[Burden of diverticular disease: an observational analysis based on Italian real-world data.] / Valutazione dell'impatto economico delle complicanze della malattia diverticolare con i dati "real life" della Regione Marche.

INTRODUCTION: Diverticular disease (DD) represent a wide variety of conditions associated with the presence of diverticula in the colon. The most serious form is an acute episode of diverticulitis which can lead to hospitalization and surgery with various types of consequences. The main aim of this study was to evaluate, from both cross-sectional and longitudinal perspective, the economic burden of diverticulitis in the real practice. METHOD: A deterministic linkage was performed at individual user level between the different administrative sources of the Marche Region through anonymised ID number for a period of analysis between 1 January 2008 and 31 December 2014. We enrolled all patients with at least one hospitalization for "diverticulitis of the colon without mention of haemorrhage" (ICD-9-CM code 562.11) or "diverticulitis of the colon with haemorrhage" (ICD-9-CM code 562.13) as primary or secondary diagnosis. Cost and outcome were analysed considering transversally (for contemporaneous) and longitudinal (for cohort) perspective. Hospital mortality at one year after discharge was evaluated by mortality rates and Kaplan-Meier curve considering the surgery performed (or not performed) during the index hospitalization. RESULTS: Considering the cross-sectional perspective, 427 patients per year were estimated (about 35 patients per 100,000 adult residents) with an average number of hospitalization equal to 1.14. The direct healthcare costs incurred by the Marche region for episodes of diverticulitis in 2008-2014 amounted to approximately € 11.4 million (€ 1.6 million a year), of which € 10.9 million (95.5%) for the hospitalizations, € 246,000 (2.1%) for pharmaceutical treatment and € 270,000 (2.4%) for specialist outpatient services. The cohort analysis estimates an intra-hospital mortality rate equal to 5.9 per 100 patients' year (5.5 for non-surgery patients and 8.9 for surgery patients - P<0.05). Kaplan-Meier curve demonstrate that there were no differences between intra-hospital mortality due to surgery during index hospitalization. CONCLUSIONS: Our study is the first analysis in Italy to use real-world data to measure the burden of DD with a cross-sectional and longitudinal perspective. This study could be useful for decision maker that could quantify the economic and epidemiological burden of DD in hospital.

Surgeon Volume Correlates with Reduced Mortality and Improved Quality in the Surgical Management of Diverticulitis.

BACKGROUND: Volume has been shown to be an important determinant of quality and cost outcomes. METHODS: We performed a retrospective study of patients who underwent surgery for diverticulitis using the University HealthSystem Consortium database from 2008­2012. Outcomes evaluated included minimally invasive approach, stoma creation, intensive-care admission, post-operative complications, length of stay, and total direct hospital costs by surgeon volume. Surgeon volume was categorized into four categories by mean annual volumes: very-high (VHVS) (>31), high (HVS) (13­31), medium (MVS) (6­12), and low (LVS) (≤5). RESULTS: A total of 19,212 patients with a mean age of 59 years, 54 % female makeup, and 55 % rate of private insurance were included. Similar to the unadjusted analysis, multivariable analysis revealed decreasing odds of stoma creation, complications, ICU admission, reoperation, readmission, and inpatient mortality with increasing surgeon volume. Additionally, compared with LVS, a higher surgeon volume was associated with higher rates of the minimally invasive approach. Median length of stay and costs were also notably lower with increasing surgeon volume. CONCLUSION: Quality and the use of minimally invasive technique are tightly associated with surgeon volume. Further studies are necessary to validate the direct association of volume with outcomes in surgery for diverticulitis.

The price of decreased mortality in the operative management of diverticulitis.

BACKGROUND: Healthcare costs in the United States are increasing. It is thought that as cost increases, outcomes should improve. The aim of this study was to analyze patient charges and mortality in the operative management of diverticulitis over time. METHODS: A retrospective analysis of the Nationwide Inpatient Sample database was performed. Adults with diverticulitis who underwent laparoscopic or open partial colectomy were identified by ICD-9 codes. Multivariate analyses examined in-hospital mortality and total charges. Results were adjusted for age, race, gender, Charlson comorbidity index, surgical approach (open vs. laparoscopic), and insurance status. RESULTS: From 1998 to 2010, 148,348 patients had a partial colectomy for diverticulitis. After adjusting for other covariates and inflation, the average charge of hospitalization per admission increased by $34,057 from 1998 to 2010. In the same observation period, adjusted in-hospital mortality decreased significantly by 2005 compared to 1998 (p < 0.001, OR 0.77, 95% CI 0.68-0.88) and remained unchanged for the remainder of the study period. Additionally, laparoscopic management was associated with lower rate of charge increase compared to open management (p < 0.001), such that charges are currently higher for open management than laparoscopic. CONCLUSION: In-hospital mortality following partial colectomy for diverticulitis has improved over time, most dramatically after 2005. With decreasing mortality, an increase in hospital charges is observed on an annual basis. However, while mortality reached a plateau after 2005, overall charges continue to rise.

Insurance but not race is associated with diverticulitis mortality in a statewide database.

OBJECTIVES: Racial identity and health insurance have been associated with differential health care outcomes for many diseases, but not for diverticulitis. We examined the association of racial identity and insurance with admission, treatment, and mortality for patients admitted to inpatient care for acute diverticulitis. METHODS: Data on adult inpatients with nonelective diverticulitis admissions between 1985 and 2006 were extracted from the New York Statewide Planning and Cooperative Systems Database. Race categories were white non-Hispanic, black non-Hispanic, Hispanic, Asian, other race, and unknown race. A multivariable logistic regression model adjusted for insurance, year, patient factors, community factors, and hospital factors was used to examine the association of racial identity and insurance with presentation, treatment, and mortality. Five outcomes were considered: 1) admission via the emergency department, 2) complicated disease presentation, 3) surgical intervention, 4) colostomy creation, and 5) mortality. White race and private insurance were reference groups. RESULTS: We identified 253,655 admissions. Race distribution included 77.7% white, 8.1% black, and 7.2% Hispanic. Medicare was the most commonly held insurance (52.7%), and 73.7% of patients were admitted through the emergency department. Of 36,190 surgeries, 20,650 (57.1%) included colostomies, and 3.0% of all patients died. Race other than white and Medicaid insurance were the strongest predictors of admission via the emergency department (OR 1.34, 95% CI 1.12-1.60; OR 1.60, 95% CI 1.44-1.78). Patients categorized as black, Hispanic, Asian, or other were less likely to have complicated disease, surgery, and colostomy creation (OR 0.81, 95% CI 0.76-0.85; OR 0.87, 95% CI 0.81-0.94; and OR 0.67, 95% CI 0.61-0.74). Insurance was associated with higher rates of mortality; having Medicaid or no insurance were the strongest predictors (OR 1.61, 95% CI 1.36-1.89; OR 1.34, 95% CI 1.06-1.69). CONCLUSIONS: In acute diverticulitis, race and insurance were associated with differential admission patterns, and patients categorized as black, Hispanic, Asian, or other were less likely to receive surgical treatment or colostomy. Insurance status, but not race, was associated with mortality. Future research is needed to further explore these differences in admission, treatment, and mortality.