantoma/diagnóstico , Ceratoacantoma/psicologia , Masculino , Melanoma/diagnóstico , Melanoma/psicologia , Recidiva Local de Neoplasia/diagnóstico , Quarentena , Encaminhamento e Consulta , Neoplasias Cutâneas/diagnóstico , Inquéritos e Questionários , TelemedicinaRESUMO
BACKGROUND: There is a major controversy over the natural behavior of keratoacanthoma (KA). KAs have been described as benign lesions, but also as variants of squamous cell carcinoma (SCC). Microscopic differentiation between these 2 entities is problematic, and sometimes impossible. Syndecan-1 (CD138) is an adhesion molecule whose expression appears to be inversely correlated with tumor invasiveness. Elevated Ki-67 expression is indicative of a high proliferation index, a feature of malignant tumors. METHODS: Syndecan-1 and Ki-67 expression were assessed in 22 KA skin samples and in 17 SCC skin biopsies. RESULTS: Syndecan-1 expression was diminished in the SCC specimens compared with the KA specimens ( P =.000). Ki-67 expression was increased in the SCC specimens compared with the KA specimens, with mean values of 9 and 0.08, respectively ( P =.000). LIMITATIONS: Further studies that compare intermediate risk KAs to typical KAs and SCCs are required to corroborate these findings. CONCLUSION: The assessment of syndecan-1 and Ki-67 expression in skin biopsies is a helpful tool for differentiating KA and SCC
