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1.
PLoS One ; 17(1): e0262190, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34986193

RESUMO

Cardiovascular care is expensive; hence, economic evaluation is required to estimate resources being consumed and to ensure their optimal utilization. There is dearth of data regarding cost analysis of treating various diseases including cardiac diseases from developing countries. The study aimed to analyze resource consumption in treating cardio-vascular disease patients in a super-specialty hospital. An observational and descriptive study was carried out from April 2017 to June 2018 in the Department of Cardiology, Cardio-Thoracic (CT) Centre of All India Institute of Medical Sciences, New Delhi, India. As per World Health Organization, common cardiovascular diseases i.e. Coronary Artery Disease (CAD), Rheumatic Heart Disease (RHD), Cardiomyopathy, Congenital heart diseases, Cardiac Arrhythmias etc. were considered for cost analysis. Medical records of 100 admitted patients (Ward & Cardiac Care Unit) of cardiovascular diseases were studied till discharge and number of patient records for a particular CVD was identified using prevalence-based ratio of admitted CVD patient data. Traditional Costing and Time Driven Activity Based Costing (TDABC) methods were used for cost computation. Per bed per day cost incurred by the hospital for admitted patients in Cardiac Care Unit, adult and pediatric cardiology ward was calculated to be Indian Rupee (INR) 28,144 (US$ 434), INR 22,210 (US$ 342) and INR 18,774 (US$ 289), respectively. Inpatient cost constituted almost 70% of the total cost and equipment cost accounted for more than 50% of the inpatient cost followed by human resource cost (28%). Per patient cost of treating any CVD was computed to be INR 2,47,822 (US $ 3842). Cost of treating Rheumatic Heart Disease was the highest among all CVDs followed by Cardiomyopathy and other CVDs. Cost of treating cardiovascular diseases in India is less than what has been reported in developed countries. Findings of this study would aid policy makers considering recent radical changes and massive policy reforms ushered in by the Government of India in healthcare delivery.


Assuntos
Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/terapia , Custos de Cuidados de Saúde/classificação , Hospitalização/economia , Adolescente , Adulto , Doenças Cardiovasculares/economia , Criança , Pré-Escolar , Feminino , Humanos , Índia , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Adulto Jovem
2.
J Cardiovasc Med (Hagerstown) ; 22(11): 832-839, 2021 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-34482324

RESUMO

INTRODUCTION: Previous cardiovascular disease (CVD) and myocardial involvement are common in coronavirus disease-19 (COVID-19). We investigated relationships between CVD, cardiac biomarkers and outcome in COVID-19. METHODS: We analyzed n = 252 patients from a multicenter study and provided comparison according to the presence or absence of underlying CVD. Cardiac biomarkers high-sensitivity Troponin [upper reference of normality (URN) 35 pg/ml for Troponin I and 14 pg/ml for Troponin T] and natriuretic peptides (Nt-pro-B-type natriuretic peptide, URN 300 pg/ml and B-type natriuretic peptide, URN 100 pg/ml) were both available in n = 136. RESULTS: Mean age was 69 ±â€Š16 years (56% men, 31% with previous CVD). Raised hs-Troponin and natriuretic peptides were detected in 36 and 50% of the cases respectively. Age, chronic obstructive pulmonary disease, hemoglobin, hs-Troponin and natriuretic peptides were independently associated with underlying CVD (P < 0.05 for all). Compared with the normal biomarkers subgroups, patients with isolated hs-Troponin elevation had higher in-hospital mortality (31 vs. 4%, P < 0.05), similar CVD prevalence (15 vs. 11%) and trend towards higher D-dimer (930 vs. 397 ng/ml, P = 0.140). Patients with both biomarkers elevated had higher age, D-dimer, CVD and in-hospital mortality prevalence compared with other subgroups (all P < 0.05 for trend). Outcome analysis revealed previous CVD [model 1: OR 2.72 (95% CI 1.14-6.49), P = 0.024. model 2: OR 2.65 (95% CI 1.05-6.71), P = 0.039], hs-Troponin (log10) [OR 2.61 (95% CI 1.21-5.66), P = 0.015] and natriuretic peptides (log10) [OR 5.84 (95%CI 2.43-14), P < 0.001] to be independently associated with in-hospital mortality. CONCLUSION: In our population, previous CVD was part of a vulnerable phenotype including older age, comorbidities, increased cardiac biomarkers and worse prognosis. Patients with isolated increase in hs-Troponin suffered higher mortality rates despite low prevalence of CVD, possibly explained by higher COVID-19-related systemic involvement.


Assuntos
COVID-19 , Doenças Cardiovasculares , Peptídeos Natriuréticos/sangue , Troponina/sangue , Idoso , Biomarcadores/sangue , COVID-19/sangue , COVID-19/diagnóstico , COVID-19/mortalidade , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/epidemiologia , Comorbidade , Feminino , Produtos de Degradação da Fibrina e do Fibrinogênio/análise , Mortalidade Hospitalar , Humanos , Itália/epidemiologia , Masculino , Avaliação de Resultados em Cuidados de Saúde , Prognóstico , Medição de Risco , Fatores de Risco , SARS-CoV-2/isolamento & purificação
3.
J Am Heart Assoc ; 10(15): e020333, 2021 08 03.
Artigo em Inglês | MEDLINE | ID: mdl-34315233

RESUMO

Background Guideline-based cardioprotective medical therapy is intended to reduce the burden of adverse cardiovascular and limb outcomes in patients with peripheral artery disease (PAD). However, contemporary data describing trends in use of medication remains limited. The present study, therefore, aims to investigate changes in use of cardioprotective medication in PAD. Methods and Results By using Danish national healthcare registries, we identified all patients with first-time diagnosis of PAD (1997-2016) and classified them into two groups: (1) PAD+ that includes all patients with PAD with a history of cardiovascular disease, ie, myocardial infarction, atrial fibrillation, and stroke (n=162 627); and (2) PAD (n=87 935) that comprise patients without a history of cardiovascular disease. We determined the use of medication in the first 12 months after the incident diagnosis of PAD and estimated age standardized 1-year mortality rates. Our results showed increase in use of cardioprotective medication throughout the study period in both groups. However, PAD+ had a higher use of medication (acetylsalicylic acid, 3.5%-48.4%; Clopidogrel, 0%-17.6%; vitamin K antagonists, 0.9%-7.8%; new oral anticoagulants, 0.0%-10.1%; Statins, 1.9%-58.1%; angiotensin-converting enzyme inhibitors, 1.2%-20.6%), compared with PAD (acetylsalicylic acid, 2.9%-54.4%; Clopidogrel, 0%-11.9%; vitamin K antagonists, 0.9%-2.4%; new oral anticoagulants, 0.0%-3.4%; Statins, 1.5%-56.9%; angiotensin-converting enzyme, 0.9%-17.2%), respectively. Furthermore, 1-year mortality rates in PAD declined with increased use of medications during study. Conclusions In this nationwide study, use of cardioprotective medication increased considerably with time, but compared to patients with other atherosclerotic diseases, there remains an underuse of guideline-based medical therapy in patients with PAD.


Assuntos
Cardiotônicos , Doenças Cardiovasculares , Conduta do Tratamento Medicamentoso/tendências , Doença Arterial Periférica , Idoso , Cardiotônicos/classificação , Cardiotônicos/uso terapêutico , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/prevenção & controle , Efeitos Psicossociais da Doença , Dinamarca/epidemiologia , Feminino , Mau Uso de Serviços de Saúde/prevenção & controle , Mau Uso de Serviços de Saúde/estatística & dados numéricos , Humanos , Masculino , Mortalidade , Doença Arterial Periférica/complicações , Doença Arterial Periférica/diagnóstico , Doença Arterial Periférica/tratamento farmacológico , Doença Arterial Periférica/epidemiologia , Guias de Prática Clínica como Assunto , Sistema de Registros/estatística & dados numéricos , Tempo para o Tratamento
4.
Heart ; 107(16): 1303-1309, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34021040

RESUMO

OBJECTIVE: More knowledge about the development of sudden cardiac death (SCD) in the general population is needed to develop meaningful predictors of SCD. Our aim with this study was to estimate the incidence of SCD in the general population and examine the temporal changes, demographics and clinical characteristics. METHODS: All participants in the Copenhagen City Heart Study were followed from 1993 to 2016. All death certificates, autopsy reports and national registry data were used to identify all cases of SCD. RESULTS: A total of 14 562 subjects were included in this study. There were 8394 deaths with all information available, whereof 1335 were categorised as SCD. The incidence of SCD decreased during the study period by 41% for persons aged 40-90 years, and the standardised incidence rates decreased from 504 per 100 000 person-years (95% CI 447 to 569) to 237 per 100 000 person-years (95% CI 195 to 289). The incidence rate ratio of SCD between men and women ≤75 years was 1.99 (95% CI 1.62 to 2.46). The proportion of SCD of all cardiac deaths decreased during the observation period and decreased with increasing age. Men had more cardiovascular comorbidities (OR 1.34, 95% CI 1.07 to 1.68, p<0. 01), and SCD was the first registered manifestation of cardiac disease in 50% of all cases. CONCLUSION: The incidence of SCD in the general population has declined significantly during the study period but should be further investigated for more recent variations as well as novel risk predictors for persons with low to medium risk of SCD.


Assuntos
Doenças Cardiovasculares , Causas de Morte/tendências , Morte Súbita Cardíaca/epidemiologia , Saúde da População Urbana/tendências , Distribuição por Idade , Idoso , Autopsia/estatística & dados numéricos , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/epidemiologia , Atestado de Óbito , Dinamarca/epidemiologia , Feminino , Carga Global da Doença , Humanos , Incidência , Estudos Longitudinais , Masculino , Fatores de Risco , Distribuição por Sexo
5.
J Am Heart Assoc ; 10(7): e018446, 2021 04 06.
Artigo em Inglês | MEDLINE | ID: mdl-33719521

RESUMO

Background Socioeconomic status is associated with differences in risk factors of cardiovascular disease and increased risks of cardiovascular disease and mortality. However, it is unclear whether an association exists between cardiovascular disease and income, a common measure of socioeconomic status, among patients with hypertension. Methods and Results This population-based longitudinal study comprised 479 359 patients aged ≥19 years diagnosed with essential hypertension. Participants were categorized by income and blood pressure levels. Primary end point was all-cause and cardiovascular mortality and secondary end points were cardiovascular events, a composite of cardiovascular death, myocardial infarction, and stroke. Low income was significantly associated with high all-cause (hazard ratio [HR], 1.26; 95% CI, 1.23-1.29, lowest versus highest income) and cardiovascular mortality (HR, 1.31; 95% CI, 1.25-1.38) as well as cardiovascular events (HR, 1.07; 95% CI, 1.05-1.10) in patients with hypertension after adjusting for age, sex, systolic blood pressure, body mass index, smoking status, alcohol consumption, physical activity, fasting glucose, total cholesterol, and the use of aspirin or statins. In each blood pressure category, low-income levels were associated with high all-cause and cardiovascular mortality and cardiovascular events. The excess risks of all-cause and cardiovascular mortality and cardiovascular events associated with uncontrolled blood pressure were more prominent in the lowest income group. Conclusions Low income and uncontrolled blood pressure are associated with increased all-cause and cardiovascular mortality and cardiovascular events in patients with hypertension. These findings suggest that income is an important aspect of social determinants of health that has an impact on cardiovascular outcomes in the care of hypertension.


Assuntos
Anti-Hipertensivos/uso terapêutico , Determinação da Pressão Arterial , Doenças Cardiovasculares , Hipertensão , Renda/estatística & dados numéricos , Fatores Socioeconômicos , Determinação da Pressão Arterial/métodos , Determinação da Pressão Arterial/estatística & dados numéricos , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/economia , Doenças Cardiovasculares/mortalidade , Causas de Morte , Feminino , Disparidades em Assistência à Saúde/estatística & dados numéricos , Humanos , Hipertensão/diagnóstico , Hipertensão/tratamento farmacológico , Hipertensão/economia , Hipertensão/epidemiologia , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , República da Coreia/epidemiologia , Medição de Risco/métodos , Fatores de Risco , Determinantes Sociais da Saúde
6.
J Am Heart Assoc ; 10(1): e017832, 2021 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-33322915

RESUMO

Background The incidence of cardiovascular disease among pregnant women is rising in the United States. Data on racial disparities for the major cardiovascular events during pregnancy are limited. Methods and Results Pregnant and post-partum women hospitalized from January 2007 to December 2017 were identified from the Nationwide Inpatient Sample. The outcomes of interest included: in-hospital mortality, myocardial infarction, stroke, pulmonary embolism, and peripartum cardiomyopathy. Multivariate regression analysis was used to assess the independent association between race and in-hospital outcomes. Among 46 700 637 pregnancy-related hospitalizations, 21 663 575 (46.4%) were White, 6 302 089 (13.5%) were Black, and 8 914 065 (19.1%) were Hispanic. The trends of mortality and stroke declined significantly in Black women, but however, were mostly unchanged among White women. The incidence of mortality and cardiovascular morbidity was highest among Black women followed by White women, then Hispanic women. The majority of Blacks (62.3%) were insured by Medicaid while the majority of White patients had private insurance (61.9%). Most of Black women were below-median income (71.2%) while over half of the White patients were above the median income (52.7%). Compared with White women, Black women had the highest mortality with adjusted odds ratio (aOR) of 1.45, 95% CI (1.21-1.73); myocardial infarction with aOR of 1.23, 95% CI (1.06-1.42); stroke with aOR of 1.57, 95% CI (1.41-1.74); pulmonary embolism with aOR of 1.42, 95% CI (1.30-1.56); and peripartum cardiomyopathy with aOR of 1.71, 95 % CI (1.66-1.76). Conclusions Significant racial disparities exist in major cardiovascular events among pregnant and post-partum women. Further efforts are needed to minimize these differences.


Assuntos
Doenças Cardiovasculares , Disparidades nos Níveis de Saúde , Disparidades em Assistência à Saúde/organização & administração , Mortalidade Hospitalar , Complicações Cardiovasculares na Gravidez , Transtornos Puerperais , Adulto , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/etnologia , Doenças Cardiovasculares/terapia , Demografia , Feminino , Necessidades e Demandas de Serviços de Saúde , Mortalidade Hospitalar/etnologia , Mortalidade Hospitalar/tendências , Hospitalização/estatística & dados numéricos , Humanos , Incidência , Medicaid , Gravidez , Complicações Cardiovasculares na Gravidez/classificação , Complicações Cardiovasculares na Gravidez/etnologia , Complicações Cardiovasculares na Gravidez/terapia , Transtornos Puerperais/classificação , Transtornos Puerperais/etnologia , Transtornos Puerperais/terapia , Fatores Socioeconômicos , Estados Unidos/epidemiologia
7.
J Cardiovasc Med (Hagerstown) ; 22(6): 453-458, 2021 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-33186238

RESUMO

AIMS: Crossover between direct oral anticoagulants (DOACs) has been underinvestigated, but happens frequently in clinical practice. The purpose of this study was to evaluate causes, rates and outcomes of a DOAC-to-DOAC switch. METHODS: Patients receiving their first DOAC prescription at the Anticoagulation Center, Cardiology Dept, Bologna-Bellaria Hospital in 2017-2018 were consecutively included and prospectively followed up. DOAC-to-DOAC switch was the main outcome; causes of switch (cardiovascular events and noncardiovascular drug-related adverse events) had direct biannual assessment before and after the switch. RESULTS: Among 300 patients enrolled (mean age = 79.3 years, mean follow-up = 1.5 years), with no difference in cardiovascular risk factors depending on index DOAC, 13% underwent DOAC-to-DOAC switch, minor bleeding and noncardiovascular adverse events being the most frequent causes. Dabigatran carried a three-fold increase in risk of switch compared with other DOACs, but the mean age of patients who switched was 83. Factors leading to switch resolved in 87% of cases afterwards. Annual rates of cardiovascular/noncardiovascular V events did not differ before and after the switch. CONCLUSION: DOAC-to-DOAC switch happens in 9% of patients using DOAC each year, and seems not to impact rates of cardiovascular events after switch. Dabigatran, in the elderly, might be associated with a higher risk of DOAC-to-DOAC switch. Further studies are needed to confirm the long-term safety and effectiveness of switching paradigm.


Assuntos
Doenças Cardiovasculares , Dabigatrana , Monitoramento de Medicamentos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Efeitos Adversos de Longa Duração , Rivaroxabana , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/tratamento farmacológico , Doenças Cardiovasculares/epidemiologia , Dabigatrana/administração & dosagem , Dabigatrana/efeitos adversos , Monitoramento de Medicamentos/métodos , Monitoramento de Medicamentos/estatística & dados numéricos , Substituição de Medicamentos/métodos , Substituição de Medicamentos/estatística & dados numéricos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/urina , Inibidores do Fator Xa/administração & dosagem , Inibidores do Fator Xa/efeitos adversos , Feminino , Fatores de Risco de Doenças Cardíacas , Humanos , Itália/epidemiologia , Efeitos Adversos de Longa Duração/induzido quimicamente , Efeitos Adversos de Longa Duração/prevenção & controle , Masculino , Conduta do Tratamento Medicamentoso/estatística & dados numéricos , Risco Ajustado/métodos , Rivaroxabana/administração & dosagem , Rivaroxabana/efeitos adversos
8.
Am J Physiol Heart Circ Physiol ; 319(6): H1409-H1413, 2020 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-33064554

RESUMO

Racial disparities in cardiovascular and cerebrovascular health outcomes are well described, and recent research has shed light on the mechanistic underpinnings of those disparities. However, "race" is a social construct that is poorly defined and continually evolving and is historically based on faulty premises. The continued categorization by race in physiological research suggests that there are inherent differences between races, rather than addressing the specific underlying factors that result in health disparities between groups. The purpose of this Perspectives article is to provide a brief history of the genesis of categorization by race, why such categorization should be reconsidered in physiology research, and offer recommendations to more directly investigate the underlying factors that result in group disparities in cardiovascular and cerebrovascular health.


Assuntos
Pesquisa Biomédica , Doenças Cardiovasculares/etnologia , Doenças Cardiovasculares/fisiopatologia , Sistema Cardiovascular/fisiopatologia , Disparidades nos Níveis de Saúde , Fisiologia , Grupos Raciais , Determinantes Sociais da Saúde/etnologia , Pesquisa Biomédica/classificação , Doenças Cardiovasculares/classificação , Humanos , Fisiologia/classificação , Fatores Raciais , Grupos Raciais/classificação
9.
Health Inf Manag ; 49(1): 47-57, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31043088

RESUMO

BACKGROUND: The All Patient-Refined Diagnosis-Related Groups (APR-DRGs) system has adjusted the basic DRG structure by incorporating four severity of illness (SOI) levels, which are used for determining hospital payment. A comprehensive report of all relevant diagnoses, namely the patient's underlying co-morbidities, is a key factor for ensuring that SOI determination will be adequate. OBJECTIVE: In this study, we aimed to characterise the individual impact of co-morbidities on APR-DRG classification and hospital funding in the context of respiratory and cardiovascular diseases. METHODS: Using 6 years of coded clinical data from a nationwide Portuguese inpatient database and support vector machine (SVM) models, we simulated and explored the APR-DRG classification to understand its response to individual removal of Charlson and Elixhauser co-morbidities. We also estimated the amount of hospital payments that could have been lost when co-morbidities are under-reported. RESULTS: In our scenario, most Charlson and Elixhauser co-morbidities did considerably influence SOI determination but had little impact on base APR-DRG assignment. The degree of influence of each co-morbidity on SOI was, however, quite specific to the base APR-DRG. Under-coding of all studied co-morbidities led to losses in hospital payments. Furthermore, our results based on the SVM models were consistent with overall APR-DRG grouping logics. CONCLUSION AND IMPLICATIONS: Comprehensive reporting of pre-existing or newly acquired co-morbidities should be encouraged in hospitals as they have an important influence on SOI assignment and thus on hospital funding. Furthermore, we recommend that future guidelines to be used by medical coders should include specific rules concerning coding of co-morbidities.


Assuntos
Doenças Cardiovasculares/classificação , Grupos Diagnósticos Relacionados/classificação , Doenças Respiratórias/classificação , Máquina de Vetores de Suporte , Doenças Cardiovasculares/epidemiologia , Comorbidade , Confiabilidade dos Dados , Feminino , Preços Hospitalares/tendências , Humanos , Masculino , Portugal/epidemiologia , Controle de Qualidade , Doenças Respiratórias/epidemiologia , Sensibilidade e Especificidade , Índice de Gravidade de Doença
10.
Sci Rep ; 7(1): 15238, 2017 11 10.
Artigo em Inglês | MEDLINE | ID: mdl-29127341

RESUMO

Cardiovascular disease(CVD) is the leading cause of mortality among patients with type 2 diabetes mellitus(T2DM), and a risk classification model for CVD among primary care diabetic patients is pivotal for risk-based interventions and patient information. This study developed a simple tool for a 5-year CVD risk prediction for primary care Chinese patients with T2DM. A retrospective cohort study was conducted on 137,935 primary care Chinese T2DM patients aged 18-79 years without history of CVD between 1 January 2010 and 31 December 2010. New events of CVD of the cohort over a median follow up of 5 years were extracted from the medical records. A classification rule of 5-year CVD risk was obtained from the derivation cohort and validated in the validation cohort. Significant risk factors included in decision tree were age, gender, smoking status, diagnosis duration, obesity, unsatisfactory control on haemoglobin A1c and cholesterol, albuminuria and stage of chronic kidney disease, which categorized patients into five 5-year CVD risk groups(<5%; 5-9%; 10-14%; 15-19% and ≥20%). Taking the group with the lowest CVD risk, the hazard ratios varied from 1.92(1.77,2.08) to 8.46(7.75,9.24). The present prediction model performed comparable discrimination and better calibration from the plot compared to other current existing models.


Assuntos
Doenças Cardiovasculares , Árvores de Decisões , Diabetes Mellitus Tipo 2 , Atenção Primária à Saúde , Adolescente , Adulto , Idoso , Povo Asiático , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/metabolismo , Doenças Cardiovasculares/patologia , China/epidemiologia , Estudos de Coortes , Diabetes Mellitus Tipo 2/classificação , Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Mellitus Tipo 2/metabolismo , Diabetes Mellitus Tipo 2/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos de Riscos Proporcionais , Fatores de Risco
11.
N C Med J ; 77(6): 406-409, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27864490

RESUMO

Cardiovascular disease impacts everybody and places significant burdens on the health care system. Educating women on their risks and how to reduce these risks will not only make women more aware but will help to improve lives and reduce health care costs. This commentary will review heart disease in women and what women can do to improve their cardiovascular health.


Assuntos
Doenças Cardiovasculares , Efeitos Psicossociais da Doença , Serviços Preventivos de Saúde , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/economia , Doenças Cardiovasculares/epidemiologia , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Pessoal de Saúde/educação , Humanos , North Carolina , Serviços Preventivos de Saúde/métodos , Serviços Preventivos de Saúde/organização & administração , Fatores de Risco
13.
Sensors (Basel) ; 15(1): 1312-20, 2015 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-25587978

RESUMO

Each year, some 30 percent of global deaths are caused by cardiovascular diseases. This figure is worsening due to both the increasing elderly population and severe shortages of medical personnel. The development of a cardiovascular diseases classifier (CDC) for auto-diagnosis will help address solve the problem. Former CDCs did not achieve quick evaluation of cardiovascular diseases. In this letter, a new CDC to achieve speedy detection is investigated. This investigation incorporates the analytic hierarchy process (AHP)-based multiple criteria decision analysis (MCDA) to develop feature vectors using a Support Vector Machine. The MCDA facilitates the efficient assignment of appropriate weightings to potential patients, thus scaling down the number of features. Since the new CDC will only adopt the most meaningful features for discrimination between healthy persons versus cardiovascular disease patients, a speedy detection of cardiovascular diseases has been successfully implemented.


Assuntos
Doenças Cardiovasculares/classificação , Técnicas de Apoio para a Decisão , Algoritmos , Bases de Dados como Assunto , Eletrocardiografia , Humanos
14.
Inform Prim Care ; 21(2): 92-101, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24841410

RESUMO

OBJECTIVE: There is no standard method of publishing the code ranges in research using routine data. We report how code selection affects the reported prevalence and precision of results. DESIGN: We compared code ranges used to report the impact of pay-for-performance (P4P), with those specified in the P4P scheme, and those used by our informatics team to identify cases. We estimated the positive predictive values (PPV) of people with chronic conditions who were included in the study population, and compared the prevalence and blood pressure (BP) of people with hypertension (HT). SETTING: Routinely collected primary care data from the quality improvement in chronic kidney disease (QICKD-ISRCTN56023731) trial. MAIN OUTCOME MEASURES: The case study population represented roughly 85% of those in the HT P4P group (PPV = 0.842; 95%CI = 0.840-0.844; p < 0.001). We also found differences in the prevalence of stroke (PPV = 0.694; 95%CI = 0.687- 0.700) and coronary heart disease (PPV = 0.166; 95%CI = 0.162-0.170), where the paper restricted itself to myocardial infarction codes. RESULTS: We found that the long-term cardiovascular conditions and codes selected for these conditions were inconsistent with those in P4P or the QICKD trial. The prevalence of HT based on the case study codes was 10.3%, compared with 11.8% using the P4P codes; the mean BP was 138.3 mmHg (standard deviation (SD) 15.84 mmHg)/79.4 mmHg (SD 10.3 mmHg) and 137.3 mmHg (SD 15.31)/79.1 mmHg (SD 9.93 mmHg) for the case study and P4P populations, respectively (p < 0.001). CONCLUSION: The case study lacked precision, and excluded cases had a lower BP. Publishing code ranges made this comparison possible and should be mandated for publications based on routine data.


Assuntos
Doenças Cardiovasculares/classificação , Codificação Clínica/normas , Reembolso de Incentivo , Doenças Cardiovasculares/epidemiologia , Registros Eletrônicos de Saúde , Humanos , Hipertensão/classificação , Hipertensão/epidemiologia , Estudos de Casos Organizacionais , Prevalência , Melhoria de Qualidade , Qualidade da Assistência à Saúde , Projetos de Pesquisa
16.
Artif Intell Med ; 58(3): 185-93, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23768975

RESUMO

OBJECTIVE: This article addresses the problem of determining optimal sequences of tests for the clinical assessment of cardiac autonomic neuropathy (CAN). We investigate the accuracy of using only one of the recommended Ewing tests to classify CAN and the additional accuracy obtained by adding the remaining tests of the Ewing battery. This is important as not all five Ewing tests can always be applied in each situation in practice. METHODS AND MATERIAL: We used new and unique database of the diabetes screening research initiative project, which is more than ten times larger than the data set used by Ewing in his original investigation of CAN. We utilized decision trees and the optimal decision path finder (ODPF) procedure for identifying optimal sequences of tests. RESULTS: We present experimental results on the accuracy of using each one of the recommended Ewing tests to classify CAN and the additional accuracy that can be achieved by adding the remaining tests of the Ewing battery. We found the best sequences of tests for cost-function equal to the number of tests. The accuracies achieved by the initial segments of the optimal sequences for 2, 3 and 4 categories of CAN are 80.80, 91.33, 93.97 and 94.14, and respectively, 79.86, 89.29, 91.16 and 91.76, and 78.90, 86.21, 88.15 and 88.93. They show significant improvement compared to the sequence considered previously in the literature and the mathematical expectations of the accuracies of a random sequence of tests. The complete outcomes obtained for all subsets of the Ewing features are required for determining optimal sequences of tests for any cost-function with the use of the ODPF procedure. We have also found two most significant additional features that can increase the accuracy when some of the Ewing attributes cannot be obtained. CONCLUSIONS: The outcomes obtained can be used to determine the optimal sequences of tests for each individual cost-function by following the ODPF procedure. The results show that the best single Ewing test for diagnosing CAN is the deep breathing heart rate variation test. Optimal sequences found for the cost-function equal to the number of tests guarantee that the best accuracy is achieved after any number of tests and provide an improvement in comparison with the previous ordering of tests or a random sequence.


Assuntos
Doenças Cardiovasculares/diagnóstico , Técnicas de Apoio para a Decisão , Neuropatias Diabéticas/diagnóstico , Diagnóstico por Computador , Técnicas de Diagnóstico Cardiovascular , Seleção de Pacientes , Algoritmos , Pressão Sanguínea , Determinação da Pressão Arterial , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/fisiopatologia , Mineração de Dados , Bases de Dados Factuais , Árvores de Decisões , Neuropatias Diabéticas/classificação , Neuropatias Diabéticas/fisiopatologia , Eletrocardiografia , Força da Mão , Frequência Cardíaca , Humanos , Valor Preditivo dos Testes , Reprodutibilidade dos Testes , Respiração
17.
Trends Cardiovasc Med ; 23(4): 104-13, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23290365

RESUMO

Novel cancer therapies targeting tumor angiogenesis have revolutionized treatment options in a variety of tumors. Specifically, VEGF signaling pathway (VSP) inhibitors have been introduced into clinical practice at a rapid pace over the last decade. It is becoming increasingly clear that VSP inhibitors can cause cardiovascular toxicities including hypertension, thrombosis, and heart failure. This review highlights these toxicities and proposes several strategies in their prevention and treatment. However, we recognize the dearth of data in this area and advocate a multi-disciplinary approach involving cardiologists and oncologists, as well as clinical and translational studies, in understanding and treating VSP-inhibitor associated toxicities.


Assuntos
Inibidores da Angiogênese/farmacologia , Antineoplásicos/farmacologia , Doenças Cardiovasculares , Neovascularização Patológica/tratamento farmacológico , Cardiotoxinas/farmacologia , Doenças Cardiovasculares/induzido quimicamente , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/metabolismo , Doenças Cardiovasculares/prevenção & controle , Humanos , Conduta do Tratamento Medicamentoso , Neovascularização Patológica/metabolismo , Equipe de Assistência ao Paciente , Transdução de Sinais/efeitos dos fármacos , Pesquisa Translacional Biomédica , Fator A de Crescimento do Endotélio Vascular/metabolismo
18.
Prehosp Emerg Care ; 17(1): 38-45, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-22913374

RESUMO

OBJECTIVE: The purpose of this analysis was to determine whether there is an association between type of emergency medical services (EMS) medical direction and local EMS agency practices and characteristics specifically related to emergency response for acute cardiovascular events. METHODS: We surveyed 1,292 EMS agencies in nine states. For each cardiovascular prehospital procedure or practice, we compared the proportion of agencies that employed paid (full- or part-time) medical directors with the proportion of agencies that employed volunteer medical directors. We also compared the proportion of EMS agencies who reported direct interaction between emergency medical technicians (EMTs) and their medical director within the previous four weeks with the proportion of agencies who reported no direct interaction. Chi-square tests were used to assess statistical differences in proportion of agencies with a specific procedure by medical director employment status and medical director interaction. We repeated these comparisons using t-tests to evaluate mean differences in call volume. RESULTS: The EMS agencies with prehospital cardiovascular response policies were more likely to report employment of a paid medical director and less likely to report employment of a volunteer medical director. Similarly, agencies with prehospital cardiovascular response practices were more likely to report recent medical director interaction and less likely to report absence of recent medical director interaction. Mean call volumes for chest pain, cardiac arrest, and stroke were higher among agencies having paid medical directors (compared with agencies having volunteer medical directors) and agencies having recent medical director interaction (compared with agencies not having recent medical director interaction). CONCLUSIONS: Our study demonstrated that EMS agencies with a paid medical director and agencies with medical director interaction with EMTs in the previous four weeks were more likely to have prehospital cardiovascular procedures in place. Given the strong relationship that both employment status and direct interaction have with the presence of these practices, agencies with limited resources to provide a paid medical director or a medical director that can be actively involved with EMTs should be supported through partnerships and other interventions to ensure that they receive the necessary levels of medical director oversight.


Assuntos
Suporte Vital Cardíaco Avançado/estatística & dados numéricos , Doenças Cardiovasculares/terapia , Serviços Médicos de Emergência/organização & administração , Diretores Médicos/organização & administração , Doença Aguda , Benchmarking , Institutos de Cardiologia/estatística & dados numéricos , Doenças Cardiovasculares/classificação , Doenças Cardiovasculares/diagnóstico , Dor no Peito/diagnóstico , Dor no Peito/terapia , Serviços Médicos de Emergência/normas , Tratamento de Emergência/normas , Emprego/economia , Emprego/estatística & dados numéricos , Pesquisas sobre Atenção à Saúde , Parada Cardíaca/diagnóstico , Parada Cardíaca/terapia , Humanos , Relações Interprofissionais , Diretores Médicos/economia , Diretores Médicos/estatística & dados numéricos , Serviços de Saúde Rural/organização & administração , Serviços de Saúde Rural/estatística & dados numéricos , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/terapia , Fatores de Tempo , Estados Unidos , Serviços Urbanos de Saúde/organização & administração , Serviços Urbanos de Saúde/estatística & dados numéricos , Voluntários/estatística & dados numéricos , Recursos Humanos
19.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 22(3,supl.A): 31-34, jul.-set. 2012. graf
Artigo em Português | LILACS | ID: lil-682788

RESUMO

A implantação do Sistema Único de Saúde (SUS), em 1990, afirma a atenção, a universalidade, a integralidade e a equidade. Sugere a exigência de novas formas de organização do trabalho em saúde, propiciando que novas demandas eclodam, exigindo aperfeiçoamento do sistema e mudança no modelo de gestão. Cria-se o Programa Nacional de Humanização da Assistência Hospitalar, com o objetivo de promover a cultura de um atendimento humanizado na área de saúde. É inserido, nesta proposta, que o Instituto Dante Pazzanese de Cardiologia (IDPC) realiza a assistência aos portadores de doenças cardiovasculares e implanta o programa Conte Comigo, no qual o serviço social se insere com um trabalho coletivo e acolhedor com a finalidade de avaliar as atividades setoriais e intensificar sentido humano no atendimento neste instituto. Portanto, o objetivo deste artigo foi analisar a satisfação dos usuários em relação ao tempo de espera o atendimento. Por meio de pesquisa de opinião pelos usuários, os relatos de queixas se evidenciaram, nos pacientes de primeira consulta ambulatorial, que por desconhecimento do processo de atendimento, inclusive o multiprofissional, exige maior permanencia do usuário na instituição. O alcance de maior satisfação será obtido com a intensificação de informação aos usuários, no ato dos respectivos agendamentos, pelas centrais de Regulação.


The implementation of the Unified Health System (SUS) in 1990, points out the attention, university, integrality and equity. It suggests a requirement for new forms of work organization providing health that demands new horizons, requiring an improvement of the system and changes in the managements model. It creates the National Program for Humanization of Hospital Care, with the aim of promoting the culture of humanization in health. It is inserted in this proposal, the Institute Dante Pazzanese of Cardiology (IDPC) which performs assistance to patients with cardiovascular diseases and implements the program Count on Me, where social work inserts a collective work and welcoming in order to assess the sectorial activities and enhance the human sense in attending this institute. Therefore, the objective of this study was to analyze users' satisfaction in relation to the time waiting for care. Through a survey about users' opinion the reports of complaints were revealed in patients of the first outpatient visit, who were not aware and informed of the multi-professional care process, requiring them a longer stay in the institution. The range of greatest satisfaction will be achieved by supplying further information to users in the elaboration of their schedules by a central regulation.


Assuntos
Doenças Cardiovasculares/classificação , Humanização da Assistência , Serviço Social , Sistema Único de Saúde , Satisfação do Paciente , Inquéritos e Questionários
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