RESUMO
Vitiligo is a complex, systemic disease associated with many autoimmune and autoinflammatory conditions. Additionally, the cutaneous changes of vitiligo have significant effects on quality of life and self-esteem. Further efforts are needed to increase our understanding of vitiligo comorbidities as well as to increase awareness of the psychological effects of vitiligo.
Assuntos
Ansiedade/psicologia , Depressão/psicologia , Qualidade de Vida/psicologia , Vitiligo/psicologia , Alopecia em Áreas/epidemiologia , Anemia Perniciosa/epidemiologia , Ansiedade/epidemiologia , Doenças Autoimunes/epidemiologia , Doença Celíaca/epidemiologia , Comorbidade , Efeitos Psicossociais da Doença , Depressão/epidemiologia , Dermatite Atópica/epidemiologia , Diabetes Mellitus Tipo 1/epidemiologia , Otopatias/epidemiologia , Oftalmopatias/epidemiologia , Infecções por HIV/epidemiologia , Infecções por Helicobacter/epidemiologia , Humanos , Líquen Escleroso e Atrófico/epidemiologia , Psoríase/epidemiologia , Doenças Reumáticas/epidemiologia , Esclerodermia Localizada/epidemiologia , Autoimagem , Doenças da Glândula Tireoide/epidemiologia , Vitiligo/epidemiologiaRESUMO
BACKGROUND: Lack of agreement on how to accurately capture disease outcomes in localized scleroderma (LS) has hindered the development of efficacious treatment protocols. The LS Cutaneous Assessment Tool (LoSCAT), consisting of the modified LS Skin Severity Index (mLoSSI) and the LS Damage Index, has potential for use in clinical trials. OBJECTIVE: The goal of this article is to further evaluate the clinical responsiveness of the LoSCAT. Based on the modifiable nature of disease activity versus damage, we expected the mLoSSI to be responsive to change. METHODS: At 2 study visits, a physician completed the LoSCAT and Physician Global Assessment (PGA) of Disease Activity and of Disease Damage for 29 patients with LS. Spearman correlations were used to examine the relationships between the change in the LoSCAT and the PGA scores. To evaluate contrasted group validity, patients were grouped according to disease activity classification and change scores of groups were compared. Minimal clinically important differences were calculated and compared with the standard error of measurement. RESULTS: Change in the mLoSSI score correlated strongly with change in the PGA of Disease Activity score, whereas change in the LS Damage Index score correlated weakly with change in the PGA of Disease Damage score. The mLoSSI and PGA of Disease Activity exhibited contrasted group validity. Minimal clinically important differences for the activity measures were greater than the respective standard errors of measurement. LIMITATIONS: Only 2 study visits were included in analysis. CONCLUSION: This study gives further evidence that the LoSCAT, specifically the mLoSSI, is a responsive, valid measure of activity in LS and should be used in future treatment studies.