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1.
In Vivo ; 34(2): 687-693, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32111771

RESUMO

BACKGROUND/AIM: The bioimpedance analysis (BIA) can provide anthropometric data on patients. The aim of the study is to evaluate the clinical relevance of these automatically obtained values. PATIENTS AND METHODS: We studied the arm circumference (AC) and arm muscle circumference (AMC) of 197 histologically proven cirrhotic patients. The BIA-based anthropometric data were compared to the manually measured data. In addition, we evaluated whether or not the BIA-based anthropometric data were associated with the prognosis of the patients. RESULTS: The data of %AC and %AMC obtained using the two methods were well correlated (p<0.001) with relatively inconspicuous differences (approximately 6.0% for %AC and 16.0% for %AMC). The data of %AC and %AMC obtained from the BIA method were significantly associated with the prognosis of the patients. CONCLUSION: The BIA-based anthropometric data were associated with the direct measurement data and related to the prognosis of cirrhotic patients.


Assuntos
Antropometria/métodos , Constituição Corporal/fisiologia , Impedância Elétrica , Cirrose Hepática/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Braço/fisiologia , Feminino , Humanos , Cirrose Hepática/diagnóstico , Masculino , Pessoa de Meia-Idade , Músculos/fisiologia , Prognóstico , Análise de Sobrevida
2.
Comp Med ; 69(2): 95-102, 2019 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-30808435

RESUMO

Well-defined, humane endpoints aid in monitoring animal health status during disease development. Body condition scoring (BCS) is a method for assessing health status in mouse studies where wasting and death are potential endpoints. Whether BCS is useful in monitoring animals with bleomycin-induced lung injury has not been reported. Body weight (BW) is a common humane endpoint for this model, but because the lungs increase in weight as BW decreases, the animal's true physical condition could be masked when using BW as the sole endpoint criterion. Therefore, our goal here was to assess the usefulness of BCS in monitoring health status in a mouse model of lung injury. Lung injury was caused by acute instil- lation of the fibrogenic antibiotic bleomycin into the lungs through the trachea. Male C57BL/6 mice received bleomycin (0.075 U) dissolved in saline or saline alone. Bleomycin instillation led to a doubling of lung weight and decreases in both BW and BCS, compared with saline instillation. The changes in BW and BCS were significantly correlated with lung weight. When the adjusted BW was used (corrected for the increase in lung weight), the correlation was unchanged, suggesting that the increase in lung weight did not significantly mask the decrease in BW. Bleomycin instillation caused decreases in both soleus and visceral epididymal fat masses. The change in BCS was significantly correlated with both soleus and VEF mass, suggesting that BCS is reflective of the systemic loss of muscle and fat mass. Our findings suggest that BW and BCS are significantly correlated to lung injury in the bleomycin model of lung fibrosis and that BCS is an appropriate alternative humane endpoint in this mouse model.


Assuntos
Indicadores Básicos de Saúde , Animais , Bleomicina/efeitos adversos , Constituição Corporal/fisiologia , Peso Corporal/fisiologia , Modelos Animais de Doenças , Lesão Pulmonar/induzido quimicamente , Camundongos , Camundongos Endogâmicos C57BL
3.
Fiziol Cheloveka ; 43(1): 45-54, 2017 Jan.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-29509362

RESUMO

We examined schoolchildren aged 11-16 years (n = 930) and determined the features of neurodynamic and vegetative parameters associated with age and sex and the factors affectingthe psycho-physiological statusof adolescents. An analysis of the relationship of studied parameters in adolescents with different types of autonomic regulation showed thatthe evaluation of functional constitution has prognostic significance since it is indicative of the adaptation potential.


Assuntos
Adaptação Fisiológica , Desenvolvimento do Adolescente/fisiologia , Sistema Nervoso Autônomo/fisiologia , Constituição Corporal/fisiologia , Caracteres Sexuais , Adolescente , Fatores Etários , Criança , Feminino , Frequência Cardíaca , Humanos , Masculino , Fatores Sexuais
4.
Animal ; 7(9): 1401-13, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23773679

RESUMO

The objective of the present review was (i) to survey different approaches for choosing the complex of traits for which economic values (EVs) are calculated, (ii) to call attention to the proper definition of traits and (iii) to discuss the manner and extent to which relationships among traits have been considered in the calculation of EVs. For this purpose, papers dealing with the estimation of EVs of traits in livestock were reviewed. The most important reasons for incompatibility of EVs for similar traits estimated in different countries and by different authors were found to be inconsistencies in trait definitions and in assumptions being made about relationships among traits. An important problem identified was how to choose the most appropriate criterion to characterise production or functional ability for a particular class of animals. Accordingly, the review covered the following three topics: (i) which trait(s) would best characterise the growth ability of an animal; (ii) how to define traits expressed repeatedly in subsequent reproductive cycles of breeding females and (iii) how to deal with traits that differ in average value between sexes or among animal groups. Various approaches that have been used to solve these problems were discussed. Furthermore, the manner in which diverse authors chose one or more traits from a group of alternatives for describing a specific biological potential were reviewed and commented on. The consequences of including or excluding relationships among economically important traits when estimating the EV for a specific trait were also examined. An important conclusion of the review is that, for a better comparability and interpretability of estimated EVs in the literature, it is desirable that clear and unique definitions of the traits, complete information on assumptions used in analytical models and details on inter-relationships between traits are documented. Furthermore, the method and the model used for the genetic evaluation of specific traits in a certain breeding organisation are important for the exact definition of traits, for which the economic values will be calculated, and for the inclusion or exclusion of relationships among traits in the calculation of the EVs in livestock breeding.


Assuntos
Constituição Corporal/fisiologia , Cruzamento/economia , Cruzamento/métodos , Gado/crescimento & desenvolvimento , Fenótipo , Animais , Peso Corporal , Feminino , Gráficos de Crescimento , Masculino , Análise de Regressão , Caracteres Sexuais
5.
Animal ; 6(2): 292-9, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22436187

RESUMO

The objective of this study was to investigate the effect of different body condition score (BCS) at 30 days before calving (-30 days) induced by a differential nutritional management from -100 days until -30 days on productive parameters, the interval to first ovulation and blood parameters in primiparous and multiparous Holstein cows under grazing conditions until 60 days post partum. The experimental arrangement was a randomized complete block design, where cows were blocked according to BW and expected calving date and then randomly assigned to different nutritional treatments from -100 to -30 days relative to calving to induce different BCS. As the assignment of cows to treatments was random, cows had to lose, maintain or gain BCS; thus, different planes of nutrition were offered with approximately 7, 14 or 20 kg dry matter per day. The BCS score was assessed every 15 days and animals were reassigned in order to achieve the desired BCS at -30 days. Only animals that responded to nutritional treatment were considered and this was defined as follows: primiparous and multiparous high cows (PH and MH) had to gain 0.5 points of BCS, primiparous low (PL) had to lose 0.5 points of BCS and multiparous low (ML) had to maintain BCS at least in two subsequent observations from -100 to -30 days. From -30 days to calving, primiparous and multiparous cows (P and M cows) were managed separately and cows were offered a diet once a day. From calving to 60 days post partum, cows of different groups grazed in separate plots a second year pasture. Cows were also supplemented individually with whole-plant maize silage and commercial concentrate. Cows had similar BCS at -100 days and differed after the nutritional treatment; however, all groups presented similar BCS at 21 days post partum. The daily milk production and milk yield at 60 days post partum was higher in M than P cows. The percentage of milk fat was higher in PH cows compared with PL cows. Concentrations of non-esterified fatty acids (NEFA) were affected by the BCS at -30 days within parity, and in PH cows the concentration of NEFA was higher than in PL cows. The concentrations of total protein were higher in M cows. A lower probability of cycling was found in PL than in PH cows (P < 0.05) and in ML than in MH cows (P < 0.05). Treatment affected various endocrine/metabolic profiles according to parity, suggesting that the metabolic reserves signal the productive/reproductive axis so as to induce a differential nutrient partitioning in adult v. first-calving cows.


Assuntos
Fenômenos Fisiológicos da Nutrição Animal/fisiologia , Constituição Corporal/fisiologia , Bovinos/fisiologia , Ciclo Menstrual/fisiologia , Leite/química , Paridade/fisiologia , Período Pós-Parto/fisiologia , Animais , Análise Química do Sangue , Gorduras/análise , Feminino , Fator de Crescimento Insulin-Like I/análise , Gravidez , Progesterona/sangue , Distribuição Aleatória , Fatores de Tempo
7.
J Dairy Sci ; 93(3): 1086-97, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20172230

RESUMO

Forty Holstein cows were used in a completely randomized design with a 2-wk covariate period followed by a 6-wk experimental period to evaluate incremental substitution of nonforage fiber provided by dried distillers grains with solubles (DDGS) and soyhulls (SH) for starch provided by corn in the diet. Diets provided decreasing concentrations of starch: 29% starch with 0% DDGS; 26% starch with 7% DDGS; 23% starch with 14% DDGS; and 20% starch with 21% DDGS. Diets contained 27% corn silage, 22% alfalfa hay, and 51% concentrate mix and were formulated to be 17% crude protein, 4.7% fat, and 23% neutral detergent fiber from forage. Total neutral detergent fiber increased as DDGS and SH were included in the diet. Soyhulls were included in a linear fashion along with DDGS to replace soybean meal and expeller soybean meal, thereby maintaining a similar crude protein content across diets. Dry matter intake decreased linearly; consequently, feed efficiency tended to increase linearly as starch was replaced by nonforage fiber. There was no effect of diet on milk production or milk fat and protein percentage or yield. Milk fatty acid profiles were similar across diets. Other response variables, including 4% fat-corrected milk, total solids, and milk urea nitrogen, were unaffected by dietary treatments. Ruminal volatile fatty acid concentration did not differ between diets. Concentrations of blood glucose and beta-hydroxybutyrate were similar across diets. Results from this research suggest that nonforage fiber from DDGS can partially substitute for starch from corn in dairy cow diets without affecting milk production and milk composition. Economic analysis of the diets showed that feeding DDGS and SH in substitution of corn was cost-effective. Results from this experiment indicate that DDGS and SH can replace corn as an energy source to decrease feed costs.


Assuntos
Bovinos/fisiologia , Indústria de Laticínios/métodos , Dieta/veterinária , Fibras na Dieta/metabolismo , Glycine max/metabolismo , Lactação/fisiologia , Amido , Ração Animal/análise , Fenômenos Fisiológicos da Nutrição Animal , Animais , Constituição Corporal/fisiologia , Peso Corporal/fisiologia , Bovinos/metabolismo , Indústria de Laticínios/economia , Dieta/economia , Fibras na Dieta/administração & dosagem , Ingestão de Alimentos/fisiologia , Feminino , Conteúdo Gastrointestinal/química , Leite/química , Leite/metabolismo , Tamanho da Partícula , Distribuição Aleatória
8.
Coll Antropol ; 34 Suppl 2: 161-8, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21302716

RESUMO

The concept of bone quality describes the sets of the characteristics of the osseous tissue that influence bone strength. The aim was to explore the influence of anthropometric parameters and age on the parameters of the bone architecture and bone mineral properties in the lumbar vertebral bone of men and women. Vertebral bone samples underwent bone histomorphometry, bone densitometry and atomic absorption spectrometry. Men have greater values of the bone volume and thicker bone trabeculae in relation to women, which indicates that vertebral bone architecture is better preserved in men than in women. Age is the best predictor of changes that affect bone architecture and bone mineral properties. Bone mineral density value and calcium concentration are both negatively predicted by age, but positively predicted by body mass index. Such result supports the opinion that low body mass index is associated with conditions of bone deficit such are osteopenia and osteoporosis.


Assuntos
Constituição Corporal/fisiologia , Densidade Óssea/fisiologia , Doenças Ósseas Metabólicas/fisiopatologia , Osteoporose/fisiopatologia , Espectrofotometria Atômica/métodos , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Antropometria , Índice de Massa Corporal , Doenças Ósseas Metabólicas/diagnóstico , Feminino , Humanos , Vértebras Lombares/fisiologia , Masculino , Pessoa de Meia-Idade , Osteoporose/diagnóstico , Valor Preditivo dos Testes , Fatores Sexuais
9.
J Dairy Sci ; 91(12): 4552-9, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19038930

RESUMO

The aim of the present study was to identify specific behavioral patterns that contribute to diminished estrus expression in lame cows. Behavioral scan and focal sampling were used to examine the effect of lameness on daily activity budgets, sexual behavior, feeding activities, and body condition score. A total of 59 milking cows (51.8 +/- 1.4 d postpartum) were monitored on a commercial dairy farm for 5 d following estrus synchronization. Overall, lame cows (n = 39) spent proportionately less time elevated on their feet and more time lying down compared with nonlame cows (n = 20). This included lame cows spending less time walking or standing. Overall, the total proportion of scans in which an estrous behavior was observed was very small but tended to be smaller for lame compared with nonlame cows. Throughout a day, lame cows displayed a lower proportion of estrous behaviors in the early morning. Lameness did not affect durations of drinking, grazing, or ruminating, or how these behavioral states fluctuated throughout the day. Similarly, rumination chewing rates were the same for lame and nonlame cows, and there was no association between lameness and dominance/displacement while feeding at a feed-fence. Lame cows did, however, have a slower bite rate at pasture and had a lower body condition score. Lame cows were also nearer the rear of the herd, both as they left the field and when entering the milking parlor. In conclusion, lame cows have longer lying times and spend less time standing, walking, and expressing an estrous behavior. Lame cows also have a lower bite rate at pasture and are more likely to be of lower body condition score.


Assuntos
Comportamento Animal/fisiologia , Estro/fisiologia , Atividade Motora/fisiologia , Comportamento Agonístico/fisiologia , Animais , Constituição Corporal/fisiologia , Bovinos , Doenças dos Bovinos/fisiopatologia , Indústria de Laticínios , Feminino , Coxeadura Animal/fisiopatologia , Mastigação/fisiologia , Comportamento Sexual Animal/fisiologia
10.
Gig Sanit ; (2): 84-7, 2008.
Artigo em Russo | MEDLINE | ID: mdl-18507175

RESUMO

Somatic trends was considered in Moscow children in a wide age range of 3 to 17 years, by attracting several series of data since the 1990s. To have the greater informative value in data analyses, investigators use the normalized rather than absolute values of various anthropometric signs in the considered data series versus the 2005 data in the age range of 3 to 7 years and versus the 1980s data in the range of 8 to 17 years. The overall somatic tendency in Moscow children aged 3 to 17 years in past decades is towards a transverse body development and some dolichomorphism with a continuous increase in longitudinal skeletal sizes. These processes are most pronounced in girls than in boys and preschool children than in school ones. The stronger somatic trend in preschool children can be associated with that they are, as compared with schoolchildren, neophytes in the compact anthropogenic space and have been, in the past decades, involved in the neurogenic growth stimulators world (a computer and computer games, unlimited TV seeing, inevitable intensive preparation for new-generation schools--increased intellectual-load lyceums and colleges). The decreased transverse body development and overall constitution asthenization seem to result from somatic muscular component abatement with no clear trends in adipopexis in schoolchildren and with an increase in subcutaneous fat deposition in preschool children.


Assuntos
Desenvolvimento do Adolescente/fisiologia , Constituição Corporal/fisiologia , Desenvolvimento Infantil/fisiologia , Nível de Saúde , População Urbana , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Moscou , Fatores Socioeconômicos
11.
J Dairy Sci ; 91(4): 1477-85, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18349241

RESUMO

The majority of dairy sheep in the world are fed pasture and supplemental grain during lactation; however, no trials have reported the effects of supplementation of dairy ewes grazing improved pastures in North America. In trial 1, 56 three-year-old grazing dairy ewes in early [21 +/- 10 d in milk (DIM)] or late (136 +/- 9 DIM) lactation were fed 0 or 0.82 kg of dry matter/d per ewe of supplement (16.5% crude protein mixture of corn and a soybean meal-based high-protein pellet) in a 2 x 2 factorial arrangement of treatments. There were no significant interactions between stage of lactation and supplementation treatments. Average test-day milk production was higher in early-lactation ewes than in late-lactation ewes (1.74 vs. 1.21 kg/d, respectively). Although test-day milk protein percentage was higher in late-lactation ewes than in early-lactation ewes (5.02 vs. 4.86%, respectively), there was no difference in milk fat percentage between stages of lactation. Supplemented ewes had higher milk production (1.59 vs. 1.36 kg/d, respectively), lower milk fat percentage (5.75 vs. 6.00%, respectively), and lower milk protein percentage (4.84 vs. 5.04%, respectively) than unsupplemented ewes. Milk urea N levels were similar between the 2 stages of lactation and between the 2 supplementation treatments and were above recommended levels for dairy sheep, indicating an excess intake or inefficient utilization of protein for both supplementation treatments. In trial 2, 96 two-, three-, and four-year-old grazing dairy ewes in midlactation (112 +/- 21 DIM) were randomly assigned to 4 treatments of 0, 0.41, 0.82, or 1.24 kg of dry matter/d per ewe of whole corn. Average test-day milk production increased linearly and milk fat percentage decreased quadratically with increasing amounts of corn supplementation. Milk protein yield increased linearly, and milk urea N levels decreased quadratically with increasing amounts of corn supplementation, suggesting an improvement in the utilization of pasture protein with increasing dietary energy intake.


Assuntos
Suplementos Nutricionais , Lactação/fisiologia , Leite/química , Ovinos/fisiologia , Ração Animal/análise , Fenômenos Fisiológicos da Nutrição Animal , Animais , Constituição Corporal/fisiologia , Peso Corporal/fisiologia , Indústria de Laticínios/economia , Indústria de Laticínios/métodos , Proteínas Alimentares/metabolismo , Gorduras/análise , Feminino , Leite/metabolismo , Proteínas do Leite/análise , Nitrogênio/análise , Distribuição Aleatória , Glycine max/metabolismo , Fatores de Tempo , Ureia/análise , Zea mays/metabolismo
12.
J Dairy Sci ; 91(4): 1510-8, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18349244

RESUMO

Information regarding health, management, and housing from birth to first calving was collected for 1,029 Swedish Reds, 991 Swedish Holsteins, and 40 heifers of crossbreed or other breeds on bimonthly farm visits made by 3 project veterinarians to 107 dairy herds in southwest Sweden. Additional data were obtained from the official milk- and health-recording program. Milk production at first test day after calving [energy-corrected milk (ECM)1] and during the first 305 d of lactation (ECM305), respectively, were analyzed by 2-level (animal; herd) linear regression, after initial screening by univariable analyses of 67 potentially important predictors. The ECM1 ranged from 7.9 to 48.0 (median = 27.1) kg, and ECM305 ranged from 3,764 to 12,136 (median = 8,006) kg. In the final models, factors associated with ECM1 or ECM305 or both were age at first calving, body condition score at first service, breed, calfhood diarrhea, calving season, composite somatic cell count at first test day, daily weight gain from weaning to first service, housing system after calving, and increase in concentrate fed around calving. Higher age at calving was associated with higher production. Production also increased with higher daily weight gains from weaning to first service. Swedish Holsteins produced more than Swedish Reds, cows calving in May to September produced more than those calving during other months, and cows housed in short stalls after calving produced more than those in cubicles. Body condition scores > or =3.2 at first service were associated with lower ECM305 than scores < or =2.9. Animals that contracted mild diarrhea during their first 3 mo of life had lower ECM305 than animals without diarrhea, whereas animals receiving a high increase in concentrate pre- and postcalving had higher ECM305 than those subjected to a more moderate increase. Cows with a composite somatic cell count >1 million cells/milliliter at first test day produced less milk on the same day than cows with lower counts. It was concluded that rearing factors and calfhood health status can influence first lactation milk production.


Assuntos
Doenças dos Bovinos/epidemiologia , Indústria de Laticínios/métodos , Diarreia/veterinária , Lactação/fisiologia , Leite/metabolismo , Animais , Constituição Corporal/fisiologia , Bovinos , Diarreia/epidemiologia , Feminino , Abrigo para Animais , Modelos Lineares , Leite/citologia , Parto , Suécia/epidemiologia , Aumento de Peso
13.
Arch Gerontol Geriatr ; 46(2): 221-6, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-17548121

RESUMO

The present study was aimed at analyzing the socio-economic influence on functional fitness parameters, described by the Fullerton tests. A pool of 180 women divided into six age groups (65-69, 70-74, 75-79, 80-84, 85-89 and 90-94 years) was examined. They all were informed-consent participants. The results clearly show that low life standard in the early biological development has a significant impact on the functional fitness in all age groups. Comparison of our results with those described previously for the USA inhabitants revealed a considerably lower level of functional fitness for the Polish population than observed in the US.


Assuntos
Constituição Corporal/fisiologia , Avaliação Geriátrica , Aptidão Física/fisiologia , Idoso , Idoso de 80 Anos ou mais , Envelhecimento/fisiologia , Feminino , História do Século XXI , Humanos , Polônia , Qualidade de Vida , Valores de Referência , Fatores Socioeconômicos , Estados Unidos , População Branca/história
14.
Gen Comp Endocrinol ; 155(3): 607-12, 2008 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-17897644

RESUMO

The body condition index is a common method for quantifying the energy reserves of individual animals. Because good body condition is necessary for reproduction in many species, body condition indices can indicate the potential reproductive output of a population. Body condition is related to glucocorticoid production, in that low body condition is correlated to high concentrations of corticosterone in reptiles. We compared the body condition index and plasma corticosterone levels of brown tree snakes on Guam in 2003 to those collected in 1992/1993 to determine whether that population still showed the chronic stress and poor condition apparent in the earlier study. We also examined the relationship between fat mass, body condition and plasma corticosterone concentrations as indicators of physiological condition of individuals in the population. Body condition was significantly higher in 2003 than in the earlier sample for mature male and female snakes, but not for juveniles. The significantly lower levels of corticosterone in all three groups in 2003 suggests that although juveniles did not have significantly improved energy stores they, along with the mature males and females, were no longer under chronic levels of stress. Although the wet season of 2002 was unusually rainy, low baseline levels of corticosterone measured in 2000 indicate that the improved body condition of snakes in 2003 is likely the result of long-term changes in prey populations rather than annual variation in response to environmental conditions.


Assuntos
Constituição Corporal/fisiologia , Corticosterona/sangue , Indicadores Básicos de Saúde , Serpentes/fisiologia , Fatores Etários , Animais , Animais Selvagens/sangue , Animais Selvagens/fisiologia , Feminino , Masculino , Chuva , Estações do Ano , Serpentes/sangue , Fatores de Tempo
15.
Semin Nucl Med ; 37(2): 64-8, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17289455

RESUMO

Aging is an extremely complex, multifactorial, and inevitable process that varies in rate from person to person and that is not fully understood at its most basic levels. Despite this complexity, knowledge of age-related changes and normal variation in organ structure and function is essential to differentiate them from alterations that are associated with pathology. Combined structural and functional imaging, which increasingly is used to assess a multitude of disorders, including cancer, cardiovascular disease, and central nervous system abnormalities, can be applied to study changes in structure and function related to aging. This article reviews the major theories of biological aging and presents our approach and rationale to study age-related changes through quantitative tomographic radiological and scintigraphic approaches. In the series of articles that follow, we have made an attempt to determine age-related changes in volume, attenuation, and function as measured by computed tomography, magnetic resonance imaging, and position emission tomography in the following organs and systems: central nervous system, head and neck, heart and major arteries, lungs, abdominal and pelvic parenchymal organs, gastrointestinal tract, genitourinary tract, breast, bone and bone marrow, joints, and skin. The population examined includes a large number of subjects in all decades of life. We have also made an effort to introduce some new concepts such as partial volume correction and measurements of global metabolic activity of the organs examined, and emphasize the importance of quantitative techniques in such applications. It is our hope that this new initiative will further enhance the role of novel imaging techniques in the management of patients with cancer and other disorders.


Assuntos
Envelhecimento/patologia , Envelhecimento/fisiologia , Constituição Corporal/fisiologia , Imageamento Tridimensional/métodos , Imageamento Tridimensional/tendências , Tomografia/métodos , Tomografia/tendências , Humanos
16.
Am J Phys Anthropol ; 132(4): 632-41, 2007 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-17274011

RESUMO

Life history theory predicts that where resources are limited, investment in reproduction will cause a decline in body condition and ultimately may lower survival rates. We investigate the relationship between reproduction and mortality in women in rural Gambia. We use a number of different measures of reproductive investment: the timing of reproduction, intensity of reproduction, and cumulative reproductive investment (parity). Though giving birth is clearly a risk factor for increased mortality, we find limited evidence that the timing, intensity, or cumulative effects of reproduction have a survival cost. Instead, there is some evidence that women who have invested heavily in reproduction have higher survival than women with lower reproductive investment: both high parity and late age at last reproduction are associated with high survival. The only evidence for any cost of reproduction is that women who have given birth to twins (considered a marker of heavy investment in reproduction) have higher mortality rates than other women, after the age of 50 years. A potential confounding factor may be differences in health between women: particularly healthy women may be able to invest substantially in both reproduction and their own survival, leading to the positive correlations between survival and both parity and age at last birth we observe. To control for differences in health between women, we reanalyze the relationship between reproduction and mortality but include variables correlating with health in our models (height, BMI, and hemoglobin). Even when controlling for health, the positive correlation between investment in reproduction and survival remains unchanged.


Assuntos
Constituição Corporal/fisiologia , Mortalidade , Reprodução/fisiologia , Fatores Etários , Estatura , Índice de Massa Corporal , Feminino , Gâmbia , Nível de Saúde , Hemoglobinas/análise , Humanos , Paridade , Gravidez , Fatores de Risco , População Rural
17.
Oecologia ; 151(1): 150-60, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17124570

RESUMO

A central point in life history theory is that parental investment in current reproduction should be balanced by the costs in terms of residual reproductive value. Long-lived seabirds are considered fixed investors, that is, parents fix a specific level of investment in their current reproduction independent to the breeding requirements. We tested this hypothesis analysing the consequences of an experimental increase in flying costs on the foraging ecology, body condition and chick condition in Cory's shearwaters Calonectris diomedea. We treated 28 pairs by reducing the wing surface in one partner and compared them with 14 control pairs. We monitored mass changes and incubation shifts and tracked 19 foraging trips per group using geolocators. Furthermore, we took blood samples at laying, hatching and chick-rearing to analyse the nutritional condition, haematology, muscle damage and stable isotopes. Eighty-day-old chicks were measured, blood sampled and challenged with PHA immune assay. In addition, we analysed the effects of handicap on the adults at the subsequent breeding season. During incubation, handicapped birds showed a greater foraging effort than control birds, as indicated by greater foraging distances and longer periods of foraging, covering larger areas. Eighty-day-old chicks reared by treated pairs were smaller and lighter and showed a lower immunity than those reared by control pairs. However, oxygen demands, nutritional condition and stable isotopes did not differ between control and handicapped birds. Although handicapped birds had to increase their foraging effort, they maintained physical condition by reducing parental investment and transferred the experimentally increased costs to their partners and the chick. This result supports the fixed investment hypothesis and is consistent with life history theory.


Assuntos
Aves/fisiologia , Constituição Corporal/fisiologia , Comportamento Alimentar/fisiologia , Voo Animal , Estado Nutricional/fisiologia , Fatores Etários , Análise de Variância , Animais , Ilhas Atlânticas , Análise Química do Sangue , Pesos e Medidas Corporais , Estudos de Casos e Controles , Geografia , Comportamento de Nidação/fisiologia , Oxigênio/metabolismo , Telemetria
18.
J Exp Zool A Ecol Genet Physiol ; 307(2): 106-12, 2007 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-17152091

RESUMO

Lizards often respond to increased predation risk by increasing refuge use, but this strategy may entail a loss of thermoregulatory opportunities, which may lead to a loss of body condition. This may be especially important for pregnant oviparous female lizards, because they need to maintain optimal body temperatures as long as possible to maximize developmental embryos rate until laying. However, little is known about how increased time spent at low temperatures in refuges affects body condition and health state of pregnant female lizards. Furthermore, it is not clear how initial body condition affects refuge use. Female Iberian rock lizards forced to increase time spent at low temperatures showed lower body condition and tended to show lower cell-mediated immune responses than control females. Therefore, the loss of thermoregulatory opportunities seems to be an important cost for pregnant females. Nevertheless, thereafter, when we simulated two repeated predatory attacks, females modified refuge use in relation to their body condition, with females with worse condition decreasing time hidden after attacks. In conclusion, female lizards seemed able to compensate increased predation risk with flexible antipredatory strategies, thus minimizing costs for body condition and health state.


Assuntos
Regulação da Temperatura Corporal/fisiologia , Meio Ambiente , Imunidade Celular/imunologia , Lagartos/imunologia , Lagartos/fisiologia , Oviparidade , Análise de Variância , Animais , Constituição Corporal/fisiologia , Feminino , Fito-Hemaglutininas/imunologia , Comportamento Predatório/fisiologia , Espanha , Temperatura
19.
Am J Epidemiol ; 163(5): 450-8, 2006 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-16421245

RESUMO

The authors investigated the association between observed neighborhood conditions and lower-body functional limitations (LBFLs) using data from 563 subjects of the African-American Health Study. This population-based cohort received in-home evaluations. Five items involving LBFL were obtained at baseline (2000-2001) and 3 years later. Subjects were considered to have LBFL if they reported difficulty on at least two of the five tasks. The external appearance of the block the respondent lived on was rated during sample enumeration by use of five items (rated excellent, good, fair, or poor). Of 563 subjects with 0-1 LBFL at baseline, 15% and 14% lived in neighborhoods with 4-5 and 2-3 fair/poor conditions, respectively. Logistic regression adjusting for propensity scores showed that persons who lived in neighborhoods with 4-5 versus 0-1 fair/poor condition were 3.07 times (95% confidence interval: 1.58, 5.94) more likely to develop two or more LBFLs. The odds ratio was 2.24 (95% confidence interval: 1.07, 4.70) when living in neighborhoods with 2-3 conditions versus 0-1 fair/poor condition. Odds ratios for individual neighborhood characteristics varied from 3.45 (fair/poor street conditions) to 2.01 (fair/poor noise level). Sensitivity analyses showed the robustness of the findings. Poor neighborhood conditions appear to be an independent contributor to the risk of incident LBFLs in middle-aged African Americans.


Assuntos
Envelhecimento , Negro ou Afro-Americano , Constituição Corporal/fisiologia , Indicadores Básicos de Saúde , Limitação da Mobilidade , Características de Residência , Estresse Psicológico/epidemiologia , Feminino , Seguimentos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Missouri/epidemiologia , Estudos Prospectivos , Estresse Psicológico/etiologia
20.
J Am Vet Med Assoc ; 227(12): 1931-6, 2005 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-16379629

RESUMO

OBJECTIVE: To determine owner impressions of 3 premium canine diets when factors such as price and retail source were removed; to compare body condition scores (BCSs) assigned by owners versus a veterinarian; and to determine consistency of owner impressions of diets when owners were not informed that they were feeding the same diet during 2 consecutive periods. DESIGN: Randomized controlled trial. ANIMALS: 44 healthy adult dogs. PROCEDURE: During the initial 12 months of the study, dogs were each fed 3 premium diets for 4 months in random order. After feeding each diet for 1 and 4 months, owners completed questionnaires regarding palatability of the diet; the dog's attitude, energy level, fecal consistency, frequency of defecation, hair coat quality, and BCS; and whether they would feed the diet if available commercially. During the last 4 months of the study, owners fed the same diet they had been feeding during the previous 4 months. RESULTS: Scores for most variables did not differ among diets. However, mean BCS assigned by owners was significantly lower than mean BCS assigned by an investigator, with a moderate correlation between scores. When asked at the end of the third and fourth study periods whether they would consider feeding the diet long-term, 12 of the 44 (27%) owners gave inconsistent responses. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicate that when unaware of retail price and source, owners have similar impressions of 3 premium diets fed to healthy adult dogs, suggesting that factors other than the diets themselves may affect owner impressions. Owners also underestimate their dog's BCS.


Assuntos
Ração Animal/normas , Fenômenos Fisiológicos da Nutrição Animal , Constituição Corporal/fisiologia , Cães/fisiologia , Ração Animal/economia , Animais , Estudos Cross-Over , Defecação/fisiologia , Cães/metabolismo , Método Duplo-Cego , Fezes , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Masculino , Inquéritos e Questionários , Paladar , Médicos Veterinários/psicologia
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