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1.
BMC Public Health ; 19(1): 77, 2019 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-30654781

RESUMO

BACKGROUND: The risk of mortgage foreclosure disproportionately burdens Hispanic/Latino populations perpetuating racial disparities in health. In this study, we examined the relationship between area-level mortgage foreclosure risk, homeownership, and the prevalence of cardiovascular disease risk factors among participants of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). METHODS: HCHS/SOL participants were age 18-74 years when recruited from four U.S. metropolitan areas. Mortgage foreclosure risk was obtained from the U.S. Department of Housing and Urban Development. Homeownership, sociodemographic factors, and cardiovascular disease risk factors were measured at baseline interview between 2008 and 2011. There were 13,856 individuals contributing to the analysis (median age 39 years old, 53% female). RESULTS: Renters in high foreclosure risk areas had a higher prevalence of hypertension and hypercholesterolemia but no association with smoking status compared to renters in low foreclosure risk areas. Renters were more likely to smoke cigarettes than homeowners. CONCLUSION: Among US Hispanic/Latinos in urban cities, area foreclosure and homeownership have implications for risk of cardiovascular disease.


Assuntos
Falência da Empresa/estatística & dados numéricos , Doenças Cardiovasculares/etnologia , Hispânico ou Latino/estatística & dados numéricos , Habitação/economia , Habitação/estatística & dados numéricos , Propriedade/estatística & dados numéricos , Adolescente , Adulto , Idoso , Cidades , Feminino , Humanos , Hipercolesterolemia/etnologia , Hipertensão/etnologia , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Fatores de Risco , Fumar/etnologia , Estados Unidos/epidemiologia , Adulto Jovem
3.
Ethn Dis ; 28(1): 49-54, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29467566

RESUMO

Objectives: To assess the prevalence of, and associated factors to, self-reported chronic diseases and health care utilization by ethnicity in the Manaus Metropolitan Region. Methods: We conducted a cross-sectional, population-based survey from May through August 2015. Using probabilistic sampling in three stages, we recruited adults aged ≥18 years. Ethnicity was self-identified as White, Black, Yellow, Brown (Brazilian mixed-race), and Indigenous. We calculated adjusted prevalence ratios (PR) and 95% CI of chronic diseases and health service utilization for each ethnic minority and compared the data using Poisson regression with data from White respondents. Results: In this study, we interviewed 4,001 people. Of these, 15.9% were White, 7.5% Black, 3.4% Yellow, 72.1% Brown, and 1.0% Indigenous. Indigenous respondents had the highest prevalence of self-reported hypertension (29.4%), diabetes (12.3%) and hypercholesterolemia (17.0%) among the ethnic respondent groups. Compared with the White population, Browns had less health insurance coverage (PR=.76; 95% CI: .62-.93) and reported hypertension (PR=.84; 95% CI: .72-0.98) and diabetes (PR=.69; 95% CI: .51-.94) less frequently. Yellows visited the doctor more frequently than Whites (PR=1.13; 95% CI: 1.04-1.22), with no significant difference in prevalence of diseases. Conclusions: Indigenous respondents had higher prevalence rates of the investigated diseases. Compared with Whites, Brown respondents had lower rates of self-reported arterial hypertension and diabetes, as well as lower rates of private health insurance coverage.


Assuntos
Diabetes Mellitus/etnologia , Etnicidade/estatística & dados numéricos , Hipercolesterolemia/etnologia , Hipertensão/etnologia , Grupos Minoritários/estatística & dados numéricos , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Adolescente , Adulto , População Negra/estatística & dados numéricos , Brasil/epidemiologia , Doença Crônica/etnologia , Estudos Transversais , Feminino , Acessibilidade aos Serviços de Saúde , Humanos , Indígenas Sul-Americanos/estatística & dados numéricos , Seguro Saúde/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Prevalência , Autorrelato , População Urbana/estatística & dados numéricos , População Branca/estatística & dados numéricos , Adulto Jovem
4.
BMC Public Health ; 18(1): 276, 2018 02 22.
Artigo em Inglês | MEDLINE | ID: mdl-29471811

RESUMO

BACKGROUND: The burden of metabolic risk factors for cardiovascular disease (CVD), such as type 2 diabetes, elevated cholesterol and hypertension, is unequally distributed across ethnic groups. Recent findings suggest an association of infectious burden (IB) and metabolic risk factors, but data from ethnic groups are scarce. Therefore, we investigated ethnic differences in IB and its association with metabolic risk factors. METHODS: We included 440 Dutch, 320 Turkish and 272 Moroccan participants, 18-70 years, of the 2004 general health survey in Amsterdam, the Netherlands. IB was defined by seropositivity to the sum of 6 infections: Herpes Simplex Virus 1 and 2; Hepatitis A, B and C; and Helicobacter pylori. Associations between IB categories 4-6 (high), 3 (intermediate) and 0-2 (low) infections and metabolic risk factors were assessed by logistic regression. Finally, we determined the contribution of IB to the association between ethnicity and the metabolic risk factors by comparing adjusted logistic regression models with and without IB categories. RESULTS: A high IB was more frequently observed among the Turkish and Moroccans than among the Dutch. After adjustment for age, sex, ethnicity, educational level, physical activity and body mass index, high IB was associated with type 2 diabetes (odds ratio high vs low IB (OR) =2.14, 95%-confidence interval (CI) 1.05-4.36). The association was weaker and not statistically significant, for elevated cholesterol (OR = 1.39, 95%-CI 0.82-2.34) and hypertension (OR = 1.49, 95%-CI 0.88-2.51). IB attenuated ethnic differences particularly for type 2 diabetes. CONCLUSIONS: Our study showed that Turkish and Moroccan adults in Amsterdam have a higher IB than Dutch adults, which was associated with the differences in type 2 diabetes. Due to the cross-sectional nature of the study, we cannot draw a conclusions with regards to the time-sequence of cause and effect. Nevertheless, the findings ask for further research into the nature of association of IB with metabolic risk factors in a longitudinal setting.


Assuntos
Doenças Cardiovasculares/etnologia , Doenças Transmissíveis/etnologia , Etnicidade/estatística & dados numéricos , Disparidades nos Níveis de Saúde , Adolescente , Adulto , Idoso , Estudos Transversais , Diabetes Mellitus Tipo 2/etnologia , Feminino , Inquéritos Epidemiológicos , Humanos , Hipercolesterolemia/etnologia , Hipertensão/etnologia , Masculino , Pessoa de Meia-Idade , Marrocos/etnologia , Países Baixos/epidemiologia , Fatores de Risco , Turquia/etnologia , Adulto Jovem
5.
Soc Sci Med ; 189: 44-52, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28780439

RESUMO

Whether minority concentration in a neighborhood exposes residents to, or protects them from, health risks has generated burgeoning scholarly interests; yet endogeneity as a result of neighborhood selection largely remains unclear in the literature. This study addresses such endogeneity and simultaneously investigates the roles of co-ethnic density and immigrant enclaves in influencing high blood pressure and high cholesterol level among Latinos, the largest minority group in the United States. Pooled cross-sectional data that included both native and foreign-born Latinos of Puerto Rican, Mexican, and other origins (N = 1563) from the 2006 and 2008 Southeastern Pennsylvania Household Health Survey were linked to census-tract profiles from the 2005-2009 American Community Survey. Results from both multilevel regression and propensity score matching analysis confirmed the deleterious effect of residential co-ethnic density on Latino adults' health risks over and above individual risk factors. We also found selection bias associated with the observed protective effect of immigrant concentration, which is likely a result of residential preference.


Assuntos
Emigrantes e Imigrantes/psicologia , Comportamentos de Risco à Saúde , Hispânico ou Latino/psicologia , Características de Residência/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Censos , Estudos Transversais , Feminino , Humanos , Hipercolesterolemia/epidemiologia , Hipercolesterolemia/etnologia , Hipertensão/epidemiologia , Hipertensão/etnologia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Grupos Minoritários , Pennsylvania/epidemiologia , Pennsylvania/etnologia , Pontuação de Propensão , Características de Residência/classificação , Inquéritos e Questionários
6.
Br J Nutr ; 116(8): 1383-1393, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27737722

RESUMO

The healthy Nordic diet has been previously shown to have health beneficial effects among subjects at risk of CVD. However, the extent of food changes needed to achieve these effects is less explored. The aim of the present study was to investigate the effects of exchanging a few commercially available, regularly consumed key food items (e.g. spread on bread, fat for cooking, cheese, bread and cereals) with improved fat quality on total cholesterol, LDL-cholesterol and inflammatory markers in a double-blind randomised, controlled trial. In total, 115 moderately hypercholesterolaemic, non-statin-treated adults (25-70 years) were randomly assigned to an experimental diet group (Ex-diet group) or control diet group (C-diet group) for 8 weeks with commercially available food items with different fatty acid composition (replacing SFA with mostly n-6 PUFA). In the Ex-diet group, serum total cholesterol (P<0·001) and LDL-cholesterol (P<0·001) were reduced after 8 weeks, compared with the C-diet group. The difference in change between the two groups at the end of the study was -9 and -11 % in total cholesterol and LDL-cholesterol, respectively. No difference in change in plasma levels of inflammatory markers (high-sensitive C-reactive protein, IL-6, soluble TNF receptor 1 and interferon-γ) was observed between the groups. In conclusion, exchanging a few regularly consumed food items with improved fat quality reduces total cholesterol, with no negative effect on levels of inflammatory markers. This shows that an exchange of a few commercially available food items was easy and manageable and led to clinically relevant cholesterol reduction, potentially affecting future CVD risk.


Assuntos
Doenças Cardiovasculares/prevenção & controle , LDL-Colesterol/sangue , Colesterol/sangue , Dieta Saudável , Ácidos Graxos Ômega-6/uso terapêutico , Alimentos Especializados , Hipercolesterolemia/dietoterapia , Adulto , Idoso , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/etnologia , Doenças Cardiovasculares/etiologia , Dieta Saudável/economia , Dieta Saudável/etnologia , Dieta Hiperlipídica/efeitos adversos , Dieta Hiperlipídica/economia , Dieta Hiperlipídica/etnologia , Método Duplo-Cego , Ácidos Graxos Ômega-6/administração & dosagem , Ácidos Graxos Ômega-6/economia , Feminino , Seguimentos , Qualidade dos Alimentos , Alimentos Especializados/economia , Humanos , Hipercolesterolemia/sangue , Hipercolesterolemia/etnologia , Hipercolesterolemia/fisiopatologia , Perda de Seguimento , Masculino , Pessoa de Meia-Idade , Noruega/epidemiologia , Pacientes Desistentes do Tratamento , Fatores de Risco , Índice de Gravidade de Doença
7.
Zhonghua Yu Fang Yi Xue Za Zhi ; 50(9): 764-768, 2016 Sep 06.
Artigo em Chinês | MEDLINE | ID: mdl-27655594

RESUMO

Objective: To analyze the burden of disease attributed to high total cholesterol(TC)in 2013 in China. Methods: We used data from the 2013 Global Burden of Disease Study. The population attributable fraction was calculated to estimate the deaths and disability-adjusted life years(DALY)attributed to high TC. Disease burden was compared by age, gender, diseases and province(not including Taiwan, China). An average world population age structure for the period 2000- 2025 was adopted to calculate age-standardized rates. Results: In 2013, high TC caused 298 952 deaths in China, accounting for 3.3% of total deaths, and caused 6 332 thousand DALYs. DALYs attributed to high TC were highest among the 50-69 years age group(3 165 thousand person years), accounting for 50.0% of the total attributed DALYs. The DALY rate in the ≥70 years age group was 2 053.3/100 000, which was 10.3 times that of 15-49 age group(198.6/100 000). DALYs among men were 4 431 thousand person years, which was 2.3 times higher than in women(1 900 thousand person years), and the age-standardized DALY rate among men was 590.6/100 000, which was 2.3 times higher than in women(257.1/100 000). DALYs attributed to high TC were mainly caused by ischemic heart disease(IHD; 5 572 thousand person years), accounting for 88.0% of the total attributed DALYs. Deaths and DALYs attributed to high TC were highest in Shandong(31 002 and 628 thousand person years for deaths and DALYs, respectively), Henan(27 398 deaths and 587 thousand person years, respectively), Hebei(25 744 deaths and 589 thousand person years, respectively), accounting for 28.1% of total attributed deaths and 28.5% of total attributed DALYs. The number of deaths and DALY were lowest in Macao(75 deaths and 1 thousand person years, respectively)and Tibet(385 deaths and 10 thousand person years, respectively). The age standardized DALY rates were highest in Beijing(794.8/100 000), Hebei(732.7/100 000), and Jilin(709.1/100 000), and lowest in Shanghai(151.4/100 000), Zhejiang(168.1/100 000), and Hong Kong(182.0/100 000). Conclusion: The burden of disease attributed to high TC in 2013 in China was mainly the result of the IHD it causes, with greater influence among males and those aged ≥50 years, and variation among provinces.


Assuntos
Colesterol , Efeitos Psicossociais da Doença , Hipercolesterolemia/mortalidade , Isquemia Miocárdica/mortalidade , Povo Asiático , China/epidemiologia , Pessoas com Deficiência , Feminino , Humanos , Hipercolesterolemia/etnologia , Masculino , Isquemia Miocárdica/etnologia , Anos de Vida Ajustados por Qualidade de Vida , Tibet
8.
J Am Heart Assoc ; 4(7)2015 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-26109505

RESUMO

BACKGROUND: We assessed high cholesterol (HC) awareness, treatment, and control rates among US Hispanic/Latino adults and describe factors associated with HC awareness and management. METHODS AND RESULTS: Baseline data (collected 2008-2011) from a multisite probability sample of Hispanic/Latino adults in the Hispanic Community Health Study/Study of Latinos (18 to 74 years old; N=16 207) were analyzed. HC was defined as low-density lipoprotein-cholesterol ≥130 mg/dL and/or total cholesterol ≥240 mg/dL or use of cholesterol-lowering medication. Among Hispanic/Latino adults with HC, almost half (49.3%) were not aware of their condition and only 29.5% were receiving treatment. Men had a higher HC prevalence than women (44.0% versus 40.5%) but a lower rate of treatment (28.1% versus 30.6%). Younger adults were significantly less likely to be HC aware compared to those who were older. Those with hypertension, diabetes, and high socioeconomic position were more likely to be HC aware. US-born Hispanic/Latino were more likely to be HC unaware than foreign-born Hispanics/Latinos, but longer US residency was significantly associated with being HC aware, treated, and controlled. Cholesterol control was achieved among 64.3% of those who were HC treated. However, younger adults, women, those with lower income, those uninsured, and more recent immigrants were less likely to be HC controlled. Individuals of Puerto Rican or Dominican background were most likely to be HC aware and treated, whereas those of Mexican or Central American background were least likely to be HC treated. Individuals of Cuban and South American background had the lowest rates of HC control, whereas Puerto Ricans had the highest. CONCLUSIONS: Understanding gaps in HC awareness, treatment, and control among US Hispanic/Latino adults can help inform physicians and policymakers to improve disease management and patient education programs.


Assuntos
Anticolesterolemiantes/uso terapêutico , Conscientização , Colesterol/sangue , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Hispânico ou Latino/psicologia , Hipercolesterolemia/tratamento farmacológico , Hipercolesterolemia/etnologia , Adolescente , Adulto , Fatores Etários , Idoso , Biomarcadores/sangue , Comorbidade , Cuba/etnologia , Feminino , Disparidades nos Níveis de Saúde , Disparidades em Assistência à Saúde/etnologia , Humanos , Hipercolesterolemia/sangue , Hipercolesterolemia/diagnóstico , Hipercolesterolemia/psicologia , Masculino , Pessoa de Meia-Idade , Educação de Pacientes como Assunto , Prevalência , Porto Rico/etnologia , Fatores de Risco , Fatores Sexuais , América do Sul/etnologia , Fatores de Tempo , Resultado do Tratamento , Estados Unidos/epidemiologia , Regulação para Cima , Adulto Jovem
9.
Clin Ther ; 35(1): 77-86, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23274145

RESUMO

BACKGROUND: A manufacturer of atorvastatin is seeking marketing approval in Korea of a generic product for adult patients with primary hypercholesterolemia. OBJECTIVE: The objective of this study was to compare the efficacy and tolerability of a new generic formulation of atorvastatin (test) with those of an original formulation of atorvastatin (reference) to satisfy regulatory requirements for marketing of the generic product in Korea. METHODS: Patients enrolled were aged 20 to 79 years with documented primary hypercholesterolemia who did not respond adequately to therapeutic lifestyle changes and with a LDL-C level >100 mg/dL from a high-risk group of coronary artery disease patients. Eligible patients were randomized to receive 1 of the 2 formulations of atorvastatin 20 mg per day for 8 weeks. The primary end point was the percent change in LDL-C level from baseline to week 8. Secondary end points included the percent change in total cholesterol, triglycerides, HDL-C level, apolipoprotein B:apolipoprotein A-I ratio, LDL:HDL ratio, LDL-C particle size, high-sensitivity C-reactive protein from baseline to week 8, and achievement rate of the LDL-C goal. RESULTS: A total of 298 patients (141 men and 157 women; 149 patients in each group; mean [SD] age, 62.4 [9.2] in the test group vs 60.3 [8.9] years in the reference group) were included. LDL-C levels were significantly decreased from baseline to week 8 in both groups, and there was no significant difference in the percent change in LDL-C level between groups (-44.0% [17.2%] in the test group, -45.4% [16.9%] in the reference group; P = 0.49). The between-group differences in the percent changes in total cholesterol and triglyceride levels were not statistically significant. In addition, there was no significant difference between the 2 groups in percent changes in HDL-C, apolipoprotein B:apolipoprotein A-I ratio, LDL-C:HDL-C ratio, LDL-C particle size, high-sensitivity C-reactive protein, and the achievement rate of the LDL-C goal. Two (1.3%) patients in the reference group (N = 150) experienced treatment-related serious adverse events (AEs): toxic hepatitis and aggravation of chest pain. Common AEs were cough (4.1%), myalgia (2.1%), and indigestion (1.4%) in the test formulation group and cough (5.3%), creatine kinase elevation (2.7%), and edema (0.7%) in the reference formulation group; however, the differences in overall prevalence of AEs between the 2 treatment groups was not significant (P = 0.88). CONCLUSIONS: There were no significant differences observed in the efficacy and tolerability between the test and reference formulations of atorvastatin in these Korean adult patients with primary hypercholesterolemia.


Assuntos
Medicamentos Genéricos/uso terapêutico , Ácidos Heptanoicos/uso terapêutico , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Hipercolesterolemia/tratamento farmacológico , Pirróis/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Apolipoproteína A-I/sangue , Apolipoproteínas B/sangue , Povo Asiático , Atorvastatina , Biomarcadores/sangue , Proteína C-Reativa/metabolismo , Química Farmacêutica , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Medicamentos Genéricos/efeitos adversos , Medicamentos Genéricos/química , Feminino , Ácidos Heptanoicos/efeitos adversos , Ácidos Heptanoicos/química , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/efeitos adversos , Inibidores de Hidroximetilglutaril-CoA Redutases/química , Hipercolesterolemia/sangue , Hipercolesterolemia/diagnóstico , Hipercolesterolemia/etnologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Pirróis/efeitos adversos , Pirróis/química , República da Coreia , Equivalência Terapêutica , Fatores de Tempo , Resultado do Tratamento , Triglicerídeos/sangue , Adulto Jovem
10.
Ethn Dis ; 22(3): 308-16, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22870574

RESUMO

OBJECTIVES: Analyze racial/ethnic disparities in the prevalence of obesity and its related diseases in Massachusetts and assess disparities in the risk of developing diseases related to overweight and obesity. DESIGN: Cross-sectional analysis of survey data. SETTING: Community-based US population. SUBJECTS: 63,235 non-institutionalized adults in Massachusetts. MAIN OUTCOME MEASURES: BMI, overweight and obesity prevalence and prevalence of obesity-related- diseases, odds of developing obesity-related diseases. Participants were considered hypercholesterolemic, diabetic, hypertensive, or having a cardiovascular disease if they reported that a health professional told them that they had such a disease. Behavioral characteristics of respondents included fruit and vegetable consumption, alcohol drinking, smoking, and physical activity. Demographic variables included sex, age, marital status, employment status, household income, region of residence, and educational status. RESULTS: Blacks (OR = 1.97) and Hispanics (OR = 1.81) had higher odds of obesity as compared to Whites. Blacks had higher odds of high blood pressure (OR = 1.88), heart attack (OR = 1.40) and stroke (OR = 2.14) than Whites. Hispanics were more likely to have high blood pressure (OR = 1.34), high cholesterol (OR = 1.56), stroke (OR = 1.71), and heart attack (OR = 1.54) than Whites. Hispanics (OR = 2.71) and Blacks (OR = 2.58) had the highest odds of diabetes. CONCLUSIONS: Minority groups share a disproportionate risk of obesity and obesity-related diseases. Hispanics and Blacks have significantly higher odds of obesity and its related diseases. Continued emphasis on racial/ethnic groups at greatest risk of obesity remains critical.


Assuntos
Negro ou Afro-Americano/estatística & dados numéricos , Disparidades nos Níveis de Saúde , Hispânico ou Latino/estatística & dados numéricos , Obesidade/complicações , Obesidade/etnologia , População Branca/estatística & dados numéricos , Adolescente , Adulto , Idoso , Análise de Variância , Sistema de Vigilância de Fator de Risco Comportamental , Índice de Massa Corporal , Estudos Transversais , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/etnologia , Feminino , Humanos , Hipercolesterolemia/complicações , Hipercolesterolemia/etnologia , Hipertensão/complicações , Hipertensão/etnologia , Masculino , Massachusetts/epidemiologia , Pessoa de Meia-Idade , Infarto do Miocárdio/complicações , Infarto do Miocárdio/etnologia , Razão de Chances , Sobrepeso/complicações , Sobrepeso/etnologia , Prevalência , Fatores de Risco , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/etnologia , Adulto Jovem
11.
Prev Chronic Dis ; 9: 110298, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22863308

RESUMO

INTRODUCTION: Diabetes, hypertension, and hypercholesterolemia are common chronic diseases among Hispanics, a group projected to comprise 30% of the US population by 2050. Mexican Americans are the largest ethnically distinct subgroup among Hispanics. We assessed the prevalence of and risk factors for undiagnosed and untreated diabetes, hypertension, and hypercholesterolemia among Mexican Americans in Cameron County, Texas. METHODS: We analyzed cross-sectional baseline data collected from 2003 to 2008 in the Cameron County Hispanic Cohort, a randomly selected, community-recruited cohort of 2,000 Mexican American adults aged 18 or older, to assess prevalence of diabetes, hypertension, and hypercholesterolemia; to assess the extent to which these diseases had been previously diagnosed based on self-report; and to determine whether participants who self-reported having these diseases were receiving treatment. We also assessed social and economic factors associated with prevalence, diagnosis, and treatment. RESULTS: Approximately 70% of participants had 1 or more of the 3 chronic diseases studied. Of these, at least half had had 1 of these 3 diagnosed, and at least half of those who had had a disease diagnosed were not being treated. Having insurance coverage was positively associated with having the 3 diseases diagnosed and treated, as were higher income and education level. CONCLUSIONS: Although having insurance coverage is associated with receiving treatment, important social and cultural barriers remain. Failure to provide widespread preventive medicine at the primary care level will have costly consequences.


Assuntos
Diabetes Mellitus/etnologia , Disparidades em Assistência à Saúde/etnologia , Hipercolesterolemia/etnologia , Hipertensão/etnologia , Americanos Mexicanos/psicologia , Adolescente , Adulto , Idoso , Estudos de Coortes , Estudos Transversais , Diabetes Mellitus/diagnóstico , Diabetes Mellitus/terapia , Feminino , Acessibilidade aos Serviços de Saúde/economia , Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Disparidades em Assistência à Saúde/estatística & dados numéricos , Humanos , Hipercolesterolemia/diagnóstico , Hipercolesterolemia/terapia , Hipertensão/diagnóstico , Hipertensão/terapia , Masculino , Pessoas sem Cobertura de Seguro de Saúde/estatística & dados numéricos , Americanos Mexicanos/estatística & dados numéricos , Pessoa de Meia-Idade , Pobreza/etnologia , Prevalência , Autorrelato , Fatores Socioeconômicos , Texas/epidemiologia
12.
Eur J Prev Cardiol ; 19(4): 781-94, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21450606

RESUMO

BACKGROUND: Treatment of hypercholesterolaemia in Asia is rarely evaluated on a large scale, and data on treatment outcome are scarce. The Pan-Asian CEPHEUS study aimed to assess low-density lipoprotein cholesterol (LDL-C) goal attainment among patients on lipid-lowering therapy. METHODS: This survey was conducted in eight Asian countries. Hypercholesterolaemic patients aged ≥18 years who had been on lipid-lowering treatment for ≥3 months (stable medication for ≥6 weeks) were recruited, and lipid concentrations were measured. Demographic and other clinically relevant information were collected, and the cardiovascular risk of each patient was determined. Definitions and criteria set by the updated 2004 National Cholesterol Education Program guidelines were applied. RESULTS: In this survey, 501 physicians enrolled 8064 patients, of whom 7281 were included in the final analysis. The mean age was 61.0 years, 44.4% were female, and 85.1% were on statin monotherapy. LDL-C goal attainment was reported in 49.1% of patients overall, including 51.2% of primary and 48.7% of secondary prevention patients, and 36.6% of patients with familial hypercholesterolaemia. The LDL-C goal was attained in 75.4% of moderate risk, 55.4% of high risk, and only 34.9% of very high-risk patients. Goal attainment was directly related to age and inversely related to cardiovascular risk and baseline LDL-C. CONCLUSION: A large proportion of Asian hypercholesterolaemic patients on lipid-lowering drugs are not at recommended LDL-C levels and remain at risk for cardiovascular disease. Given the proven efficacy of lipid-lowering drugs in the reduction of LDL-C, there is room for further optimization of treatments to maximize benefits and improve outcomes.


Assuntos
LDL-Colesterol/sangue , Hipercolesterolemia/tratamento farmacológico , Hipolipemiantes/uso terapêutico , Adulto , Ásia/epidemiologia , Povo Asiático , Biomarcadores/sangue , Doenças Cardiovasculares/etnologia , Doenças Cardiovasculares/prevenção & controle , Estudos Transversais , Regulação para Baixo , Prescrições de Medicamentos , Uso de Medicamentos , Feminino , Fidelidade a Diretrizes , Pesquisas sobre Atenção à Saúde , Humanos , Hipercolesterolemia/sangue , Hipercolesterolemia/etnologia , Modelos Lineares , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Razão de Chances , Guias de Prática Clínica como Assunto , Padrões de Prática Médica , Estudos Prospectivos , Medição de Risco , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento
13.
Br J Gen Pract ; 61(586): e262-70, 2011 May.
Artigo em Inglês | MEDLINE | ID: mdl-21619750

RESUMO

BACKGROUND: Multimorbidity is common in primary care populations. Within cardiovascular disease, important differences in disease prevalence and risk factor management by ethnicity are recognised. AIM: To examine the population burden of cardiovascular multimorbidity and the management of modifiable risk factors by ethnicity. DESIGN AND SETTING: Cross-sectional study of general practices (148/151) in the east London primary care trusts of Tower Hamlets, City and Hackney, and Newham, with a total population size of 843 720. METHOD: Using MIQUEST, patient data were extracted from five cardiovascular registers. Logistic regression analysis was used to examine the risk of being multimorbid by ethnic group, and the control of risk factors by ethnicity and burden of cardiovascular multimorbidity. RESULTS: The crude prevalence of cardiovascular multimorbidity among patients with at least one cardiovascular condition was 34%. People of non-white ethnicity are more likely to be multimorbid than groups of white ethnicity, with adjusted odds ratios of 2.04 (95% confidence interval [CI] = 1.94 to 2.15) for South Asians and 1.23 (95% CI = 1.18 to 1.29) for groups of black ethnicity. Achievement of targets for blood pressure, cholesterol, and glycated haemoglobin (HbA(1c)) was higher for patients who were multimorbid than unimorbid. For cholesterol and blood pressure, South Asian patients achieved better control than those of white and black ethnicity. For HbA(1c) levels, patients of white ethnicity had an advantage over other groups as the morbidity burden increased. CONCLUSION: The burden of multiple disease varies by ethnicity. Risk factor management improves with increasing levels of cardiovascular multimorbidity, but clinically important differences by ethnicity remain and contribute to health inequalities.


Assuntos
Doenças Cardiovasculares/etnologia , Adulto , Ásia/etnologia , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/prevenção & controle , Comorbidade , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/etnologia , Humanos , Hipercolesterolemia/epidemiologia , Hipercolesterolemia/etnologia , Hipertensão/epidemiologia , Hipertensão/etnologia , Prevalência , Fatores de Risco , Reino Unido/epidemiologia
14.
J Epidemiol Community Health ; 63(12): 1022-7, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19622520

RESUMO

BACKGROUND: Ethnic/racial inequalities in access to and quality of healthcare have been repeatedly documented in the USA. Although there is some evidence of inequalities in England, research is not so extensive. Ethnic inequalities in use of primary and secondary health services, and in outcomes of care, were examined in England. METHODS: Four waves of the Health Survey for England were analysed, a representative population survey with ethnic minority oversamples. Outcome measures included use of primary and secondary healthcare services and clinical outcomes of care (controlled, uncontrolled and undiagnosed) for three conditions - hypertension, raised cholesterol and diabetes. RESULTS: Ethnic minority respondents were not less likely to use GP services. For example, the adjusted odds ratios for Indian, Pakistani and Bangladeshi versus white respondents were 1.29 (95% confidence intervals 1.07 to 1.54), 1.32 (1.10 to 1.58) and 1.35 (1.10 to 1.65) respectively. Similarly, there were no ethnic inequalities for the clinical outcomes of care for hypertension and raised cholesterol, and, on the whole, no inequalities in outcomes of care for diabetes. There were ethnic inequalities in access to hospital services, and marked inequalities in use of dental care. CONCLUSION: Ethnic inequalities in access to healthcare and the outcomes of care for three conditions (hypertension, raised cholesterol and diabetes), for which treatment is largely provided in primary care, appear to be minimal in England. Although inequalities may exist for other conditions and other healthcare settings, particularly internationally, the implication is that ethnic inequalities in healthcare are minimal within NHS primary care.


Assuntos
Serviços de Saúde Comunitária/estatística & dados numéricos , Diabetes Mellitus/terapia , Disparidades em Assistência à Saúde , Hipercolesterolemia/terapia , Hipertensão/terapia , Avaliação de Resultados em Cuidados de Saúde , Adolescente , Adulto , Idoso , Serviços de Saúde Bucal/estatística & dados numéricos , Diabetes Mellitus/etnologia , Inglaterra/epidemiologia , Feminino , Acessibilidade aos Serviços de Saúde , Inquéritos Epidemiológicos , Hospitalização/estatística & dados numéricos , Humanos , Hipercolesterolemia/etnologia , Hipertensão/etnologia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Grupos Minoritários/estatística & dados numéricos , Análise Multivariada , Atenção Primária à Saúde/estatística & dados numéricos , Resultado do Tratamento
15.
Postgrad Med J ; 84(996): 518-23, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19017836

RESUMO

Cardiovascular disease (CVD) has become a major clinical and public health problem. South Asian countries, namely India, Pakistan, Sri Lanka, Bangladesh and Nepal, not only represent a quarter of the world's population but also contribute to the highest proportion of CVD burden when compared with any other regions globally. This population carries the increased risk even if they migrate to other countries and have increased mortality due to CVD at a younger age in comparison to the local population. In this review, the risk factors and reasons for the higher rate of CVD in South Asians are discussed.


Assuntos
Povo Asiático/etnologia , Doenças Cardiovasculares/etnologia , Efeitos Psicossociais da Doença , Diabetes Mellitus Tipo 2/etnologia , Humanos , Hipercolesterolemia/etnologia , Síndrome Metabólica/etnologia , Obesidade/etnologia , Fatores de Risco , Fumar/etnologia
17.
J Public Health (Oxf) ; 29(1): 40-7, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17071815

RESUMO

We aimed to study the relationship between the prescribing of lipid-lowering medication, social deprivation and other general practice characteristics. We conducted a cross-sectional survey of all general practices in England, 2004-05. For each practice, the following variables were obtained: standardized cost and volume data for lipid-lowering medication, descriptors of general practices, Index of Multiple Deprivation, 2004, ethnicity data from the 2001 Census and Quality and Outcomes Framework data. A regression model was constructed which explained 34.5% of the variation in statin prescribing by general practitioners. The most powerful predictors were higher social deprivation, higher prevalence of coronary heart disease and achievement of cholesterol targets for diabetics. Negative regression coefficients were demonstrated for the proportion of elderly patients in the practice and, to a lesser extent, for the proportion of south Asian and Afro-Caribbean patients. In conclusion, contrary to previous local studies, we found that statin prescribing was higher in more deprived communities, even after adjustment for increased disease prevalence and practice variables associated with deprivation. Statin prescribing was also independently associated with success at achieving cholesterol targets in established disease (secondary prevention). However, our findings suggest under-prescribing of statins to the elderly and possibly also to ethnic minorities.


Assuntos
Uso de Medicamentos/estatística & dados numéricos , Medicina de Família e Comunidade/normas , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Áreas de Pobreza , Padrões de Prática Médica/estatística & dados numéricos , Atenção Primária à Saúde/normas , Indicadores de Qualidade em Assistência à Saúde , Populações Vulneráveis/classificação , Adolescente , Adulto , Fatores Etários , Idoso , Doenças Cardiovasculares/etnologia , Doenças Cardiovasculares/prevenção & controle , Estudos Transversais , Diabetes Mellitus/etnologia , Diabetes Mellitus/prevenção & controle , Inglaterra/epidemiologia , Pesquisas sobre Atenção à Saúde , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/economia , Hipercolesterolemia/tratamento farmacológico , Hipercolesterolemia/etnologia , Modelos Lineares , Pessoa de Meia-Idade , Análise de Pequenas Áreas , Fatores Socioeconômicos , Populações Vulneráveis/etnologia
18.
Ethn Dis ; 16(2): 443-51, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-17682247

RESUMO

OBJECTIVES: To compare the effectiveness and cost effectiveness of minimal contact nutrition interventions that varied in intensity on lowering total blood cholesterol (BC) levels. DESIGN: A randomized trial in which public, work, religious, and medical sites were randomly assigned to one of six minimal-contact nutrition interventions for lowering total BC. SETTING: 36 public, work, religious, and medical sites in southern New England (total sites = 144). PARTICIPANTS: The number of eligible participants at baseline was 10,144, which included 1425 Hispanics, who were over-recruited for this study. INTERVENTION: One of six brief interventions was provided to participants: 1) feedback tip sheet only; 2) tip sheet plus Rate Your Plate (RYP); 3) tip sheet, RYP, plus Let's Eat Kit (LEK); 4) all written materials plus CD audio intervention (AUD); 5) all written materials plus counseling from a trained lay person (LAY-C); and 6) all written materials plus counseling by a nutritionist (NUT-C). The educational materials were adapted to be culturally and linguistically appropriate for a Hispanic audience, and the counselors for the Hispanic participants were bilingual. MEASURES: Total blood cholesterol levels were measured using fingerstick methods at baseline, 3 months, and 12 months after the intervention. RESULTS: Blood cholesterol (BC) was significantly reduced from baseline to 12-month follow-up among most experimental groups. Only LAY-C and NUT-C conditions demonstrated significant BC reductions at three months. The BC change in the NUT-C group was statistically different from the feedback only condition at three months only. At three-month followup, BC was reduced 1.6% for the total sample, 2.8% for participants with borderline-high BC levels, and 3.4% for participants with high BC. Generally, the two conditions receiving counseling resulted in the largest percentage changes in BC levels. When examining BC change data by ethnicity, Hispanic participants in the audio condition achieved the largest overall 12-month change (4%). Generally, total costs increased as the intensity of the experimental condition increased. When comparing 3-month and 12-month cost effectiveness, LAY-C and NUT-C were approximately the same, whereas LEK and AUD conditions tended to become more expensive than the other interventions. CONCLUSIONS: Brief nutrition counseling is an effective component of BC reduction programs. Culturally tailoring programs can result in substantial reductions in BC among Hispanic participants. Overall, even the most expensive intervention was fairly inexpensive compared to other, more intensive clinical interventions.


Assuntos
Hispânico ou Latino , Hipercolesterolemia/dietoterapia , Avaliação de Programas e Projetos de Saúde , Colesterol/análise , Colesterol/sangue , Análise Custo-Benefício , Feminino , Humanos , Hipercolesterolemia/etnologia , Masculino , Pessoa de Meia-Idade , New England
20.
J Gen Intern Med ; 17(6): 405-11, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12133153

RESUMO

OBJECTIVE: To evaluate racial and ethnic disparity in blood pressure and cholesterol measurement and to analyze factors associated with any observed disparity. DESIGN: Cross-sectional analysis of the household component of the 1996 Medical Expenditure Panel Survey. PARTICIPANTS: Representative sample of the U.S. non-institutionalized population age 21 or older. MEASUREMENTS: Prevalence of self-reported blood pressure measurement within 2 years and cholesterol measurement within 5 years were calculated by race/ethnicity. Logistic regression was used to adjust for health insurance status, having a usual source of care, health status, and socioeconomic and demographic factors. Odds ratios and 95% confidence intervals (95% CIs) from the logistic regression were converted to prevalence ratios to estimate relative risk (RR). MAIN RESULTS: Mexican Americans compared to non-Hispanic whites were less likely to have a blood pressure measurement (RR, 0.85; 95% CI, 0.81 to 0.89) or a cholesterol measurement (RR, 0.72; 95% CI, 0.65 to 0.78). Non-Hispanic blacks had blood pressure and cholesterol measurements similar to non-Hispanic whites. In a multivariate analysis, Mexican Americans had similar blood pressure measurements (RR, 0.97; 95% CI, 0.94 to 1.00) and cholesterol measurements (RR, 1.04; 95% CI, 0.99 to 1.08). The factors associated with the largest disparity were lack of health insurance, not having a usual source of care, and low education. CONCLUSIONS: No disparity was found between non-Hispanic blacks and non-Hispanic whites in undergoing blood pressure and cholesterol measurement. Disparities in cardiovascular preventive services for Mexican Americans were associated with lack of health insurance and a usual source of care, but other demographic and socioeconomic factors were also important.


Assuntos
Hipercolesterolemia/diagnóstico , Hipercolesterolemia/etnologia , Hipertensão/diagnóstico , Hipertensão/etnologia , Adulto , Idoso , Determinação da Pressão Arterial/estatística & dados numéricos , Estudos Transversais , Feminino , Nível de Saúde , Humanos , Seguro Saúde/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Análise de Regressão , Fatores Socioeconômicos
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