Electron, Photon, and Neutron Dose Conversion Coefficients of Lens and Non-Lens Tissues Using a Multi-Tissue Eye Model to Assess Risk of Cataracts and Retinitis.

Previous publications describe the estimation of the dose from ionizing radiation to the whole lens or parts of it but have not considered other eye tissues that are implicated in cataract development; this is especially critical for low-dose, low-ionizing-density exposures. A recent review of the biological mechanisms of radiation-induced cataracts showed that lenticular oxidative stress can be increased by inflammation and vascular damage to non-lens tissues in the eye. Also, the radiation oxygen effect indicates different radiosensitivities for the vascular retina and the severely hypoxic lens. Therefore, this study uses the Monte Carlo N-Particle simulations to quantify dose conversion coefficients for several eye tissues for incident antero-posterior exposure to electrons, photons, and neutrons (and the tertiary electron component of neutron exposure). A stylized, multi-tissue eye model was developed by modifying a model by Behrens etal. (2009) to include the retina, uvea, sclera, and lens epithelial cell populations. Electron exposures were simulated as a single eye, whereas photon and neutron exposures were simulated employing two eyes embedded in the ADAM-EVA phantom. For electrons and photons, dose conversion coefficients are highest for either anterior tissues for low-energy incident particles or posterior tissues for high-energy incident particles. Neutron dose conversion coefficients generally increase with increasing incident energy for all tissues. The ratio of the absorbed dose delivered to each tissue to the absorbed dose delivered to the whole lens demonstrated the considerable deviation of non-lens tissue doses from lens doses, depending on particle type and its energy. These simulations demonstrate that there are large variations in the dose to various ocular tissues depending on the incident radiation dose coefficients; this large variation will potentially impact cataract development.

A NEW DOSE DETERMINATION METHOD FOR HP(3) AND DP LENS FOR BETA REFERENCE RADIATION QUALITIES.

For the purpose of obtaining the smaller uncertainties for Hp(3) and Dp lens in 90Sr/90Y beta reference fields, a new dose determination method based on the Monte-Carlo simulation was proposed. The conversion coefficients from the absorbed dose in air, at the reference point of the extrapolation ionisation chamber, Dair, det to Hp(3; α) and the conversion factors from Dair, det to Dp lens(α) were calculated with EGSnrc, respectively, for the irradiation angles from 0° to 60°. Compared with the dose determination method in International Organization for Standardization (ISO) 6980 standard, the uncertainty reductions of 7.7-52.8% for Hp(3; α) and 7.9-55.0% for Dp lens(α) were achieved, respectively. In addition, for the conversion coefficients from the reference absorbed dose DR to Hp(3; α), the calculations were performed for more irradiation conditions, which are not included in the current ISO 6980 standard. For the calculations of the conversion factors from DR to Dp lens(α), the eye and head phantoms with Chinese characteristics were utilised, which makes the conversion factors more suitable for use in China.

Eye-lens dose rate conversion factors due to hot particles and surface contaminations on the cornea.

In 2012, the International Commission on Radiological Protection issued new recommendations, in publication 118, regarding the dose limits to the eye-lens. New analyses of historical exposure data had indicated that radiation-induced cataracts may appear at lower doses than previously assumed. This spurred largescale efforts in a variety of fields including dosimetry, radiation effects simulations, and the review of national regulatory limits. On the simulation side, much work led to the publication of dose rate conversion factors (DRCFs), to calculate the dose to the radiosensitive part of the eye-lens, and to the whole eye-lens as functions of the incident fluence of electron, photon, positron, and neutron radiation. The standard, ISO-15382 (2015Radiological Protection-Procedures for Monitoring the Dose to the Lens of the Eye, the Skin and the Extremities), from the International Organization for Standardization (ISO), stated that the direct contact of a hot radioactive particle on the eye-lens represents a special contamination condition that must be considered. The aim of this work was to produce tabulated data of eye-lens dose rates, per activity (MBq), for a variety of radionuclides. In this work, the dose to the eye-lens from contamination directly in contact with the cornea, expressed in terms of DRCFs for eye-lens, in units of Gy h-1MBq-1, are presented for 102 radionuclides of interest. These radionuclides were selected as they had been considered by the International Atomic Energy Agency of importance for skin dose. The method consisted of two steps. The first was the determination of the DRCFs for mono-energetic electrons and photons for a hot particle in contact with the eye-lens, followed by the folding of these quantities with the emissions of the radionuclides of interest. Contributions from spontaneous fission neutrons were considered separately. Exposure geometries for spherical hot particles of different dimensions, materials and locations on the cornea were considered. In addition, partial surface coverage of the cornea, consistent with an accidental exposure to a contaminated liquid, was also modelled. Resulting radionuclide DRCFs were verified, for a few specific geometries and radionuclides with dedicated Monte Carlo simulations. The final data are presented in several tables included in this paper.

Zebrafish (Danio rerio) Is an Economical and Efficient Animal Model for Screening Potential Anti-cataract Compounds.

Purpose: To develop a zebrafish cataract model for screening potential anti-cataract compounds. Methods: Living zebrafish were anesthetized and exposed to ultraviolet-C (UV-C) irradiation at a dosage of 3250 mJ/cm2/d until they developed severe cataracts. These cataracts were graded based on photographs analyzed with ImageQuant TL version 7.0. Fish with severe cataracts were used to evaluate a range of compounds for cataract treatment, including the previously demonstrated hit compound lanosterol. For the initial evaluation, fish were divided into four groups: no treatment, balanced salt solution, ß-cyclodextrin (ß-CD), and lanosterol dissolved in ß-CD. The treatments were performed for 10 days, and the clarity of lenses was evaluated. To assess the persistence of treatment, fish were treated with ß-CD and lanosterol dissolved in ß-CD for seven consecutive days followed by monitoring for three days without treatment. Results: The average time for zebrafish to develop severe cataracts using the present UV-C irradiation protocol was 7.8 days (range 4-15 days). Both study designs required only another 10 days to determine the effect of hit compounds. The total experimental period could be completed within one month, and the entire experiment was economical. Conclusions: We could assay a large number of hit compounds at a reasonable cost and within a short time using this newly developed zebrafish cataract model. These assays may allow development of an efficient platform for screening potential anti-cataract compounds. Translational Relevance: The results may facilitate the development of ani-cataract medication for humans after further experiments and investigations.

Environmental and industrial developments in radiation cataractogenesis.

PURPOSE: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protective equipment (PPE) and standards in clinical and nuclear settings motivated by the updated ICRP recommendations to mitigate exposures to the lens of the eye. The review also looks at evidence from the field linking cataracts in birds and mammals to low dose exposures. CONCLUSIONS: The review suggests that there is evidence that cataractogenesis is not a tissue reaction (deterministic effect) but rather is a low dose effect which shows a saturable dose response relationship similar to that seen for non-targeted effects in general. The review concludes that new research is needed to determine the dose response relationship in environmental studies where field data are contradictory and lab studies confined to rodent models for human exposure studies.

Quantification of pure beta spectra in mixed beta gamma fields as part of eye lens dosimetry at CANDU power plants.

To address the issue of eye lens dosimetry in nuclear industry, we initiated the project to quantify the beta and gamma-ray source term in CANDU power plants and to convert this source term into dosimetric quantities of interest, such as eye lens dose and personal dose equivalents Hp(10), Hp(0.07). This way, the eye lens dose can be compared with dosimetric operational quantities to evaluate whether independent dosimetry is required for eye lens protection, or present dosimetry is adequate.

A cost-effective way to reduce the equivalent eye lens dose fromYttrium-90 radiopharmaceuticals.

PURPOSE: We analyzed the effect of the use of Eye Protective Equipment (EPE) and the best position to use individual dosimeters to estimate the eye lens radiation dose to a medical staff that works with yttrium-90. METHODS: Three Alderson-Head-Phantoms were exposed to 58MBq of 90Y for 24h, in two different experiments: (1) at different dosimeter placements and (2) with and without the use of EPE. The measurements were carried on by thermoluminescent technique. RESULTS: Doses received by dosimeters on both lenses were more closely represented by the ones placed between the eyes than those on the temples, which underestimated the doses by a factor of 3. Also, the transmission factors showed that the EPE was able to reduce the Hp(3) values from about 78% to 92%. CONCLUSIONS: This study demonstrated that the use of EPE can optimize the 90Y eye lens dose. An individual dosimeter should be worn between the eyes for an appropriate estimate of this equivalent dose.

DNA damage in lens epithelial cells exposed to occupationally-relevant X-ray doses and role in cataract formation.

The current framework of radiological protection of occupational exposed medical workers reduced the eye-lens equivalent dose limit from 150 to 20 mSv per year requiring an accurate dosimetric evaluation and an increase understanding of radiation induced effects on Lens cells considering the typical scenario of occupational exposed medical operators. Indeed, it is widely accepted that genomic damage of Lens epithelial cells (LEC) is a key mechanism of cataractogenesis. However, the relationship between apoptosis and cataractogenesis is still controversial. In this study biological and physical data are combined to improve the understanding of radiation induced effects on LEC. To characterize the occupational exposure of medical workers during angiographic procedures an INNOVA 4100 (General Electric Healthcare) equipment was used (scenario A). Additional experiments were conducted using a research tube (scenario B). For both scenarios, the frequencies of binucleated cells, micronuclei, p21-positive cells were assessed with different doses and dose rates. A Monte-Carlo study was conducted using a model for the photon generation with the X-ray tubes and with the Petri dishes considering the two different scenarios (A and B) to reproduce the experimental conditions and validate the irradiation setups to the cells. The simulation results have been tallied using the Monte Carlo code MCNP6. The spectral characteristics of the different X-ray beams have been estimated. All irradiated samples showed frequencies of micronuclei and p21-positive cells higher than the unirradiated controls. Differences in frequencies increased with the delivered dose measured with Gafchromic films XR-RV3. The spectrum incident on eye lens and Petri, as estimated with MCNP6, was in good agreement in the scenario A (confirming the experimental setup), while the mean energy spectrum was higher in the scenario B. Nevertheless, the response of LEC seemed mainly related to the measured absorbed dose. No effects on viability were detected. Our results support the hypothesis that apoptosis is not responsible for cataract induced by low doses of X-ray (i.e. 25 mGy) while the induction of transient p21 may interfere with the disassembly of the nuclear envelop in differentiating LEC, leading to cataract formation. Further studies are needed to better clarify the relationship we suggested between DNA damage, transient p21 induction and the inability of LEC enucleation.

Artifact-free CT images for electron beam therapy using a patient-specific non metallic shield.

Patient's CT images taken with metallic shields for radiotherapy suffer from artifacts. Furthermore, the treatment planning system (TPS) has a limitation on accurate dose calculations for high density materials. In this study, a Monte Carlo (MC)-based method was developed to accurately evaluate the dosimetric effect of the metallic shield. Two patients with a commercial tungsten shield of lens and two patients with a custom-made lead shield of lip were chosen to produce their non-metallic dummy shields using 3D scanner and printer. With these dummy shields, we generated artifact-free CT images. The maximum CT number allowed in TPS was assigned to metallic shields. MC simulations with real material information were carried out. In addition, clinically relevant dose-volumetric parameters were calculated for the comparison between MC and TPS. Relative dosimetry was performed using radiochromic films. The dose reductions below metallic structures were shown on MC dose distributions, but not evident on TPS dose distributions. The differences in dose-volumetric parameters of PTV between TPS and MC for eye shield cases were not clearly shown. However, the mean dose of lens from TPS and MC was different. The MC results were in superior agreement with measured data in relative dosimetry. The lens dose could be overestimated by TPS. The differences in dose-volumetric parameters of PTV between TPS and MC were generally larger in lip cases than in eye cases. The developed method is useful in predicting the realistic dose distributions around the organs blocked by the metallic shields.

Assessment of Eye Lens Dose Reduction When Using Lateral Lead Shields on the Patient's Head during Neurointerventional Fluoroscopic Procedures and Cone-beam Computed Tomography (CBCT) Scans.

The purpose of this study was to evaluate the effect of placing small lead shields on the temple region of the skull to reduce radiation dose to the lens of the eye during interventional fluoroscopically-guided procedures and cone-beam computed tomography (CBCT) scans of the head. EGSnrc Monte-Carlo code was used to determine the eye lens dose reduction when using lateral lead shields for single x-ray projections, CBCT scans with different protocols, and interventional neuroradiology procedures with the Zubal computational head phantom. A clinical C-Arm system was used to take radiographic projections and CBCT scans of anthropomorphic head phantoms without and with lead patches, and the images were compared to assess the effect of the shields. For single lateral projections, a 0.1 (0.3)-mm-thick lead patch reduced the dose to the left-eye lens by 40% to 60% (55% to 80%) from 45° to 90° RAO and to the right-eye lens by around 30% (55%) from 70° to 90° RAO. For different CBCT protocols, the reduction of lens dose with a 0.3-mm-thick lead patch ranged from 20% to 53% at 110 kVp. For CBCT scans of the anthropomorphic phantom, the lead patch introduced streak artifacts that were mainly in the orbital regions but were insignificant in the brain region where most neurointerventional activity occurs. The dose to the patient's eye lens can be reduced considerably by placing small lead shields over the temple region of the head without substantially compromising image quality in neuro-imaging procedures.

Review of experimental estimates for the protection afforded by eyewear for interventional x-ray staff.

This paper attempts to systematise all published experimental results for the dose reduction factor (DRF) offered by leaded eyewear on clinicians performing interventional procedures. We aim to present a comprehensive analysis of the issue and a comparison of the various equipment models at different exposure geometries. The main purpose of the paper is, however, to clarify the best choice for the DRF within the possible diverse contexts and approaches to eye lens dose assessment. Evidence has been obtained that the lowest estimates of DRF are associated with larger scatter incidence angles and that, except for the slightly better performance exhibited by wraparound eyeglasses, there is no real distinction between the DRFs for the different equipment categories. The dataset as a whole confirms that, when measurements for the concerned eyewear model and irradiation conditions are unattainable, assuming DRF = 2 represents an adequately conservative choice. Nonetheless, this value includes only 17% of all results from the literature, whereas their histogram follows a distribution skewed towards higher values, represented by a median equal to 5. Therefore, if more realistic dose reconstructions are necessary, such as for purposes of epidemiological investigations or compensation decisions, the adoption of this central tendency index appears to be more reasonable. The complexity of characterising the DRF behaviour as a function of the various exposure factors reinforces the consideration of a statistical approach to eye lens dose assessment as a viable alternative. In this perspective, assuming for DRF a lognormal distribution with parameters [Formula: see text] and [Formula: see text] which has been verified to satisfactorily approximate the literature data distribution, should be deemed to be an appropriate option.

Assessment of the Annual Eye Lens Dose for Cardiologists During Interventional Procedures Using Anthropomorphic Phantoms and mEyeDose_X Tool.

OBJECTIVES: In this study, eye lens dose measurements were performed using two anthropomorphic phantoms simulating the cardiologist and patient during interventional procedures. BACKGROUND: Interventional procedures known as areas with high potential risk and the cardiologists can receive relatively high doses to their eyes. METHODS: This study was comprised of both phantom and computer simulations. Thermoluminescent dosimeters (TLDs) and mEyeDose_X tool were used to measure and calculate eye lens doses for the cardiologist. 144 TLDs measurements were performed using cardiac protocol for three angiographic projections: anterior-posterior (AP), left anterior oblique 90° (LAO90) and left anterior oblique 45° with cranial 30° (spider) angulations. All cine and fluoroscopy modes including the projections used in this study performed with and without protection tools. RESULTS: The annual equivalent doses with protective tools using mEyeDose_X were found to be 1.831 and 1.424 mSv/year, whereas the values using phantom were found to be 2.204 and 1.802 mSv/year for the lens of lift and right eye respectively. CONCLUSION: The annual doses reported in this study are almost comparable to other studies performed on interventional cardiology (IC) procedures. The highest dose rate in the lens was 20.21 ±â€¯0.015 mSv/h without protective tools in cine mode for spider projection. Cardiologists may therefore easily exceed the lens dose limit if protective tools are not used.

Trends in Estimated Thyroid, Salivary Gland, Brain, and Eye Lens Doses From Intraoral Dental Radiography Over Seven Decades (1940 TO 2009).

The purpose of this study is to support retrospective dose estimation for epidemiological studies by providing estimates of historical absorbed organ doses to the brain, lens of the eye, salivary glands, and thyroid from intraoral dental radiographic examinations performed from 1940 to 2009. We simulated organ doses to an adult over 10 y time periods from 1940 to 2009, based on commonly used sets of x-ray machine settings collected from the literature. Simulations to estimate organ dose were performed using personal computer x-ray Monte Carlo software. Overall, organ doses were less than 1 mGy for a single intraoral radiograph for all decades. From 1940 to 2009, doses to the brain, eye lens, salivary glands, and thyroid decreased by 86, 96, 95, and 89%, respectively. Of these four organs, the salivary glands received the highest doses, with values decreasing from about 0.23 mGy in the 1940s to 0.025 mGy in the 2000s for a single intraoral radiograph. Based on simulations using collected historical data on x-ray technical parameters, improvements in technology and optimization of the technical settings used to perform intraoral dental radiography have resulted in a decrease in absorbed dose to the brain, eye lens, salivary glands, and thyroid over the period from 1940 to 2009.

A study of the underestimation of eye lens dose with current eye dosemeters for interventional clinicians wearing lead glasses.

The reduction in the occupational dose limit of the eye lens has created the need for optimising eye protection and dose assessment, in particular for interventional clinicians. Lead glasses are one of the protection tools for shielding the eyes, but assessing the eye lens dose when these are in place remains challenging. In this study, we evaluated the impact of the position of H p (3) dosemeters on the estimated eye lens dose when lead glasses are used in interventional settings. Using the Monte Carlo method (MCNPX), an interventional cardiology setup was simulated for two models of lead glasses, five beam projections and two patient access routes. H p (3) dosemeters were placed at several positions on the operator and the obtained dose was compared to the dose to the sensitive part of the eye lens (H lens). Furthermore, to reproduce an experimental setup, a reference dosemeter, H p (3)ref, was placed on the surface of the eye. The dose measured by H p (3)ref was, on average, only 60% of H lens. Dosemeters placed on the glasses, under their shielding, underestimated H lens for all parameters considered, by from 10% up to 90%. Conversely, dosemeters placed on the head or on the glasses, over their shielding, overestimated H lens, on average, up to 60%. The presence or lack of side shielding in lead glasses affected mostly dosemeters placed on the forehead, at the left side. Results suggest that both use of a correction factor of 0.5 to account for the presence of lead glasses in doses measured outside their shielding and placing an eye lens dosemeter immediately beneath the lenses of lead glasses may lead to the underestimation of the eye lens dose. Most suitable positions for eye lens dose assessment were on the skin, unshielded by the glasses or close to the eye, with no correction to the dose measured.

An age-dependent series of eye models for radiation dosimetry.

Several studies have been appeared, up to now, that indicate the effect of accurate simulation on dose received by different substructures of the eye, irradiated by external beams of short-range radiation such as electron. Different representations of the eye have consequently been introduced. Their accuracies depend on the purpose for which models are described or the degree of accuracy of information that models are based upon. All of developed models have presented the eye of an adult human, while the size, shape, and thickness of the eye substructures change with age. This work offers a series of age-dependent eye models including five models of different ages to investigate the influence of the individual age on doses to eye substructures. The absorbed dose conversion coefficients were calculated using Monte Carlo MCNP code for 17 monoenergetic broad electron beams in the range of 100 keV to 10 MeV and for 0°, 30° and 45° angles of incidence. Results showed the strong dependency of sclera and iris doses to the age (PDD above 105), for low-energies electrons. Increasing the electron energy, the PDD decreases severely for these substructure which means dose fluctuation in the age-dependent eye models reduces. For higher energies, dose fluctuations due to age become small and for some substructures could be negligible. Highlights - A series of age-dependent eye models was developed based on the realistic anatomy. - Dose conversion coefficients of eye substructures were calculated for each models. - 17 monoenergetic electron beams and three angles of incidence were considered. - Fluctuations of doses to eye sections due to the age were obtained.

Influences of operator head posture and protective eyewear on eye lens doses in interventional radiology: A Monte Carlo Study.

PURPOSE: To quantify the effects of operator head posture and different types of protective eyewear on the eye lens dose to operators in interventional radiology (IR). METHODS: A deformable computational human phantom, Rensselaer Polytechnic Institute (RPI) Adult Male, consisting of a high-resolution eye model, was used to simulate a radiologist who is performing an interventional radiology procedure. The radiologist phantom was deformed to a set of different head postures. Three different protective eyewear models were incorporated into the posture-deformed radiologist phantom. The eye lens dose of the radiologist was calculated using the Monte Carlo code, MCNP. Effects of the radiologist's head posture and different types of protective eyewear on eye lens doses were studied. The relationship between efficacy of protective eyewear and the radiologist's head posture was investigated. Effects of other parameters on efficacy of protective eyewear were also studied, including the angular position of the radiologist, the gap between the eyewear and the face of the radiologist, and the lead equivalent thickness. RESULTS: The dose to both lenses decreased by 80% as the head posture moved from looking downward to looking upward. Sports wrap glasses were found to reduce doses further than the other two studied models. The efficacy of eyewear was found to be related to radiologist's head posture as well. When the radiologist was looking up, the protective eyewear almost provided no protection to both lenses. Other factors such as the face-to-eyewear distance and the lead equivalent thickness were also found to have an impact on the efficacy of protective eyewear. The dose reduction factor (DRF), defined as the ratio of the dose to the lens without protection to that with protection, decreased from 4.25 to 1.07 as the face-to-eyewear distance increased. The DRF almost doubled when the lead equivalent thickness increased from 0.07 to 0.35 mm. However, further increase in lead equivalent thickness showed little improvement in dose reduction. CONCLUSION: The radiologist's head posture has a significant influence on the eye lens dose in IR. Sports wrap protective eyewear which conforms to the curve of the face is essential for the radiation protection of the eye lens. However, the radiologist's head posture and other exposure parameters should be considered when evaluating the protection of the radiologist's eyes.

PRELIMINARY STAFF DOSE ASSESSMENT FOR COMMON FLUOROSCOPY GUIDED PROCEDURES AT KORLE-BU TEACHING HOSPITAL, ACCRA, GHANA.

Preliminary studies on effective and eye lens doses of six Radiologists, four Cardiologists have been conducted for a period of 3 months. Electronic dosemeters positioned under and over lead apron of staff were used for the dosimetry. The estimated effective dose per month to Cardiologist and Radiologist were 0.01-0.07 mSv and 0.03-0.14 mSv, respectively. The estimated eye lens doses per month to Cardiologists and Radiologists were also 0.15-0.30 mSv and 0.53-3.39 mSv, respectively. The effective doses per month to staff were below the ICRP acceptable limit of 1.67 mSv/month but the upper limit of the range of estimated eye lens dose exceeded the ICRP acceptable limit by a factor of 2. Regular use of protective goggles and consistent eye lens dose monitoring is encouraged at the hospital for dose optimization.

Determination of Whole-Body and Lens Dose Conversion Factors for Japanese Field Mice, Apodemus Speciosus.

The 11 March 2011 Fukushima nuclear accident in Japan resulted in widespread radioactive contamination within the 20 km evacuation zone. Japanese field mice (Apodemus speciosus) living within the contaminated region received radiation doses from external environmental contamination as well as internally deposited radionuclides. Cataract formation in the lens of eyes of these mice is a possible deterministic effect of ionizing radiation; however, determination of actual doses is difficult. Since no dose conversion factors currently exist for the lens of the eyes of Japanese field mice, lens dose conversion factors were created using a Monte Carlo N-Particle simulation and compared to the International Commission on Radiological Protection Publication 108 reference rat whole-body dose conversion factors. Monte Carlo N-Particle simulations included doses to the lens of the eyes from external sources (received while both above and below ground), as well as doses from internal contamination. Although the Publication 108 reference rat is almost twice the average mass of the Japanese field mouse, all dose conversion factor calculations using Monte Carlo N-Particle methods were within approximately 37% of the Publication 108 values for the reference rat.

OCCUPATIONAL EYE LENS DOSE ESTIMATED USING WHOLE-BODY DOSEMETER IN INTERVENTIONAL CARDIOLOGY AND RADIOLOGY: A MONTE CARLO STUDY.

Medical personnel performing interventional procedures in cardiology and radiology is considered to be a professional group exposed to high doses of ionizing radiation. Reduction of the eye lens dose limit made its assessment in the interventional procedures one of the most challenging topics. The objective of this work is to assess eye lens doses based on the whole-body doses using methods of computational dosimetry. Assessment included different C-arm orientations (PA, LAO and RAO), tube voltages (80 -110 kV) and efficiency of different combinations of protective equipment used in interventional procedures. Center position at the height of the thyroid gives best estimate of eye lens dose, with spreads of 11% (13%), 13% (17%) and 14% (13%) for the left (right) eye lens. The conversion factors of 1.03 (0.83), 1.28 (1.06) and 1.36 (1.06) to convert whole body to eye lens dose were derived for positions of first operator, nurse and radiographer, respectively. The eye lens dose reduction factors for different combinations of applied protective equipment are 178, 5 and 6, respectively.

Studies on pelletised lithium magnesium borate TL material for eye lens dosimetry.

Recent epidemiological studies in various cohorts confirm that radiation induced cataract may occur at a threshold dose as low as 0.5 Gy. ICRP has recognised the higher radiosensitivity of eye lens and recommended to reduce annual eye lens dose limit from 150 to 20 mSv. Present dosimetry for eye lens is largely based on LiF based dosimeters. The present work is an attempt towards using near tissue equivalent lithium borate material namely lithium magnesium borate doped with terbium (LMB:Tb) in eye lens dosimetry. The material in powder form was synthesised using solid state sintering method and pelletised using poly tetra fluoro ethylene (PTFE) as binding agent. It was observed that 130 mg of 1 mm thick LMB:Tb pellet bound with PTFE showed stable glow curve structure and attractive dosimetric features in terms of sensitivity, fading, linearity, reusability etc. A proposal of 1.5 mm Teflon encapsulation corresponding to tissue equivalent thickness of 3 mm was put forward for an ideal dosimeter for the measurement in terms of Hp(3). Energy and angular dependence studies based on FLUKA simulations suggest a flat response for the prototype design. In addition to PTFE, various tissue equivalent encapsulations such as polyimide, polyamide 6 and PMMA were also evaluated using FLUKA code.